Acetylides
Medchemexpress LLC Propargyl-PEG5-NHS ester | 1393330-40-9 | 98.0% | 1 G
Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker primarily used in the synthesis of PROTACs. It also functions as a cleavable ADC linker, crucial for synthesizing antibody-drug conjugates (ADCs).
- Functions as a cleavable ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Click chemistry reagent
- Contains an alkyne group
- Engages in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Propargyl-PEG4-CH2COOH | 1429934-37-1 | ≥97.0% | 290.31 | 1 G
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This compound is a colorless to light yellow liquid.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent with an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules
- Appearance: colorless to light yellow liquid
- Molecular formula: C13H22O7
Medchemexpress LLC Propargyl-PEG3-OCH2-Boc | 888010-02-4 | 302.36 | 250 MG
Propargyl-PEG3-OCH2-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent containing an alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
- Utilizes two different ligands connected by a linker; one ligand for an E3 ubiquitin ligase and another for the target protein
- Employs the intracellular ubiquitin-proteasome system to selectively degrade target proteins
STA Pharmaceutical 2'-propargyl G(iBu) amidite | 1 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 30 mL Glass (20-400)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 47.3 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
Medchemexpress LLC Propargyl-PEG5-acid | 1245823-51-1 | 98.0% | 304.34 g/mol | C14H24O7 | 1 G
Propargyl-PEG5-acid is a polyethylene glycol-based linker with a terminal propargyl (alkyne) group and a terminal carboxylic acid. It is used as a non-cleavable PEG spacer in bioconjugation, including antibody-drug conjugate and PROTAC synthesis, and as a reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition.
- Terminal carboxylic acid allows amide bond formation with primary amines.
- Five-unit PEG spacer improves solubility and reduces steric hindrance.
- High purity (98.0%) suitable for bioconjugation.
- Applicable to ADC, PROTAC, and general linker development workflows.
Medchemexpress LLC Propargyl-PEG7-acid | 2093154-00-6 | ≥98.0% | 1 G
Propargyl-PEG7-acid is a PEG-based PROTAC linker and a cleavable ADC linker, making it valuable for synthesizing PROTACs and antibody-drug conjugates. It also functions as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Used in the synthesis of PROTACs
- Cleavable ADC linker
- Utilized in the synthesis of antibody-drug conjugates (ADCs)
- Functions as a click chemistry reagent
- Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition
Medchemexpress LLC Propargyl-peg1-acid | 55683-37-9 | 97.0% | 250 MG
Propargyl-PEG1-acid is a PEG-based PROTAC linker. It is utilized in the synthesis of BTK-CRBN PROTACs and functions as a click chemistry reagent. This product incorporates an Alkyne group which can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Utilized in the synthesis of BTK-CRBN PROTACs
- Functions as a click chemistry reagent
- Incorporates an Alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Propargyl-PEG3-bromide | 203740-63-0 | 97.7% | 251.12 | 5 G
Propargyl-PEG3-bromide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound functions as a click chemistry reagent, containing an Alkyne group that can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- PEG-based PROTAC linker for synthesizing PROTACs.
- Functions as a click chemistry reagent.
- Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc).
- Facilitates selective degradation of target proteins via the ubiquitin-proteasome system.
Medchemexpress LLC Propargyl-PEG3-OCH2-Boc | 888010-02-4 | 302.36 | 25 MG
Propargyl-PEG3-OCH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Used in the synthesis of PROTACs
- For research use only
Medchemexpress LLC 2-((Benzo[d]thiazol-2-ylmethyl)thio)-4,5,6,7-tetrahydro-8H-cyclopenta[d]triazolo[1,5-a]pyrimidin-8 | 3112403-98-9 | 99.9% | 355.44 | 25 MG
WS-917 is a potent and orally active ABCB1 modulator that enhances ABCB1 ATPase activity. It significantly enhances the antitumor effect of paclitaxel when combined with an anti-PD-1 antibody, and also promotes CD8+ T-cell activation. This product is for research use only and has not been fully validated for medical applications.
- Potent and orally active ABCB1 modulator
- Enhances ABCB1 ATPase activity
- Significantly enhances antitumor effect of paclitaxel combined with anti-PD-1 antibody
- Promotes CD8+ T-cell activation
Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | MFCD28950778 | >98.0% | 348.39 | C16H28O8 | 1 G
Propargyl-PEG6-acid is a polyethylene glycol (PEG6) linker bearing a terminal propargyl (alkyne) group and a carboxylic acid functional handle, used for click chemistry conjugation such as copper-catalyzed azide-alkyne cycloaddition (CuAAC) in ADC, PROTAC, and bioconjugation workflows.
- Terminal alkyne functional handle for CuAAC click reactions.
- Carboxylic acid group enables amide coupling and further derivatization.
- PEG6 spacer imparts hydrophilicity and flexible linker properties.
- Molecular weight approximately 348.39, suitable for small-molecule linker applications.
- Available in common laboratory quantities for synthesis and conjugation workflows.
Medchemexpress LLC Propargyl-PEG12-OH 250mg | 1036204-61-1 | 584.69 | C27H52O13 | 250 MG
Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs Propargyl-PEG12-OH is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Accela Chembio Inc MF: C10H8O2 | MW: 160.17 | >97% | Flash Point: 92? | BP: 239.4? at 760 mmHg.
MF: C10H8O2 | MW: 160.17 | >97% | Flash Point: 92? | BP: 239.4? at 760 mmHg.