Phenylpropanoids and polyketides
TARGETMOL CHEMICALS INC 4-Hydroxychalcone 500MG
Also available in 5 g, 1 mL, 100 mg and bulk. Please contact Fisher for quotes. 4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity Purity 99.86%
Apexbio Technology LLC Esculin 531-75-9 20mg
Esculin (CAS 531-75-9) is a coumarin glucoside isolated from the bark of Aesculus hippocastanum It functions primarily as a -glucosidase substrate hydrolyzing to esculetin and glucose upon enzymatic action Esculin s fluorescence properties make it valuable in assays monitoring -glucosidase activity in microbiological and biochemical research Additionally its antioxidant and vasoprotective effects have supported investigations into microcirculatory disorders and oxidative stress-related models Esculin is soluble in hot ethanol methanol pyridine ethyl acetate and acetic acid and should be stored in sealed cool and dry conditions
Cayman Chemical Methyl SalIcylate-d4 10mg
An internal standard for the quantification of methyl salicylate by GC- or LC-MS
Medchemexpress LLC Myricetin | 529-44-2 | C15H10O8 | 500 MG
Myricetin is a naturally occurring plant-derived flavonoid known for its diverse biological activities, including potent anti-oxidant, anticancer, antidiabetic, and anti-inflammatory properties. It operates through various mechanisms, influencing key cellular pathways and demonstrating potential therapeutic applications.
- Scavenges various radicals and ions
- Prevents cancer cell death through apoptosis regulation
- Exhibits antiphotoaging effects by neutralizing free radicals in the skin
- Inhibits viability of ovarian cancer cells
- Inhibits human Hsp70
- Shows potential in reducing tumor growth and metastatic spread
- Inhibits platelet aggregation
eMolecules 57543-37-0 | 6-Bromo-2H-chromene-3-carbaldehyde | Chem-Impex | MFCD01662415 | 239.068 | C10H7BrO2 | 95.000 | Brc1ccc2OCC(C=O)=Cc2c1 | 1g | 112753564
6-Bromo-2H-chromene-3-carbaldehyde | Chem-Impex | 57543-37-0 | MFCD01662415 | 239.068 | C10H7BrO2 | 95.000 | Brc1ccc2OCC(C=O)=Cc2c1 | 1g | 112753564
Indofine Chemical 7-HYDROXYFLAVONE, Flavonoid & Coumarins, 6665-86-7, 98%, 5 gm
7-HYDROXYFLAVONE, Flavonoid & Coumarins, 6665-86-7, 98%, 5 gm
Apexbio Technology LLC Daunorubicin 20830-81-3 50mg
Daunorubicin (20830-81-3) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit this target thereby disrupting nucleic acid synthesis within tumor cells Daunorubicin exerts its biological activity primarily through stabilizing the topoisomerase II-DNA cleavage complex interfering with DNA replication and transcription In in vitro studies daunorubicin demonstrates inhibition of metabolic incorporation of nucleoside precursors into DNA and RNA with reported IC50 values for inhibition of leukemia cell growth ranging from 0 02 1 M depending on cellular context and assay conditions Based on these pharmacological properties daunorubicin holds research potential in oncology studies related to chemotherapy-induced genotoxicity and nucleic acid metabolism
Apexbio Technology LLC Entacapone 130929-57-6 10mM (in 1mL DMSO)
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Medchemexpress LLC AMG 487 | 473719-41-4 | C32H28F3N5O4 | 100 MG
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). It inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
- Targets CXCR3
- Involved in GPCR/G Protein and immunology/inflammation pathways
- Inhibits CXCR3-mediated cell migration
- Inhibits calcium mobilization
- Leads to fewer lung metastases
- Reduces tumor volume
Cayman Chemical 7-AmIno-4-methylcoumarIn 250mg
A fluorescent probe for peptide labeling commonly used in the study of proteases; conjugation via its amino group to a peptide substrate results in quenching of the fluorescent signal; upon enzymatic cleavage of the peptide by proteases, AMC is released and its fluorescence can be used to quantify enzyme activity; ex/em = 345/445 nm, respectively
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 10mg
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Medchemexpress LLC γ-Glutamyl-S-1-propenyl cysteine | 91216-96-5 | 98.5% | 290.34 | 1 MG
γ-Glutamyl-S-1-propenyl cysteine is a compound isolated from garlic. It has a molecular weight of 290.34 and a CAS number of 91216-96-5. This compound is intended for research use only.
- Isolated from garlic
- Storage at -20°C, stored under nitrogen
- In solvent storage at -80°C for 6 months; -20°C for 1 month (stored under nitrogen)
- Solubility in H2O: 130 mg/mL (need ultrasonic)
- Solubility in DMSO: 4.23 mg/mL (need ultrasonic)
- Molecular formula: C11H18N2O5S