Organic potassium salts
Medchemexpress LLC Bleximenib (oxalate) | 2866179-95-3 | MFC32H50FN7O3.C2H2O4 | 98.0% | 689.82 | 100 MG
Bleximenib oxalate (JNJ-75276617) is an orally active and selective menin-KMT2A inhibitor. It exhibits IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. This compound can inhibit the proliferation and induce apoptosis and differentiation of tumor cells, making it valuable for research into tumors such as leukemia.
- Orally active and selective menin-KMT2A inhibitor
- Inhibits proliferation of tumor cells
- Induces apoptosis and differentiation of tumor cells
- Exhibits anti-tumor activity in mouse models of leukemia
- Reduces expression of MEIS1, PBX3, FLT3, and JMJD1C in MOLM-14 and OCI-AML3 cells
Medchemexpress LLC Bleximenib (oxalate) | 2866179-95-3 | 98.0% | 689.82 | 50 MG
Bleximenib oxalate is an orally active and selective menin-KMT2A inhibitor with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. It can inhibit the proliferation and induce apoptosis and differentiation of tumor cells and can be used in the research of tumors such as leukemia.
- Orally active and selective menin-KMT2A inhibitor
- Inhibits proliferation of tumor cells
- Induces apoptosis of tumor cells
- Induces differentiation of tumor cells
- Exhibits anti-tumor activity in mouse models of leukemia
- Increases the lifespan of mice in leukemia models
- Increases the expression of differentiation markers
Medchemexpress LLC N,N'-Dinitrosopiperazine | 140-79-4 | 99.9% | 144.13 | 50 MG
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is identified as a carcinogen that specifically targets the nasopharyngeal epithelium and contributes to nasopharyngeal carcinoma (NPC) metastasis. It influences various signaling pathways through protein phosphorylation, including LYRIC at serine 568.
- Does not inhibit 6-10B cells at lower concentrations (0-8 μm)
- Exhibits cytotoxicity from 10 μm upwards
- Enhances 6-10B cell invasion and motility in a dose-dependent manner (2-8 μm)
- Increases cell invasion by 421.7% and motility by 328.2% at 6 μm
- Upregulates phospho-LYRIC s568 and LYRIC expression in CNE1 cells
- Inhibits cell motility and invasion in vivo at 40 mg/kg
- Facilitates NPC metastasis in vivo at 40 mg/kg
- Shows higher phospho-LYRIC expression in metastatic tumors in DNP-treated mice
Medchemexpress LLC Acesulfame potassium | 55589-62-3 | 99.38% | 5 G
Acesulfame potassium is a synthetic sweetener that can affect cognitive function and may be related to immune evasion in cancer cells by suppressing autophagic degradation of PD-L1. It is for research use only and suitable for studies on neurological diseases, metabolic disorders, cancer, and immune evasion.
- Upregulates PD-L1 protein levels in RIL-175 and SK-Hep1 cells.
- Increases granzyme B production in RIL-175 and SK-Hep1 cells co-cultured with T cells.
- Activates ERK1/2-mTORC1-ULK1 pathway to suppress autophagic degradation of PD-L1.
- Inhibits mitochondrial metabolism and ATP production in SH-SY5Y cells.
- Impairs energy metabolism and neuroprotective functions.
- Increases body weight in male CD-1 mice and alters gut microbiome.
- Affects neurometabolic functions in C57BL/6J mice with long-term intake.
Medchemexpress LLC Acesulfame (potassium) | 55589-62-3 | 99.4% | 10 G
Acesulfame potassium is a synthetic sweetener that can affect cognitive function by altering neurometabolic functions. It can also suppress autophagic degradation of PD-L1 in cancer cells, which may be related to immune evasion. This product is suitable for research on neurological diseases, metabolic disorders, cancer, and immune evasion.
- Research applications include neurological diseases, metabolic disorders, cancer, and immune evasion.
- Upregulates PD-L1 protein levels in RIL-175 and SK-Hep1 cells.
- Increases granzyme B production in co-cultured T cells.
- Activates ERK1/2-mTORC1-ULK1 pathway to suppress autophagic degradation of PD-L1.
- Inhibits mitochondrial metabolism and impairs neuroprotective functions in SH-SY5Y cells.
- Affects body weight and gut microbiome composition in male CD-1 mice.
- Alters neurometabolic functions in C57BL/6J mice.
Medchemexpress LLC N,N'-Dinitrosopiperazine | 140-79-4 | 99.9% | 144.13 | 100 MG
N,N'-Dinitrosopiperazine (DNP) is identified as a carcinogen with specificity for nasopharyngeal epithelium, facilitating nasopharyngeal carcinoma (NPC) metastasis. It regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568.
- Specific carcinogen for nasopharyngeal epithelium
- Facilitates NPC metastasis
- Regulates multiple signaling pathways through protein phosphorylation
- Induces cell invasion and motility in a dose-dependent manner in vitro
- Increases expression of phospho-LYRIC s568 and LYRIC in CNE1 cells
- Promotes NPC metastasis in vivo by inhibiting cell motility and invasion
- Induces LYRIC phosphorylation at serine 568 in vivo
Medchemexpress LLC Bleximenib (oxalate) | 2866179-95-3 | 98.0% | 689.82 | 5 MG
Bleximenib oxalate is an orally active and selective menin-KMT2A inhibitor. It demonstrates high potency, inhibiting the proliferation and inducing apoptosis and differentiation of tumor cells. This compound is valuable for research into tumors like leukemia.
- Orally active and selective menin-KMT2A inhibitor
- Inhibits proliferation and induces apoptosis and differentiation of tumor cells
- Suitable for research into tumors such as leukemia
- Potent IC50 values (0.1 nM for humans, 0.045 nM for mice, and ≤0.066 nM for dogs)
- Reduces expression of MEIS1, PBX3, FLT3, and JMJD1C in MOLM-14 and OCI-AML3 cells
- Exhibits anti-tumor activity in mouse models of leukemia
- Increases lifespan of mice and expression of differentiation markers in animal models
Medchemexpress LLC Bleximenib oxalate | 2866179-95-3 | 98.0% | 689.82 | 25 MG
Bleximenib oxalate is an orally active and selective menin-KMT2A inhibitor. It inhibits proliferation, induces apoptosis and differentiation of tumor cells, and is used in the research of tumors such as leukemia.
- Reduces gene expression of MEIS1, PBX3, FLT3, JMJD1C
- Inhibits proliferation of leukemia cells
- Induces apoptosis and differentiation
- Exhibits anti-tumor activity in leukemia mouse models
- Increases lifespan in mouse models
Medchemexpress LLC Bleximenib oxalate | 2866179-95-3 | 98.0% | 689.82 | 1 MG
Bleximenib oxalate is an orally active and selective menin-KMT2A inhibitor with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. It can inhibit the proliferation and induce apoptosis and differentiation of tumor cells, making it suitable for research into tumors such as leukemia.
- Orally active and selective menin-KMT2A inhibitor
- Inhibits proliferation and induces apoptosis and differentiation of tumor cells
- Reduces expression of MEIS1, PBX3, FLT3, and JMJD1C
- Exhibits anti-tumor activity in mouse models of leukemia
Apexbio Technology LLC Malachite green oxalate 2437-29-8 100mg
Malachite green oxalate (CAS 2437-29-8) is a triphenylmethane dye commonly utilized for quantifying phosphate release in enzymatic assays Mechanistically it functions as a selective inhibitor of IKBKE kinase resulting in reduced phosphorylation and activity of downstream effectors including I B p65 and IRF3 Experimental studies have demonstrated its ability to suppress tumor cell proliferation and interfere with related signaling pathways in various cell lines and animal models Malachite green oxalate serves as a valuable tool for investigating tumorigenic mechanisms and exploring targeted therapeutic strategies
Medchemexpress LLC GJ071 oxalate | 1216676-34-4 | 99.7% | 455.53 g/mol | C20H29N3O7S | 5 MG
GJ071 oxalate is a research-grade small molecule reported to induce ATM kinase activity in ataxia telangiectasia (A-T) cells carrying homozygous TGA or TAG stop codons. Supplied as the oxalate salt for laboratory research use.
- Induces ATM kinase activity in A-T cells with TGA or TAG stop codons.
- High purity: 99.74%.
- Molecular formula: C20H29N3O7S; molecular weight: 455.53 g/mol.
- Available in small-scale laboratory quantities (1 mg-100 mg).
- Suitable for cellular research applications; soluble in DMSO.
Biotium 5, 5'-Dibromo BAPTA, tetrapotassium salt
BAPTA and its derivatives are calcium chelators that are commonly used to form calcium buffers with well-defined calcium concentrations. By injecting the chelators into cells or by incubating cells with the AM ester form of the chelators, one can control the cytosolic calcium concentration, an important means to study the roles of calcium. Key advantages of these calcium chelators include relative insensitivity toward intracellular pH change and fast release of calcium.Several BAPTA chelators with calcium dissociation constants covering the biologically significant range from 10-7 to 10-2 M are available. Properties: Kd (no Mg2 ): 3.6 uM; White to off-white solid soluble in water; Store at 4°C; C22H18Br2K4N2O10; MW: 786.59; [73630-11-2]
Medchemexpress LLC GJ071 oxalate | 1216676-34-4 | 99.7% | C20H29N3O7S | 10MG
GJ071 oxalate is a research-grade small molecule that induces ATM kinase activity in ataxia telangiectasia (A-T) cells carrying homozygous TGA or TAG stop codons. Supplied as a solid with high reported purity, it is intended for in vitro biochemical and cellular studies; follow supplier handling and storage recommendations.
Medchemexpress LLC Xanomeline (oxalate) | 141064-23-5 | MFCD12828778 | 99.9% | 371.45 | 50 MG
Xanomeline oxalate is a potent and selective muscarinic receptor agonist (SMRA) that stimulates phosphoinositide hydrolysis in vivo. This compound is used for the research of Alzheimer's disease. It stimulates phosphoinositide (PI) hydrolysis in A9 L m1 cells and inhibits [3H]-pirenzepine and [3H]-oxotremorine-M binding to rat brain. This product is for research use only.
- Potent and selective muscarinic receptor agonist
- Stimulates phosphoinositide hydrolysis in vivo
- Used for Alzheimer's disease research
- Stimulates PI hydrolysis in A9 L m1 cells
- Inhibits [3H]-pirenzepine and [3H]-oxotremorine-M binding to rat brain
- Robustly stimulates in vivo PI hydrolysis, an effect blocked by muscarinic antagonists
Medchemexpress LLC GJ071 oxalate | 1216676-34-4 | 99.7% | 455.53 | 1 MG
GJ071 oxalate is a chemical that induces ATM kinase activity in ataxia telangiectasia (A-T) cells carrying homozygous TGA or TAG stop codons. It is intended for research use only and is not for patient use.
- Induces ATM kinase activity
- White to off-white solid appearance
- Shipping at room temperature (continental US)
- Storage at -20°C (sealed, away from moisture)
- For research use only
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