Dimethyl Sulfoxide
Apexbio Technology LLC Macitentan 441798-33-0 10mM (in 1mL DMSO)
Macitentan (CAS 441798-33-0) is a small molecule endothelin receptor antagonist acting as a dual inhibitor of ETA and ETB receptors Experimental data using recombinant ETA-expressing CHO cells show that macitentan exhibits potent inhibition of ET-1 ligand binding with an IC50 of approximately 0 5 nM whereas its inhibitory effect on ETB receptors in similar CHO cell systems is weaker (IC50 391 nM) In vivo rodent studies indicate macitentan rapidly converts into ACT-132577 a circulating metabolite with extended half-life and retained dual receptor antagonism This pharmacological profile makes macitentan relevant for biomedical research on endothelin-associated vascular pathologies
Apexbio Technology LLC Decernotinib(VX-509) 944842-54-0 10mM (in 1mL DMSO)
Decernotinib (VX-509) is an orally bioavailable inhibitor targeting Janus kinase 3 (JAK3) with additional inhibitory activities toward JAK1 JAK2 and TYK2 (Ki values JAK3 2 nM JAK1 11 nM JAK2 13 nM TYK2 11 nM) Janus kinases are intracellular tyrosine kinases critical for cytokine-mediated signal transmission involved notably in immune cell activation and inflammatory responses By inhibiting JAK-mediated STAT5 phosphorylation VX-509 modulates cytokine-dependent lymphocyte proliferation and activation This compound has been employed in preclinical models exploring therapeutic potential in autoimmune conditions and inflammatory disorders such as rheumatoid arthritis
Apexbio Technology LLC SB202190 (FHPI) 152121-30-7 10mM (in 1mL DMSO)
SB202190 (FHPI CAS 152121-30-7) is a selective MAPK inhibitor targeting specifically the p38 isoforms and with reported IC50 values of approximately 50 nM and 100 nM respectively Through inhibition of p38 signaling SB202190 has been observed to stimulate the proliferation of leukemia cell lines including THP-1 and MV4-11 via activation of ERK and C-Raf phosphorylation pathways Additionally SB202190 modulates cellular responses to genotoxic stress such as hydroxyurea-induced premature chromosome condensation and influences histone acetylation status (Lys5 of histone H4) in plant systems Such activities render SB202190 useful for investigating MAP kinase-dependent pathways in cell proliferation and stress responses
Apexbio Technology LLC ORY-1001 1431326-61-2 10mM (in 1mL DMSO)
ORY-1001 is a selective inhibitor targeting the lysine-specific histone demethylase KDM1A (also known as LSD1) an FAD-dependent amine oxidase enzyme responsible for the removal of histone methylation marks particularly dimethylation of histone H3 lysine 4 (H3K4me2) By inhibiting KDM1A ORY-1001 promotes accumulation of H3K4me2 at gene targets and induces cellular differentiation in acute myeloid leukemia (AML) cell models In vitro assays demonstrated dose- and time-dependent increases in H3K4me2 and expression of differentiation markers in treated AML cells ORY-1001 exhibited oral bioavailability in animal xenograft models reducing tumor growth at low daily doses This molecule serves as a valuable research tool in epigenetics oncology pharmacology and studies regarding AML differentiation pathways with ongoing evaluation in early-phase clinical trials
Apexbio Technology LLC PF-04449913 1095173-27-5 10mM (in 1mL DMSO)
PF-04449913 (CAS 1095173-27-5) is an orally bioavailable small molecule inhibitor targeting smoothened (SMO) a critical component of the Hedgehog (Hh) signaling pathway Activation of SMO by Hh ligands typically initiates signaling cascades involving Gli transcription factors influencing cellular proliferation and oncogenesis PF-04449913 inhibits SMO activity with an IC50 of 5 nM thereby suppressing downstream Gli-mediated signaling Preclinical pharmacokinetic studies demonstrated favorable properties including a half-life of approximately 30 hours 55% oral bioavailability low plasma clearance (1 03 mL/min/kg) and moderate distribution (2 7 L/kg) PF-04449913 is actively explored in cancer research contexts
Sigma Aldrich Fine Chemicals Biosciences Methyl phenyl sulfoxide >=97% | 1193-82-4 | MFCD00002088 | 25G
Methyl phenyl sulfoxide >=97% | Purity: >=97% | Mol Wt: 140.2 | 1193-82-4 | MFCD00002088 | 25G
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 4 x 2 mL
Dimethyl sulfoxide | Purity: ≥99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 4 x 2 mL
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology | 67-68-5 | MFCD00002089 | 1L
Dimethyl sulfoxide for molecular biology | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 1L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology | 67-68-5 | MFCD00002089 | 50ml
Dimethyl sulfoxide for molecular biology | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 50ml
Apexbio Technology LLC ML216 1430213-30-1 10mM (in 1mL DMSO)
ML216 (CAS 1430213-30-1) is a small molecule inhibitor targeting Bloom (BLM) helicase a DNA unwinding enzyme essential for homologous recombination-mediated DNA repair ML216 inhibits DNA unwinding activity of full-length BLM (IC50 3 0 M) and a truncated form BLM636-1298 (IC50 0 97 M) displaying sub-micromolar selectivity relative to other helicases such as RECQ1 RECQL5 and bacterial UvrD In cellular assays ML216 selectively suppresses proliferation in BLM-containing fibroblasts increasing sister chromatid exchange frequency consistent with BLM functional deficiency By inhibiting BLM helicase ML216 may sensitize tumor cells to conventional DNA-damaging therapeutics indicating potential application in cancer research and therapy development
Apexbio Technology LLC Protionamide 14222-60-7 10mM (in 1mL DMSO)
Protionamide is a thiophene-derived antibacterial compound that inhibits the synthesis of mycolic acids a major component of the mycobacterial cell wall Through disruption of mycolic acid biosynthesis it interferes with cell wall integrity exhibiting antibacterial activity against pathogenic mycobacteria Protionamide is commonly employed in research involving Mycobacterium tuberculosis and Mycobacterium leprae primarily for investigating molecular mechanisms underlying drug resistance and cell wall biosynthesis pathways In laboratory experiments this compound is frequently utilized in vitro for cultivation assays antimicrobial screening and studies on synergistic effects when combined with other antimycobacterial agents It demonstrates reported IC50 values in the micromolar range dependent on experimental conditions and mycobacterial strains used
Apexbio Technology LLC GW4064 278779-30-9 10mM (in 1mL DMSO)
GW4064 (CAS 278779-30-9) is a non-steroidal agonist targeting the farnesoid X receptor (FXR) a nuclear receptor involved in lipid and cholesterol regulation Reported EC50 values of GW4064 for FXR activation are approximately 15 nM in isolated receptor assays and 90 nM in human FXR-transfected cell studies In animal models including KK-Ay and ob/ob mice GW4064 administration was associated with reduced serum triglyceride (TG) concentrations and diminished very-low-density lipoprotein (VLDL) production However due to limitations such as poor solubility chemical instability under UV exposure and a potentially toxic stilbene pharmacophore GW4064 primarily serves as a research tool for investigating FXR signaling pathways
Apexbio Technology LLC SB742457 607742-69-8 10mM (in 1mL DMSO)
SB742457 (CAS 607742-69-8) is a selective antagonist of the serotonin 5-HT6 receptor with high affinity demonstrated by a reported pKi of 9 63 Due to effective brain penetration and oral bioavailability SB742457 has shown the ability to reverse cognitive deficits induced by the cholinergic antagonist scopolamine in rodent novel object recognition tests Acutely administered SB742457 increases extracellular glutamate and acetylcholine levels in the rat medial prefrontal cortex Given these pharmacological properties SB742457 is investigated in cognitive enhancement studies notably related to Alzheimer s disease research
Apexbio Technology LLC Z-IETD-FMK 210344-98-2 10mM (in 1mL DMSO)
Z-IETD-FMK (CAS 210344-98-2) is a cell-permeable peptide-derived inhibitor targeting caspase-8 It reduces T-cell proliferation induced by stimuli such as phytohemagglutinin (PHA) or anti-CD3/anti-CD28 antibodies primarily through downregulation of CD25 expression without affecting IL-2 or IFN- secretion Additionally Z-IETD-FMK inhibits NF- B activation at higher concentrations (100 M) Studies also demonstrate its protective effects against TRAIL-induced apoptosis by inhibiting processing of procaspases-2 -3 -9 and PARP cleavage in cancer cell lines such as HCT116 and SW480
Apexbio Technology LLC Ornidazole 16773-42-5 10mM (in 1mL DMSO)
Ornidazole a 5-nitroimidazole derivative exhibits antibacterial and antiprotozoal activities by interfering with DNA synthesis in anaerobic microorganisms through the reduction of its nitro group forming cytotoxic intermediates In experimental assays Ornidazole demonstrates inhibitory activity against diverse anaerobic bacterial strains including Bacteroides and Clostridium species and protozoan pathogens such as Giardia lamblia and Trichomonas vaginalis typically showing IC50 values ranging from micromolar to low millimolar concentrations This compound is widely utilized in microbiology and infectious disease research to elucidate anaerobic microbial drug sensitivity pathogen resistance mechanisms and protozoan infection biology