Benzoxazines
TARGETMOL CHEMICALS INC RIDAFOROLIMUS 25MG
Also available in 5 mg 10 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR) which may result in cell cycle arrest and consequently the inhibition of tumor cell growth and proliferation. Upregulated in some tumors mTOR is a serine/threonine kinase involved in regulating cellular proliferation motility and survival that is located downstream of the PI3K/Akt signaling pathway. purity: 98%
TARGETMOL CHEMICALS INC JAK3-IN-14 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. JAK3-IN-14 is a potent selective and orally active FLT3 inhibitor with IC50s of ∼40 8 and 4 nM for FLT3-WT FLT3-D835Y and FLT3-D835H respectively. purity: 98%
TARGETMOL CHEMICALS INC QN523 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. QN523 represents a novel scaffold with drug-like properties showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 shows significant in vivo efficacy in a pancreatic cancer xenograft model. Autophagy is a major mechanism of action. purity: 97%
TARGETMOL CHEMICALS INC MCUF-651 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators EC50=0.45 uM. purity: 99%
TARGETMOL CHEMICALS INC TCID 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. TCID (UCH-L3 Inhibitor)(IC50=0.6 uM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1. purity: 99%
TARGETMOL CHEMICALS INC SIRTINOL 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sirtinol is a selective SIRT1/2 inhibitor (IC50 131/38 uM). purity: 99%
TARGETMOL CHEMICALS INC SNX2112 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor with a Kd of 16 nM. purity: 99%
TARGETMOL CHEMICALS INC RLX-33 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation. RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3/I5 in rats.RLX-33 can be used to study the metabolic syndrome. purity: 99%
TARGETMOL CHEMICALS INC NELDAZOSIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Neldazosin is used as a potent (alpha)1-adrenoceptor antagonist. purity: 99%
TARGETMOL CHEMICALS INC A-674563 2HCL552325-73-2 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM modest potent to PKA and >30-fold selective for Akt1 over PKC.
TARGETMOL CHEMICALS INC SELINEXOR KPT-330 25MG
Also available in 2 mg 5 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Selinexor (KPT-330) is an orally available small molecule inhibitor of CRM1 (chromosome region maintenance 1 protein exportin 1 or XPO1) with potential antineoplastic activity. purity: 99%
TARGETMOL CHEMICALS INC MKK7-COV-9 5MG
Also available in 1 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MKK7-COV-9 is a selective and potent covalent inhibitor of MKK7 with inhibitory effects on MKK7-induced protein-protein interactions.MKK7-COV-9 interrupts the activation of primary B-cells in response to LPS.MKK7-COV-9 shows low cytotoxicity at high concentrations. purity: 99%
TARGETMOL CHEMICALS INC ISOORIENTIN 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Isoorientin (Homoorientin) has antioxidant activity. purity: 98%
TARGETMOL CHEMICALS INC AILANTHONE 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ailanthone ((delta)13-Dehydrochaparrinone) is an effective inhibitor of both full-length androgen receptor (AR) (IC50 69 nM) and constitutively active truncated AR splice variants (IC50 309 nM). purity: 99%
TARGETMOL CHEMICALS INC EPIMEDIN B 20MG
Also available in 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Epimedin B (Epmedin B) has potential activity against osteoporosis by stimulating osteoblasts. purity: 99%