Benzoxazines
AdipoGen Resorufin
Chemical. CAS 635-78-9. Formula C12H7NO3. MW 213.19. Resorufin is a stable red fluorophore standard widely used in biochemical and molecular biology research. It is used in enzyme assay systems e.g. Amplex Red and as an indicator of cell viability in assays. Resorufin represents the reduced dye formed from Amplex Red reaction or resazurin reductions. One common application of resorufin is in the measurement of mitochondrial activity. When cells are metabolically active, they can reduce resazurin to resorufin, producing a measurable fluorescent signal. This property makes resorufin a valuable tool in various research applications, such as assessing cell health, drug screening, and enzyme activity studies. It is unstable in the presence of thiols such as dithiothreitol DTT and 2-mercaptoethanol. This compound can be used as a standard for enzyme substrates whose end product is resorufin.
TARGETMOL CHEMICALS INC E6446 5MG
Also available in 1 mg 2 mg 10 mg 25 mg and bulk. Please contact Fisher for quotes. E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA which stimulates TLR9. purity: 99%
TARGETMOL CHEMICALS INC Research Chemical 10mg
Also available in 1 mg, 5 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid that improves adipocyte metabolic functions and exerts insulin-sensitizing effects by activating an adiponectin-related pathway. Naringenin chalcone exhibits anti-inflammatory properties by inhibiting the production of proinflammatory cytokines in the interaction between adipocytes and macrophages, may be useful for ameliorating the inflammatory changes in obese adipose tissue. purity: 99%
TARGETMOL CHEMICALS INC Research Chemical 25mg
Also available in 5 mg, 10 mg, 50 mg, 100 mg, 500 mg, 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin. GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE SOD activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis. purity: 99%
TARGETMOL CHEMICALS INC JD-5037 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. JD-5037 is a novel peripherally restricted CB1R antagonist with an IC50 of 1.5 nM. purity: 98%
TARGETMOL CHEMICALS INC PIM1/AKK1-IN-1 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively and also inhibits MPSK1 and TNIK. purity: 98%
TARGETMOL CHEMICALS INC SANGGENON C 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability via induction of cell cycle arrest and cell death inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO production and iNOS expression by suppressing NF-(kappa)B activity and I(kappa)B(alpha) activation; inhibited TNF-alpha -stimulated PMN-HSC adhesion and expression of VCAM-1 by suppressing the activation of NF-kappaB. purity: 98%
TARGETMOL CHEMICALS INC BLU0588 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BLU0588 is a selective PRKACA inhibitor. BLU0588 inhibits PRKACA catalytic activity with a half-maximal inhibitory concentration (IC50) of 1 nM.
TARGETMOL CHEMICALS INC THIAMET G 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Thiamet G is a potent selective O-GlcNAcase inhibitor with Kiof 21 nM while exhibiting 37 000-fold selectivity over human lysosomal –hexosaminidase. purity: 99%
TARGETMOL CHEMICALS INC MK-2461 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met with a mean IC50 of 2.5 nM. purity: 99%
TARGETMOL CHEMICALS INC WAY-600 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. WAY-600 is a potent ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3K(alpha) (>100-fold) and PI3K(gamma) (>500-fold). purity: 99%
Aat Bioquest 6CR6G SE 6Carboxyrhodamine
6CR6G SE [6Carboxyrhodamine 6G succinimidyl ester] *Single isomer*
Aat Bioquest Caliber Fluor™ 580
Caliber Fluor™ 580 is an extremely stable fluorophore that has its absorption and fluorescence independent of pH change from pH 3 to 10.
Cell Signaling Technology TNF-R2 (E8D7P) Rabbit mAb (Alexa Fluor(R) 488 Conjugate) 100 ul
TNF-R2 (E8D7P) Rabbit mAb (Alexa Fluor(R) 488 Conjugate) 100 ul
Cell Signaling Technology HER2/ErbB2 (29D8) Rabbit mAb (PE Conjugate) 100 ul
HER2/ErbB2 (29D8) Rabbit mAb (PE Conjugate) 100 ul