Hydrochlorides
Medchemexpress LLC Vu 0238429 | 1160247-92-6 | 99.9% | 100 MG
VU 0238429 is a selective positive allosteric modulator of the muscarinic acetylcholine receptor subtype 5 (mAChR5, M5) used as a research tool to probe M5 receptor pharmacology.
- Positive allosteric modulator of mAChR5 with EC50 1.16 μM.
- High purity (≈99.9%), suitable for research applications.
- Solid, light yellow to orange appearance.
- Stable under recommended storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
- Relevant to GPCR/G protein and neuronal signaling studies.
Medchemexpress LLC PXS-4787 hydrochloride | 2409964-40-3 | C10H13ClFNO2S | 100 MG
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor that abolishes lysyl oxidase activity.
- Inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4).
- Reduces the deposition and crosslinking of collagen I secreted by human fibroblasts.
- Purity of 99.71%.
- Appears as a white to off-white solid.
- Molecular weight of 265.73.
Medchemexpress LLC CS-VIP 8 hydrochloride | 961.40 | 5 MG
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (Kᵢ= 0.008 μM). It induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. This compound shows promise for research into hematological diseases like leukemia.
- Selective allosteric WDR5 protein inhibitor (Kᵢ= 0.008 μM).
- Induces conformational changes in the MLL1 complex.
- Leads to the dissociation of MLL1 from the complex.
- Inhibits MLL1 histone methyltransferase activity.
- Regulates HOX gene expression.
- Promising for research into hematological diseases such as leukemia.
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 100 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. While it exhibits less than ideal PK properties for in vivo use, it demonstrates better stability in HLM (63% remaining) compared to RLM (2% remaining).
- mGlu4 positive allosteric modulator
- Exhibits an EC50 of 19.8 nM
- Shows improved stability in HLM (63% remaining) compared to RLM (2% remaining)
- Soluble in DMSO (50 mg/mL)
- Targets mGluR in GPCR/G Protein and neuronal signaling pathways
Medchemexpress LLC Icotinib hydrochloride | 1204313-51-8 | C22H22ClN3O4 | 50 MG
Icotinib Hydrochloride (BPI-2009) is a potent, CNS-penetrant, and specific EGFR inhibitor with an IC50 of 5 nM. It also inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Potent, CNS-penetrant, and specific EGFR inhibitor
- Inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
- Has an IC50 of 5 nM for EGFR
- Functions as a click chemistry reagent with an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Exhibits potent dose-dependent antitumor effects in nude mice
- Blocks EGFR-mediated intracellular tyrosine phosphorylation (IC50=45 nM)
- Well tolerated in mice without significant body weight loss
Medchemexpress LLC SKF89976A hydrochloride | 85375-15-1 | 98.7% | 371.90 | C22H26ClNO2 | 50 MG
SKF89976A hydrochloride is a selective inhibitor of the GABA transporter GAT-1 used in research to probe GABA uptake and transporter pharmacology. It exhibits high potency at GAT-1 with markedly lower potency at GAT-2 and GAT-3, and shows weak activity at monoamine transporters. Supplied as a solid for in vitro and in vivo preclinical studies.
- Selective GAT-1 inhibition with IC50 0.28 μM.
- Lower potency at GAT-2 and GAT-3 (IC50 137.34 μM and 202.8 μM).
- Weak activity at SERT, NET, and DAT consistent with transporter profiling.
- High purity solid suitable for biochemical assays (98.73%).
- Usable in both in vitro transporter assays and preclinical in vivo models.
Medchemexpress LLC (±)-1-(3,4-dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride | 112282-24-3 | MFCD00672679 | >98.0% | 391.76 g·mol⁻¹ | C18H25Cl3N2O | 50 MG
BRL 52537 hydrochloride is a selective kappa-opioid receptor (KOR) agonist used in preclinical research. It exhibits potent KOR activity and has been reported to reduce ischemia-evoked nitric oxide production and attenuate early stroke-related damage. The compound is supplied as a solid for laboratory use and should be stored sealed and protected from moisture at recommended temperatures.
- Selective kappa-opioid receptor agonist.
- Potent KOR affinity with low nanomolar activity.
- Demonstrated neuroprotective effects in preclinical studies.
- Suitable for in vitro and in vivo research applications.
- Store sealed and protected from moisture under recommended conditions.
Medchemexpress LLC Phenibut hydrochloride | 3060-41-1 | ≥98.0% | 215.68 | C10H14ClNO2 | 1 ML
Phenibut hydrochloride is a GABAB receptor agonist supplied as a 10 mM solution in DMSO for research use. It is provided as a ready-to-use solution intended for in vitro and neuroscience applications.
- supplied concentration: 10 mM in DMSO
- volume: 1 mL per vial
- cas number: 3060-41-1
- molecular formula: C10H14ClNO2
- molecular weight: 215.68
- assay purity (nmr): ≥98.0%
- storage: 4°C sealed; in solvent -80°C (6 months), -20°C (1 month)
Medchemexpress LLC JDTic dihydrochloride | 785835-79-2 | MFCD22419279 | 98.0% | 538.55 | C28H41Cl2N3O3 | 25 MG
JDTic dihydrochloride is the dihydrochloride salt of JDTic, a potent and selective kappa-opioid receptor (KOR) antagonist used as a research reagent to inhibit κ-agonist (e.g., U50,488)-induced antinociception and to study KOR signaling. It is supplied as a characterized solid for laboratory assays and is not for human use.
- Potent kappa-opioid receptor (KOR) antagonist used in pharmacological research.
- Blocks κ-agonist U50,488-induced antinociception in model systems.
- High purity (98.03%) suitable for research applications.
- White to off-white solid appearance.
- Dissolves in DMSO (100 mg/mL) and H2O (50 mg/mL); ultrasonic assistance recommended.
- Store sealed, away from moisture; in solvent store at -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or patient use.
Medchemexpress LLC TC-A 2317 hydrochloride | 1245907-03-2 | MFCD19690936 | >=98.0% | 392.93 | C19H29ClN6O | 1 MG
TC-A 2317 hydrochloride is the hydrochloride salt of TC-A 2317, a small-molecule Aurora kinase inhibitor used in cell-cycle and DNA damage research. It is supplied as a research reagent for biochemical and cellular studies.
- Used in cell-cycle and DNA damage pathway studies.
- Hydrochloride salt form for improved stability and solubility.
- Molecular formula C19H29ClN6O; molecular weight 392.93.
- Available in small pack sizes suitable for screening and assay work.
- Store sealed at 4°C; in solvent, store at -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC A 438079 hydrochloride | 899431-18-6 | C13H10Cl3N5 | 1 ML
A 438079 hydrochloride is a potent and selective P2X7 receptor antagonist with a pIC50 of 6.9, suitable for research applications. It blocks BzATP-evoked changes in intracellular calcium concentrations with an IC50 of 321 nM in rat P2X7 receptor-expressing cells, showing selectivity up to 100 μM. It has demonstrated efficacy in reducing pain and seizure severity in various in vivo models.
- Potent and selective P2X7 receptor antagonist
- Blocks BzATP-evoked intracellular calcium changes
- Selective for P2X7 receptor
- Reduces noxious and innocuous evoked activity in neuropathic rats
- Raises withdrawal thresholds in SNL and CCI models
- Reduces seizure severity and neuronal death
- Prevents 6-OHDA-induced depletion of striatal dopamine stores
- Reduces nociceptive behavior
![Medchemexpress LLC 1-[(3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride | 172895-15-7 | 99.5% | 372.89 g·mol⁻¹ | C21H24N2O2·HCl | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211724.png-250.jpg)
Medchemexpress LLC 1-[(3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride | 172895-15-7 | 99.5% | 372.89 g·mol⁻¹ | C21H24N2O2·HCl | 100 MG
LY-272015 hydrochloride is a selective, orally active 5-HT2B receptor antagonist supplied as the hydrochloride salt for research use. Provided as an off-white to light yellow solid, it is used in pharmacology and receptor-binding studies to probe serotonergic signaling and cardiovascular effects in preclinical models.
- Selective 5-HT2B receptor antagonist for targeted pharmacological studies.
- High purity suitable for research and assay development.
- Hydrochloride salt in solid form for stable handling and storage.
- Applicable to in vitro receptor assays and in vivo pharmacology studies.
- Well characterized in the literature with established physicochemical data.
eMolecules 1845716-99-5 | 3,3-Difluoropiperidine-1-sulfonyl chloride | Combi-Blocks, Inc. | MFCD29074690 | 219.630 | C5H8ClF2NO2S | 95.000 | FC1(F)CCCN(C1)S(Cl)(=O)=O | 5g | 703124135
3,3-Difluoropiperidine-1-sulfonyl chloride | Combi-Blocks, Inc. | 1845716-99-5 | MFCD29074690 | 219.630 | C5H8ClF2NO2S | 95.000 | FC1(F)CCCN(C1)S(Cl)(=O)=O | 5g | 703124135
Medchemexpress LLC 3-Pyridylacetic acid hydrochloride | 6419-36-9 | 173.60 | 10 G
3-Pyridineacetic acid hydrochloride is a high homolog of nicotinic acid and a decomposition product of nicotine (and other tobacco alkaloids). It can be used to synthesize anti-inflammatory agents or as a precursor for herbicides.
- High homolog of nicotinic acid
- Decomposition product of nicotine
- Precursor for herbicides
- Can be used to synthesize anti-inflammatory agents
- White to off-white solid appearance