Biotin and derivatives
Medchemexpress LLC Methoxy polyethylene glycol N-hydroxysuccinimide ester | 92451-01-9 | 98.0% | 10MG
Methoxy polyethylene glycol N-hydroxysuccinimide ester, average molecular weight 20,000 Da, is an NHS-activated methoxy-PEG reagent that reacts efficiently with primary amines to form stable amide bonds. It is supplied as a solid for research use and is commonly used for PEGylation of peptides and proteins, linker construction in targeted degraders, and general bioconjugation to improve solubility and pharmacokinetic properties.
- Reacts with primary amines to form stable amide linkages.
- Improves solubility and reduces immunogenicity of conjugates.
- Provides a 20 kDa hydrophilic spacer for linker design.
- Supplied as a high-purity reagent suitable for research applications.
- Compatible with standard coupling and purification workflows.
Medchemexpress LLC Methoxy polyethylene glycol 11 N-hydroxysuccinimide ester | 00-00-0 | MFCD28976661 | >98.0% | C28H51NO15 | 10MG
m-PEG11-NHS ester is a PEG-based linker bearing an N-hydroxysuccinimide (NHS) ester functional group that enables efficient covalent coupling to primary amines. It provides an ~11-unit PEG spacer for use in small-molecule-protein conjugation, PROTAC assembly, and other bioconjugation workflows. The product is supplied as a solid with high purity appropriate for research applications.
- NHS ester reactive toward primary amines.
- Approximately 11 ethylene glycol units provide a flexible spacer.
- Suitable for PROTAC linker synthesis and protein or peptide labeling.
- >98.0% purity as supplied.
- Molecular weight approximately 641.7; formula C28H51NO15.
Medchemexpress LLC M-PEG11-acid | 2280998-74-3 | 98.0% | 544.63 g·mol⁻¹ | C24H48O13 | 50 MG
m-PEG11-acid is a monomethyl polyethylene glycol (11 ethylene glycol units) acid linker used as a reagent for antibody-drug conjugate and PROTAC linker synthesis, and for general bioconjugation.
- Monomethyl PEG with 11 ethylene glycol units.
- Molecular weight 544.63 g·mol⁻¹.
- Purity 98.0%.
- Cas number 2280998-74-3.
- Available in small pack sizes, including 50 mg and 100 mg.
Medchemexpress LLC m-PEG11-acid | 2280998-74-3 | 98.0% | 544.63 | C24H48O13 | 100 MG
m-PEG11-acid is a monomethyl-capped polyethylene glycol (PEG) linker containing 11 ethylene glycol units. It is supplied as a non-cleavable, hydrophilic spacer for use in antibody-drug conjugate (ADC) synthesis and proteolysis-targeting chimera (PROTAC) linker construction.
- Monomethyl-capped polyethylene glycol linker with 11 ethylene glycol units.
- Non-cleavable design suitable for stable conjugation.
- Provides a hydrophilic spacer to improve solubility and reduce steric hindrance.
- Commonly used in ADC and PROTAC linker synthesis.
- Molecular weight approximately 544.63 g/mol.
- High purity, specified at 98.0%.
- Available in small-scale packaging suitable for research (100 MG).
Medchemexpress LLC Mal-PEG3-C1-NHS ester | 2230016-26-7 | 95.0% | 384.34 g/mol | C16H20N2O9 | 50 MG
Mal-PEG3-C1-NHS ester is a non-cleavable 3-unit polyethylene glycol (PEG) linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester. It is supplied for research use to facilitate conjugation between amine and thiol groups during antibody-drug conjugate (ADC) synthesis, and is provided as a solution for low-temperature storage.
- Non-cleavable 3-unit polyethylene glycol linker.
- Terminal maleimide and NHS ester functional groups for thiol and amine coupling.
- Suitable for antibody-drug conjugate (ADC) synthesis.
- Purity approximately 95.0%.
- Supplied as a solution; store at -20°C for up to 2 years.
Medchemexpress LLC Biotin-PEG5-NHS ester | 98.0% | 632.72 | 100 MG
Biotin-PEG5-NHS ester is a heterobifunctional crosslinker and a polyethylene glycol-containing bioconjugation reagent. It is used in scientific research for constructing highly sensitive biosensors, developing targeted drug delivery systems (e.g., liposome modification), immunofluorescence imaging, and protein affinity purification. It serves as a tool for precise labeling and functionalization of biomolecules.
- Heterobifunctional crosslinker.
- Polyethylene glycol-containing bioconjugation reagent.
- Specific introduction of biotin tags onto molecules with primary amine groups (-NH2), such as proteins, antibodies, and polypeptides, or material surfaces.
- NHS ester group reacts rapidly with amine groups under mild conditions to form stable amide bonds.
- Intermediate PEG5 chain acts as a flexible spacer arm, increasing spatial freedom and improving water solubility while reducing non-specific adsorption.
Medchemexpress LLC M-PEG-NHS ester | 92451-01-9 | MFCD01867746 | 98.0% | 2000 (average) | (C2H4O)nC7H9NO5 | 100 MG
m-PEG-NHS ester (MW 2000) is an NHS-activated methoxy poly(ethylene glycol) reagent for PEGylation of biomolecules. It reacts with primary amines to modify proteins, peptides, and small molecules to improve solubility, stability, and pharmacokinetics. Supplied as a white to off-white solid for research use, it is offered in multiple pack sizes and stored sealed away from moisture.
Medchemexpress LLC Bis-PEG30-NHS ester | 95.0% | 1633.81 g·mol⁻¹ | C72H132N2O38 | 10 MG
Bis-PEG30-NHS ester is a homobifunctional, non-cleavable polyethylene glycol (PEG) linker containing 30 ethylene glycol units and two N-hydroxysuccinimide (NHS) ester reactive groups. It is used to conjugate antibodies and other amine-containing biomolecules in antibody-drug conjugate (ADC) synthesis and general bioconjugation. Supplied as a white to off-white powder, it has a molecular weight of 1633.81 g·mol⁻¹ and a reported purity of 95.0%.
- Homobifunctional NHS ester termini for efficient amine coupling.
- 30-unit PEG spacer provides hydrophilicity and distance between conjugated moieties.
- Suitable for antibody-drug conjugate (ADC) synthesis and general bioconjugation applications.
- Powder form with recommended storage at -20°C for long-term stability.
- Characterized by 1H NMR and mass spectrometry to confirm structure and purity.
Apexbio Technology LLC DMG-PEG2000-NHS(Synonyms: DMG-PEG2000-NHS ester, NHS-PEG2000-DMG, DMG PEG NHS ester), 500mg.
DMG-PEG2000-NHS is a polyethylene glycol (PEG) derivative functionalized with an N-hydroxysuccinimide (NHS) ester The reactive NHS ester readily forms stable amide linkages upon interaction with primary amine (-NH ) groups facilitating covalent attachment to peptides proteins or amino-functionalized small molecules Due to these conjugation properties DMG-PEG2000-NHS is commonly employed in biomedical research for constructing drug delivery platforms such as lipid nanoparticles (LNPs) or liposomes particularly for siRNA delivery systems
Apexbio Technology LLC DMG-PEG2000-NHS(Synonyms: DMG-PEG2000-NHS ester, NHS-PEG2000-DMG, DMG PEG NHS ester), 100mg.
DMG-PEG2000-NHS is a polyethylene glycol (PEG) derivative functionalized with an N-hydroxysuccinimide (NHS) ester The reactive NHS ester readily forms stable amide linkages upon interaction with primary amine (-NH ) groups facilitating covalent attachment to peptides proteins or amino-functionalized small molecules Due to these conjugation properties DMG-PEG2000-NHS is commonly employed in biomedical research for constructing drug delivery platforms such as lipid nanoparticles (LNPs) or liposomes particularly for siRNA delivery systems
Medchemexpress LLC Biotin-PEG1-azide | 1204085-48-2 | 99.9% | 356.44 g/mol | C14H24N6O3S | 50 MG
Biotin-PEG1-azide is a biotinylated polyethylene glycol (PEG1) azide reagent used as a linker and click-chemistry handle for conjugation, labeling, and affinity-based capture in research applications.
- introduces a biotin tag and an azide functional group for covalent conjugation
- suitable for copper-catalyzed and strain-promoted azide-alkyne cycloaddition
- high purity for reliable experimental results
- available in small-scale quantities suitable for synthesis and labeling workflows
- storage recommended at low temperatures to preserve stability
Medchemexpress LLC Biotin-PEG3-NHS ester | 1253286-56-4 | 98.4% | 100 MG
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. PROTACs typically consist of two different ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Serves as a linker in the construction of PROTACs
- Linker is based on Polyethylene Glycol (PEG)
- Intended for research purposes only
- Primary application is in the synthesis of PROTACs
Medchemexpress LLC Mal-PEG3-C1-NHS ester | 2230016-26-7 | 95.0% | 384.34 g/mol | C16H20N2O9 | 25 MG
Mal-PEG3-C1-NHS ester is a non-cleavable, three-unit polyethylene glycol (PEG) linker bearing maleimide and N-hydroxysuccinimide (NHS) ester functional groups, designed for use in antibody-drug conjugate (ADC) synthesis and related bioconjugation research.
- Non-cleavable three-unit PEG linker
- Contains maleimide and NHS ester functional groups
- Enables conjugation to thiols and amines for ADC assembly
- Purity ≥95.0% and molecular weight 384.34 g/mol
- Available in small milligram packaging for research applications
Medchemexpress LLC Biotin-PEG5-NHS ester | 98.0% | 632.72 | 250 MG
Biotin-PEG5-NHS ester is a heterobifunctional crosslinker and a polyethylene glycol-containing bioconjugation reagent. It is utilized in scientific research for developing highly sensitive biosensors, targeted drug delivery systems, immunofluorescence imaging, and protein affinity purification, serving as a tool for precise biomolecule labeling and functionalization.
- Efficiently introduces biotin tags onto primary amine groups.
- Forms stable amide bonds under mild conditions.
- Incorporates a flexible spacer arm for increased molecular freedom.
- Enhances water solubility.
- Reduces non-specific adsorption.
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1237.34 | C54H96N2O29 | 10 MG
Bis-PEG21-NHS ester is a bifunctional polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester reactive groups separated by a PEG21 spacer. It is supplied as a high-purity reagent for bioconjugation, PROTAC synthesis, and antibody-drug conjugate construction.
- Two NHS ester reactive groups for amine coupling.
- PEG21 spacer provides hydrophilicity and flexibility.
- High purity suitable for conjugation chemistry applications.
- Intended for PROTAC and ADC linker development and general PEGylation chemistry.
- Available in small-scale quantities for research use.