Acrylic acids and derivatives
Selleck Chemical LLC Etretinate S4699-20mg
Etretinate (Tegison Ethyl etrinoate Retinoid Etretinato Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes It activates retinoid receptors causing an induction of cell differentiation inhibition of cell proliferation and inhibition of tissue infiltration by inflammatory cells
Medchemexpress LLC Monastrol | 329689-23-8 | MFCD00813077 | 99.9% | 292.35 g/mol | C14H16N2O3S | 100 MG
Monastrol is a cell-permeable small-molecule inhibitor of the mitotic kinesin Eg5, used in cell biology and mitosis research to perturb spindle dynamics and study chromosome segregation. It displays an IC50 of 14 μM against Eg5 and is provided as a high-purity research reagent for in vitro and cell-based assays.
- Inhibits Eg5 with an IC50 of 14 μM.
- High purity suitable for research applications.
- Cell-permeable for use in live-cell assays.
- Available in multiple pack sizes, including 100 MG.
- Useful for studying spindle assembly and mitotic progression.
Medchemexpress LLC Desacetylcinobufotalin | 4099-30-3 | 416.51 | 1 MG
Desacetylcinobufotalin is a natural compound and an apoptosis inducer. It demonstrates a marked inhibitory effect on HepG2 cells, with an IC50 value of 0.0279 μmol/mL. It is for research use only and not sold to patients. The product appears as a solid, white to light yellow in color.
- Purity: 99.41%
- Induces apoptosis
- Inhibitory effect on HepG2 cells with anIC50 of 0.0279 μmol/mL
- Cytotoxicity against human HL60 cells: IC50 4.3 μg/mL
- Cytotoxicity against human KB cells: IC50 10 μg/mL
Medchemexpress LLC Salvianolic acid Y | 1638738-76-7 | 5 MG
Salvianolic acid Y is a phenolic acid sharing the same planar structure as Salvianolic acid B. It is known for its ability to rescue cell injury caused by H2O2. In vitro studies demonstrate that Salvianolic acid Y provides protection against hydrogen peroxide (H2O2)-induced cell lesions.
- Shares planar structure with Salvianolic acid B
- Rescues cell injury induced by H2O2
- Offers 54.2% protection rate in rat PC12 cells against H2O2-induced lesions
- Intended for research use only
Medchemexpress LLC Picrocrocin | 138-55-6 | 5 MG
Picrocrocin is an apocarotenoid found in Saffron. It exhibits anticancer effects and growth inhibitory effects against SKMEL-2 human malignant melanoma cells. Its antiproliferative activity is attributed to apoptosis and cell cycle arrest, along with enhancing ROS levels, decreasing MMP levels, and inhibiting the JAK/STAT5 signaling pathway.
- Apocarotenoid found in Saffron
- Shows anticancer effects
- Inhibits growth of SKMEL-2 melanoma cells
- Induces apoptosis and cell cycle arrest
- Enhances ROS levels and decreases MMP levels
- Inhibits JAK/STAT5 signaling pathway
Apexbio Technology LLC Monastrol 329689-23-8 10mg
Monastrol (CAS 329689-23-8) is a cell-permeable small molecule inhibitor that selectively targets the mitotic kinesin Eg5 a motor protein essential for bipolar spindle formation in cell division Monastrol impedes microtubule motility mediated by Eg5 resulting in mitotic arrest without affecting progression through S or G2 phases or centrosome duplication In vitro it demonstrates an IC50 of 14 M for Eg5 inhibition and induces reversible mitotic arrest with chromosomes attached to microtubules extending from centrosomes Monastrol is widely utilized in cell biology research to probe spindle assembly mechanisms and investigate mitotic kinesin function
Apexbio Technology LLC 7ACC1 50995-74-9 100mg
7ACC1 (CAS 50995-74-9) also known as DEAC or Coumarin D1421 is a selective inhibitor of monocarboxylate transporters MCT-1 and MCT-4 which facilitate lactate transmembrane transport By blocking these transporters 7ACC1 disrupts cellular lactate efflux and modulates the metabolic environment of tumor cells In vitro studies demonstrate that treatment with 7ACC1 reduces lactate secretion in renal cancer cells accompanied by decreased cell proliferation migration and invasion as well as downregulation of MCT-1 and MCT-4 protein expression 7ACC1 is a useful tool for investigating tumor metabolism and the mechanisms underlying tumor growth and metastasis
Medchemexpress LLC Elaiophylin | 37318-06-2 | C54H88O18 | 5 MG
Elaiophylin is an autophagy inhibitor that exhibits antitumor activity in ovarian cancer cells. With a molecular weight of 1025.27, it appears as a white to off-white solid and is intended for research use only.
- Autophagy inhibitor
- Exhibits antitumor activity in ovarian cancer cells
- Molecular weight of 1025.27
- White to off-white solid appearance
- Soluble in DMSO for in vitro experiments
- Affects ovarian cancer cell survival during hypoxia
- Leads to activation of cleaved CASP9/caspase-9 and PARP1
- Downregulates BIRC5/survivin
- Suppresses ovarian cancer SKOV3 cell growth in athymic mice
- Achieves significant antitumor effects without toxicity at lower doses
Apexbio Technology LLC HA14-1 65673-63-4 20mg
HA14-1 (CAS 65673-63-4) is a small molecule inhibitor of B-cell lymphoma 2 (Bcl-2) protein By binding to the BH3 domain of Bcl-2 HA14-1 antagonizes its anti-apoptotic function thereby promoting the activation of pro-apoptotic proteins such as Bax In NIH3T3 HL60 and H1299 cell lines HA14-1 induces apoptosis with reported IC50 values ranging from 10 to 20 M Additionally it has been shown to inhibit ceramide glucosyltransferase HA14-1 is widely utilized as a chemical tool to investigate Bcl-2-mediated apoptotic pathways and is of interest in cancer research exploring targeted induction of cell death
Apexbio Technology LLC Cefepime Dihydrochloride Monohydrate(Synonyms: Cefepime hydrochloride, Cefepime HCl, Maxipime, Cefepime hydrochloride hydrate), 500mg, CAS: 123171-59-5.
Cefepime Dihydrochloride Monohydrate (CAS 123171-59-5) is a cephalosporin antibiotic that acts by inhibiting bacterial cell wall synthesis disrupting the structural integrity and causing cell death Experimental data indicate antimicrobial activity against both Gram-positive and Gram-negative bacteria This compound is utilized in clinical investigations targeting complex urinary tract infections severe pneumonia and multidrug-resistant bacterial infections
Apexbio Technology LLC ITD 1 1099644-42-4 5mg
ITD-1 (CAS 1099644-42-4) is a selective inhibitor of transforming growth factor beta (TGF ) signaling TGF plays a critical role in early cardiac development particularly during the formation of endocardial cushions which give rise to cardiac valves ITD-1 promotes the degradation of the TGF type II receptor thereby modulating TGF -mediated pathways In vitro studies have demonstrated that ITD-1 specifically enhances mesodermal differentiation into cardiomyocytes from embryonic stem cells without promoting differentiation into vascular smooth muscle or endothelial cells ITD-1 serves as a valuable tool for investigating mesoderm and cardiac lineage specification in stem cell research
Medchemexpress LLC Desacetylcinobufagin | 4026-95-3 | 400.51 | 1 MG
Desacetylcinobufagin is a natural compound primarily used for microbial transformation research. This product is intended for research use only.
- Derived from animals (toad)
- Exhibits cytotoxicity against HL-60 cells (IC50 of 1 μg/mL)
- Exhibits cytotoxicity against KB cells (IC50 of 0.44 μg/mL)
- Used in microbial transformation studies
Selleck Chemical LLC 7ACC2
7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells
Medchemexpress LLC Elaiophylin | 37318-06-2 | 98.0% | 1025.27 g/mol | C54H88O18 | 10 MG
Elaiophylin is a macrolide antibiotic and autophagy inhibitor commonly used as a research reagent. It exhibits antitumor activity in multiple cancer cell lines and is employed in cellular assays to study autophagy, cytotoxicity, and related mechanisms. The compound is supplied as a solid powder appropriate for laboratory use.
- Macrolide antibiotic and autophagy inhibitor.
- Reported antitumor activity in multiple cancer cell lines.
- High purity (98.0%).
- Chemical formula C54H88O18; molecular weight 1025.27 g/mol; CAS 37318-06-2.
- Solid white to off-white powder suitable for cell-based assays.
- Storage: powder stable at -20°C for about 3 years; in solvent: -80°C for 6 months or -20°C for 1 month.
- Pack size suitable for research applications (10 mg typical).
Selleck Chemical LLC Oleandrin
Oleandrin (PBI-05204 Foliandrin Neriolin Neriostene Folinerin Corrigen Neriol) is an inhibitor of Na /K -ATPase with IC50 of 0 62 M Oleandrin induces apoptosis and reduces migration of human glioma cells in vitro