Biotin and derivatives
Medchemexpress LLC N3-peg3-c2-nhs ester | 1245718-89-1 | MFCD23726613 | 99.9% | 344.32 g/mol | C13H20N4O7 | 10 G
Azide-terminated PEG3 NHS ester linker for bioconjugation and click-chemistry labeling. The reagent contains an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC). It is supplied as a high-purity NHS ester for amine conjugation and includes a three-unit PEG spacer to improve solubility and reduce steric hindrance.
- Azide functional group for click chemistry reactions.
- NHS ester for efficient conjugation to primary amines.
- Three-unit PEG spacer to enhance solubility.
- Noncleavable linker for stable conjugation.
- High purity suitable for research applications.
- Available in laboratory-scale 10 g packaging.
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1237.34 | C54H96N2O29
Bis-PEG21-NHS ester is a polyethylene glycol (PEG)-based bifunctional N-hydroxysuccinimide (NHS) ester linker used for bioconjugation. It provides a hydrophilic PEG21 spacer with two NHS-activated ester termini for conjugation to primary amines and is used in the synthesis of antibody-drug conjugates and PROTAC linkers. Typical purity is 98.0% and molecular weight is 1,237.34.
- Bifunctional PEG linker with two NHS ester termini.
- Hydrophilic PEG21 spacer to improve solubility.
- Suitable for ADC and PROTAC linker synthesis.
- High purity (98.0%) for research applications.
- Available in multiple pack sizes for synthetic workflows.
![Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[1,2-ethanediylbis[oxy(1-oxo-3,1-propanediyl)oxy]]bis(9CI) | 65869-63-8 | 99.2% | 400.34 | C16H20N2O10 | 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203833.png-250.jpg)
Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[1,2-ethanediylbis[oxy(1-oxo-3,1-propanediyl)oxy]]bis(9CI) | 65869-63-8 | 99.2% | 400.34 | C16H20N2O10 | 5 G
Bis-PEG2-NHS ester is a non-cleavable two-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC). It contains an N-hydroxysuccinimide (NHS) ester reactive group for efficient amine coupling and is supplied as a white to off-white solid.
- Non-cleavable two-unit PEG linker
- NHS-ester functional group for amine coupling
- High purity suitable for conjugation chemistry
- Available in multiple pack sizes, including 5 G
- Powder storage: -20°C for up to 3 years
Medchemexpress LLC Cyanine5.5 NHS ester chloride | 1469277-96-0 | MFCD28385524 | 95.7% | 716.31 g·mol-1 | C44H46ClN3O4 | 5 MG
Cyanine5.5 NHS ester chloride is a near-infrared reactive dye supplied as a solid NHS-activated ester that covalently labels primary amines in proteins, peptides, antibodies, and small molecules for fluorescence detection and imaging. The reagent is provided with analytical documentation to support purity and identity.
Medchemexpress LLC DBCO-NHS ester 3 250mg | 1393350-27-0 | 416.43 g·mol⁻1 | C24H20N2O5 | 250 MG
DBCO-NHS ester 3 is a dibenzocyclooctyne (DBCO)-N-hydroxysuccinimide (NHS) ester reagent used to functionalize primary amines for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) bioconjugation. It enables installation of a DBCO handle for subsequent conjugation to azide-labeled partners.
- Installs DBCO onto primary amines for SPAAC (copper-free) click chemistry.
- Suitable for antibody-drug conjugate linker installation, probe labeling, and general bioconjugation.
- High purity, typically 95.6%, provided as a solid white to off-white powder.
- Molecular weight 416.43 g·mol⁻1; formula C24H20N2O5.
- Available in laboratory-scale 250 MG pack size.
Medchemexpress LLC Pomalidomide-C3-NHS ester | 2828476-87-3 | 98.7% | 456.41 g·mol⁻1 | C21H20N4O8 | 10 MG
Pomalidomide-C3-NHS ester is a synthesized E3 ligase ligand-linker conjugate that combines a cereblon-binding pomalidomide scaffold with an NHS-activated C3 linker. It is designed as a conjugation-ready building block for targeted protein degradation chemistry and other bioconjugation applications, supplied with high purity and recommended storage conditions for research use.
- E3 ligase recruiting building block for targeted protein degradation.
- NHS ester functionalized C3 linker for efficient amide coupling to amines.
- High purity (>98%) suitable for synthetic workflows.
- Soluble in DMSO at 100 mg/mL for convenient stock preparation.
- Offered in small research sizes, including 10 MG, for medicinal chemistry.
- Store sealed, away from moisture, with recommended cold storage for solutions.
Medchemexpress LLC Biotin-PEG24-NHS ester | 00-00-0 | 98.0% | C65H120N4O30S | 10MG
Biotin-PEG24-NHS ester is a polyethylene glycol-based biotinylation reagent that couples to primary amines via NHS-ester chemistry to form stable amide bonds. The long PEG24 spacer improves aqueous solubility and reduces steric hindrance, making the reagent suitable for PROTAC linker assembly and bioconjugation of proteins, peptides, and small molecules.
- Reacts with primary amines via NHS-ester chemistry.
- Long PEG24 spacer enhances solubility and reduces steric hindrance.
- High purity (98.0%) for consistent conjugation performance.
- White to off-white solid, convenient for handling and storage.
- Stable under recommended storage conditions and in solvent for defined timeframes.
eMolecules Medchem Express | Fmoc-NH-PEG11-CH2CH2COOH | 100mg | 532149897 | HY-130870 | 795.92 | C40H61NO15
Medchem Express | Fmoc-NH-PEG11-CH2CH2COOH | 100mg | 532149897 | HY-130870 | | 795.920 | C40H61NO15
Medchemexpress LLC 4,7,12-Trioxa-10-azatetradecanoic acid, 13,13-dimethyl-11-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | 2183440-73-3 | ≥98.0% | C16H26N2O8 | 1 G
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product is a white to off-white solid and is intended for research use only.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- White to off-white solid appearance
- For research use only
Medchemexpress LLC Bis-PEG25-NHS ester | 2221948-96-3 | 99.8% | 1413.55 | C62H112N2O33 | 100 MG
Bis-PEG25-NHS ester is a bifunctional PEG-based linker bearing two N-hydroxysuccinimide (NHS) ester groups for efficient amine conjugation. It is used as a cleavable linker in antibody-drug conjugate (ADC) synthesis and as a spacer in PROTAC construction; the PEG25 spacer improves aqueous solubility. Intended for research use only.
- Contains two NHS ester groups for amine coupling.
- PEG25 spacer enhances solubility in aqueous media.
- Suitable for ADC linker and PROTAC synthesis.
- High purity (99.75%) for reproducible conjugation.
- Store sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
TARGETMOL CHEMICALS INC TCO-NHS ester 5MG
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. Purity 99.77%
Selleck Chemical LLC Biotin (Vitamin B7) S3130-500mg
Biotin(Vitamin B7) is a B-vitamin and acts as a necessary coenzyme for cell growth the production of fatty acids and the metabolism of fats and amino acids Biotin is covalently attached to distinct lysine residues in histones affecting chromatin structure and mediating gene regulation
Medchemexpress LLC DBCO-NHS ester 2 500mg | 1384870-47-6 | 430.45 | C25H22N2O5 | 500 MG
DBCO-NHS ester 2 is a dibenzylcyclooctyne (DBCO)-derived N-hydroxysuccinimide (NHS) ester used as an amine-reactive linker for bioconjugation and antibody-drug conjugate synthesis. The reagent enables copper-free click chemistry via strain-promoted alkyne-azide cycloaddition (SPAAC) and is supplied as a powder for laboratory use.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free click chemistry.
- Amine-reactive NHS ester for efficient labeling of proteins, peptides, and small molecules.
- Appropriate for antibody-drug conjugate (ADC) linker synthesis and general bioconjugation.
- High reported purity in product documentation.
- Powder form with long-term storage at -20°C; soluble in DMSO (≈14.29 mg/mL) with ultrasonic assistance.
Medchemexpress LLC Biotin-Val-Ala-Asp(OMe)-FMK | 1135688-15-1 | ≥95.0% | 672.81 g/mol | C30H49FN6O8S | 50 MG
Biotin-VAD-FMK is a biotin-labeled, cell-permeable, irreversible pan-caspase inhibitor used to identify and label active caspases in cell lysates. It serves as an affinity probe for detection or capture of active caspases in apoptosis research and protease-profiling workflows, and is compatible with biochemical assays and pull-down experiments.
- Biotin-labeled for affinity capture and detection.
- Cell-permeable, irreversible caspase inhibitor.
- Enables identification and labeling of active caspases in cell lysates.
- Compatible with biochemical assays, protease profiling, and pull-down workflows.
- Supplied as a solid with defined molecular weight and formula for experimental planning.
Medchemexpress LLC Biotin-Gastrin Releasing Peptide, human TFA | 3085.67 | 25 MG
Biotin-Gastrin Releasing Peptide, human TFA is a biotinylated gastrin releasing peptide (GRP). Gastrin-releasing peptide (GRP) is a neuropeptide known for its growth-stimulatory and tumorigenic properties.
- Biotinylated gastrin releasing peptide (GRP)
- Neuropeptide with growth-stimulatory properties
- Relevant for cancer and neurological disease research
- Related to GPCR/G protein and Bombesin Receptor studies