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Tetrahydrofuran

Tetrahydrofuran is an organic, polar, water-miscible, cyclic ether and aprotic solvent with low viscosity. Available in various quantities, purities, and reagent grades, it has applications including use in polymer science and reversed phase chromatography.

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1

Medchemexpress LLC Pelcitoclax | 1619923-36-2 | 99.7% | 1281.85 | 10 MG
SDP

Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects. It is for research use only. In vitro, APG-1252 changes to a reactive metabolite named APG-1252-M1, which has remarkable antitumor effects in acute myeloid leukemia. In vivo, Pelcitoclax (APG-1252) treatment inhibits xenograft tumor growth.

  • Potent Bcl-2/Bcl-xl inhibitor
  • Antineoplastic and pro-apoptotic effects
  • Changes to reactive metabolite APG-1252-M1 with antitumor effects in acute myeloid leukemia
  • Inhibits xenograft tumor growth in vivo
  • Solid appearance
  • White to off-white color

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2

Medchemexpress LLC Pelcitoclax | 1619923-36-2 | 99.7% | 1281.85 | 1 ML
SDP

Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects. In vitro, APG-1252 changes to the reactive metabolite named APG-1252-M1, which has remarkable antitumor effects in acute myeloid leukemia. Pelcitoclax treatment inhibits xenograft tumor growth more obviously than other groups. In an animal model using BALB/c athymic nude mice, intravenous injection of Pelcitoclax once a day for 10 days inhibited xenograft tumor growth.

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3

Medchemexpress LLC RS 09 | 1449566-36-2 | 99.83% | 691.78 | 10 MG
SDP

RS 09 is a peptide mimic of LPS and acts as a TLR4 agonist. It binds to TLR-4 and activates NF-κB, and can function as an adjuvant in vivo to enhance the antigen-specific immune response. This compound has been shown to stimulate TLR-4 and activate NF-κB in HEK-BLUE™-4 cells and induce nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells.

  • Acts as a TLR4 agonist
  • Binds to TLR-4 and activates NF-κB
  • Enhances antigen-specific immune response in vivo
  • Stimulates TLR-4 and activates NF-κB in HEK-BLUE™-4 cells
  • Induces nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells

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4

Medchemexpress LLC Pelcitoclax (APG-1252) | 1619923-36-2 | 99.7% | 1281.85 g·mol⁻¹ | C57H66ClF4N6O11PS4 | 5 MG
SDP

Pelcitoclax is a small-molecule dual inhibitor of Bcl-2 and Bcl-xL used in oncology research. It induces apoptosis and has demonstrated antitumor activity in preclinical models, and is supplied with characterized molecular properties and high analytical purity for research applications.

  • Dual Bcl-2 and Bcl-xL inhibition mechanism
  • Promotes apoptosis in tumor cells
  • Demonstrated antitumor activity in preclinical studies
  • High analytical purity for consistent results
  • Available as solid and ready-to-use DMSO solution formats

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5

Medchemexpress LLC 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid | 140405-36-3 | 99.7% | 312.37 | C17H20N4O2 | 25 MG
SDP

RSVA405 is a potent, orally active activator of AMP-activated protein kinase (AMPK) used in preclinical research. It facilitates CaMKKβ-dependent AMPK activation, inhibits mTOR, promotes autophagy and lysosomal degradation of Aβ, and exhibits anti-inflammatory effects via STAT3 inhibition. Activity is observed in vitro (EC50 ≈ 1 μM) and in vivo in metabolic and renal models.

  • Potent AMPK activator with an EC50 of approximately 1 μM.
  • Promotes autophagy and lysosomal degradation of Aβ.
  • Inhibits mTOR and modulates adipocyte differentiation.
  • Exhibits anti-inflammatory effects through STAT3 inhibition.
  • Demonstrated in vitro and in vivo activity in metabolic and renal models.
  • Supplied as a light yellow to yellow solid with high purity.

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6

Medchemexpress LLC L-homopropargylglycine (2S)-2-amino-5-hexynoic acid | 98891-36-2 | MFCD11052896 | 98.0% | 127.14 g/mol | C6H9NO2 | 5 MG
SDP

L-homopropargylglycine is an alkyne-bearing amino acid analog used as a PROTAC linker and for bioorthogonal click chemistry. The compound contains a terminal alkyne for azide-alkyne cycloaddition and is supplied as a small, crystalline reagent suitable for synthetic and conjugation workflows.

  • Alkyne-functional amino acid ideal for click chemistry applications.
  • Suitable as a PROTAC linker or for probe conjugation.
  • High purity of 98.0% supports reliable synthesis.
  • Low molecular weight (127.14 g/mol) simplifies handling and analysis.
  • Stable when stored sealed at recommended cold temperatures.
  • Available in small pack sizes for research-scale use.

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7

Medchemexpress LLC 3-fluoro-N-[(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide | 352336-36-8 | 99.4% | C17H12FN3O2S | 10MG
SDP

HY-133511 (MLS000544460) is a selective, reversible inhibitor of Eya2 phosphatase used in biochemical and cellular research. It is supplied as a white to off-white solid (C17H12FN3O2S) with high reported purity and characterized potency for use in mechanism and preclinical studies.

  • selective, reversible inhibition of Eya2 phosphatase
  • high reported purity (99.42%) suitable for research assays
  • characterized potency: Kd 2.0 μM and IC50 4 μM
  • high solubility in DMSO (125 mg/mL) and formulatable for animal dosing
  • powder storage stability: -20°C for up to 3 years
  • white to off-white solid with molecular weight 341.36 g/mol

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8

Medchemexpress LLC N'-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide | 140405-36-3 | MFCD00542031 | 99.7% | 312.37 | C17H20N4O2 | 100 MG
SDP

RSVA405 is a small-molecule activator of AMP-activated protein kinase (AMPK) that promotes CaMKKβ-dependent AMPK activation, inhibits mTOR signaling, enhances autophagy and Aβ degradation, and exhibits anti-inflammatory activity via STAT3 inhibition. It is used in metabolic, neurodegenerative, and obesity research.

  • Potent AMPK activation and mTOR inhibition.
  • Promotes autophagy and Aβ degradation.
  • Reported anti-inflammatory activity through STAT3 inhibition.
  • High purity (99.72%) suitable for research applications.
  • Available as solid and as 10 mM solution in DMSO; multiple package sizes.
  • Stable when stored as powder at -20°C and in solvent under recommended conditions.

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9

Medchemexpress LLC N'-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide | 140405-36-3 | MFCD00542031 | 99.7% | 312.37 g/mol | C17H20N4O2 | 10 MG
SDP

RSVA405 (CAS 140405-36-3) is a small-molecule activator of AMP-activated protein kinase (AMPK) used in cellular and biochemical research. It promotes CaMKKβ-dependent AMPK activation, inhibits mTOR signaling, and can induce autophagy; supplied at high purity for research applications.

  • Potent AMPK activator; reported EC50 = 1 μM.
  • High purity (~99.7%).
  • Molecular formula C17H20N4O2; molecular weight 312.37 g/mol.
  • Soluble in DMSO; available as solid or DMSO solution.
  • For research use only; not for human consumption.

ENCOMPASS_PREFERRED
10

Medchemexpress LLC 9,19-Cyclolanostan-3-ol, 24-methylene-, 3-(4-hydroxy-3-methoxyphenyl)-2-propenoate, (3β)- | 469-36-3 | 5 MG
SDP

24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. It promotes parvin-beta expression in human breast cancer cells and is a potential ATP-competitive Akt1 inhibitor.

  • Purity of 98.53%
  • White to off-white solid appearance
  • Soluble in DMSO at ≥ 12.5 mg/mL
  • Classified as a terpenoid and phenol
  • Derived from plants

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11

Medchemexpress LLC 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperaz... | 1224964-36-6 | 98.3% | 548.92 | C21H21ClF2N3O8S | 10 MG
SDP

XL-784 is a small-molecule selective matrix metalloproteinase (MMP) inhibitor provided for research use. It exhibits potent activity across multiple MMP isoforms and is applied in studies of extracellular matrix remodeling, tumor invasion, and metastasis.

  • Selective inhibition of multiple MMPs with reported IC50s in the subnanomolar to micromolar range (e.g., MMP-13 0.56 nM, MMP-2 0.81 nM).
  • Suitable for biochemical and cell-based studies of extracellular matrix and cancer biology.
  • High purity (98.3%) for reliable experimental outcomes.
  • Provided as a solid and as a DMSO solution for flexible dosing.
  • Molecular weight 548.92 g/mol; CAS number 1224964-36-6.

ENCOMPASS_PREFERRED
12

Medchemexpress LLC N-[(E)-[4-(diethylamino)-2-hydroxyphenyl]methylideneamino]pyridine-4-carboxamide | 140405-36-3 | MFCD00542031 | 99.7% | 312.37 g/mol | C17H20N4O2 | 50 MG
SDP

RSVA405 is a small-molecule research compound that potently activates AMP-activated protein kinase (AMPK) and is orally active in vivo. It facilitates CaMKKβ-dependent AMPK activation (EC50 = 1 μM), inhibits mTOR signaling, promotes autophagy and amyloid-β (Aβ) degradation, and shows anti-inflammatory activity via STAT3 inhibition.

  • Potent AMPK activator (EC50 = 1 μM).
  • Orally active small-molecule research compound.
  • Promotes autophagy and increases Aβ degradation.
  • Inhibits mTOR signaling and STAT3-mediated inflammation.
  • High purity (≈99.7%) light yellow solid.
  • Recommended storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).

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13

Medchemexpress LLC 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol | 315698-36-3 | MFCD02330713 | >=98.0% | 354.83 g/mol | C19H19ClN4O | 5 MG
SDP

MLS1547 is a small-molecule, G protein-biased agonist of the dopamine D2 receptor used in research to probe receptor signaling bias. It preferentially stimulates G protein-mediated signaling with micromolar potency while showing reduced β-arrestin recruitment, making it useful for studies of biased agonism and D2 receptor pharmacology.

  • Preferentially activates G protein signaling over β-arrestin pathways.
  • D2 receptor agonist activity (Ki ≈ 1.2 μM; EC50 ≈ 0.37 μM).
  • Antagonizes dopamine-stimulated β-arrestin recruitment (IC50 ≈ 9.9 μM).
  • High purity suitable for biochemical assays (≥98% HPLC).
  • Supplied in small research quantities for laboratory studies.
  • Store refrigerated at +4 °C to maintain stability.

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14

Medchemexpress LLC RNA, [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G) | 1258984-36-9 | 98.9% | 7127.3 | 1 MG
SDP

Nusinersen sodium is an antisense oligonucleotide active molecule. It modifies the pre-messenger RNA splicing of the SMN2 gene, which promotes the production of full-length SMN protein. This action helps to improve spinal muscular atrophy. It is intended for research use only and not for sale to patients.

  • Antisense oligonucleotide active molecule.
  • Modifies pre-messenger RNA splicing of the SMN2 gene.
  • Promotes production of full-length SMN protein.
  • Improves spinal muscular atrophy.
  • Demonstrated improvement in motor function, preservation of αMN number, reduced motor neuron degeneration, and rescued skeletal muscle fiber size and oxidative metabolism in a severe SMA mouse model.

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