Drug Standards
Apexbio Technology LLC Methylprednisolone(Synonyms: Medrol, Depo-Medrol, Solu-Medrol, Advantan, Urbason, Metipred, Medrate, Metilprednisolone), 100mg, CAS: 83-43-2.
Methylprednisolone (CAS 83-43-2) is a synthetic glucocorticoid receptor agonist that exerts anti-inflammatory effects by inhibiting pro-inflammatory cytokines notably TNF- and modulating NF- B signaling pathways In vitro studies demonstrate that methylprednisolone reduces TNF production and enhances IL-10 synthesis in mouse macrophages upon LPS stimulation suppresses chemokine secretion from human peripheral blood mononuclear cells and inhibits acantholysis in skin cultures Animal models indicate that intravenous methylprednisolone administration attenuates inflammation decreases macrophage infiltration and tissue damage post-spinal cord injury Clinically methylprednisolone is investigated for therapeutic use in acute spinal cord injury severe vasculitis and lupus nephritis
Selleck Chemical LLC Gallamine Triethiodide 50mg 65-29-2
Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ¿ 8.4 ?M. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Vindesine sulfate European Pharmacopoeia (EP) Reference Standard | 59917-39-4 | MFCD01636152 |
Vindesine sulfate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 852 | 59917-39-4 | MFCD01636152 |
Sigma Aldrich Fine Chemicals Biosciences Mexiletine impurity D European Pharmacopoeia (EP) Reference Standard | 26583-71-1 |
Mexiletine impurity D European Pharmacopoeia (EP) Reference Standard | Mol Wt: 179.26 | 26583-71-1 |
Apexbio Technology LLC Cabozantinib (XL184, BMS-907351) 849217-68-1 10mM (in 1mL DMSO)
Cabozantinib (XL184 BMS-907351 CAS 849217-68-1) is a small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) notably VEGFR2 MET and RET with reported IC50 values of 0 035 nmol/L 1 3 nmol/L and 5 2 nmol/L respectively Acting by blocking downstream phosphorylation events cabozantinib disrupts RTK-mediated cell signaling pathways fundamental to cellular proliferation and differentiation In vitro studies utilizing RET-mutant TT cells showed dose-dependent inhibition of RET autophosphorylation (IC50 85 nmol/L) and reduced cellular proliferation In vivo experiments using TT-cell xenograft mouse models demonstrated tumor growth suppression and decreased serum calcitonin levels Cabozantinib serves as a valuable tool in oncology and RTK-related signaling research
Apexbio Technology LLC Cabazitaxel 183133-96-2 5mg
Cabazitaxel (CAS 183133-96-2) is a semisynthetic compound derived from the natural precursor 10-deacetylbaccatin III belonging to the taxoid class of antineoplastic agents It exerts its biological effects primarily by stabilizing microtubules thus disrupting mitotic and interphase cellular functions and causing cell-cycle arrest leading to apoptosis Due to this microtubule-targeting activity cabazitaxel is extensively studied in oncology research particularly investigating chemoresistant tumor cell lines and therapeutic approaches for taxane-resistant cancers
Medchemexpress LLC 5H-1-Benzazepin-5-one, 1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro- | 137977-97-0 | 99.9% | 328.80 | 500 MG
Tolvaptan Impurity from MedChemExpress is a chemical compound with the molecular formula C18H17ClN2O2 and a molecular weight of 328.80. It is provided as a white to off-white solid with a purity of 99.92%. This product is intended for research use only and has not been fully validated for medical applications.
- Provided as a white to off-white solid
- Purity of 99.92%
- Suitable for research applications
- Store as powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Selleck Chemical LLC Cefditoren Pivoxil 10mg 117467-28-4 ME-1207
Cefditoren Pivoxil (ME-1207) is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Fenofibrate Related Compound B United States Pharmacopeia (USP) Reference Standard | 42017-89-0 | MFCD00792461 | 25MG
Fenofibrate Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 318.75 | 42017-89-0 | MFCD00792461 | 25MG
Apexbio Technology LLC Glycopyrrolate 596-51-0 25mg
Glycopyrrolate (CAS 596-51-0) is a small molecule that acts as a competitive antagonist of muscarinic acetylcholine receptors By blocking muscarinic receptor-mediated cholinergic signaling it inhibits smooth muscle contractions and reduces secretory gland activity This pharmacological profile makes glycopyrrolate a valuable tool in studies investigating muscarinic receptor function neurotransmission and cholinergic pathways It is frequently used in research focused on gastrointestinal motility airway regulation and autonomic nervous system modulation
Sigma Aldrich Fine Chemicals Biosciences Voriconazole United States Pharmacopeia (USP) Reference Standard | 137234-62-9 | MFCD00905717 | 100MG
Voriconazole United States Pharmacopeia (USP) Reference Standard | Mol Wt: 349.31 | 137234-62-9 | MFCD00905717 | 100MG
Sigma Aldrich Fine Chemicals Biosciences forskolin United States Ph40MG
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Medchemexpress LLC Impurity C of calcitriol | 86307-44-0 | MFCD22124487 | 99.8% | C35H49N3O5 | 10MG
Impurity C of calcitriol (CAS 86307-44-0) is a characterized impurity of calcitriol used as an analytical reference standard in research and method development. Supplied as a high-purity solid, it is intended for chromatographic and spectroscopic applications; users should consult the lot-specific certificate of analysis for exact specifications.
- High purity suitable for analytical standards and reference use.
- Provided as a solid for convenient handling and storage.
- Compatible with chromatographic and spectroscopic methods.
- Useful for impurity profiling and method validation.
- Batch-specific certificate of analysis available for exact specifications.
Medchemexpress LLC Ganoderic acid A | 81907-62-2 | 516.67 | 1 ML
Ganoderic acid A can inhibit the JAK-STAT3 signaling pathway, and also inhibit proliferation, viability, and ROS. This compound is intended for research use only and not for sale to patients.
- Inhibits JAK-STAT3 signaling pathway
- Inhibits proliferation, viability, and ROS
- Cytotoxic against Bel-7402 cells with an IC50 of 7.25 μM
- Cytotoxic against HepG2 cells with a CC50 of 80 μM and IC50 of 38.7 μM
- Enhances HLA class II-mediated antigen presentation
- Promotes cisplatin-induced cell death via STAT3 suppression
- Inhibits proliferation and induces apoptosis in human osteosarcoma HOS and MG-63 cells
- High purity of 99.26%
- Soluble in DMSO and ethanol
- Shipped at room temperature
- Storage at 4°C (solid) and -80°C/-20°C (in solvent)
Medchemexpress LLC Fexofenadine (hydrochloride) | 153439-40-8 | 99.9% | 50 MG
Fexofenadine hydrochloride is an orally active and nonsedative H1 receptor antagonist. It can be used in allergic rhinitis and chronic idiopathic urticarial research. In vitro studies show that Fexofenadine inhibits IL-6 protein expression and blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts. In vivo, it suppresses eosinophilia and systemic anaphylaxis in T. spiralis-infected mice.
- Orally active H1 receptor antagonist
- Nonsedative properties
- Inhibits IL-6 protein expression in nasal fibroblasts
- Blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts
- Suppresses eosinophilia and systemic anaphylaxis in relevant animal models