Hydrochlorides
![Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244527.png-250.jpg)
Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML
VU 0365114 is a selective muscarinic acetylcholine receptor (mAChR) M5 positive allosteric modulator used in research to probe M5 receptor pharmacology and β-cell insulin secretion. It displays an EC50 of 2.7 μM at M5 and EC50 >30 μM at M1-M4, enabling selective modulation of M5-mediated responses.
- Selective positive allosteric modulation of mAChR M5.
- EC50 2.7 μM at M5 and EC50 >30 μM at M1-M4, indicating high selectivity.
- Enhances acetylcholine-stimulated insulin secretion in human β-cells.
- Available as solid or as a 10 mM solution in DMSO for flexible application.
- High purity suitable for biochemical and cellular assays.
Medchemexpress LLC Azaphen dihydrochloride monohydrate | 63302-99-8 | 99.9% | C16H23Cl2N5O2 | 500 MG
Azaphen dihydrochloride monohydrate, also known as Pipofezine or Azafen, is a potent inhibitor of serotonin reuptake. It functions as a tricyclic antidepressant (TCA) and is approved in Russia for the treatment of depression.
- Potent inhibitor of serotonin reuptake
- Acts as a tricyclic antidepressant
- Used for the treatment of depression
Medchemexpress LLC 5-Hydroxytryptamine creatinine sulfate monohydrate | 61-47-2 | 99.9% | 405.43 | 1 ML
5-Hydroxytryptamine creatinine sulfate monohydrate is an endogenous metabolite. This product is a 10 mM solution in 1 mL of DMSO, suitable for various research applications.
- Purity of 99.87%
- Endogenous metabolite
- Solution in DMSO
- For research use only
Medchemexpress LLC N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide monohydrochloride | 402713-81-9 | >98.0% | 482.8 g·mol⁻¹ | C18H21Cl2N3O4S · HCl | 25 MG
SB-399885 hydrochloride is a research compound that acts as a selective antagonist of the serotonin 5-HT6 receptor (CAS 402713-81-9). It is used in vitro and in vivo to study 5-HT6-mediated signaling and cognitive effects, and is supplied as the monohydrochloride salt to improve solubility for biological assays.
- 5-HT6 receptor antagonist activity for receptor pharmacology studies.
- Reported high purity for reliable experimental results.
- Monohydrochloride salt form improves solubility in aqueous media.
- Suitable for in vitro and in vivo neuroscience applications.
- Supplied in small research pack sizes for dose-response and pilot studies.
Medchemexpress LLC Benzamil hydrochloride | 161804-20-2 | 99.7% | 100 MG
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). It is also a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
- Na+/Ca2+ exchanger (NCX) inhibitor
- Non-selective Deg/epithelial sodium channels (ENaC) blocker
- Can potentiate myogenic vasoconstriction
- Inhibits TRPP3-mediated Ca2+-activated currents
Medchemexpress LLC 1-(2-Hydroxy-4,6-dimethoxyphenyl)-4-(piperazin-1-yl)butan-1-one dihydrochloride | 99.9% | 381.29 | 50 MG
Y13g dihydrochloride is a chemical compound supplied by MedChemExpress. It has a molecular weight of 381.29 and a purity of 99.89% as determined by LCMS. It appears as an off-white to light yellow solid and is stored at -20°C in sealed conditions away from moisture.
- Appears as an off-white to light yellow solid
- Purity of 99.89% verified by LCMS
- Consistent with ¹H NMR spectrum and LCMS analysis
- Recommended storage at -20°C in sealed conditions away from moisture
Medchemexpress LLC TPT-260 dihydrochloride | 2076-91-7 | 98.0% | C8H14Cl2N4S3 | 10MG
TPT-260 Dihydrochloride is a thiourea-derived small-molecule research compound supplied as a light yellow to yellow solid with high reported purity. It is used in preclinical biochemical and pharmacological studies where controlled solubility and defined storage stability are required.
- High purity: 98.0% ensuring reproducible results.
- Light yellow solid with defined appearance for easy identification.
- Well characterized solubility in common solvents (DMSO and water); ultrasonic assistance recommended.
- Clear storage guidance for stability in solid and solution states.
- Available in small pack sizes suitable for research-scale experiments.
Medchemexpress LLC (S)-1-(4-bromo-6-pyrimidinyl)-N-(2,4-dichlorobenzyl)-2-(pyrrolidin-1-yl)ethan-1-amine hydrochloride | 885104-09-6 | 99.9% | 438.58 g·mol⁻¹ | C15H16BrCl3N4 | 50 MG
LY2389575 hydrochloride is the hydrochloride salt of a small-molecule negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), intended for preclinical research. It is supplied as a solid powder with high purity and defined storage conditions for long-term stability.
- Negative allosteric modulator of mGlu3 for preclinical research
- High purity (99.9%) suitable for analytical and biological assays
- Solid powder form for convenient handling and formulation
- Defined storage stability: powder -20°C up to 3 years or 4°C up to 2 years
- Molecular weight 438.58 g·mol⁻¹ and formula C15H16BrCl3N4
Medchemexpress LLC 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]- | 1246086-78-1 | C18H13Cl2N3O3S | 1 ML
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It demonstrates positive allosteric modulation of the human mGlu4 receptor, expressed in CHO cells, by potentiating glutamate-induced calcium mobilization. While showing better stability in human liver microsomes (HLM) with 63% remaining than rat liver microsomes (RLM) with 2% remaining, its pharmacokinetic properties are less than ideal, limiting its direct use as an in vivo tool.
- Acts as a mGlu4 positive allosteric modulator
- Has an EC50 of 19.8 nM
- Potentiates glutamate-induced calcium mobilization in human mGlu4 receptor
- Exhibits better stability in HLM (63% remaining) than RLM (2% remaining)
Medchemexpress LLC PD 128907 hydrochloride | 112960-16-4 | MFCD01529976 | 99.5% | 285.77 | C14H20ClNO3 | 25 MG
PD 128907 hydrochloride is a potent and selective dopamine D3 receptor agonist supplied as a solid biochemical reagent for life-science research. It is used in pharmacology and neurobiology to probe D3-mediated signaling and dopaminergic mechanisms, and is provided at high purity in small pack sizes for laboratory experiments.
- Potent D3 receptor agonist with low-nanomolar activity.
- High selectivity over D2 receptors for receptor-specific studies.
- High purity suitable for research applications.
- Solid form with white to light yellow appearance.
- Available in multiple small pack sizes for dosing flexibility.
- Recommended sealed storage away from moisture to preserve stability.
Medchemexpress LLC TAK-960 dihydrochloride | 99.2% | 634.52 | 5 MG
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. It also demonstrates inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and shows significant efficacy against various tumor xenografts.
- Orally available
- Selective inhibitor of polo-like kinase 1 (PLK1)
- Inhibits proliferation of multiple cancer cell lines
- Exhibits significant efficacy against various tumor xenografts
- Causes accumulation of G2-M cells
- Leads to G2/M cell cycle arrest
Medchemexpress LLC BAY-6672 hydrochloride | 2247520-31-4 | C26H28BrCl2N3O3 | 1 ML
BAY-6672 hydrochloride is a chemical compound supplied as a solid, primarily intended for laboratory research and the manufacture of substances.
- Identified for laboratory chemical applications
- Recommended storage at 4°C under nitrogen, away from moisture
- Store in solvent at -80°C for 6 months or -20°C for 1 month, under nitrogen
- Ships at room temperature if transit is less than 2 weeks
- For research use only
Medchemexpress LLC Benzenepropanoic acid, ß-(aminomethyl)-4-chloro-, hydrochloride (1:1) | 28311-31-1 | 99.8% | C10H13Cl2NO2 | 1 ML
Baclofen hydrochloride is a lipophilic derivative of γ-aminobutyric acid (GABA) and an orally active, selective metabotropic GABAB receptor (GABABR) agonist. It mimics the action of GABA, producing slow presynaptic inhibition through the GABAB receptor. This compound exhibits high blood-brain barrier penetrance, making it suitable for muscle spasticity research.
- Orally active, selective GABAB receptor agonist.
- Mimics GABA action for slow presynaptic inhibition.
- Exhibits high blood-brain barrier penetrance.
- Increases cell viability in huntingtin-expressing striatal cells.
- Enhances chymotrypsin-like proteasome activity.
- Ameliorates motor deficits in Huntington's disease animal models.
- Reduces neuronal intranuclear inclusions in animal models.
Medchemexpress LLC K-604 dihydrochloride | 217094-32-1 | MFCD30738203 | >=98.0% | 575.64 | C23H32Cl2N6OS3 | 25 MG
K-604 dihydrochloride is a research reagent that selectively inhibits acyl-CoA:cholesterol acyltransferase 1 (ACAT-1), with a reported IC50 of 0.45 ± 0.06 μM. Supplied as the dihydrochloride salt, it is intended for biochemical and cellular studies probing ACAT-1 activity and cholesterol esterification pathways.
- Selective ACAT-1 inhibitor with reported IC50 of 0.45 ± 0.06 μM.
- Dihydrochloride salt form for improved solubility in polar solvents.
- Molecular weight 575.64 g/mol and formula C23H32Cl2N6OS3.
- Purity reported as ≥98% by HPLC in supplier and database listings.
- CAS number 217094-32-1 for unambiguous identification.
- Suitable for biochemical and cellular assays targeting cholesterol metabolism.
Medchemexpress LLC DPTN (dihydrochloride) | 325767-87-1 | C22H20Cl2N4OS | 50 MG
DPTN dihydrochloride is a potent and selective antagonist for human, mouse, and rat A3 adenosine receptors. It exhibits Ki values of 1.65 nM for human A3AR, 9.61 nM for mouse A3AR, and 8.53 nM for rat A3AR. While it is weaker at mouse and rat A3AR compared with human A3AR, it also shows reduced selectivity (approximately 20-fold) versus the A2B adenosine receptor.
- Potent and selective A3 adenosine receptor antagonist
- Effective in human, mouse, and rat models
- Solid, light yellow to yellow appearance
- Stable under recommended storage conditions