Hydrobromides
Apexbio Technology LLC A 61603 hydrobromide 107756-30-9 10mg
A 61603 hydrobromide (CAS 107756-30-9) is a potent and highly selective agonist of the 1A-adrenergic receptor one of the 1-adrenergic receptor subtypes involved in cellular growth and proliferation Compared to its activity at 1B- and 1D-adrenergic receptors A 61603 demonstrates approximately 35-fold higher potency for 1A-AR In cellular assays it robustly induces phosphoinositide hydrolysis in 1A-AR-expressing fibroblasts (pEC50 8 24) and in neonatal rat cardiomyocytes it increases calcium transient frequency in a dose-dependent manner (EC50 6 9 nM) In vascular models A 61603 markedly elevates perfusion pressure demonstrating significantly greater efficacy than noradrenaline This compound serves as a valuable tool for delineating 1A-AR-mediated signaling and vascular regulation
Medchemexpress LLC Vortioxetine (hydrobromide) | 960203-27-4 | C18H23BrN2S | 1 G
Vortioxetine hydrobromide (Lu AA 21004) is a multimodal serotonergic agent that acts as an antagonist of 5-HT3A (Ki: 3.7 nM) and 5-HT7 (Ki: 19 nM) receptors. It also inhibits the 5-hydroxytryptamine transporter (SERT) with a Ki of 1.6 nM. Furthermore, it functions as a 5-HT1A agonist (Ki: 15 nM) and a partial 5-HT1B agonist (Ki: 33 nM), exhibiting potent inhibition of SERT.
- Antagonist of 5-HT3A and 5-HT7 receptors
- Inhibitor of 5-hydroxytryptamine transporter (SERT)
- Acts as a 5-HT1A agonist
- Functions as a partial 5-HT1B agonist
- High purity of 99.87%
- Light yellow to yellow solid appearance
TARGETMOL CHEMICALS INC TC-E 5003 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 uM. Purity 97.01%
Medchemexpress LLC Darifenacin hydrobromide | 133099-07-7 | 99.8% | C28H31BrN2O2 | 5 MG
Darifenacin hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist. It is used in the study of urinary incontinence and other symptoms of overactive bladder, and has demonstrated anti-tumor effects by inhibiting tumor growth in colorectal cancer cells. In vitro, it inhibits Kv currents and the phosphorylation of p38, ERK1/2, and Akt. In vivo studies showed antitumor effects in xenograft mouse models and decreased afferent activity in rat bladders.
- Selective and orally active M3 muscarinic receptor antagonist
- Used in the study of urinary incontinence and overactive bladder symptoms
- Exhibits anti-tumor effects in colorectal cancer cells
- Inhibits Kv currents in coronary arterial smooth muscle cells
- Decreases afferent activity of bladder Aδ and C fibers in female rats
Apexbio Technology LLC NAN-190 hydrobromide 115338-32-4 10mg
NAN-190 hydrobromide (CAS 115338-32-4) is a selective antagonist of the serotonin 5-HT1A receptor functioning by inhibiting receptor-mediated signal transduction pathways In receptor binding assays NAN-190 hydrobromide demonstrates high affinity for 5-HT1A receptors and modulates neurotransmitter release This compound is frequently employed in neurobiology and psychiatric disorder studies to investigate 5-HT1A-related mechanisms serving as a valuable tool for elucidating serotonergic signaling and its implications in neural function and pathology
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 50 MG
Eletriptan hydrobromide (Eletriptan HBr) is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, with Ki values of 0.92 nM and 3.14 nM, respectively. It is for research use only and not sold to patients.
- 5-HT1B and 5-HT1D receptor agonist
- Antimigraine activity
Medchemexpress LLC Arecoline | 63-75-2 | 50 MG
Arecoline is a naturally occurring, brain-penetrant, and orally active psychoactive alkaloid. It acts as a partial agonist of both nicotinic and muscarinic acetylcholine receptors. It has been observed to induce stimulation, alertness, anxiolysis, and anti-parasitic effects, and can also induce oxidative stress.
- Naturally brain-penetrant and orally active psychoactive alkaloid.
- Partial agonist of nicotinic and muscarinic acetylcholine receptors.
- Exhibits stimulation, alertness, anxiolysis, and anti-parasitic effects.
- High purity: 99.84%.
Apexbio Technology LLC Arecoline hydrobromide 300-08-3 1g
Arecoline hydrobromide (CAS 300-08-3) is a nicotinic alkaloid that acts as a partial agonist at muscarinic acetylcholine receptors M1 M4 In electrophysiological studies it significantly inhibits the hERG potassium channel current with an IC50 of 9 55 mol/L The compound s inhibitory effect on IhERG displays concentration time and voltage dependency with blockade intensity influenced by stimulation frequency Subcutaneous administration in mice yields an LD50 of 100 mg/kg Arecoline hydrobromide is utilized in research on cardiac electrophysiology and muscarinic receptor pharmacology particularly for investigating frequency- and state-dependent modulation of cardiac ion channels
Medchemexpress LLC CPTH6 hydrobromide 10mg | 2321332-57-2 | 386.74 g/mol | C15H17BrClN3S | 10 MG
CPTH6 hydrobromide is the hydrobromide salt of a thiazole-derived small molecule used to study histone acetylation, apoptosis, and autophagy in cancer cell models. It is supplied as a white to off-white solid with high reported purity and good solubility in polar solvents.
- Inhibits histone acetyltransferase activity, reported for Gcn5 and pCAF.
- Induces apoptotic and autophagic features in leukemia cell lines.
- Supplied as a hydrobromide salt for improved handling and solubility.
- High purity suitable for research applications (≥99.0%).
- Soluble in DMSO (≈66.67 mg/mL) for in vitro assays.
- Store sealed at -20°C; in solution, store at -80°C for long-term stability.
Medchemexpress LLC Guvacoline hydrobrom 5mg | 17210-51-4 | 222.08 g/mol | C7H12BrNO2 | 5 MG
Guvacoline hydrobromide is the hydrobromide salt of guvacoline, a pyridine alkaloid that acts as a weak full agonist of atrial and ileal muscarinic acetylcholine receptors (mAChR). It is supplied as a solid reagent intended for biochemical and pharmacological research applications.
- Hydrobromide salt form suitable for laboratory handling
- CAS number 17210-51-4
- Molecular formula C7H12BrNO2; molecular weight 222.08 g/mol
- Purity 96.09% as verified by certificate of analysis
- Used as a pharmacological tool for muscarinic receptor studies