Hydrochlorides
Medchemexpress LLC Icotinib hydrochloride | 1204313-51-8 | C22H22ClN3O4 | 25 MG
Icotinib hydrochloride is a potent and specific EGFR inhibitor that is CNS-penetrant. It is effective against wild-type and various mutant EGFR forms, including EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound also functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Potent and specific EGFR inhibitor
- CNS-penetrant
- Inhibits mutant EGFR forms: EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
- Click chemistry reagent with an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
eMolecules 4781-83-3 | 2-Iminothiolane HCl salt | Broadpharm | MFCD00216010 | 101.170 | C4H7NS | 97.000 | N=C1CCCS1 | 500mg | 686681063
2-Iminothiolane HCl salt | Broadpharm | 4781-83-3 | MFCD00216010 | 101.170 | C4H7NS | 97.000 | N=C1CCCS1 | 500mg | 686681063
TARGETMOL CHEMICALS INC Anabasine 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. (±) Anabasine is a muscle relaxant that can be used for muscle relaxation during surgery.
![Medchemexpress LLC 6-(4-(4-methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride | 2459963-17-6 | MFCD32633583 | 99.2% | 334.85 g/mol | C14H11ClN4S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000308312.png-250.jpg)
Medchemexpress LLC 6-(4-(4-methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride | 2459963-17-6 | MFCD32633583 | 99.2% | 334.85 g/mol | C14H11ClN4S2 | 10 MG
TP0427736 hydrochloride is a research-grade small-molecule ALK5 (TGF-β receptor I) inhibitor supplied as the hydrochloride salt. The compound is provided as a high-purity solid intended for in vitro biochemical and cellular studies, with documented solubility in water and DMSO and recommended cold storage for long-term stability.
- High purity suitable for research assays.
- Hydrochloride salt form improves aqueous and DMSO solubility.
- Documented solubility values aid experimental planning.
- Stable when stored as powder at recommended cold temperatures.
- Appropriate for pathway, target validation, and pharmacology studies.
Medchemexpress LLC OTSSP167 hydrochloride | 1431698-10-0 | 99.78% | 523.88 | 50 MG
OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive MELK inhibitor with an IC50 value of 0.41 nM. For research use only, this product is not sold to patients. It inhibits the growth of various cancer cell lines including lung (A549), breast (T47D, DU4475), prostate (22Rv1), and bladder (HT1197) with IC50 values ranging from 2.3 to 97 nM. OTSSP167 can also abrogate the mitotic checkpoint and disrupt MCC and MCC-APC/C interaction in MCF7 cells.
- Highly potent and ATP-competitive MELK inhibitor.
- Exhibits strong in vitro activity with an IC50 of 0.41 nM.
- Inhibits the growth of multiple cancer cell lines (lung, breast, prostate, bladder).
- Can abrogate the mitotic checkpoint and disrupt MCC/MCC-APC/C interaction.
- Causes GFP-MELK localization to the cell cortex in prometaphase cells.
- Results in tumor growth inhibition in xenograft mouse models.
Apexbio Technology LLC Dapoxetine HCl 129938-20-1 10mM (in 1mL DMSO)
Dapoxetine hydrochloride (CAS 129938-20-1) is a short-acting selective serotonin reuptake inhibitor (SSRI) It exerts its pharmacological effect by inhibiting the reuptake of serotonin (5-HT) at the presynaptic membrane thereby increasing serotonin activity in the synaptic cleft This modulation of serotonergic neurotransmission has been shown to delay ejaculation latency making dapoxetine hydrochloride an established model compound for investigating serotonergic regulation of ejaculatory control It is widely used in research on the neurobiology and therapeutic approaches to premature ejaculation and related disorders
Apexbio Technology LLC Terbinafine HCl 78628-80-5 10mM (in 1mL DMSO)
Terbinafine hydrochloride (CAS 78628-80-5) is a small-molecule inhibitor targeting squalene epoxidase It is designed to selectively inhibit this key enzyme within the fungal sterol biosynthesis pathway thereby disrupting cell membrane integrity Terbinafine hydrochloride exerts its biological activity primarily through non-competitive inhibition of squalene epoxidase In experimental studies Terbinafine hydrochloride demonstrates potent antifungal activity with reported IC50 values against fungal squalene epoxidase in the nanomolar range Based on these pharmacological properties Terbinafine hydrochloride holds research potential in antifungal drug mechanism studies fungal sterol metabolism and therapeutic strategies against fungal pathogens in experimental models
Medchemexpress LLC Nifenalol hydrochloride | 5704-60-9 | 99.9% | 260.72 g/mol | C11H17ClN2O3 | 1 ML
Nifenalol hydrochloride is a β-adrenergic receptor antagonist used in cardiovascular and cardiac electrophysiology research. The product is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) and is accompanied by standard documentation for handling and quality verification.
- β-adrenergic receptor antagonist for cardiac research.
- High purity suitable for research applications.
- Supplied as a 10 mM solution in DMSO, 1 mL volume.
- White to off-white solid appearance when provided as a solid.
- Includes data sheet, COA, and SDS for safety and compliance.
- Storage recommendations provided for solid and solution forms.
Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.9% | 1088.21 | 25 MG
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively, and induces apoptosis.
- Antagonist of inhibitor of apoptosis proteins (IAPs)
- Binds to BIR3 domains of cIAP1, cIAP2, and XIAP
- Induces apoptosis
- Inhibits cell viability in H1975 NSCLC cells in cooperation with IFNγ or viral double-stranded RNA (dsRNA)
- Downregulates cIAP-1, activates RIPK1, and triggers activation of extrinsic and intrinsic apoptosis pathways in H1975 NSCLC cells
- Involves in apoptosis in HCC827 NSCLC cells due to induction of cell death and active caspase-3/8 activities by AZD5582 and IFNγ co-treatment
- Causes degradation of cIAP1 and caspase 3 cleavage in tumor cells in MDA-MB-231 xenograft-bearing mice
Medchemexpress LLC GW405833 hydrochloride | 1202865-22-2 | 99.6% | 483.82 | 25 MG
GW405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB2) agonist with EC50 and Ki values of 0.65 nM and 3.92 nM for CB2, and 16.1 μM and 4772 nM for CB1. It also acts as a non-competitive CB1 antagonist, achieving its analgesic effect through a CB1 receptor-dependent mechanism. It significantly inhibits the production of cAMP stimulated by Forskolin and inhibits glycolysis by down-regulating HIF-1α, thereby alleviating acute liver failure (ALF). This compound exhibits low-efficacy agonism in spleen membranes and reverse agonist effects in hCB2-CHO cells. It inhibits proliferation of hepatic macrophages, reduces TNF-α and IL-1β expressions, and protects against cell death in ALF models.
- Potent and selective CB2 agonist
- Non-competitive CB1 antagonist
- Inhibits cAMP production
- Alleviates acute liver failure by down-regulating HIF-1α
- Reduces TNF-α and IL-1β expressions
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 10 MM * 1 ML
RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It exhibits 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites. This product is intended for research use only.
- Selective and high affinity 5-HT2B receptor antagonist.
- Exhibits 1000-fold selectivity for the 5-HT2B receptor.
- Orally bioavailable.
- Potently displaces [3H]-5-HT from human recombinant 5-HT2B receptors.
- Blocks 5-HT-evoked increases in intracellular calcium.
- Antagonizes 5-HT-evoked formation of inositol phosphates.
- Dose-dependently reduces faecal output in rats.
Medchemexpress LLC UAMC-3203 hydrochloride | 2271358-65-5 | 98.1% | 508.12 | 100 MG
UAMC-3203 hydrochloride is a potent and selective ferroptosis inhibitor with an IC50 of 12 nM. It is for research use only and not sold to patients.
- No toxicity observed in mice after repeated injections.
- Available in solid and solution forms.
- Ships at room temperature in continental US.
- Store at 4°C, sealed, away from moisture and light.
- When in solvent, store at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture and light.
Medchemexpress LLC Procaine hydrochloride | 51-05-8 | 99.8% | 25 MG
Procaine hydrochloride (Standard) is the analytical standard of Procaine (hydrochloride), intended for research and analytical applications. It functions as a DNA-demethylating agent, acting through multiple targets with a slow onset and short duration of action. As an analytical grade compound, it serves as a reference standard and is commonly utilized in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- It is the analytical standard of procaine (hydrochloride).
- The product is intended for research and analytical applications.
- It is a DNA-demethylating agent.
- It acts through multiple targets.
- It has a slow onset and a short duration of action.
- It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Medchemexpress LLC O-Ethylhydroxylamine-d5 hydrochloride | 118087-07-3 | 99.7% | 102.57 | 5 MG
O-Ethylhydroxylamine-d5 (hydrochloride) is a deuterium-labeled form of O-Ethylhydroxylamine hydrochloride. It serves as a valuable tool for research, functioning as a tracer and an internal standard in quantitative analysis methods such as NMR, GC-MS, or LC-MS. The incorporation of stable heavy isotopes, like deuterium, into drug molecules is a growing area of study, primarily utilized for quantitative analysis during the drug development process. Deuteration specifically holds promise for modifying the pharmacokinetic and metabolic profiles of pharmaceutical compounds.
- Used as a tracer for quantitative analysis.
- Functions as an internal standard in analytical techniques.
- Suitable for NMR, GC-MS, and LC-MS applications.
- Contains stable heavy isotopes for research in drug development.
- Potential to affect pharmacokinetic and metabolic profiles of drugs.