Hydrochlorides
Medchemexpress LLC CP-100356 hydrochloride | 142715-48-8 | MFCD00911858 | 99.1% | 597.10 g·mol⁻1 | C31H37ClN4O6 | 100 MG
CP-100356 hydrochloride is a research-grade P-glycoprotein (MDR1) and BCRP inhibitor provided as the monohydrochloride salt for in vitro and preclinical studies. It is used to inhibit efflux transporters in cell-based assays to improve intracellular exposure and to evaluate transporter-mediated clearance. The compound is supplied as a solid powder and is available in small pack sizes suitable for screening and experimental use.
- Research-grade P-gp and BCRP inhibitor for cellular assays.
- Provided as the monohydrochloride salt in solid powder form.
- High reported purity suitable for biochemical and cell-based studies.
- Molecular weight 597.10 g·mol⁻1 and formula C31H37ClN4O6.
- Available in small pack sizes and solution formats for flexible use.
Apexbio Technology LLC Dapoxetine HCl 129938-20-1 50mg
Dapoxetine hydrochloride (CAS 129938-20-1) is a short-acting selective serotonin reuptake inhibitor (SSRI) It exerts its pharmacological effect by inhibiting the reuptake of serotonin (5-HT) at the presynaptic membrane thereby increasing serotonin activity in the synaptic cleft This modulation of serotonergic neurotransmission has been shown to delay ejaculation latency making dapoxetine hydrochloride an established model compound for investigating serotonergic regulation of ejaculatory control It is widely used in research on the neurobiology and therapeutic approaches to premature ejaculation and related disorders
Medchemexpress LLC VU 0240551 | 893990-34-6 | 99.7% | 342.44 | 100 MG
VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) that is selective versus NKCC1. It also inhibits hERG and L-type Ca2+ channels, making it a valuable tool in neuroscience research. This compound attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential, and enhances P cell synaptic transmission.
- Potent neuronal K-Cl cotransporter KCC2 inhibitor
- Selective inhibition over NKCC1
- Inhibits hERG and L-type Ca2+ channels
- Attenuates GABA-induced hyperpolarization of P cells
- Enhances P cell synaptic transmission
Medchemexpress LLC N-desmethyl venlafaxine hydrochloride | 93413-90-2 | MFCD18711349 | 99.9% | C16H26ClNO2 | 10MG
Wy-45494 hydrochloride (N-desmethyl venlafaxine hydrochloride) is the hydrochloride salt of a minor active metabolite of the SNRI venlafaxine. It is supplied as an analytical standard for research, quality control, and method development in chromatographic and mass spectrometry applications.
- High purity: 99.85% (analytical standard).
- Suitable for HPLC, GC, and MS method development and quantitation.
- Hydrochloride salt form provides enhanced solubility and stability.
- Chemical formula C16H26ClNO2 and molecular weight ~299.84 g/mol.
- Intended for research use only; not for human or veterinary use.
Medchemexpress LLC ARC 239 dihydrochloride | 55974-42-0 | 99.2% | 50 MG
ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist. It binds to CHO cell membranes expressing human recombinant α2A-, α2B-, or α2C-adrenoceptor subtypes. It has pKd values of 5.95, 7.41, and 7.56 at α2A, α2B, and α2C receptors respectively, and pKi values of 5.6, 8.4, and 7.08 for α2A-, α2B- or α2C-adrenoceptor subtypes respectively.
- Selective α2B/2C adrenoceptor antagonist.
- High purity of 99.2%.
- Available in various pack sizes.
Medchemexpress LLC Procaine (hydrochloride) | 51-05-8 | 97.9% | 1 G
Procaine hydrochloride is a DNA-demethylating agent for research use only, acting through multiple targets with a slow onset and short duration of action. In laboratory settings, it inhibits 5-HT3 receptor-mediated inward current and decreases 5-methylcytosine DNA content. It can also demethylate highly hypermethylated CpG islands, suppress cancer cell growth by inducing mitotic arrest, stimulate limbic system cells, and modify synaptic transmission in amygdala output pathways.
- Inhibits 5-HT3 receptor-mediated inward current
- Decreases 5-methylcytosine DNA content
- Demethylates highly hypermethylated CpG islands
- Suppresses cancer cell growth by inducing mitotic arrest
- Stimulates limbic system cells
- Modifies synaptic transmission in amygdala output pathways
Medchemexpress LLC Tirofiban hydrochloride monohydrate | 150915-40-5 | 99.9% | 495.07 | 50 MG
Tirofiban hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and possesses antithrombotic activity. It induces proliferation and migration of endothelial cells by stimulating VEGF production, and can significantly reduce myocardial no-reflow and ischemia-reperfusion injury.
- Inhibits fibrinogen binding to platelet integrin receptor (Gp IIb/IIIa).
- Possesses antithrombotic activity.
- Induces proliferation and migration of endothelial cells.
- Reduces myocardial no-reflow and ischemia-reperfusion injury.
- Increases contraction force and improves heart function in rats.
- Demonstrates anticoagulant effect after microvascular anastomosis.
Medchemexpress LLC Mln120b dihydrochloride | 1782573-78-7 | C19H17Cl3N4O2 | 50 MG
MLN120B dihydrochloride is a potent, orally active IKKβ inhibitor (IC50 60 nM) that inhibits multiple myeloma cell growth in vitro and in vivo. It is also used for rheumatoid arthritis research. In vitro, it blocks IκB phosphorylation/degradation and TNF-a-induced p65 NF-κB phosphorylation, reducing proliferation in various multiple myeloma cell lines. In vivo, oral administration reduces tumor growth markers and protects against bone and cartilage destruction in rheumatoid arthritis models.
- Potent, ATP competitive, orally active IKKβ inhibitor.
- Inhibits IκB phosphorylation and degradation.
- Blocks TNF-a-induced p65 NF-κB phosphorylation.
- Reduces proliferation of multiple myeloma cells.
- Inhibits IL-6 secretion from BMSCs.
- Protects against bone and cartilage destruction in rheumatoid arthritis models.
- Prolongs survival in treated animals.
Medchemexpress LLC Amastatin hydrochlor 1mg | 100938-10-1 | 511.01 g/mol | C21H39ClN4O8 | 1 MG
Amastatin hydrochloride is a research-grade, slow, tight-binding competitive inhibitor of aminopeptidases, used in enzymology and biochemical assays to probe aminopeptidase activity. It is supplied as the hydrochloride salt and is provided in small quantities for laboratory research.
- Inhibits multiple aminopeptidases with low-nanomolar Ki values.
- Suitable for enzymology and biochemical research applications.
- Provided as hydrochloride salt for improved handling and solubility.
- High purity (98.0%).
- Molecular weight 511.01 g/mol.
- Available in small pack sizes (1 mg, 5 mg, 10 mg, 50 mg).
Medchemexpress LLC Tirofiban | 144494-65-5 | 440.60 | 5 MG
Tirofiban is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist. It inhibits fibrinogen binding to this receptor, providing antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cells by stimulating VEGF production. It can significantly reduce myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.
- Selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist
- Inhibits fibrinogen binding
- Provides antithrombotic activity
- Induces endothelial cell proliferation and migration
- Stimulates vascular endothelial growth factor (VEGF) production
- Reduces myocardial no-reflow
- Alleviates myocardial microvascular structural and endothelial dysfunction
- Targets integrin
- Affects cytoskeleton pathway
Medchemexpress LLC Piperoxan hydrochloride | 135-87-5 | MFCD00079224 | 99.7% | 269.77 | C14H20ClNO2 | 5 MG
Piperoxan hydrochloride is a small-molecule research reagent described as an α2 adrenoceptor antagonist and a first-generation antihistamine. Supplied as the hydrochloride salt (CAS 135-87-5), it is used in pharmacology and receptor-binding studies to probe adrenergic and histaminergic mechanisms.
- High purity research-grade small molecule (molecular weight 269.77).
- Acts as an α2 adrenoceptor antagonist for receptor pharmacology studies.
- Exhibits first-generation antihistamine properties relevant to histamine assays.
- Available in milligram-scale quantities suitable for in vitro research.
- Provided with SDS and COA documentation for handling and quality assurance.
Medchemexpress LLC 3-Pyridylacetic acid hydrochloride | 6419-36-9 | 173.60 | 1 ML
3-Pyridylacetic acid hydrochloride is a high homolog of nicotinic acid and a decomposition product of nicotine (and other tobacco alkaloids). It can be used to synthesize anti-inflammatory agents or as a precursor for the preparation of herbicides.
- Used to synthesize anti-inflammatory agents
- Precursor for the preparation of herbicides
Medchemexpress LLC Cp-100356 monohydrochloride | 142715-48-8 | MFCD00911858 | >98.0% | 597.10 g·mol⁻¹ | C31H37ClN4O6 | 1 ML
CP-100356 hydrochloride is a research-grade inhibitor of multidrug transporters used to study transporter-mediated drug disposition and drug-drug interactions. It is supplied in both solid form and as a ready-to-use 10 mM solution in DMSO for in vitro assays, and it is commonly used in pharmacokinetic and cellular uptake studies.
- Potent inhibitor of P-gp and BCRP transporters.
- Available as a 10 mM solution in DMSO or as solid packs (5-100 mg).
- High purity suitable for in vitro assays (>98% by HPLC).
- Well characterized molecular properties for experimental reproducibility.
- Used for transporter assays and drug-drug interaction studies.
eMolecules 1069115-10-1 | 4-PYRIDINEACETIC ACID, 3-BROMO-ALPHA,ALPHA-DIMETHYL-, ETHYL ESTER | AstaTech | MFCD25372692 | 272.142 | C11H14BrNO2 | 95.000 | CCOC(=O)C(C)(C)c1ccncc1Br | 0.25g | 434268991
4-PYRIDINEACETIC ACID, 3-BROMO-ALPHA,ALPHA-DIMETHYL-, ETHYL ESTER | AstaTech | 1069115-10-1 | MFCD25372692 | 272.142 | C11H14BrNO2 | 95.000 | CCOC(=O)C(C)(C)c1ccncc1Br | 0.25g | 434268991
Medchemexpress LLC Nilotinib hydrochloride dihydrate | 99.9% | 602.01 g/mol | C28H27ClF3N7O3 | 50 MG
Nilotinib hydrochloride dihydrate is a small-molecule Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity, supplied as a solid research reagent for preclinical studies including chronic myelogenous leukemia models. The product includes analytical characterization and handling guidance for laboratory use.
- High purity suitable for research applications.
- Soluble in DMSO at 100 mg/mL; ultrasonic aid recommended.
- Solid form with molecular weight 602.01 g/mol.
- Storage: room temperature guidance, 4°C sealed, solvent stability at -80°C/-20°C.
- Suitable for in vitro and in vivo kinase inhibition studies.