Organic sulfuric acids and derivatives
Selleck Chemical LLC Vindesine sulfate S2440-5mg
Vindesine sulfate a vinca alkaloid derived from Catharanthus roseus is a potent inhibitor of mitosis with antineoplastic activities Vindesine binds to the microtubular proteins of the mitotic spindle leading to crystallization of the microtubule and mitotic arrest or cell death
Selleck Chemical LLC Vindesine sulfate S2440-25mg
Vindesine sulfate a vinca alkaloid derived from Catharanthus roseus is a potent inhibitor of mitosis with antineoplastic activities Vindesine binds to the microtubular proteins of the mitotic spindle leading to crystallization of the microtubule and mitotic arrest or cell death
Medchemexpress LLC Vincristine sulfate | 2068-78-2 | 923.04 | 100 MG
Vincristine sulfate is an antitumor vinca alkaloid that inhibits microtubule formation in the mitotic spindle, leading to an arrest of dividing cells at the metaphase stage. It binds to microtubules with a Ki of 85 nM.
- Inhibits microtubule formation in the mitotic spindle.
- Leads to an arrest of dividing cells at the metaphase stage.
- Binds to microtubules with a Ki of 85 nM.
- Induces apoptosis in tumor cells.
- Inhibits SH-SY5Y cell proliferation.
- Induces mitotic arrest and promotes expression of caspase-3 and -9 and cyclin B.
- Decreases cyclin D expression.
TARGETMOL CHEMICALS INC Vindesine sulfate 20MG
Also available in 1 mL, 5 mg and bulk. Please contact Fisher for quotes. Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Purity 99.93%
Medchemexpress LLC Octadecyl rhodamine B chloride | 65603-19-2 | MFCD00467892 | 98.7% | 731.49 g/mol | C46H67ClN2O3 | 10 MG
Octadecyl rhodamine B chloride is an amphiphilic fluorescent probe for staining cell membranes and investigating membrane dynamics. It associates with lipid bilayers and exhibits strong fluorescence as a monomer; in aqueous media it can form aggregates that are blue-shifted and lead to self-quenching. It is used in membrane biology, cell labeling, and fluorescence-based assays.
Medchemexpress LLC Vinblastine (sulfate) | 143-67-9 | 99.86% | 909.05 | 100 MG
Vinblastine sulfate is a cytotoxic alkaloid that targets various cancer types by inhibiting microtubule formation and suppressing nAChR (IC50 8.9 μM). It blocks mitosis (IC50 0.8 nM in HeLa cells), leading to cell apoptosis. For storage, keep sealed at 4°C, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month, similarly sealed. Room temperature shipping is suitable for durations under 2 weeks.
- Inhibits microtubule formation.
- Suppresses nAChR with an IC50 of 8.9 μM.
- Blocks mitosis, leading to cell apoptosis.
- Induces apoptosis via Bax/Bcl-2 imbalance.
- Suppresses NFκB expression and depresses NFκB-DNA binding activity.
- Triggers apoptosis by causing a loss of mitochondrial membrane potential and activating caspases.
AdipoGen Colistin sulfate USP Grade
Chemical. CAS 1264-72-8. Formula 2C52H98N16O13 . 5H2SO4 unspec.. MW 2801.7. Isolated from Bacillus polymyxa. Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide LPS of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations Ca2 and Mg2 from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.
Apexbio Technology LLC Salbutamol Sulfate 51022-70-9 500mg
Salbutamol Sulfate (CAS 51022-70-9) is a short-acting selective 2-adrenergic receptor agonist widely employed in studies related to bronchial smooth muscle relaxation The compound exerts its pharmacological effects by selectively activating 2-adrenergic receptors leading to increased intracellular cyclic AMP and subsequent airway smooth muscle relaxation Research indicates that the R-enantiomer is primarily responsible for the observed physiological effects in guinea-pig skeletal muscle with minimal contribution from the S-enantiomer Salbutamol Sulfate is commonly utilized in biomedical research focused on asthma chronic obstructive pulmonary disease (COPD) and 2-receptor pharmacodynamics
Medchemexpress LLC Tasipimidine sulfate | 1465908-73-9 | 99.3% | 330.36 | 10 MG
Tasipimidine sulfate is an orally active and selective α2A-adrenoceptor agonist with a pEC50 of 7.57 for human α2A-adrenoceptors and an EC50 of 5.7 nM for rat α2-adrenoceptor. It can be used in research related to situational anxiety and fear.
- Orally active and selective α2A-adrenoceptor agonist.
- Reduces spontaneous locomotor activity in mice.
- Reduces the amplitude of the acoustic startle reflex in rats.
- Improves separation anxiety in dogs, leading to more positive owner ratings and significantly reduced destructive/rearranging behavior and vocalization at a dose of 30 μg/kg.
Apexbio Technology LLC Salbutamol Sulfate 51022-70-9 250mg
Salbutamol Sulfate (CAS 51022-70-9) is a short-acting selective 2-adrenergic receptor agonist widely employed in studies related to bronchial smooth muscle relaxation The compound exerts its pharmacological effects by selectively activating 2-adrenergic receptors leading to increased intracellular cyclic AMP and subsequent airway smooth muscle relaxation Research indicates that the R-enantiomer is primarily responsible for the observed physiological effects in guinea-pig skeletal muscle with minimal contribution from the S-enantiomer Salbutamol Sulfate is commonly utilized in biomedical research focused on asthma chronic obstructive pulmonary disease (COPD) and 2-receptor pharmacodynamics
Medchemexpress LLC Bm 15766 sulfate | 86621-94-5 | MFCD07370131 | 98.2% | 482.98 g·mol⁻¹ | C22H27ClN2O6S | 5 MG
BM 15766 sulfate is a research-grade hypolipidemic compound that inhibits 7-dehydrocholesterol (δ7) reductase (DHCR7), leading to reduced plasma cholesterol levels. It is provided as the sulfate salt in solid form for laboratory research use only.
- Inhibits 7-dehydrocholesterol (δ7) reductase (DHCR7).
- Reduces plasma cholesterol levels in research models.
- Supplied as a sulfate salt, solid, white to off-white.
- High purity (≈98.2%) suitable for analytical and biological studies.
- Molecular weight 482.98 g·mol⁻¹; formula C22H27ClN2O6S.
- Intended for laboratory research use only.
Medchemexpress LLC Colistin (sulfate) | 1264-72-8 | ≥98.0% | C52H98N16O13.2.5H2O4S | 100 MG
Colistin sulfate is a polypeptide antibiotic effective against gram-negative bacteria. It functions by binding to lipopolysaccharides and phospholipids in the outer cell membrane, competitively displacing divalent cations. This leads to a detergent-like mechanism that is bactericidal to gram-negative bacteria. It is characterized by rapid bacterial killing, a narrow spectrum of activity, and slow development of resistance.
- Inhibits gram-negative bacteria
- Binds to lipopolysaccharides and phospholipids
- Displaces divalent cations (calcium and magnesium)
- Bactericidal through a detergent-like mechanism
- Rapid bacterial killing
- Narrow spectrum of activity
- Slow development of resistance
Medchemexpress LLC Vincristine sulfate | 2068-78-2 | 923.04 | 5 MG
Vincristine sulfate is an antitumor vinca alkaloid that inhibits microtubule formation in mitotic spindle, leading to an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
- Antitumor vinca alkaloid
- Inhibits microtubule formation in mitotic spindle
- Results in arrest of dividing cells at the metaphase stage
- Binds to microtubule with a Ki of 85 nM
- Induces apoptosis in tumor cells
- Inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM
- Induces mitotic arrest and promotes expression of caspase-3 and -9 and cyclin B, while decreasing expression of cyclin D
Apexbio Technology LLC Cefoselis Sulfate 122841-12-7 5mg
Cefoselis Sulfate (CAS 122841-12-7) is a beta-lactam antibiotic targeting penicillin-binding proteins (PBPs) It is designed to inhibit bacterial cell wall synthesis by covalently binding PBPs thereby disrupting peptidoglycan cross-linking and leading to bacterial cell lysis Cefoselis Sulfate exerts its biological activity primarily through inhibition of bacterial cell wall biosynthesis In in vitro antimicrobial assays Cefoselis Sulfate demonstrates antibacterial activity with reported IC50 values varying depending on the bacterial strain and experimental conditions Based on these pharmacological properties Cefoselis Sulfate holds research potential in studies examining antimicrobial resistance patterns bacterial sensitivity profiles and bacterial resistance mechanisms
Apexbio Technology LLC Cefoselis Sulfate 122841-12-7 50mg
Cefoselis Sulfate (CAS 122841-12-7) is a beta-lactam antibiotic targeting penicillin-binding proteins (PBPs) It is designed to inhibit bacterial cell wall synthesis by covalently binding PBPs thereby disrupting peptidoglycan cross-linking and leading to bacterial cell lysis Cefoselis Sulfate exerts its biological activity primarily through inhibition of bacterial cell wall biosynthesis In in vitro antimicrobial assays Cefoselis Sulfate demonstrates antibacterial activity with reported IC50 values varying depending on the bacterial strain and experimental conditions Based on these pharmacological properties Cefoselis Sulfate holds research potential in studies examining antimicrobial resistance patterns bacterial sensitivity profiles and bacterial resistance mechanisms
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