Hydrochlorides
Medchemexpress LLC Pyridine, 3-(2S)-2-piperidinyl- | 494-52-0 | 99.02% | 1 ML
Anabasine is an alkaloid found in tobacco, acting as a full agonist of nicotinic acetylcholine receptors (nAChRs). It induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs. This product is suitable for various laboratory applications and research studies related to nicotinic receptor activity. It is supplied as a liquid, ready for reconstitution in DMSO, and has been tested to ensure high purity and consistency.
- Acts as a full agonist of nicotinic acetylcholine receptors (nAChRs)
- Induces depolarization of TE671 cells
- High purity of 99.02%
- Supplied as a colorless to light yellow liquid
- Molecular formula C10H14N2 and molecular weight 162.24
- Suitable for in vitro and in vivo dissolution protocols
Medchemexpress LLC Doxepin impurity 1 (hydrochloride) | 4504-96-5 | MFCD00135797 | 5mg
Doxepin impurity 1 hydrochloride is an impurity of Doxepin (HY-B0725A)
Medchemexpress LLC RS-127445 | 199864-87-4 | C17H16FN3 | 50 MG
RS-127445 is a selective, high-affinity, orally bioavailable 5-HT2B receptor antagonist. It demonstrates 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites, making it suitable for research applications.
- High affinity for the 5-HT2B receptor (pKi = 9.5)
- 1000-fold selectivity for 5-HT2B receptor
- Orally bioavailable
- Appearance: solid, white to off-white
- Purity: 99.95%
- Store at 4°C, sealed, away from moisture; In solvent: -80°C for 6 months, -20°C for 1 month (sealed, away from moisture)
Medchemexpress LLC Carteolol hydrochloride | 51781-21-6 | 99.96% | 328.83 | 500 MG
Carteolol hydrochloride (OPC-1085 hydrochloride) is a non-selective beta blocker used to treat glaucoma. It is a beta-adrenergic antagonist used as an anti-arrhythmia, anti-angina, antihypertensive, and antiglaucoma agent. It significantly inhibited H2O2-induced cell damage and was able to scavenge O2, showing protective action against UVB-induced HCEC damage.
- Non-selective beta blocker
- Treats glaucoma
- Anti-arrhythmia agent
- Anti-angina agent
- Antihypertensive agent
- Protective action against UVB-induced HCEC damage in vitro
- Radical scavenging ability (scavenges O2)
- Long-acting alginate formulation is as effective as standard for glaucoma treatment
Medchemexpress LLC Benzamide, N-(aminoiminomethyl)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl) hydrochloride | 211813-86-4 | MFCD31560490 | 99.5% | 356.83 | C14H17ClN4O3S | 50 MG
Eniporide hydrochloride is a research-grade Na+/H+ exchange inhibitor provided as the hydrochloride salt for in vitro and in vivo studies of cellular pH regulation and myocardial ischemia/reperfusion. The reagent is characterized by high purity, defined solubility in common solvents, and recommended storage conditions to preserve stability for research use.
- High purity suitable for research applications.
- Available as solid and as solution in DMSO for experimental flexibility.
- Soluble in DMSO and water with documented concentrations and handling notes.
- Stable when stored under recommended sealed, low-temperature conditions.
- Selective inhibition of Na+/H+ exchanger for mechanistic studies.
Medchemexpress LLC Dcpt1061 hydrochloride | 2289726-31-2 | 99.9% | 375.72 | 1 ML
DCPT1061 hydrochloride exhibits a potent inhibitory effect on PRMT1, PRMT6, and PRMT8 in vitro, with minimal inhibitory effects on epigenetic enzymes such as PRMT3, PRMT4, and PRMT5. It also possesses antitumor properties.
- Solid appearance
- Color is white to off-white
- Ships at room temperature in continental US
- Store at -20°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at 50 mg/mL (133.08 mM)
Medchemexpress LLC Ynt-185 dihydrochloride | 1804978-82-2 | 99.8% | C33H39Cl2N5O5S | 10MG
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist used as a research tool to probe orexin signaling and sleep disorder models. It exhibits high potency at OX2R (EC50 = 0.028 μM) and lower activity at OX1R, and is supplied as a solid or as a 10 mM DMSO stock solution for laboratory use. For research use only.
- Selective OX2R agonist with nanomolar potency (EC50 = 0.028 μM).
- Lower activity at OX1R, enabling receptor subtype studies.
- High purity for reproducible biochemical and pharmacological results.
- Available in multiple pack sizes and as a 10 mM DMSO stock solution.
- Supplied as an off-white to light-yellow solid suitable for formulation.
Medchemexpress LLC LP-533401 hydrochloride | 1040526-12-2 | 99.4% | 562.94 | 5 MG
LP-533401 hydrochloride is an inhibitor of tryptophan hydroxylase 1, an enzyme that regulates the production of serotonin in the gut. It is intended for research use only. Studies have shown that this compound can inhibit serotonin production in Tph1-expressing cells. When administered orally to rodents, it dose-dependently prevents and rescues osteoporosis by increasing bone formation. Pharmacokinetic studies suggest that it has negligible brain penetration.
- Negligible brain penetration after oral administration in rodents.
- Reduces 5-HT content in the gut, lungs, and blood of mice.
- Increases osteoblast numbers and inhibits the decrement in trabecular bone volume in mice.
- Can be dissolved in DMSO for in vitro studies.
- Protocols for in vivo dissolution in various solvent mixtures are available.
Medchemexpress LLC Dasatinib hydrochloride | 854001-07-3 | MFCD26960525 | 99.3% | 524.5 g/mol | C22H27Cl2N7O2S | 1 ML
Dasatinib hydrochloride is the hydrochloride salt of dasatinib, a potent ATP-competitive inhibitor of Src and Bcr-Abl family tyrosine kinases used in preclinical research. It is typically supplied as a pre-dissolved 10 mM solution in DMSO for in vitro assays (CAS 854001-07-3).
- Potent ATP-competitive inhibitor of Src and Bcr-Abl kinases.
- Supplied as a 10 mM solution in DMSO (1 mL).
- High purity suitable for analytical and biological research (approx. 99.3%).
- Useful for in vitro kinase inhibition and cell signaling studies.
- For research use only; not for human or veterinary use.
Medchemexpress LLC Vasicine (hydrochloride) | 7174-27-8 | 224.69 | 1 ML
Vasicine hydrochloride is a quinazoline alkaloid isolated from Justicia adhatoda. It activates the PI3K/Akt signaling pathway and exhibits antioxidant, anti-inflammatory, and antibacterial activities. This product is for research use only.
- Activates the PI3K/Akt signaling pathway.
- Exhibits antioxidant, anti-inflammatory, and antibacterial activities.
- Shows moderate inhibitory activity against H+/K+-ATPase.
- Scavenges DPPH free radicals.
- Reduces gastric acid secretion and has an anti-ulcer effect.
- Improves cardiac function and inhibits myocardial cell apoptosis.
- Alleviates myocardial necrosis, edema, and inflammatory cell infiltration.
Medchemexpress LLC VU0360172 hydrochloride | 1309976-62-2 | 98.9% | 330.78 g/mol | C18H16ClFN2O | 25 MG
VU0360172 hydrochloride is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5) used as a research tool in pharmacology and neuroscience. Supplied as the hydrochloride salt, the compound is intended for in vitro assays and preclinical in vivo studies and is provided with high purity and defined storage recommendations.
- Potent mGlu5 positive allosteric modulator (EC50 = 16 nM).
- Selective pharmacological tool for mGlu5 receptor studies.
- High purity suitable for biochemical and preclinical assays.
- Multiple milligram pack sizes available for laboratory experiments.
- Recommended storage conditions provided to maintain stability.
Medchemexpress LLC DPTN (dihydrochloride) | 325767-87-1 | C22H20Cl2N4OS | 50 MG
DPTN dihydrochloride is a potent and selective antagonist for human, mouse, and rat A3 adenosine receptors. It exhibits Ki values of 1.65 nM for human A3AR, 9.61 nM for mouse A3AR, and 8.53 nM for rat A3AR. While it is weaker at mouse and rat A3AR compared with human A3AR, it also shows reduced selectivity (approximately 20-fold) versus the A2B adenosine receptor.
- Potent and selective A3 adenosine receptor antagonist
- Effective in human, mouse, and rat models
- Solid, light yellow to yellow appearance
- Stable under recommended storage conditions
Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 50 MG
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor known for its good skin penetrability, ability to reduce collagen deposition, and significant improvement of scar appearance. This compound is intended for research use only.
- Irreversible lysyl oxidase inhibitor
- Exhibits IC50s for Bovine LOX (3.7 μM), rh LOXL1 (3.4 μM), rh LOXL2 (0.4 μM), rh LOXL3 (1.5 μM), and rh LOXL4 (0.3 μM)
- Reduces collagen deposition and cross-linking in murine models of injury and fibrosis with topical application
- Significantly improves scar appearance in porcine injury models without reducing tissue strength
- Inhibits LOX and reduces crosslinking in porcine models of excisional and burn injury
Medchemexpress LLC UPSEM792 hydrochloride | 2341841-08-3 | 99.9% | 277.75 | 25 MG
uPSEM792 hydrochloride is a PSAM4-GlyR agonist.
- Purity: 99.94%
- Molecular weight: 277.75
- CAS number: 2341841-08-3
- Formula: C14H16ClN3O
- Appearance: Solid
- Color: White to light yellow
- Shipping: Room temperature in continental US
- Storage: 4°C, sealed, away from moisture and light (solid)
- Storage in solvent: -80°C for 6 months; -20°C for 1 month (sealed, away from moisture and light)
Medchemexpress LLC 2,4-dichloro-5-(((2-((dimethylamino)methyl)phenyl)methoxy)methyl)pyrimidine hydrochloride | 2289726-31-2 | 99.9% | 375.72 | 50 MG
DCPT1061 hydrochloride is a potent inhibitor of histone methyltransferases, specifically targeting PRMT1, PRMT6, and PRMT8 in vitro. It exhibits weak inhibitory effects on other epigenetic enzymes like PRMT3, PRMT4, and PRMT5. This compound has demonstrated antitumor effects, making it a promising agent for cancer research.
- Strong inhibitory effect on PRMT1, PRMT6, and PRMT8.
- Minimal inhibition of PRMT3, PRMT4, and PRMT5.
- Exhibits antitumor properties.
- Suitable for research applications.