Drug Standards
Medchemexpress LLC Voriconazole (Standard) | 137234-62-9 | 99.9% | C16H14F3N5O | 25 MG
Voriconazole (Standard) is the analytical standard of Voriconazole, intended for research and analytical applications. It is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis by inhibiting 14-α-lanosterol demethylation, a process mediated by fungal cytochrome P450 enzymes. This product serves as a reference standard for assay, commonly utilized in qualitative, quantitative, and methodological research experiments involving HPLC, GC, and MS.
- Analytical standard grade
- Inhibits fungal ergosterol biosynthesis
- Broad-spectrum triazole antifungal agent
- Used in HPLC, GC, and MS experiments
- For research use only
- Stable under recommended storage conditions
- Not a hazardous substance or mixture
Medchemexpress LLC Crizotinib | 877399-52-5 | 99.97% | C21H22Cl2FN5O | 1 ML
Crizotinib is an orally bioavailable, ATP-competitive inhibitor of ALK, c-Met, and ROS1. It inhibits tyrosine phosphorylation in cell-based assays and demonstrates effective tumor growth inhibition. This product is for research use only.
- Orally bioavailable ALK, c-Met, and ROS1 inhibitor
- Inhibits tyrosine phosphorylation of NPM-ALK and c-Met
- Demonstrates effective tumor growth inhibition
- Powder storage: -20°C for 3 years; 4°C for 2 years
- In-solvent storage: -80°C for 1 year; -20°C for 6 months
Medchemexpress LLC Granisetron | 109889-09-0 | 100.0% | C18H24N4O | 25 MG
Granisetron, also known by its synonym BRL 43694, is a highly effective serotonin 5-HT3 receptor antagonist. It is primarily utilized as an antiemetic, playing a crucial role in preventing and treating nausea and vomiting, particularly those induced by chemotherapy. This compound works by blocking serotonin receptors, thereby interrupting the signaling pathways that lead to emesis.
- Functions as a serotonin 5-HT3 receptor antagonist
- Used as an antiemetic
- Effective in treating nausea and vomiting following chemotherapy
- High purity of 99.95%
Selleck Chemical LLC Elacridar
Elacridar (GF120918 GW120918 GG918 GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor
Cayman Chemical HarpagosIde 10mg
An iridoid glycoside with diverse biological activities; inhibits LPS-induced increases in COX-2 and NO levels, as well as TNF mRNA expression in HepG2 cells from 50-200 µM; reduces synovial inflammation, joint destruction, and bone erosion in a mouse model of collagen-induced arthritis at 10 mg/kg; decreases substantia nigra pars compacta neuronal cell death and increases time spent on the rod in a rotarod test in a mouse model of MPTP-induced Parkinson’s disease
Medchemexpress LLC Enzalutamide | 915087-33-1 | 99.9% | C21H16F4N4O2S | 5 MG
Enzalutamide is an analytical standard used in research and analytical applications. It is identified as an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells and acts as an autophagy activator.
- Intended for research and analytical applications
- Utilized in qualitative, quantitative, and methodological research experiments
- Used as a reference standard in assays
- Androgen receptor (AR) antagonist
- Autophagy activator
- Commonly used in techniques such as HPLC, GC, and MS
Medchemexpress LLC Chitosan oligosaccharide (COS) | 148411-57-8 | 91.0% | 5 G
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.
- Activates AMPK.
- Inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.
- Possesses anti-inflammation, anti-cancer, and anti-diabetes effects.
- Interrupts cancer progression by modulating signaling proteins/pathways.
- Induces death in various cancer cell types.
- Suppresses production of proinflammatory cytokines.
- Demonstrates anti-inflammatory effect on lymphocyte activation.
- Inhibits UV-induced macroscopic appearance in mice skin, reducing signs of photoaging.
Selleck Chemical LLC Crizotinib (PF-02341066) 5mg 877399-52-5
Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Larotrectinib | 1223403-58-4 | 99.9% | 10 MG
Larotrectinib is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors. It demonstrates low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C) and exhibits 1,000-fold or greater selectivity relative to other kinases. This product is for research use only.
- Targets TrkA, TrkB, and TrkC
- Exhibits antiproliferative activity against various cell lines
- Demonstrates dose-dependent inhibition of cell proliferation
- Has low brain penetration in animal studies
- Well tolerated in GLP toxicology studies
- Reduces tyrosine phosphorylation of TRKA and downstream signal transduction in tumors
- Shows dose-dependent tumor inhibition in athymic nude mice
- Reduces leukemic infiltration in bone marrow and spleen in mice
Medchemexpress LLC Clotrimazole | 23593-75-1 | 99.91% | 344.84 | 5 G
Clotrimazole is an imidazole derivative and an antifungal compound. It acts as a CYP (cytochrome P450) inhibitor and also exhibits antibacterial activity, making it suitable for studying fungal infections such as vaginal yeast infections, oral thrush, and ringworm.
- Antifungal properties
- CYP (cytochrome P450) inhibitor
- Antibacterial activity
- Useful for research into fungal infections
Medchemexpress LLC Meropenem trihydrate (Standard) | 119478-56-7 | 100.0% | 437.51 | 50 MG
Meropenem trihydrate (Standard) | 119478-56-7 | 100.0% | 437.51 | 50 MG
U.S. Pharmacopeia L-Tyrosine, 60-18-4, MFCD00002606, 500mg
Molecular formula C9H11NO3, Molecular weight 181.19, Melting Point 647.6 - 651.2 °F (342 - 344 °C) (decomposes), Synonyms: Tyrosine, p-Tyrosine, 4-Hydroxy-L-phenylalanine
U.S. Pharmacopeia Isomalt | 64519-82-0 | MFCD00190708 | 200 mg
Isomalt | Mol Wt: 688.621 | 64519-82-0 | MFCD00190708 | 200 mg
Sigma Aldrich Fine Chemicals Biosciences Riboflavin 5′-phosphate sodium salt hydrate | MFCD00150992 | 25g
Riboflavin 5′-phosphate sodium salt hydratePurity: | MW: 478.33 | MFCD00150992 | 25g
Selleck Chemical LLC Osimertinib (AZD9291) 5mg 1421373-65-0
Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.