Hydrochlorides
Medchemexpress LLC GSK-LSD1 dihydrochloride | 2102933-95-7 | 99.5% | 289.24 | C14H22Cl2N2 | 10 MG
GSK-LSD1 dihydrochloride is a potent, selective, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with an IC50 of 16 nM. Provided as a solid for research use, the compound has been used in cellular studies to modulate gene expression, induce autophagy markers, and inhibit proliferation in various cancer cell lines. Handle and store according to safety data sheet recommendations.
Medchemexpress LLC Ly-272015 hydrochloride | 172895-15-7 | MFCD00933882 | 99.5% | 372.89 g/mol | C21H25ClN2O2 | 10 MG
LY-272015 hydrochloride is the hydrochloride salt of LY-272015, a selective, orally active 5-HT2B receptor antagonist. It blocks 5-HT or BW723C86-induced ERK2 phosphorylation and has demonstrated antihypertensive activity in DOCA-salt hypertensive rat models. Supplied as a high-purity off-white to light-yellow solid for research use.
- Selective 5-HT2B receptor antagonist.
- Orally active compound suitable for in vivo studies.
- Inhibits 5-HT or BW723C86-induced ERK2 phosphorylation.
- Demonstrated antihypertensive effects in DOCA-salt hypertensive rats.
- High reported purity (99.5%).
- Soluble in DMSO at 5 mg/mL with ultrasonic assistance.
![Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244527.png-250.jpg)
Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML
VU 0365114 is a selective muscarinic acetylcholine receptor (mAChR) M5 positive allosteric modulator used in research to probe M5 receptor pharmacology and β-cell insulin secretion. It displays an EC50 of 2.7 μM at M5 and EC50 >30 μM at M1-M4, enabling selective modulation of M5-mediated responses.
- Selective positive allosteric modulation of mAChR M5.
- EC50 2.7 μM at M5 and EC50 >30 μM at M1-M4, indicating high selectivity.
- Enhances acetylcholine-stimulated insulin secretion in human β-cells.
- Available as solid or as a 10 mM solution in DMSO for flexible application.
- High purity suitable for biochemical and cellular assays.
Medchemexpress LLC Azaphen dihydrochloride monohydrate | 63302-99-8 | 99.9% | C16H23Cl2N5O2 | 500 MG
Azaphen dihydrochloride monohydrate, also known as Pipofezine or Azafen, is a potent inhibitor of serotonin reuptake. It functions as a tricyclic antidepressant (TCA) and is approved in Russia for the treatment of depression.
- Potent inhibitor of serotonin reuptake
- Acts as a tricyclic antidepressant
- Used for the treatment of depression
Medchemexpress LLC (S)-1-(4-bromo-6-pyrimidinyl)-N-(2,4-dichlorobenzyl)-2-(pyrrolidin-1-yl)ethan-1-amine hydrochloride | 885104-09-6 | 99.9% | 438.58 g·mol⁻¹ | C15H16BrCl3N4 | 50 MG
LY2389575 hydrochloride is the hydrochloride salt of a small-molecule negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), intended for preclinical research. It is supplied as a solid powder with high purity and defined storage conditions for long-term stability.
- Negative allosteric modulator of mGlu3 for preclinical research
- High purity (99.9%) suitable for analytical and biological assays
- Solid powder form for convenient handling and formulation
- Defined storage stability: powder -20°C up to 3 years or 4°C up to 2 years
- Molecular weight 438.58 g·mol⁻¹ and formula C15H16BrCl3N4
Medchemexpress LLC 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]- | 1246086-78-1 | C18H13Cl2N3O3S | 1 ML
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It demonstrates positive allosteric modulation of the human mGlu4 receptor, expressed in CHO cells, by potentiating glutamate-induced calcium mobilization. While showing better stability in human liver microsomes (HLM) with 63% remaining than rat liver microsomes (RLM) with 2% remaining, its pharmacokinetic properties are less than ideal, limiting its direct use as an in vivo tool.
- Acts as a mGlu4 positive allosteric modulator
- Has an EC50 of 19.8 nM
- Potentiates glutamate-induced calcium mobilization in human mGlu4 receptor
- Exhibits better stability in HLM (63% remaining) than RLM (2% remaining)
Medchemexpress LLC Tirofiban (hydrochloride monohydrate) | 150915-40-5 | MFCD07368623 | 99.9% | 495.07 g/mol | C22H39ClN2O6S | 10 MG
Tirofiban hydrochloride monohydrate is the hydrochloride monohydrate salt of tirofiban, a selective and reversible platelet integrin (Gp IIb/IIIa) antagonist supplied for research and analytical applications. It inhibits fibrinogen binding to the Gp IIb/IIIa receptor and is provided as a high-purity solid suitable for in vitro studies.
- Selective, reversible Gp IIb/IIIa antagonist suitable for platelet research.
- Inhibits fibrinogen binding to the Gp IIb/IIIa receptor.
- High purity (≈99.9%) for reproducible experimental results.
- Available in small laboratory quantities for analytical and preparative use.
- Supplied as a stable hydrochloride monohydrate salt for consistent handling.
Apexbio Technology LLC RS 127445 HCl 199864-87-4 10mM (in 1mL DMSO)
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Medchemexpress LLC SB-258585 hydrochloride | 1216468-02-8 | 99.7% | 523.82 g/mol | C18H23ClIN3O3S | 10 MG
SB-258585 hydrochloride is a research compound used as a high-affinity ligand and antagonist for the serotonin 5-HT6 receptor (CAS 1216468-02-8). Supplied as the hydrochloride salt, it has molecular formula C18H23ClIN3O3S, molecular weight 523.82 g/mol, and is provided for in vitro and ex vivo pharmacological and receptor-binding studies.
- High-affinity antagonist of the serotonin 5-HT6 receptor.
- High reported purity, suitable for analytical and biological assays.
- Appropriate for radioligand binding and receptor labeling studies.
- Supplied in small-mass research quantities for laboratory use.
- Molecular weight 523.82 g/mol and defined molecular formula.
Medchemexpress LLC TG 100572 hydrochloride | 867331-64-4 | MFCD18251422 | 98.8% | 512.43 g/mol | C26H27Cl2N5O2 | 50 MG
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor supplied as a hydrochloride salt for laboratory research. It inhibits several receptor tyrosine kinases and Src family kinases and is used in vitro to study signaling pathways and kinase-dependent cellular processes. Offered in multiple pack sizes with high listed purity for biochemical and cell-based studies.
- Multi-targeted kinase inhibition profile (VEGFR, FGFR, PDGFR, Src family).
- High listed purity suitable for in vitro assays.
- Available in small pack sizes and solution format for flexibility.
- Compatible with biochemical and cell-based assay workflows.
- For research use only; not for human or veterinary use.
Medchemexpress LLC Bestatin hydrochloride (Ubenimex hydrochloride) | 65391-42-6 | MFCD00058004 | 99.9% | 100 MG
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research. Bestatin hydrochloride is also known to have several biological activities, including:
- Inhibitor of CD13 (aminopeptidase N)/APN and leukotriene A4 hydrolase
- Enhances ATRA-induced differentiation in ATRA-sensitive APL NB4 cells
- Inhibits ATRA-driven phosphorylation of p38 MAPK
- Slows cell cycle progression in D. discoideum
- Inhibits mitosis and inherent multinuclearity in D. discoideum
- Reduces CD13 expression in diabetic mice
- Inhibits MMP-9 specific gelationolytic band densities in diabetic mice
- Inhibits VEGF and heparanase expression in diabetic mice
- Increases splenocytes producing hemolytic anti-SRBC antibodies (at 0.1 mg/kg)
Medchemexpress LLC Lycorine Hydrochloride Monohydrate | 6150-58-9 | 99.2% | 341.79 | 100 MG
Lycorine Hydrochloride Monohydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
- Biochemical reagent.
- Can be used as a biological material.
- Can be used as an organic compound for life science related research.
Medchemexpress LLC GSK-LSD1 dihydrochloride | 2102933-95-7 | 99.5% | 289.24 g/mol | C14H22Cl2N2 | 1 ML
GSK-LSD1 dihydrochloride is a potent, selective, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1) with an IC50 of 16 nM. It is intended for research use to probe LSD1 function, study gene expression changes, and evaluate effects on cancer cell proliferation. Supplied as a high-purity solid or as a solution in DMSO.
Medchemexpress LLC 4-amino-3-phenylbutanoic acid hydrochloride | 3060-41-1 | 98.0% | 215.68 | C10H14ClNO2 | 5 G
Phenibut hydrochloride is the hydrochloride salt of β-phenyl-GABA, an orally active GABAB receptor agonist used as a research reagent with anxiolytic and cognition-enhancing effects. Supplied as a high-purity powder for laboratory research and pharmacology studies.
- Orally active GABAB receptor agonist used in pharmacology research.
- Anxiolytic and nootropic effects relevant to central nervous system studies.
- High purity suitable for analytical and experimental use.
- Molecular weight 215.68 g/mol and chemical formula C10H14ClNO2.
- Available in multiple pack sizes including 5 g.
Medchemexpress LLC N-(1,3-diphenylpyrazol-5-yl)-4-nitrobenzamide | 890764-36-0 | MFCD12546140 | 99.6% | 384.39 g/mol | C22H16N4O3 | 10 MG
VU-29 is a research-stage positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5), used in preclinical pharmacology to selectively potentiate mGlu5 signaling. It is supplied as a powder with high chemical purity and is intended for in vitro and in vivo formulation following recommended solvent systems and storage conditions.
- Positive allosteric modulator of mGlu5 receptor, suitable for receptor pharmacology studies.
- High purity (99.6%) for reliable experimental results.
- Powder form for flexible dosing and formulation.
- Soluble in DMSO at 50 mg/mL; recommended vehicle progression for in vivo administration.
- Stable under recommended storage conditions for extended shelf life in powder form.