Phenylpropanoids and polyketides
Medchemexpress LLC 2-Propen-1-ol,3-phenyl-,(2E)- | 4407-36-7 | 134.18 | 25 G
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite.
- Purity: 98.0%
- Appearance: Solid
- Color: Off-white to light yellow
- Initial source: Plants Rosaceae
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Cinnamyl-3,4-dihydroxy-α-cyanocinnamate | 132465-11-3 | 99.41% | 321.33 | 25 MG
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent inhibitor of 12/15-Lipoxygenases (LO) with potential for research into type 1 diabetes mellitus. It has been shown to antagonize the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier in a mouse diabetes mellitus model. In vitro, CDC partially suppressed dextran transport increased by high glucose or 12(S)-HETE.
- Potent inhibitor of 12/15-Lipoxygenases (LO)
- Potential for type 1 diabetes mellitus research
- Antagonizes high glucose effect on protein phosphorylation
- Mitigates endothelial cell barrier destruction in mouse models
- Partially suppresses dextran transport increased by high glucose or 12(S)-HETE
Medchemexpress LLC Rifabutin | 72559-06-9 | 99.2% | 847.00 | 25 MG
Rifabutin is a semisynthetic ansamycin antibiotic that exhibits potent antimycobacterial properties by inhibiting DNA-dependent RNA polymerase. It is primarily used as a bactericidal agent for treating tuberculosis and is effective against a range of resistant mycobacteria, including Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare. It also acts as an antibiotic and antitumor agent, influencing HSP-90 molecular chaperone and inactivating bacterial RNA polymerase.
- Semisynthetic ansamycin antibiotic
- Inhibits DNA-dependent RNA polymerase
- Bactericidal against resistant mycobacteria
- Effective against Gram-positive and some Gram-negative bacteria
- Treats tuberculosis and other mycobacterial infections
- Acts as an antitumor agent
- Modulates HSP-90 molecular chaperone
- Inactivates bacterial RNA polymerase
Cambridge Isotope Laboratories Predominant Bioaccumulative Toxaphene Congeners Parlar 26 50 62 2 ug/mL in nonane 1 2 mL
Predominant Bioaccumulative Toxaphene Congeners Parlar 26 50 62 2 ug/mL in nonane 1 2 mL
Medchemexpress LLC 1-(2-dimethylaminoethyl)-1,2,3,4-tetrahydro-2-methylcarbazole hydrochloride | 54-84-2 | MFCD00055609 | 99.5% | 376.9 g/mol | C20H25ClN2OS | 1 ML
Cinanserin hydrochloride is the hydrochloride salt of cinanserin, supplied for research use as a 10 mM solution in DMSO (1 mL) and as solid quantities. It functions as a 5-HT2 receptor antagonist in pharmacological and biochemical studies and is provided with supporting documentation for quality control.
- Provided as 10 mM solution in DMSO (1 mL) and as solid pack sizes.
- High purity suitable for biochemical and pharmacological assays.
- Accompanied by a datasheet and certificate of analysis.
- Used as a 5-HT2 receptor antagonist in research applications.
- CAS number 54-84-2 for unambiguous chemical identification.
- Molecular weight 376.9 g/mol.
Cayman Chemical ANTIBODY AMG 9810 25mg
A competitive antagonist of capsaicin activation of the TRPV1 (IC50s = 24.5 and 85.6 nM for human and rat, respectively); reverses thermal and mechanical hyperalgesia in a rat model of inflammatory pain
Sigma Aldrich Fine Chemicals Biosciences SB-366791 >=98% (HPLC), powder | 472981-92-3 | MFCD01033818 | 25MG
SB-366791 >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 287.74 | 472981-92-3 | MFCD01033818 | 25MG
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 1 ML
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, inhibits Apoptosis, and improves insulin resistance and insulin sensitivity.
- Potent and orally active curcumin analog
- Inhibits lipid droplet formation
- Increases autophagy
- Inhibits apoptosis
- Improves insulin resistance and insulin sensitivity
- Decreases palmitic acid (PA)-induced SREBP1 expression levels in AML12 cells
- Ameliorates insulin resistance and hepatic steatosis in mice with high-fat diet-induced obesity
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 25 MG
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. Curcumin 5-8 also improves insulin resistance and insulin sensitivity. This product is for research use only and not sold to patients.
- Potent and orally active naturally active curcumin (CUR) analog.
- Inhibits lipid droplet formation.
- Increases autophagy.
- Inhibits apoptosis.
- Improves insulin resistance and insulin sensitivity.
- For research use only and not sold to patients.
Selleck Chemical LLC AG 494
AG-494 a member of the tyrphostin family of tyrosine kinase inhibitors is a potent inhibitor of EGF receptor autophosphorylation (IC50 1 2 M) and EGF-dependent cell growth (IC50 6 M)
Medchemexpress LLC Tyrphostin AG 112 | 144978-82-5 | 98.3% | 236.23 | 25 MG
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor intended for research use only. It inhibits EGFR in human A431 cells with an IC50 of 0.1 μM.
- EGFR phosphorylation inhibitor
- Inhibits EGFR in human A431 cells with an IC50 of 0.1 μM
- For research use only
- Appears as a light yellow to yellow solid
eMolecules 2699937-04-5 | Medchem Express | MRL-494 (hydrochloride) | 5mg | 552386588 | HY-128773A | 659.13 | C26H36ClFN16O2
Medchem Express | Apramycin (sulfate) | 100mg | 446273816 | HY-B1329 | 65710-07-8 | 637.660 | C21H43N5O15S
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TARGETMOL CHEMICALS INC SAR405 R enantiomer 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.SAR405 (R enantiomer) is the less active form of SAR405, an inhibitor of PIK3C3/Vps34. Purity 98.04%
Medchemexpress LLC Z-Entacapone | 145195-63-7 | 305.29 | 25 MG
(Z)-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor Entacapone. It is also a potential impurity found in commercial preparations of Entacapone and a degradant of Entacapone formed by UV light exposure.
- Metabolite of the catechol-O-methyltransferase (COMT) inhibitor Entacapone
- Potential impurity in commercial Entacapone preparations
- Degradant of Entacapone formed by UV light exposure
- Molecular formula: C14H15N3O5
- SMILES: O=C(N(CC)CC)/C(C#N)=C\C1=CC([N+]([O-])=O)=C(O)C(O)=C1
- Targets COMT
- Involves metabolic enzyme/protease and neuronal signaling pathways