Dimethyl Sulfoxide
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL
Apexbio Technology LLC Salirasib 162520-00-5 10mM (in 1mL DMSO)
Salirasib (CAS 162520-00-5) chemically known as S-trans trans-farnesylthiosalicylic acid (FTS) is a synthetic inhibitor targeting Ras proteins Structurally mimicking the carboxy-terminal farnesylated cysteine found in Ras Salirasib disrupts Ras localization at the cellular membrane thereby reducing activity of H-ras K-ras and N-ras isoforms Research indicates that Salirasib reduces Ras protein levels by approximately 50% at concentrations of 25 50 M in Panc-1 pancreatic cancer cells In xenograft models it exhibits tumor growth inhibition alone and synergistically with gemcitabine Clinical phase I studies support its continued investigation in solid-tumor therapy recommending a dose of 600 mg/day
Apexbio Technology LLC PD 173074 219580-11-7 10mM (in 1mL DMSO)
PD 173074 (CAS 219580-11-7) is a selective inhibitor targeting fibroblast growth factor receptors (FGFR) exerting its effects by suppressing FGFR tyrosine kinase phosphorylation It has demonstrated dose-dependent inhibitory activity against small cell lung cancer (SCLC) cell lines including H-510 and H-69 by reducing their proliferation colony formation and FGF-2 induced chemotherapy resistance in vitro In murine xenograft models of SCLC PD 173074 reduced tumor progression and significantly prolonged animal survival achieving durable complete responses in some cases PD 173074 represents an important tool compound for investigating the oncogenic role of FGFR signaling in cancer research
Apexbio Technology LLC MRT67307 HCl 2095432-39-4 10mM (in 1mL DMSO)
MRT67307 HCl (CAS 2095432-39-4) is a small-molecule inhibitor targeting several kinases including TBK1 IKK MARK1-4 NUAK1 ULK1/2 and salt-inducible kinases (SIK1-3) It inhibits TBK1 and IKK to block phosphorylation of IRF3 reducing interferon- synthesis without affecting NF- B activation Additionally MRT67307-mediated SIK inhibition promotes regulatory macrophage differentiation leading to elevated anti-inflammatory cytokines (e g IL-10 IL-1ra) and decreased pro-inflammatory cytokines (IL-6 IL-12 TNF) It is utilized to investigate innate immunity macrophage polarization autophagy and inflammation pathways
Apexbio Technology LLC SAG(Synonyms: Smoothened Agonist, SAG dihydrochloride, Hh-Smo agonist, SAG hydrochloride), 10mM (in 1mL DMSO), CAS: 912545-86-9.
SAG (CAS 912545-86-9) is a synthetic small-molecule agonist targeting the Smoothened (SMO) receptor a GPCR-like protein central to the Hedgehog (Hh) signaling pathway It activates SMO with an EC50 of approximately 3 nM thus stimulating downstream Gli transcription factor activity involved in embryonic development and adult tissue homeostasis At concentrations above 1 M SAG exhibits inhibitory effects on pathway signaling It binds directly to SMO forming an interaction with a reported dissociation constant (K D) around 59 nM SAG is employed in biomedical research notably to mitigate glucocorticoid-induced cerebellar injury in primary mouse neuronal cell cultures
Apexbio Technology LLC Tetracaine HCl 136-47-0 10mM (in 1mL DMSO)
Tetracaine hydrochloride (CAS 136-47-0) is a small molecule local anesthetic commonly used in biomedical research It acts through allosteric modulation of ion channel function specifically inhibiting calcium channels and effectively suppressing voltage-dependent calcium release from the sarcoplasmic reticulum Due to its ability to regulate calcium channel activity tetracaine HCl serves as an important investigative tool in studies exploring calcium signaling pathways muscle physiology and neuronal excitability
Apexbio Technology LLC Mocetinostat (MGCD0103, MG0103) 726169-73-9 10mM (in 1mL DMSO)
Mocetinostat (MGCD0103 MG0103 CAS 726169-73-9) is an isotype-selective inhibitor of human histone deacetylases (HDACs) It selectively targets class I HDAC enzymes (HDAC1 HDAC2 HDAC3) and class IV HDAC11 without affecting class II HDACs Mocetinostat inhibits these isoforms with IC50 values of 0 15 mol/L (HDAC1) 0 29 mol/L (HDAC2) 1 66 mol/L (HDAC3) and 0 59 mol/L (HDAC11) resulting in histone hyperacetylation cell cycle arrest and apoptosis in various cancer cell lines It serves as a research tool for studying epigenetic regulation and as a candidate compound for anticancer drug development
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Medchemexpress LLC SJ6986, Solution 10 mM * 1 mL in DMSO | CAS No. : 2765625-93-0
SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1.
Apexbio Technology LLC SW033291 459147-39-8 10mM (in 1mL DMSO)
SW033291 (CAS 459147-39-8) is a small molecule inhibitor targeting the prostaglandin-degrading enzyme 15-PGDH It inhibits 15-PGDH activity non-competitively displaying potent inhibition with an IC50 of 1 5 nM and an apparent dissociation constant (Ki app) of approximately 0 1 nM Cellular assays in A549 cells demonstrate that SW033291 elevates prostaglandin E2 (PGE2) levels (EC50 75 nM) In vivo administration of SW033291 in mice significantly elevates tissue PGE2 concentrations stimulates hematopoietic cytokine expression expands hematopoietic stem and progenitor cell populations and promotes neutrophil expansion Thus SW033291 represents a research tool for studying PGE2-related pathways in tissue regeneration and hematopoiesis
Cayman Chemical L-MethIonIn SulfoxIde 25g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
U.S. Pharmacopeia Dimethyl Sulfoxide, 67-68-5, MFCD00002089, 3g
Molecular formula C2H6OS, Molecular weight 78.13, Melting Point 64.4 - 66.2 °F (18 - 19 °C), Boiling Point 372.2 °F (189 °C), Synonyms: DMSO, Methyl sulfoxide
Apexbio Technology LLC KPT-330 1393477-72-9 10mM (in 1mL DMSO)
KPT-330 (CAS 1393477-72-9) is an orally bioavailable small-molecule inhibitor selectively targeting chromosome region maintenance 1 protein (CRM1) a nuclear export receptor involved in the active transport of tumor suppressors transcription factors and cell-cycle regulators Overexpression and deregulation of CRM1 are frequently associated with cancer progression KPT-330 inhibits CRM1 function promoting nuclear retention of regulatory proteins such as p21 and inducing apoptosis through activation of apoptotic signaling pathways (e g PAR-4 activation Bax upregulation PARP cleavage caspase-3 activation) In preclinical studies KPT-330 demonstrated antitumor activity against renal cell carcinoma non-small cell lung cancer and pancreatic cancer models
Apexbio Technology LLC BML-277 516480-79-8 10mM (in 1mL DMSO)
BML-277 (CAS 516480-79-8) is a potent ATP-competitive inhibitor of checkpoint kinase 2 (Chk2) with an IC50 of approximately 15 nM and a Ki value of 37 nM Mechanistically BML-277 binds specifically to the ATP-binding site of Chk2 blocking its kinase activity In cellular assays BML-277 demonstrates concentration-dependent protective effects against irradiation-induced apoptosis in T-cells with EC50 values ranging from 3 to 7 6 M Due to its selective Chk2 inhibition BML-277 serves as a valuable reagent in studying DNA damage checkpoint pathways and their roles in cell survival and apoptosis