Hydrobromides
Medchemexpress LLC Nan-190 (hydrobromide) | 115338-32-4 | 99.1% | 474.39 | 5 MG
NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist and a selective antagonist of 5-HT1A. This compound is intended for research use only.
- Serotonin receptor 5-HT antagonist
- Selective antagonist of 5-HT1A
- Targets 5-HT1A receptor and 5-HT1 receptor
- Involved in GPCR/G protein and neuronal signaling pathways
- Reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats
Medchemexpress LLC Burixafor hydrobromide | 1191450-19-7 | 98.0% | 769.01 | 500 MG
Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. It inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood.
- Can be used for research on autologous hematopoietic stem cell transplantation (ASCT).
- Potent CXCR4 antagonist.
- Inhibits CXCL12 binding to CXCR4.
- Blocks Gαᵢ-mediated inhibitory effect on cAMP signal transduction.
- Mobilizes CD34+ hematopoietic stem/progenitor cells.
Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 25 MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist.
- Suppresses p53 protein transcription
- Prevents glucose oxidase (GOX)-induced p53 protein increase, Bcl-2 protein reduction, and Bax increase
- Inhibits p53-dependent apoptosis
- Acts as a potent AhR agonist, activating reporter activity, and up-regulating the AhR target gene CYP1A1
- Reduces the percentage of annexin V-positive Foxe3-/- SMCs
- Significantly reduces the incidence of aortic rupture and intramural hematomas
- Normalizes aortic diameter and TUNEL-positive cells in surviving Foxe3-/- animals
Medchemexpress LLC Fatostatin hydrobromide (125B11 hydrobromide) | 298197-04-3 | 99.5% | C18H19BrN2S | 200 MG
Fatostatin hydrobromide (125B11 hydrobromide) is a specific inhibitor of SREBP activation that impairs the activation of SREBP-1 and SREBP-2. It binds to SCAP (SREBP cleavage-activating protein) and inhibits the ER-Golgi translocation of SREBPs.
- Impairs the activation of SREBP-1 and SREBP-2
- Binds to SCAP (SREBP cleavage-activating protein)
- Inhibits ER-Golgi translocation of SREBPs
- Decreases transcription of lipogenic genes in cells
- Possesses antitumor properties
- Lowers hyperglycemia in ob/ob mice
- For research use only
Apexbio Technology LLC TC-E 5003 17328-16-4 50mg
TC-E 5003 (CAS 17328-16-4) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) exhibiting an IC50 of 1 5 M1 PRMT1 a member of the PRMT family mediates post-translational arginine methylation and is implicated in regulating diverse cellular processes Aberrant PRMT1 activity has been associated with a range of malignancies making it of interest for oncology research In cellular studies TC-E 5003 has been shown to inhibit proliferation and induce apoptosis in MCF7a breast cancer and LNCaP prostate cancer cell lines as well as attenuate androgen-induced gene expression in LNCaP cells This compound serves as a useful tool for investigating PRMT1 function and its role in cancer biology
Medchemexpress LLC Pifithrin-β hydrobromide | 511296-88-1 | 99.9% | 349.29 | 1 ML
Pifithrin-β hydrobromide is a potent p53 inhibitor with an IC50 of 23 μM. It is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α, an inhibitor of the p53 protein, is unstable in culture medium and quickly converts to pifithrin-β. Studies show that pretreatments with 1 and 10 μM pifithrin-β can exert neuroprotective effects after 24 hours.
- Potent p53 inhibitor with an IC50 of 23 μM.
- Regarded as a lead compound for cancer and neurodegenerative disease therapy.
- Exerts neuroprotective effects.
Medchemexpress LLC MTSEA hydrobromide | 16599-33-0 | 97.9% | 50 MG
MTSEA hydrobromide is a sulfhydryl-reactive reagent used to modify free cysteine residues in proteins, introducing a positively charged side chain approximately the size of lysine. The hydrobromide salt is supplied as a solid and is used in biochemical assays and site-directed cysteine modification to probe protein structure and function.
- Sulfhydryl-reactive reagent for cysteine modification.
- Introduces a positively charged side chain similar in size to lysine.
- Suitable for biochemical assays and site-directed mutagenesis studies.
- Soluble in water and common organic solvents such as DMSO.
- High purity suitable for research applications.
eMolecules 542-11-0 | Aniline hydrobromide | Oakwood Chemicals | MFCD00035465 | 174.041 | C6H8BrN | 98.000 | Br.Nc1ccccc1 | 1g | 480148775
Aniline hydrobromide | Oakwood Chemicals | 542-11-0 | MFCD00035465 | 174.041 | C6H8BrN | 98.000 | Br.Nc1ccccc1 | 1g | 480148775
![Medchemexpress LLC Piperidine, 4-[2-[(4-methylphenyl)thio]phenyl]-, hydrobromide | 960151-65-9 | 99.8% | 364.34 g/mol | C18H22BrNS | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000249020.png-250.jpg)
Medchemexpress LLC Piperidine, 4-[2-[(4-methylphenyl)thio]phenyl]-, hydrobromide | 960151-65-9 | 99.8% | 364.34 g/mol | C18H22BrNS | 1 ML
Tedatioxetine hydrobromide is the hydrobromide salt of tedatioxetine, a serotonin- and norepinephrine-preferring triple reuptake inhibitor that also antagonizes 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors. It is supplied for research use as a solid and as a 10 mM solution in DMSO, intended for in vitro transporter and receptor pharmacology studies.
- High purity (99.83%) suitable for research applications.
- Supplied as solid and as a 10 mM solution in DMSO (1 mL).
- Suitable for transporter and receptor pharmacology assays.
- Molecular formula C18H22BrNS; molecular weight 364.34 g/mol.
- Store sealed, away from moisture; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC CPTH6 hydrobromide 10mg | 2321332-57-2 | 386.74 g/mol | C15H17BrClN3S | 10 MG
CPTH6 hydrobromide is the hydrobromide salt of a thiazole-derived small molecule used to study histone acetylation, apoptosis, and autophagy in cancer cell models. It is supplied as a white to off-white solid with high reported purity and good solubility in polar solvents.
- Inhibits histone acetyltransferase activity, reported for Gcn5 and pCAF.
- Induces apoptotic and autophagic features in leukemia cell lines.
- Supplied as a hydrobromide salt for improved handling and solubility.
- High purity suitable for research applications (≥99.0%).
- Soluble in DMSO (≈66.67 mg/mL) for in vitro assays.
- Store sealed at -20°C; in solution, store at -80°C for long-term stability.
Medchemexpress LLC SCH-202676 hydrobromide | 265980-25-4 | 96.8% | 348.26 g·mol⁻¹ | C15H14BrN3S | 5 MG
SCH-202676 hydrobromide is a small-molecule allosteric modulator of G protein-coupled receptors and adenosine receptors with reported antiviral activity, including inhibition of 3CLpro. The compound is supplied for research use in solid and solution forms and is intended for biochemical and pharmacological studies.
- Allosteric modulator of GPCRs and adenosine receptors.
- Reported antiviral activity; inhibits 3CLpro with low-micromolar potency.
- Available as solid and 10 mM solution in DMSO.
- High purity (96.81%).
- Molecular formula C15H14BrN3S; molecular weight 348.26 g·mol⁻¹.
- Store at -20°C long term; in solvent store at -80°C for extended stability.
eMolecules 2403-33-0 | 2-BROMOPROPYLAMINE HBR | MFCD22055759 | 1g
AstaTech | 34-DIMETHOXY-2-METHYLBENZOIC ACID | 0.25g | 256638766 | 31432 | 95.000 | 5722-94-1 | MFCD09701444 | 196.202 | C10H12O4
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Medchemexpress LLC Vortioxetine hydrobromide | 960203-27-4 | MFCD22383961 | C18H23BrN2S | 50 MG
Vortioxetine hydrobromide is a multimodal serotonergic agent exhibiting antidepressant and anxiolytic potential. It functions as an antagonist of 5-HT3A and 5-HT7 receptors, an inhibitor of the 5-hydroxytryptamine transporter (SERT), a 5-HT1A agonist, and a partial 5-HT1B agonist. Research indicates its ability to increase cell proliferation and survival in the dentate gyrus of the hippocampus.
- Antagonizes 5-HT3A and 5-HT7 receptors
- Inhibits 5-hydroxytryptamine transporter (SERT)
- Acts as a 5-HT1A receptor agonist
- Functions as a partial 5-HT1B receptor agonist
- Demonstrates antidepressant and anxiolytic properties
- Increases cell proliferation and survival in the hippocampus
- Does not cause cognitive or psychomotor impairment
eMolecules 62595-74-8 | 3-Bromopiperidine-2,6-dione | AA Blocks LLC | MFCD11053059 | 192.012 | C5H6BrNO2 | 0.000 | BrC1CCC(=O)NC1=O | 25g | 560591993
3-Bromopiperidine-2,6-dione | AA Blocks LLC | 62595-74-8 | MFCD11053059 | 192.012 | C5H6BrNO2 | 0.000 | BrC1CCC(=O)NC1=O | 25g | 560591993
Medchemexpress LLC Remodelin hydrobromide | 1622921-15-6 | 99.6% | 363.28 | 1 ML
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10, which inhibits NAT10 activity and slows DNA replication.
- Suppresses the growth of prostate cancer cells.
- Inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft models.
- Enhances the healthspan in a Hutchinson-Gilford progeria syndrome (HGPS) mouse model.