Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Bio-AMS TFA | 1393881-52-1 | 98.0% | 685.65 | 1 MG
Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. It exhibits selective activity against *Mycobacterium tuberculosis* (Mtb) and hinders fatty acid and lipid biosynthesis. It is for research use only and not sold to patients.
- Potent bacterial biotin protein ligase inhibitor.
- Selective activity against *Mycobacterium tuberculosis* (Mtb).
- Arrests fatty acid and lipid biosynthesis.
- Excellent antitubercular activity against Mtb H37Rv and MDR/XDR-TB strains with MICs ranging from 0.16 to 0.625 μM.
- Its activity is not affected by changes to the primary carbon source.
- Inhibits growth of Mtb in Mtb-infected mouse macrophages in a concentration-dependent manner (2.5, 5 and 10 μM; 24 h).
- Shows no signs of mitochondrial toxicity.
Medchemexpress LLC Rf470 TFA | 2369899-34-1 | 624.63 | 25 MG
Rf470 TFA is a FMR-probe-D-lysine conjugate (Max Ex: 470 nM; Max Em: 640 nM) that can be covalently incorporated into peptidoglycan by bacteria. It exhibits extremely weak fluorescence in its free state, but its fluorescence significantly increases when it is catalytically incorporated into peptidoglycan by transpeptidases.
- Can be used for real-time monitoring of peptidoglycan biosynthesis.
- Can be used for detection of transpeptidase activity.
- Can be used for screening of antibiotics through fluorescence changes.
Medchemexpress LLC Jbsnf-000028 Tfa | C13H14F3N3O2 | 1 ML
JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. It can reduce endogenous MNA levels in U2OS osteosarcoma cells, with an EC50 of 2.5 μM. This compound exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model and can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of NNMT
- Reduces endogenous MNA levels in U2OS osteosarcoma cells
- Exhibits anti-obesity and anti-diabetic activities
- Useful for studying metabolic diseases like obesity, type 2 diabetes, and non-alcoholic fatty liver disease
Medchemexpress LLC F9170 (TFA) | >98% | 2097.33 | 1 MG
F9170 (trifluoroacetate salt) is an antiviral peptide that corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein. This product is identified as a laboratory chemical for the manufacture of substances and is strictly for research use only. It must be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- Antiviral peptide.
- Corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein.
- Intended for research use only.
- Suitable for laboratory chemical applications.
- Recommended for handling by experienced personnel.
Medchemexpress LLC DPC-AJ1951 (TFA) | 99.4% | 1666.99 (free base) | 1 MG
DPC-AJ1951 TFA is a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption. In vitro, it induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR.
- Acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo assays of bone resorption
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR
- 14 amino acid peptide
Medchemexpress LLC Lagipra peptide (TFA) | 98.2% | 5756.50 (free base) | 1 MG
LAGIPRA peptide TFA is a long-acting GIP1R agonist. It enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. This peptide has potential for the research of type 2 diabetes.
- Long-acting GIP1R agonist
- Enhances insulin sensitivity
- Reduces branched-chain amino acids (BCAAs)
- Reduces ketoacids
- Potential for type 2 diabetes research
Medchemexpress LLC Astax-35r TFA | 99.1% | 2392.86 | 5 MG
aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. It competitively inhibits the binding of β-catenin to TCF4 and selectively induces growth inhibition of Wnt-dependent cancer cells.
- Antagonizes nuclear form of β-catenin.
- Inhibits Wnt signaling.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition of Wnt-dependent cancer cells.
Medchemexpress LLC Pepinh-MYD TFA | 3388.03 (free base) | 1 MG
Pepinh-MYD TFA is a MyD88 inhibitor that contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling it to penetrate the cell membrane. It interferes with MyD88-mediated TLR signaling pathways, thereby inhibiting related immune responses.
- Includes a domain sequence from MyD88 TIR
- Contains a protein transduction sequence
- Penetrates the cell membrane
- Interferes with MyD88-mediated TLR signaling pathways
- Inhibits related immune responses
- Holds potential for studying the role of MyD88 in viral infections
Medchemexpress LLC D2A21 TFA | 95.6% | 2775.42 | 5 MG
D2A21 TFA is an antimicrobial peptide with significant antimicrobial activity against Pseudomonas and a bactericidal effect on burn scabs. It also exhibits antitumor activity and can be used in prostate cancer research.
- Antimicrobial peptide with significant antimicrobial activity against Pseudomonas
- Bactericidal effect on burn scabs
- Has antitumor activity
- Can be used in prostate cancer research
Medchemexpress LLC Ela-32(human) (tfa) | 99.9% | 3967.82 | 1 MG
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist with an IC50 of 0.27 nM and a Kd of 0.51 nM. This product does not bind to GPR15 and GPR25. It activates the PI3K/AKT pathway, promoting the self-renewal of hESCs via cell-cycle progression and protein translation. Additionally, it potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage, and stimulates angiogenesis in HUVEC cells.
- Potent, high affinity apelin receptor agonist
- IC50 of 0.27 nM and a Kd of 0.51 nM
- Exhibits no binding to GPR15 and GPR25
- Activates the PI3K/AKT pathway
- Promotes self-renewal of hESCs via cell-cycle progression and protein translation
- Potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage
- Stimulates angiogenesis in HUVEC cells
Medchemexpress LLC Mm-102 trifluoroacetate | 1883545-52-5 | 99.7% | 1 ML
MM-102 TFA is the trifluoroacetate salt of MM-102, a potent inhibitor of the WDR5/MLL protein-protein interaction, supplied as a ready-to-use 10 mM solution in DMSO for research applications.
- Potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM).
- Supplied as a 10 mM solution in DMSO, 1 mL volume.
- High purity listed at 99.68% (reported as 99.7%).
- Molecular weight 783.83 g·mol⁻1; formula C37H50F5N7O6.
- For research use only; not for human or clinical use.
Medchemexpress LLC Pyridostatin (TFA) | 1472611-44-1 | 1037658 | C33H33F3N8O7 | 25 MG
Pyridostatin TFA is a G-quadruplex DNA stabilizing agent with a Kd of 490 nM, targeting both DNA and RNA G4s within cells. This selective small molecule promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage and affects proto-oncogene Src.
- Targets DNA and RNA G4s in cells
- Promotes growth arrest in human cancer cells
- Induces replication- and transcription-dependent DNA damage
- Reduces SRC protein levels and cellular motility in breast cancer cells
- Causes neurite retraction, synaptic loss, and dose-dependent neuronal death in cultured primary neurons
- Induces DNA DSBs in cultured primary neurons
- Downregulates BRCA1 protein at the transcriptional level
- High purity: 99.17%
- Solid, white to off-white appearance
Medchemexpress LLC ATX-II TFA | 99.7% | 4934.62 (free acid) | 1 MG
ATX-II TFA is a selective sodium channel modulator toxin. It enhances late sodium current and prevents full sodium channel inactivation, leading to persistent current fractions. This can have pro-arrhythmic effects, such as slowing intrinsic heart rate and prolonging the QT interval. It is suitable for research on atrial fibrillation and long QT syndromes.
- Selective sodium channel modulator toxin
- Enhances late sodium current
- Prevents full sodium channel inactivation
- Generates persistent current fractions
- Has a pro-arrhythmic effect
- Slows intrinsic heart rate
- Prolongs QT interval
- Suitable for research on atrial fibrillation
- Suitable for research on long QT syndrome
- Purity of 99.7%
- Molecular weight of 4934.62 (free acid)
- Appearance as a solid
- White to off-white color