Dimethyl Sulfoxide
Methylsulfoxide, 99.9%, MilliporeSigma™
CAS: 67-68-5 Molecular Weight (g/mol): 78.14
Medchemexpress LLC HY-Y0320 100mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 100mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC SJ6986, Solution 10 mM * 1 mL in DMSO | CAS No. : 2765625-93-0
SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1.
Medchemexpress LLC HY-Y0320 500mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 500mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-Y0320 200mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 200mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC ML-792 | CAS No. : 1644342-14-2 | 10 mM * 1 mL in DMSO
ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively).
Apexbio Technology LLC N6022(Synonyms: N6022, GSNOR inhibitor N6022, N-6022, N 6022, GSNOR Inhibitor N-6022, CAS 1208315-24-5, GSNORi N6022), 10mM (in 1mL DMSO), CAS: 1208315-24-5.
N6022 (CAS 1208315-24-5) is a selective reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) an enzyme involved in regulating the levels of S-nitrosoglutathione (GSNO) Inhibition of GSNOR leads to elevated GSNO concentrations promoting vasodilatory and anti-inflammatory effects In biochemical assays N6022 exhibits IC50 values of 8 nM (GSNO reduction assay) and 32 nM (HMGSH oxidation assay) with corresponding Ki values of 2 5 nM and 3 1 nM respectively Due to its selectivity profile and potency N6022 has entered clinical evaluation for inflammatory pulmonary conditions
Apexbio Technology LLC Simeprevir(Synonyms: Olysio, TMC435, TMC435350, Simeprevir sodium), 10mM (in 1mL DMSO), CAS: 923604-59-5.
Simeprevir (CAS 923604-59-5) is a small molecule inhibitor targeting the hepatitis C virus (HCV) NS3/4A protease a viral serine protease essential for viral polyprotein processing and replication Simeprevir inhibits NS3/4A protease with a Ki of 0 36 nM and demonstrates antiviral activity by reducing viral replication in Huh-7 replicon cells (EC50 of 7 8 nM) and Huh7-Luc HCV genotype 1b replicon cells (EC50 of 8 nM EC90 of 24 nM) Simeprevir is widely utilized in research on antiviral mechanisms and therapeutic strategies against HCV infections
Apexbio Technology LLC Darapladib(Synonyms: SB-480848, Darapladib, LP-PLA2 inhibitor, SB480848), 10mM (in 1mL DMSO), CAS: A3349.
Darapladib (CAS 356057-34-6) is a selective inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) an enzyme strongly implicated in the progression and instability of atherosclerotic plaques In vitro Darapladib shows high potency toward Lp-PLA2 (IC50 approximately 270 pM) with minimal inhibition of other secretory PLA2 isoforms (e g III V X) Preclinical studies in ApoE-deficient mouse models demonstrate that inhibition of Lp-PLA2 attenuates vascular inflammatory processes and markedly reduces atherosclerotic lesion formation Clinically Darapladib administration in statin-treated patients significantly decreases plasma Lp-PLA2 activity and inflammatory markers indicating potential applications in cardiovascular research related to atherosclerosis and associated inflammation
Apexbio Technology LLC Mesoridazine(Synonyms: Serentil, Mesoridazine besylate, TPS-23), 10mM (in 1mL DMSO), CAS: 5588-33-0.
Mesoridazine (CAS 5588-33-0) is a dopaminergic antagonist primarily targeting dopamine D2 receptors (K d 19 nM) As an active metabolite of the atypical antipsychotic thioridazine mesoridazine demonstrates marked inhibitory effects on both pre- and postsynaptic dopamine receptors impacting dopamine and acetylcholine neurotransmission Furthermore mesoridazine engages histamine H1 (K d 1 8 nM) muscarinic acetylcholine (K d 69 nM) 1-adrenergic (K d 2 nM) and 2-adrenergic (K d 1600 nM) receptors Its receptor profile makes mesoridazine valuable for neuroscience research into antipsychotic mechanisms and neurotransmitter regulation
Apexbio Technology LLC Maraviroc(Synonyms: Selzentry, Celsentri, UK-427857, MVC), 10mM (in 1mL DMSO), CAS: 376348-65-1.
Maraviroc (CAS 376348-65-1) is a potent selective antagonist of the chemokine receptor CCR5 CCR5 functions as a coreceptor expressed on immune cells and facilitates entry of certain HIV-1 virus strains (R5-tropic) By binding CCR5 maraviroc effectively blocks HIV-1 envelope protein gp120 anchoring and consequently prevents viral fusion and subsequent cell entry In cellular assays with CCR5-tropic HIV-1 maraviroc demonstrates substantial antiviral activity (IC50 approximately 2 0 nM) and efficiently inhibits gp120-CCR5 interaction Maraviroc serves as a valuable research tool to explore CCR5-mediated viral entry and HIV tropism dynamics
Apexbio Technology LLC Kaempferol(Synonyms: Kempferol, Kaempherol, Kaempferide, Robigenin, Rhamnolutein, Populnetin), 10mM (in 1mL DMSO), CAS: 520-18-3.
Kaempferol (CAS 520-18-3) is a naturally derived flavonoid isolated from sources including Gingko biloba and red wine It functions biologically by activating the mitochondrial calcium uniporter (EC50 7 M) Additionally kaempferol promotes apoptosis through the caspase-9 pathway by suppressing polo-like kinase 1 (PLK1) expression thereby inhibiting cancer cell proliferation in diverse cell lines It also demonstrates antioxidant properties and reduces osteoclast-mediated bone resorption in vitro These characteristics make kaempferol valuable for researching mitochondrial physiology cancer biology and bone metabolism
Apexbio Technology LLC Peramivir(Synonyms: Rapivab, BCX-1812, RWJ-270201, Peramiflu), 10mM (in 1mL DMSO), CAS: 330600-85-6.
Peramivir (CAS 330600-85-6) is a neuraminidase inhibitor under investigation for antiviral activity against influenza virus Structurally peramivir functions as a transition-state analogue inhibitor selectively targeting viral neuraminidase to obstruct enzymatic cleavage required for virion release from infected host cells By this action peramivir effectively impedes viral propagation It has undergone clinical evaluation in research contexts notably receiving emergency use authorization for hospitalized patients during the 2009 H1N1 influenza pandemic
Apexbio Technology LLC Brefeldin A(Synonyms: BFA, Ascotoxin, Cyanein, Decumbin, Brefeldin, γ), 10mM (in 1mL DMSO), CAS: 20350-15-6.
Brefeldin A (CAS 20350-15-6) commonly abbreviated as BFA is a small-molecule inhibitor targeting ATPase activity with a reported IC50 of approximately 0 2 M Its primary mechanism of action involves disruption of intracellular vesicle transport by blocking protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus and inhibiting GTP/GDP exchange Through these activities BFA reduces ATP-mediated vesicular exocytosis thereby diminishing stimulus-dependent hyperalgesia Additionally it induces endoplasmic reticulum stress and promotes p53 expression in tumor cell models like MCF-7 and HeLa ultimately enhancing apoptosis in colorectal cancer cells (HCT116) BFA is widely employed as a pharmacological tool in cellular biology research to study protein secretion vesicular transport dynamics and ER stress pathways