Acetylides
Medchemexpress LLC Propargyl-peg8-nh2 | 1196732-52-1 | ≥98.0% | 407.50 | C19H37NO8 | 25 MG
Propargyl-PEG8-NH2 is a polyethylene glycol (PEG) based bifunctional linker bearing a terminal propargyl (alkyne) group and a primary amine. It is used for bioconjugation and as a non-cleavable linker in ADC and PROTAC synthesis, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) and amine-based coupling reactions.
- Contains terminal alkyne (propargyl) and primary amine functional groups.
- PEG8 spacer provides flexibility and solubility for conjugates.
- Suitable for CuAAC click chemistry with azide-containing partners.
- High purity (≥98.0%) for research and conjugation workflows.
- Molecular weight approximately 407.50 Da and formula C19H37NO8.
- Available in multiple package sizes to suit synthesis scale.
Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 25 G
Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 has demonstrated BTK degradation with a DC50 of 200 nM in THP-1 cells. This compound also serves as a click chemistry reagent, featuring an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of BTK-IAP PROTACs
- Functions as a click chemistry reagent
- Possesses an Alkyne group for copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules
- Demonstrates BTK degradation in THP-1 cells
- Intended for research use only
Medchemexpress LLC E -Pent-2-enal 25g
(E)-Pent-2-enal has a pungent fruity odor This compound is commonly used in the flavor and fragrance industry because of its strong aroma often described as fresh and green Furthermore (E)-Pent-2-enal can be used as an intermediate in the synthesis of various organic compounds including pharmaceuticals and agrochemicals Its unique chemical properties make it an important ingredient in many commercial products including perfumes air fresheners and cleaners
eMolecules Chem-Impex Trimethylsilylacetylene 1kg 112760621 24539 0 000 1066-54-2 MFCD00008569 98 220 C5H10Si
Chem-Impex Trimethylsilylacetylene 1kg 112760621 24539 0 000 1066-54-2 MFCD00008569 98 220 C5H10Si
eMolecules Combi-Blocks (Bicyclo[1 1 1]pent-1-yl)methanol 100mg 388722070 QJ-7542 98 000 22287-32-7 MFCD28040494 98 145 C6H10O
Combi-Blocks (Bicyclo[1 1 1]pent-1-yl)methanol 100mg 388722070 QJ-7542 98 000 22287-32-7 MFCD28040494 98 145 C6H10O
Medchemexpress LLC Boc-Propargylamine | 92136-39-5 | 99.5% | C8H13NO2 | 25 G
Boc-Propargylamine is a biochemical reagent suitable for use as a biological material or organic compound in life science research. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Used to prepare triazolobenzylidene-thiazolopyrimidines, which act as CDC25 phosphatase inhibitors.
- Used for the synthesis of beta-glucan polysaccharide analogs.
- Involved in the Pauson-Kh reaction of norbornadiene and N-Boc-propargylamine to prepare 4,5-dissubstituted cyclopentenones.
eMolecules 5-Chloro-2-(trifluoromethoxy)phenol | 1092461-24-9 | MFCD11519363 | 1g
Apollo Scientific | 5-Chloro-2-(trifluoromethoxy)phenol | 1g | 562454745 | PC302760 | 97.000 | 1092461-24-9 | MFCD11519363 | 212.550 | C7H4ClF3O2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC Propargyl-PEG24-amine | 98.0% | 1112.34 | 25 MG
Propargyl-PEG24-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Peg-based protac linker
- Used in the synthesis of protacs
- Click chemistry reagent
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC N-(Propargyl-PEG4)-biocytin | 2055042-71-0 | 98.0% | C28H46N4O9S | 250 MG
N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs consist of two different ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other the protein of interest, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Supports targeted protein degradation
Chem-Impex International, Inc. 4-Ethynylaniline | MFCD00168824 | 5G
4-Ethynylaniline, MFCD00168824, 5G
Medchemexpress LLC Propargyl-PEG1-bromide | 18668-74-1 | MFCD00099299 | 98.0% | 163.01 | C5H7BrO | 1 G
Propargyl-PEG1-bromide is an alkyne-functionalized short polyethylene glycol (PEG) linker bearing a terminal bromide. It is used in bioconjugation and medicinal chemistry to introduce a clickable propargyl handle while providing a reactive leaving group for further substitution, enabling efficient incorporation of a short PEG spacer into synthetic linkers and small-molecule constructs.
- Provides an alkyne (propargyl) handle for click chemistry.
- Contains a terminal bromide for nucleophilic substitution reactions.
- Short PEG1 spacer improves solubility and minimizes steric hindrance.
- Molecular weight ~163.01 g/mol for predictable stoichiometry.
- Suitable for linker synthesis, bioconjugation, and small-molecule modification.
Medchemexpress LLC Propargyl-PEG3-NHS ester | 1428629-71-3 | MFCD23726610 | 97.0% | 313.30 g/mol | C14H19NO7 | 100 MG
Propargyl-PEG3-NHS ester is an NHS-activated PEG3 linker bearing a terminal propargyl (alkyne) group used for bioconjugation and linker synthesis. It couples to primary amines to form amide bonds and enables click chemistry via CuAAC.
- Reactive NHS ester for selective coupling to primary amines.
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Three-unit PEG spacer improves solubility and flexibility.
- High purity (97.0% by NMR) suitable for research applications.
- Soluble in DMSO; store under nitrogen at -20°C for stability.
Medchemexpress LLC Fmoc-amino-PEG3-CH2COOH | 139338-72-0 | 99.8% | 429.46 | 500 MG
Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are molecules containing two different ligands connected by a linker. One ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | ≥98.0% | 407.50 g/mol | C19H37NO8 | 250 MG
Propargyl-PEG8-NH2 is a PEG-based linker reagent containing a terminal propargyl (alkyne) group and a terminal primary amine for conjugation. It is used in proteolysis targeting chimera (PROTAC) and antibody-drug conjugate (ADC) linker synthesis, and as a click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Contains a terminal propargyl alkyne group for copper-catalyzed azide-alkyne cycloaddition.
- Provides a terminal primary amine (NH2) for amide coupling or conjugation.
- High purity suitable for synthetic applications and linker assembly.
- Available in small-scale quantities suitable for research use.
- Stable when stored under recommended conditions to preserve reactivity.