Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Mans peptide Tfa | 99.88% | 2498.83 | 5 MG
Mans peptide Tfa | 99.88% | 2498.83 | 5 MG
Apexbio Technology LLC Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) 10x(1ml A 1ml B)
Under stable environmental conditions endogenous protein synthesis and degradation are balanced thus maintaining stable cellular protein levels Cell crude extracts contain numerous endogenous enzymes such as phosphatases and proteases that can degrade proteins in the extracts During in vitro protein extraction from cells and tissues protein synthesis practically ceases while protein degradation increases The optimal way to enhance yields of intact proteins is to add inhibitors for these known enzymes The Protease Inhibitor Cocktail for bacterial cell extracts (100X in DMSO) is designed for bacterial extracts to enhance the stability of proteins This cocktail inhibits proteases responsible for degrading non-phosphorylated or phosphorylated protein substrates This Protease Inhibitor Cocktail is provided as a ready-to-use solution and it is formulated in DMSO
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | >91.6% | 4907.523 | 25 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist, suitable for various laboratory research applications. This synthetic peptide is often studied in antidiabetic research and related metabolic disease areas.
- Dual GIP/GLP-1 receptor agonist
- Ideal for antidiabetic research
- High purity for reliable results
- Synthetic peptide for consistent quality
- Suitable for various laboratory applications
Medchemexpress LLC XMD-17-51 TFA 10mM 1mL | 2436579-93-8 | 1 ML
XMD-17-51 (TFA) is a pyrimido-diazepinone small molecule that modulates protein kinases. It is supplied as the trifluoroacetate (TFA) salt and is provided as either a dry solid or a ready-to-use solution for biochemical and cell signaling research.
- Modulates protein kinases for biochemical and cellular studies
- Supplied as trifluoroacetate (TFA) salt, available as dry solid or solution
- Typical solution: 10 mM in DMSO, 1 mL
- High purity (LCMS 99.46%)
- White to off-white solid appearance
- Storage: 4°C for solid; in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
Medchemexpress LLC REDV TFA | >99.81% | 517.53 | 25 MG
REDV TFA is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. It mediates adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1 (α4β1). This peptide can be utilized in the research of cell adhesion.
- Target: Integrin
- Pathway: Cytoskeleton
- Storage (powder): -80°C for 2 years, -20°C for 1 year (sealed, away from moisture and light)
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month (sealed, away from moisture and light)
- Solubility (in vitro): H₂O: 100 mg/mL (requires ultrasonic)
- Biological activity: Mediates adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(a4β1)
Medchemexpress LLC Frakefamide TFA 10mM 1mL | 10MM 1ML
Frakefamide TFA is a potent analgesic that acts as a peripheral active -selective receptor agonist Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1 [2
Medchemexpress LLC L-lysine, L-valyl-L-glutaminyl-L-isoleucyl-L-valyl-L-tyrosyl- (TFA) | 99.45% | 748.91 | 25 MG
PHF6 TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation, mapped to the third microtubule-binding repeat region of the tau protein. Aggregated PHF6 TFA potentiates NLRP3 inflammasome expression and autophagy in human microglial cells.
- Purity: 99.45%
- Molecular weight: 748.91 (free base)
- Chemical formula: C36H60N8O9.xC2HF3O2
- Appearance: Solid
- Color: White to off-white
- Sequence: Val-Gln-Ile-Val-Tyr-Lys
- Solubility in H2O: ≥ 50 mg/mL
- Store sealed and away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In-solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC G-Pen-GRGDSPCA TFA | 111844-17-8 | 948.04 | 1 MG
G-Pen-GRGDSPCA TFA is a peptide identified by its CAS number 111844-17-8. It has a molecular weight of 948.04 and its molecular formula is C35H57N13O14S2. This compound is characterized by the IUPAC Condensed sequence H-Gly-Pen(1)-Gly-Arg-Gly-Asp-Ser-Pro-Cys(1)-Ala-OH.
- Peptide with the sequence GXGRGDSPCA
- Molecular formula C35H57N13O14S2
- Bicyclic heptapeptide structure with disulfide bonds
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 | C25H31F3N12O10S2 | 5 MG
Ceftolozane TFA is the trifluoroacetic acid (TFA) salt of a cephalosporin antibiotic supplied as a solid for research use. It is used to study and inhibit Gram-negative bacterial infections and as a synthetic building block for development of new antibiotic derivatives.
- Cephalosporin-class antibiotic active against Gram-negative bacteria.
- Useful as a synthetic intermediate for antibiotic development.
- High purity (98.2%) suitable for analytical and synthetic work.
- White to off-white solid form for easy handling and storage.
- Available in milligram-scale quantities for research applications.
- Store at -20°C sealed; in solvent, store at -80°C up to 6 months or -20°C up to 1 month.
- For research use only; not for human or veterinary use.
Medchemexpress LLC FRETS-VWF73 | 97.3% | 8314.28 | 1 MG
FRETS-VWF73 is a 73-amino-acid peptide that serves as a fluorogenic substrate for the ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). It is utilized as a predictive tool for thrombotic thrombocytopenic purpura and is intended for research use only.
- Functions as a fluorogenic substrate for ADAMTS13 assay
- Predictive tool for thrombotic thrombocytopenic purpura
- Excitation wavelength: 340 nm
- Emission wavelength: 450 nm
- Purity: 97.3%
- Molecular weight: 8314.28
- Appearance: Solid, light yellow to yellow
- Solubility: 25 mg/mL in DMSO
TARGETMOL CHEMICALS INC LEVOROTATION NIMORAZOLE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Levorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.
Medchemexpress LLC Caloxin 2A1 TFA | 99.9% | 1592.54 | 25 MG
Caloxin 2A1 TFA is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. It does not affect basal Mg2+-ATPase or Na+-K+-ATPase.
- Extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor.
- Does not affect basal Mg2+-ATPase or Na+-K+-ATPase.
- Inhibits Ca2+-Mg2+-ATPase in human erythrocyte leaky ghosts.
- Inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate.
- Increases airway smooth muscle cells (ASMCs) apoptosis.
Medchemexpress LLC Pep2-8 TFA | 98.8% | 1715.85 (free base) | 1 MG
Pep2-8 is a peptide that enhances the antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9). It binds to C-terminally truncated PCSK9 and restored LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity at a concentration of 50 μM.
- Enhances antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9)
- Binds to C-terminally truncated PCSK9
- Restores LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity
- For research use only
Medchemexpress LLC PSMA I&S TFA | 98.2% | 1413.43 | 1 MG
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, appearing as a white to off-white solid.
- Target PSMA
- Inhibits immunology/inflammation pathway
- Soluble in DMSO (100 mg/mL)
- Soluble in various in vivo dissolution methods
- Store at -20°C, protected from light and under nitrogen