Drug Standards
Medchemexpress LLC Ibiglustat (succinate) | 1629063-80-4 | 99.7% | 507.57 | 50 MG
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. It can be utilized for research related to Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
- Orally active.
- Brain-penetrant glucosylceramide synthase (GCS) inhibitor.
- Can be used for research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
Medchemexpress LLC Diclofenac ethyl ester | 15307-77-4 | 99.3% | 100 MG
Diclofenac ethyl ester is a prodrug of Diclofenac, designed for enhanced delivery. It is encapsulated in polymer micelles in vitro and released with prolonged circulation time and reduced drug concentrations in the heart and kidneys in vivo.
- Prodrug of Diclofenac
- Encapsulated in polymer micelles
- Prolonged circulation time
- Reduced drug concentrations in heart and kidneys
Medchemexpress LLC Sulfamerazine | 127-79-7 | 99.8% | 1 G
Sulfamerazine (RP-2632) is a sulfonamide antibacterial, identified as the monomethyl derivative of sulfadiazine (2-sulfanilamido-4-methylpyrimidine). It acts as a bacteriostatic agent by inhibiting bacterial synthesis of dihydrofolic acid, competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes, which ultimately reduces the synthesis of bacterial nucleotides and DNA.
- Appearance: Solid
- Color: White to off-white
- Molecular weight: 264.30
- Formula: C11H12N4O2S
- Solubility in DMSO: ≥ 100 mg/mL (378.36 mM)
- Solubility in H2O: < 0.1 mg/mL (insoluble)
Medchemexpress LLC Fluticasone propionate | 80474-14-2 | 99.9% | 5 MG
Fluticasone propionate is a potent topical anti-inflammatory corticosteroid and a selective glucocorticoid receptor agonist with an absolute affinity (KD) of 0.5 nM. It exhibits minimal or no activity at other steroid receptors and also possesses anti-viral activity.
- Potent topical anti-inflammatory corticosteroid.
- Selective glucocorticoid receptor agonist with a KD of 0.5 nM.
- Exhibits minimal or no activity at other steroid receptors.
- Possesses anti-viral activity.
- Has an EC50 of 0.7 nM for transactivation activity at glucocorticoid receptor in HepG2 cells.
- Shows an ED50 of 3 μg for anti-inflammatory activity in neutrophils.
- Achieves an IC50 of 0.1 nM for inhibition of TNFalpha release in PBMC.
- Demonstrates an EC50 of 1.09 nM for agonist activity at GR in SW1353 cells.
- Inhibits TNFα-induced E-selectin expression with an IC50 of 1 nM.
Medchemexpress LLC Citalopram (hydrobromide) | 59729-32-7 | 99.9% | 50 MG
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) that can cross the blood-brain barrier. It inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM and inhibits 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM, demonstrating an antidepressant effect.
- It is a selective serotonin reuptake inhibitor.
- It exhibits blood-brain barrier permeability.
- It inhibits 5-HT uptake into synaptosomes.
- It inhibits 5-HT uptake in rabbit blood platelets.
- It has an antidepressant effect.
Medchemexpress LLC Carboprost tromethamine | 58551-69-2 | 99.9% | C25H47NO8 | 25 MG
Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F2α. It effectively promotes uterine contraction and significantly reduces bleeding during and after delivery. It is for research use only and not sold to patients. It has been reported to be 84-96% successful in treating persistent hemorrhage due to uterine atony.
- Synthetic 15-methyl analogue of prostaglandin F2α
- Effectively promotes uterine contraction
- Significantly reduces bleeding during and after delivery
- Intended for research purposes only
- 84-96% successful in treating persistent hemorrhage due to uterine atony
Medchemexpress LLC (R,1R)-Tenofovir amibufenamide | 1571076-37-3 | 98.9% | 490.49 | 1 MG
(R,1R)-Tenofovir amibufenamide is a drug intermediate that can be used for purifying a tenofovir prodrug. Tenofovir is a nucleoside acid reverse transcriptase inhibitor. It appears as a white to off-white solid and is for research use only.
- Can be used for purifying a tenofovir prodrug
- Appears as a white to off-white solid
- For research use only
Medchemexpress LLC (3S,4S)-Tofacitinib | 1092578-47-6 | MFCD11035920 | 99.8% | 312.37 g/mol | C16H20N6O | 10 MG
(3S,4S)-Tofacitinib is the S-enantiomer of the JAK inhibitor tofacitinib and is provided as a research reference compound for biochemical and cellular studies. It is reported to be less active than the clinical racemate and is characterized by CAS 1092578-47-6, formula C16H20N6O, and molecular weight 312.37 g/mol.
- Enantiomeric reference for JAK signaling studies.
- High purity (99.75%) suitable for analytical and biochemical assays.
- Molecular formula C16H20N6O and molecular weight 312.37 g/mol.
- Supplied as a 10 mg research quantity.
- Useful as a reference standard for selectivity and potency comparisons.
Apexbio Technology LLC Gonadorelin Acetate 71447-49-9 10mg
Gonadorelin Acetate is a synthetic peptide agonist targeting gonadotropin-releasing hormone (GnRH) receptors It is designed to bind specifically to GnRH receptors on pituitary gonadotrophs thereby modulating secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) Gonadorelin Acetate exerts its biological activity primarily through receptor-mediated regulation of the reproductive hormone axis Based on these pharmacological properties Gonadorelin Acetate holds research potential in studies of reproductive hormone signaling pathways endocrine regulation associated with infertility disorders and characterization of gonadotropin responses in cellular or animal models
Medchemexpress LLC Tofacitinib impurity 3 | 1616761-00-2 | 99.84% | C₁₆H₁₉ClN₆O | 5 MG
Tofacitinib impurity 3 is an impurity of Tofacitinib, primarily used as a laboratory chemical and for the manufacture of substances.
- Suitable for laboratory use.
- Used in the manufacture of substances.
- Store sealed at 4°C, away from moisture.
- Stable in solvent at -80°C for 6 months, or -20°C for 1 month.
- Can be shipped at room temperature if less than 2 weeks.
Medchemexpress LLC Pinaverium impurity 1 | 54370-00-2 | MFCD02093896 | 247.09 | C9H11BrO3 | 5 G
Pinaverium impurity 1 is a characterized impurity of the L-type calcium channel blocker pinaverium, supplied for research and analytical use as a drug intermediate and reference material. It is intended for laboratory method development and impurity profiling and is not for human or clinical use.
- Chemical identification: CAS 54370-00-2.
- Chemical formula: C9H11BrO3.
- Molecular weight: 247.09.
- Intended use: research and analytical applications.
- Pack quantity: 5 G.
- Storage: follow conditions in the certificate of analysis.
Medchemexpress LLC Benzoic-1,2,3,4,5,6-13C6 acid, 4-hydroxy-, butyl ester | 1416711-53-9 | 99.8% | 500 UG
Butylparaben-13C6 is the 13C labeled Butylparaben. Butylparaben is an organic compound that has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food. This compound is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC Racecadotril 81110-73-8 1g
Racecadotril (CAS 81110-73-8) also known as acetorphan is a small molecule inhibitor of enkephalinase an enzyme responsible for the degradation of endogenous enkephalins By inhibiting enkephalinase with an IC50 of 4 5 M racecadotril increases the availability of enkephalins thereby modulating the activity of enkephalinergic pathways This mechanism is of interest in studies investigating the regulation of opioid-mediated physiological processes including analgesia and intestinal secretion Racecadotril is widely utilized in biomedical research focused on peptide degradation and the pharmacological modulation of endogenous opioid systems
Medchemexpress LLC Afatinib impurity 33 | 2475094-87-0 | 10mg
Afatinib impurity 33 is an impurity of Afatinib (HY-10261)