Benzoxadiazoles
Medchemexpress LLC NBD-F (4-Fluoro-7-nitrobenzofurazan) | 29270-56-2 | 100 MG
NBD-F (4-Fluoro-7-nitrobenzofurazan) is a pro-fluorescent reagent developed for amino acid analysis. It reacts with primary or secondary amines to produce a fluorescent product, making it useful for the analysis of amino acids and low molecular weight amines. This fluorescent derivatization reagent has also been applied to the analysis of other amino acid derivatives like N-methyl-D-aspartic acid and glutathione, offering advantages such as a simple derivatization procedure and highly stable derivatives.
- Pro-fluorescent reagent.
- Developed for amino acid analysis.
- Reacts with primary or secondary amines to produce a fluorescent product.
- Used for analysis of amino acids and low molecular weight amines.
- Derivatization procedure is simple.
- Derivatives are highly stable.
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.9% | 390.46 | C19H28N5O4 | 5 MG
NBD-Pen is a turn-on fluorescent probe for selective detection of lipid-derived radicals in biological systems. It enables live-cell imaging and biochemical studies of lipid peroxidation and oxidative stress with sensitive fluorescence readout.
- High selectivity and sensitivity for lipid radicals.
- Turn-on fluorescence enables low-background detection in cells.
- Excitation at 470 nm and emission at 530 nm for standard imaging.
- High purity (99.94%) suitable for research use.
- Soluble in DMSO (100 mg/mL); ultrasonic assistance recommended.
- Store protected from light; follow solvent storage guidelines.
Medchemexpress LLC TNF-alpha/TNFSF2 Bo 10ug
Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1] TNF alpha binds to its receptors mainly TNFR1 and TNFR2 and then transmits molecular signals for biological functions such as inflammation and cell death[2] TNF alpha stimulates NF- B pathway via TNFR2 promotes cancer growth invasion and metastasis Anti-TNF- MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3] TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4] TNF-alpha/TNFSF2 Protein Bovine is produced in E coli
Medchemexpress LLC 6alpha-ethyl-3alpha,7alpha,23-trihydroxy-24-nor-5beta-cholan-23-sulfate sodium salt | 1000403-03-1 | 98.0% | 494.7 g/mol | C25H43NaO6S | 1MG
INT-767 is a semisynthetic bile acid-derived small molecule used in preclinical research as a potent dual agonist of the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor TGR5. It modulates bile acid signaling and has been studied in liver and metabolic disease models in vitro and in vivo.
Medchemexpress LLC 4-nitro-2,1,3-benzoxadiazol-7-amine | 10199-91-4 | 96.7% | 25 MG
NBD-amine is a fluorogenic amine used as a fluorescent probe and labeling reagent. It fluoresces weakly in aqueous solution and strongly in organic solvents, lipid membranes, and other hydrophobic environments, making it suitable for sensing, labeling, and studies of membrane-associated processes.
- Fluorogenic amine that fluoresces weakly in water and strongly in hydrophobic environments.
- Useful as a fluorescent probe and labeling reagent for synthesis and detection.
- Suitable for studying membrane interactions and lipid environments.
- Provided as a solid with purity 96.7% and molecular weight 180.12 g/mol.
- Documentation available: data sheet, safety data sheet (SDS), and certificate of analysis (COA).
Medchemexpress LLC Ikky nbd inhibitory peptide tfa | 98.2% | 3807.32 | 5 MG
IKKγ NBD Inhibitory Peptide TFA is a highly specific NF-κB inhibitor. It functions by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) and IKKα and IKKβ, thereby blocking TNF-α-induced NF-kB activation. This peptide can significantly suppress inflammation and ameliorate cerebral ischemia-induced neurological deficits.
- Prevents p65 phosphorylation in BT-474 cells.
- Slightly inhibits BT-474 cell viability while markedly enhancing Doxorubicin's effects.
- Exhibits neuroprotective effect with reduction in DNA fragmentation in a rat model.
- Reduces striatal IL-1b level and microglial OX-42 staining.
- Protects the blood-brain barrier from ischemic insult.
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | C18H16F4N4O2S | 5 MG
NBD-14189 is a small-molecule HIV-1 entry antagonist that binds the viral gp120 protein and exhibits potent antiviral activity in cell-based assays. It is provided as a high-purity research reagent available as solids and as a DMSO solution, with characterized activity in single- and multi-cycle assays.
- Binds HIV-1 gp120 to inhibit viral entry.
- Potent antiviral activity (IC50 ≈ 89 nM; EC50 <200 nM).
- Characterized in single-cycle (0.089 μM) and multi-cycle (0.18 μM) assays.
- Available as solid quantities and as a 10 mM solution in DMSO.
- High purity (99.84%) suitable for research use.
- Storage recommendations provided for solids and solutions.
Apexbio Technology LLC NBD-Cl 10199-89-0 500mg
NBD-Cl (10199-89-0) is a fluorescent labeling reagent that covalently reacts with nucleophilic groups specifically amines and thiols It is designed to derivatize these functional groups enabling detection through the formation of highly fluorescent conjugates NBD-Cl exerts its biological utility primarily through its electrophilic reaction mechanism with free amino and thiol groups in biomolecules No specific experimental model or quantitative activity metric is provided Based on these chemical properties NBD-Cl holds research potential in the labeling and detection of amino acid residues peptides proteins and thiol-containing enzymes as well as in studies of enzyme activities and biomolecular interactions
Accela Chembio Inc 4-methyl-2 | 1 | 3-benzoxadiazole | 5g | 29091-40-5 | MFCD00100600 | 97+% | Shelf Life: 1440 Days | Light Sensitive/+4
4-methyl-2 | 1 | 3-benzoxadiazole | 5g | 29091-40-5 | MFCD00100600 | 97+% | Shelf Life: 1440 Days | Light Sensitive/+4
Medchemexpress LLC NBD-556 | 333353-44-9 | 99.6% | C17H24ClN3O2 | 50 MG
NBD-556 is a CD4 mimetic and a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. It demonstrates potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Functions as a CD4 mimetic
- Potent HIV-1 entry inhibitor
- Blocks gp120-CD4 interaction
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion
- Inhibits infection of MT-2 cells by laboratory-adapted HIV-1 strains
- Inhibits CD4-dependent virus in a dose-dependent manner
Medchemexpress LLC NBD-PE | 178119-00-1 | 99.9% | 956.24 | 5 MG
NBD-PE is an effective lipid fluorescent probe with Excitation/Emission at 465/535 nm and a green color. It has wide applications in membrane and cell biology.
- Effective lipid fluorescent probe
- Excitation/emission: 465/535 nm
- Color: green
- Wide array of applications in membrane and cell biology
eMolecules Medchem Express / MBD / 100mg / 642185116 / HY-141667 / / 33984-50-8 / MFCD00042778 / 300.274 / C14H12N4O4
Medchem Express / MBD / 100mg / 642185116 / HY-141667 / / 33984-50-8 / MFCD00042778 / 300.274 / C14H12N4O4
Medchemexpress LLC Nbd-14270 | 2411819-82-2 | 99.5% | 425.43 | C18H18F3N5O2S | 5 MG
NBD-14270 is a pyridine analogue that functions as a potent HIV-1 entry antagonist by binding to the gp120 envelope protein. It exhibits sub-micromolar antiviral activity with low cytotoxicity and is provided for research applications with characterized purity, formula, and storage recommendations.
- High purity: 99.53%.
- Chemical formula: C18H18F3N5O2S; molecular weight: 425.43.
- CAS number: 2411819-82-2.
- Recommended solvent: DMSO; use ultrasonic aid for dissolution.
- Storage: solid at 4°C; in solvent store at -80°C for long-term stability.
- Typical applications: in vitro antiviral and HIV-1 entry assays.