Dimethyl Sulfoxide
Apexbio Technology LLC A-740003(Synonyms: A740003, A 740003, P2X7 Receptor Antagonist A-740003, A-740003 P2X7 Antagonist, 861393-28-4), 10mM (in 1mL DMSO), CAS: 861393-28-4.
A-740003 (CAS 861393-28-4) is a selective and competitive antagonist targeting the P2X7 receptor a member of the ATP-gated ionotropic P2X receptor family involved in immune cell signaling cytokine secretion apoptosis and cellular proliferation The antagonist displays IC50 values of 18 nM and 40 nM against mouse and human P2X7 receptors respectively In human THP-1 macrophage-like cells A-740003 inhibits pore formation assessed by Yo-Pro uptake assay (IC50 92 nM) and reduces interleukin-1 secretion (IC50 156 nM) This compound is employed in research investigating P2X7-mediated inflammatory pathways and neuropathic pain mechanisms
Medchemexpress LLC Ru.521 10Mm Dmso Solid 1Nl | HY-114180-10MM DMSO SOLID
Ru.521 10Mm Dmso Solid 1Nl
Apexbio Technology LLC PCI-34051(Synonyms: PCI 34051, PCI34051, HDAC8 inhibitor PCI-34051, PCI-34051 HDAC inhibitor), 10mM (in 1mL DMSO), CAS: 950762-95-5.
PCI-34051 (CAS 950762-95-5) is a selective inhibitor of histone deacetylase 8 (HDAC8) with over 200-fold specificity compared to other HDAC isoforms including HDAC1 HDAC2 HDAC3 HDAC6 and HDAC10 Through selective HDAC8 inhibition PCI-34051 preferentially triggers caspase-dependent apoptosis in T-cell lymphoma and leukemia-derived cell lines while sparing normal hematopoietic (e g PBMCs) and fibroblast cells Cell death induction by PCI-34051 occurs without detectable histone or tubulin hyperacetylation This compound serves as a valuable research tool for dissecting HDAC8-related pathways and evaluating therapeutic potential for hematologic malignancies
Apexbio Technology LLC GDC-0879(Synonyms: AR-00341677, GDC0879, GDC 0879, G-0879, G0879), 10mM (in 1mL DMSO), CAS: 905281-76-7.
GDC-0879 (CAS 905281-76-7) is a selective inhibitor of B-Raf kinase targeting the Raf/MEK/ERK signaling cascade implicated in tumorigenesis It specifically inhibits B-Raf harboring the V600E mutation demonstrating IC50 values of 0 13 nM against purified mutant B-Raf and 63 nM for phosphorylated ERK in MALME-3M cells In vitro assays using V600E mutant cell lines (A375 melanoma Colo205 colorectal cancer) illustrate the compound s selectivity towards B-Raf and related C-Raf kinases In mouse xenografts expressing human BRAFV600E tumors GDC-0879 treatment results in sustained ( 90%) inhibition of ERK phosphorylation and reduced tumor progression highlighting its research value in oncology studies involving Raf pathway modulation
Medchemexpress LLC Carbocysteine sulfoxide | 5439-87-2 | MFCD21364079 | 99.0% | 195.19 g/mol | C5H9NO5S | 10 MG
Carbocysteine sulfoxide is a small-molecule impurity of carbocisteine intended for research use. The substance is identified by CAS number 5439-87-2, has the molecular formula C5H9NO5S, and a molecular weight of 195.19 g/mol. It is provided in small-mass packages for laboratory and analytical applications.
- Used as an impurity reference for analytical method development.
- Supplied in small-mass packages suitable for laboratory research.
- Identified by CAS number 5439-87-2 for substance tracking.
- Molecular formula C5H9NO5S and molecular weight 195.19 g/mol.
- Intended for research use only; not for human or clinical use.
Apexbio Technology LLC Pioglitazone(Synonyms: Actos, Pioglitazone Hydrochloride, AD-4833, U-72107, Glustin, Zactos, Piozone), 10mM (in 1mL DMSO), CAS: 111025-46-8.
Pioglitazone (CAS 111025-46-8) is a small-molecule agonist selectively targeting peroxisome proliferator-activated receptor gamma (PPAR ) By activating this nuclear receptor pioglitazone influences gene expression pathways involved primarily in glucose and lipid metabolism insulin sensitivity and adipocyte differentiation It is widely employed in biomedical research focusing on metabolic disorders including type 2 diabetes mellitus insulin resistance mechanisms and associated inflammatory processes
Apexbio Technology LLC Pirfenidone 53179-13-8 10mM (in 1mL DMSO)
Pirfenidone (CAS 53179-13-8) is a small molecule antifibrotic agent exhibiting anti-inflammatory properties Mechanistically pirfenidone reduces levels of pro-inflammatory mediators notably TNF- via translational regulation independent of MAPK pathway activation It suppresses TGF- -mediated signaling and extracellular matrix protein production contributing to decreased fibrotic responses in cellular and animal models In vivo pirfenidone administration mitigates fibrosis and inflammatory cytokine expression in tissues such as lung liver and kidney Clinically pirfenidone is investigated primarily for idiopathic pulmonary fibrosis demonstrating reductions in fibrosis progression and improved functional parameters
Apexbio Technology LLC Bendamustine HCl 3543-75-7 10mM (in 1mL DMSO)
Bendamustine HCl (CAS 3543-75-7) is an alkylating agent that induces cytotoxicity primarily through DNA damage Mechanistically it disrupts the mitotic checkpoint by downregulating key regulators such as polo-like kinase 1 Aurora kinase A and cyclin B1 leading to mitotic failure and subsequent apoptosis In myeloma models bendamustine activates apoptosis signaling that involves ATM-mediated G2 cell cycle arrest cleavage of caspase-3 and mitochondrial apoptotic pathways It demonstrates dose-dependent antiproliferative activity in dexamethasone-sensitive (MM1 S IC50 119 8 M) and resistant (MM1 R IC50 138 M) multiple myeloma cell lines Bendamustine represents a useful research tool for studying DNA damage response and apoptosis in hematological malignancy contexts
Apexbio Technology LLC OTX-015 202590-98-5 10mM (in 1mL DMSO)
OTX-015 (CAS 202590-98-5) is a selective inhibitor of BRD2 BRD3 and BRD4 proteins within the BET (bromodomain and extra-terminal) family involved in transcriptional regulation By disrupting the interaction between these BRD proteins and acetylated histone H4 OTX-015 exhibits inhibitory activity demonstrated by IC50 values between 92 and 112 nM and in vitro EC50 ranging from 10 to 19 nM OTX-015 treatment reduces proliferation (GI50 60 200 nM) induces G1 arrest and promotes apoptosis in various human cancer cell models In xenograft mouse studies of BRD-NUT midline carcinoma orally administered OTX-015 significantly suppresses tumor growth showing potential utility for cancer research
Apexbio Technology LLC BLZ945 953769-46-5 10mM (in 1mL DMSO)
BLZ945 (CAS 953769-46-5) is a selective small-molecule inhibitor targeting colony-stimulating factor 1 receptor (CSF-1R) a receptor tyrosine kinase critical for macrophage and osteoclast differentiation proliferation migration and survival in response to macrophage colony-stimulating factor (M-CSF) BLZ945 inhibits CSF-1R kinase activity with an IC50 of 1 2 nM and reduces proliferation of M-CSF-dependent cells in vitro (e g EC50 of 71 M in MNFS-60 cells) In murine tumor models CSF-1R inhibition by BLZ945 reduces tumor-associated macrophage turnover and delays progression of breast and cervical tumors highlighting its utility in cancer and immune research
Apexbio Technology LLC Ramelteon(Synonyms: Rozerem, TAK-375, Ramelteon, Melatonin receptor agonist, MT1/MT2 agonist), 10mM (in 1mL DMSO), CAS: 196597-26-9.
Ramelteon (CAS 196597-26-9) is a potent orally active agonist selective for MT1 and MT2 melatonin receptors Structurally characterized by its S-enantiomer and ether functional group ramelteon exhibits high binding affinity toward MT1 and MT2 receptors with reported Ki values of 14 pM and 112 pM respectively whereas affinity for the MT3 receptor is considerably lower (Ki 2650 nM) By activating MT1 and MT2 receptors ramelteon suppresses cAMP production in human cells expressing these receptors with IC50 values of 21 2 pM/L (MT1) and 53 4 pM/L (MT2) Given its receptor selectivity and minimal side-effect profile ramelteon is frequently utilized in research investigating circadian rhythms and sleep disorders
Apexbio Technology LLC Caspofungin(Synonyms: Cancidas, Caspofungin acetate, MK-0991, L-743872), 10mM (in 1mL DMSO), CAS: 162808-62-0.
Caspofungin (CAS 162808-62-0) is a small-molecule inhibitor of -1 3-glucan synthase an enzyme essential for the biosynthesis of -(1 3)-D-glucan a fundamental cell wall component in pathogenic fungi such as Candida albicans Caspofungin selectively inhibits -1 3-glucan synthase activity with a reported IC50 of approximately 0 6 nmol/L in membrane preparations of C albicans Caspofungin demonstrates potent antifungal activity against various Candida isolates including azole-resistant strains (MIC90 0 5 g/mL) and shows prolonged post-antifungal effects lasting 6 8 hours It is widely utilized in biomedical research involving fungal infections and antifungal therapeutics
Apexbio Technology LLC N6022(Synonyms: N6022, GSNOR inhibitor N6022, N-6022, N 6022, GSNOR Inhibitor N-6022, CAS 1208315-24-5, GSNORi N6022), 10mM (in 1mL DMSO), CAS: 1208315-24-5.
N6022 (CAS 1208315-24-5) is a selective reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) an enzyme involved in regulating the levels of S-nitrosoglutathione (GSNO) Inhibition of GSNOR leads to elevated GSNO concentrations promoting vasodilatory and anti-inflammatory effects In biochemical assays N6022 exhibits IC50 values of 8 nM (GSNO reduction assay) and 32 nM (HMGSH oxidation assay) with corresponding Ki values of 2 5 nM and 3 1 nM respectively Due to its selectivity profile and potency N6022 has entered clinical evaluation for inflammatory pulmonary conditions
Apexbio Technology LLC Linezolid(Synonyms: Zyvox, Zyvoxid, U-100766, PNU-100766, U-100766E, PNU100766, Linezolide), 10mM (in 1mL DMSO), CAS: 165800-03-3.
Linezolid (CAS 165800-03-3) is a synthetic oxazolidinone antimicrobial compound with broad-spectrum activity primarily against Gram-positive bacteria including multi-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) vancomycin-resistant Enterococcus (VRE) and penicillin-resistant Streptococcus pneumoniae Linezolid inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit thereby preventing formation of the functional 70S initiation complex In cell-free transcription-translation assays using E coli linezolid demonstrates an IC50 of approximately 1 8 mM Due to its pharmacokinetics and high oral bioavailability linezolid is widely utilized in clinical research related to complicated skin infections and bacterial pneumonia
Apexbio Technology LLC Linsitinib(Synonyms: OSI-906, ASP7487, IGF-1R inhibitor OSI-906, IGF-1R/IR inhibitor OSI-906, OSI906), 10mM (in 1mL DMSO), CAS: 867160-71-2.
Linsitinib (CAS 867160-71-2) also known as OSI-906 is a small-molecule inhibitor targeting both insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R) kinases It exhibits potent inhibitory effects with IC50 values of 75 nM against IR and 35 nM against IGF-1R In vitro studies using the 3T3/hulGF-1R (LISN) cell line demonstrate that Linsitinib inhibits IGF-1R ligand-dependent autophosphorylation and downstream signaling via pERK1/2 pAKT and p-p70S6K It shows antiproliferative activity across multiple cancer cell lines and exhibits dose-dependent tumor growth inhibition in LISN xenograft animal models supporting its utility in oncology research