Organooxygen compounds
Medchemexpress LLC Adrogolide hydrochloride | 166591-11-3 | 99.6% | 435.96 g/mol | C22H26ClNO4S | 5 MG
Adrogolide hydrochloride is the hydrochloride salt of adrogolide, a prodrug that is converted in plasma to the dopamine D1 receptor agonist A-86929. It is provided as a research-grade compound for pharmacology and neuroscience studies where selective D1 activation is required.
- High purity suitable for research applications.
- Soluble in DMSO; documented in vivo formulation options for administration.
- Available in small and larger pack sizes to support screening and in vivo studies.
- Stable when stored dry at room temperature; stock solutions stable at -20°C to -80°C.
- Used to study dopamine D1 receptor-mediated pharmacology in vitro and in vivo.
Medchemexpress LLC Nimustine hydrochloride | 55661-38-6 | MFCD01676942 | 98.2% | C9H14Cl2N6O2 | 10MG
Nimustine hydrochloride is the hydrochloride salt of nimustine, an alkylating antitumor agent used in research to induce DNA damage and study DNA-damage response pathways. It produces DNA double-strand breaks and inter-strand crosslinks and activates signaling cascades involved in the DNA damage response.
Medchemexpress LLC Emixustat hydrochloride (ACU-4429 hydrochloride) | 1141934-97-5 | 99.3% | 299.84 | 1 ML
Emixustat hydrochloride (ACU-4429 hydrochloride) is an orally active RPE65 inhibitor. It functions as a visual cycle modulator, regulating visual cycle activity by inhibiting retinol isomerization, and shows potential for studying vision disorders, including age-related macular degeneration (AMD).
- Orally active RPE65 inhibitor
- Functions as a visual cycle modulator
- Regulates visual cycle activity by inhibiting retinol isomerization
- Potential for studying vision disorders such as age-related macular degeneration (AMD)
- Inhibits RPE65 activity with an IC50 of 4.4 nM
- Reduces 11-cis-retinol production
- Shown to inhibit neovascularization and protect the retina in an oxygen-induced retinopathy mouse model
Medchemexpress LLC CZC-54252 hydrochloride | 1784253-05-9 | 98.4% | 5 MG
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50 values of 1.28 nM for wild-type LRRK2 and 1.85 nM for G2019S LRRK2. This compound can attenuate G2019S LRRK2-induced human neuronal injury with an EC50 of approximately 1 nM, exhibiting neuroprotective activity.
- Potent and selective LRRK2 inhibitor
- Attenuates G2019S LRRK2-induced human neuronal injury
- Exhibits neuroprotective activity
- Molecular weight: 541.45
- Chemical formula: C22H26Cl2N6O4S
- Appearance: Solid
- Color: Light yellow to orange
- Recommended storage: 4°C, sealed, away from moisture
Medchemexpress LLC Buspirone hydrochloride | 33386-08-2 | 99.99% | 1 ML
Buspirone hydrochloride is a 5-HT1A receptor agonist. It can be used for anxiety and depression research.
- 5-HT1A receptor agonist
- Can be used for anxiety and depression research
- Has cytotoxic effect in lymphocytes (0-400 μg/mL; 6 hours)
- Induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG) (0-180 μg/mL; 0-3 hours; lymphocytes)
- Reduces anxiety/depression behaviors in C57BL/6N mice (1-5 mg/kg; i.p. and i.g.; for 5 days)
- Restores IS-shifted β-diversity in the gut microbiota in C57BL/6N mice (1-5 mg/kg; i.p. and i.g.; for 5 days)
- Reduces TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon in C57BL/6N mice
- Reduces the IS- or EC-induced gut proteobacteria population in C57BL/6N mice
Medchemexpress LLC Aptiganel hydrochloride | 137160-11-3 | 99.9% | 339.86 | 25 MG
Aptiganel hydrochloride (Cerestat) is a non-competitive NMDA receptor antagonist with a neuroprotective effect. This product is for research use only.
- Acts as a non-competitive NMDA receptor antagonist.
- Exhibits neuroprotective properties.
- Intended for research use only.
Medchemexpress LLC CHK1-IN-4 hydrochloride | 00-00-0 | 480.75 g/mol | C18H19BrClN7O2 | 5 MG
CHK1-IN-4 hydrochloride is the hydrochloride salt of a small-molecule inhibitor of checkpoint kinase 1 (CHK1). It is used in preclinical biochemical and cell-based studies to inhibit CHK1 phosphorylation and evaluate antitumor activity. Supplied as a solid with defined solubility and storage recommendations for research use.
- Potent checkpoint kinase 1 (CHK1) inhibitor active in tumor cells.
- Hydrochloride salt form for improved solubility and handling.
- Solid material; soluble in DMSO at 5 mg/mL with ultrasonic and warming.
- Storage: in solvent -80°C for up to 6 months; sealed -20°C for up to 1 month.
- Supplied in small research pack sizes suitable for preclinical studies.
Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | 99.5% | 576.13 g·mol⁻¹ | C28H42ClN7O4 | 10 MG
EPZ004777 hydrochloride is a potent, selective inhibitor of the histone methyltransferase DOT1L used in epigenetic and leukemia research. It inhibits DOT1L with an IC50 of 0.4 nM, reduces H3K79 methylation in cells, and has been used to selectively kill MLL-rearranged leukemia cells. This material is supplied for research use only.
- Potent DOT1L inhibition (IC50 0.4 nM).
- Selective activity in biochemical and cellular assays.
- Reduces H3K79 methylation and downregulates leukemogenic gene expression.
- High chemical purity (99.5%).
- Available as solid and as DMSO solution for flexible use in experiments.
- CAS number 1380316-03-9; molecular weight 576.13 g·mol⁻¹.
Medchemexpress LLC Midodrine hydrochloride | 43218-56-0 | 99.9% | 10 MG
Midodrine hydrochloride is a selective and orally active adrenergic α1-receptor agonist. It strengthens vascular contraction and is utilized in research concerning cardiovascular diseases, such as orthostatic hypotension.
- Selective and orally active adrenergic α1-receptor agonist
- Strengthens vascular contraction
- Utilized in research for cardiovascular diseases like orthostatic hypotension
- Increases p-AMPK and PPARδ expression
- Increases Ca2+ in C2C12, HL1 and HepG2 cells
- Increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells
- Reduces cellular lipid content in 3T3-L1 cells
- Reduces platelet-activating factor-induced death in mice
- Shows anti-hypotensive effects in orthostatic hypotension rat models
- Relieves hypertension in spontaneously hypertensive rat models
Medchemexpress LLC Viloxazine hydrochloride | 35604-67-2 | MFCD00661100 | 98.9% | 273.75 g/mol | C13H20ClNO3 | 50MG
Viloxazine hydrochloride is a research-grade small molecule used as a selective norepinephrine transporter (NET) inhibitor and a modulator of serotonin (5-HT) receptors. Presented as the hydrochloride salt (CAS 35604-67-2) and supplied for preclinical laboratory use, it is commonly employed as a tool compound in studies of norepinephrine and serotonin signaling and in ADHD-related research.
- Research-grade hydrochloride salt with defined purity for laboratory use.
- Selective norepinephrine transporter inhibitor activity (IC50 = 0.26 μM).
- Modulates 5-HT receptors, including 5-HT2B antagonist and 5-HT2C agonist actions.
- Available in small pack sizes suitable for assays, including a 50 mg pack.
- Provided with molecular and analytical data to support traceability and reproducibility.
Medchemexpress LLC Abeprazan hydrochloride | 1902954-87-3 | 99.9% | 446.87 | 50 MG
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker that inhibits H+, K+- ATPase through reversible potassium-competitive ionic binding without requiring acid activation. It is being developed as a potential alternative to proton pump inhibitors for treating acid-related diseases.
- Potassium-competitive acid blocker.
- Inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding.
- Does not require acid activation for its inhibitory mechanism.
- Developed as a potential alternative for proton pump inhibitors.
- Inhibits acid secretion in a dose-dependent manner in in vivo studies.
- Efficacy is equal to or greater than that of vonoprazan in various in vivo studies.