Furans
Medchemexpress LLC Trotabresib | 1706738-98-8 | 99.7% | 383.46 | 100 MG
Trotabresib is a reversible and orally active BET inhibitor used in the study of advanced solid tumors. It inhibits the proliferation of diffuse midline glioma (DMG) cells and shows stronger antitumor activity against H3K27M mutant DMG cells than DMG wildtype.
- Reversible and orally active BET inhibitor
- Applied in studies for advanced solid tumors
- Inhibits proliferation of diffuse midline glioma (DMG) cells
- Shows stronger antitumor activity against H3K27M mutant DMG cells than DMG wildtype
Medchemexpress LLC Nitrofurantoin | 67-20-9 | C8H6N4O5 | 1 G
Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. It acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections.
- Potent and orally active
- Broad-spectrum beta-lactamase antimicrobial agent
- Acts as an antibiotic
- Used for the study of urinary tract infections (UTIs), including cystitis and kidney infections
![Medchemexpress LLC Urea, N-[4-[8-amino-3-(1-methylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]- | 1414938-21-8 | 99.2% | 504.51 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387909-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Urea, N-[4-[8-amino-3-(1-methylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]- | 1414938-21-8 | 99.2% | 504.51 | 5 MG
IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor with an EC50 of 0.82 μM. It inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM) and XBP1 mRNA splicing in WT cell lines.
- Potent IRE1α kinase inhibitor.
- Inhibits IRE1α kinase autophosphorylation.
- Inhibits XBP1 mRNA splicing.
- For research use only.
Medchemexpress LLC Pyribencarb | 799247-52-2 | MFCD22200855 | 98.8% | 361.83 | C18H20ClN3O3 | 5 MG
Pyribencarb is a benzylcarbamate-type fungicide supplied as a research-grade analytical standard. It functions as a Qo inhibitor of fungal respiration and is used as a reference material in laboratory and environmental analyses. Supplied in small pack sizes, the compound requires cold storage and is intended for research use only.
- Benzylcarbamate-type fungicide and Qo inhibitor.
- Intended for use as an analytical reference standard in laboratory and environmental testing.
- Available in small pack sizes suitable for analytical workflows.
- Molecular formula C18H20ClN3O3; molecular weight 361.83.
- Store powder at -20°C; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 2-isopropylphenyl (2-(naphthalen-2-yl)ethyl)carbamate | 1354359-53-7 | MFCD20926355 | 99.5% | 333.42 | C22H23NO2 | 5 MG
JW480 is a potent, selective small-molecule inhibitor of the serine hydrolase KIAA1363, supplied as a high-purity research reagent for biochemical and cellular studies. It is provided as a solid or as a 10 mM solution in DMSO for in vitro applications.
- Potent and selective inhibitor of KIAA1363.
- High purity (about 99.5%).
- Available as solid in multiple sizes and as a 10 mM DMSO solution.
- Molecular formula C22H23NO2; molecular weight 333.42 g/mol.
- Soluble in DMSO and suitable for biochemical and cellular assays.
- For research use only; not for human or diagnostic use.
Medchemexpress LLC Pf-06456384 trihydrochloride | 1834610-75-1 | 99.4% | 829.18 g/mol | C35H35Cl3F3N7O3S2 | 5 MG
PF-06456384 trihydrochloride is a research-grade small-molecule trihydrochloride salt and a highly potent, selective NaV1.7 inhibitor (reported IC50 = 0.01 nM) provided for preclinical pharmacology and pain-model studies.
- High potency and selectivity toward NaV1.7 for target validation and pharmacology studies.
- Trihydrochloride salt form improves compound handling and solubility for assays.
- High purity (reported ~99.38%) suitable for research applications.
- Molecular weight 829.18 g/mol; white to off-white solid.
- Supplied in small research quantities for assay development and in vivo pilot studies.
Medchemexpress LLC Chdi-390576 | 1629729-98-1 | 98.1% | 25 MG
This small-molecule class IIa histone deacetylase (HDAC) inhibitor is reported to be cell-permeable and to penetrate the central nervous system. It is supplied in research pack sizes and analytical formats, with molecular formula C19H13F4N3O2, molecular weight 391.32 g/mol, and reported purity 98.10%.
- Potent inhibition of class IIa HDACs (IC50s: 54 nM, 60 nM, 31 nM, 50 nM).
- Cell permeable and CNS penetrant.
- Available in multiple pack sizes and solution formats.
- High reported purity suitable for research assays.
- Analytical documentation available (COA, SDS, HNMR, LCMS, RP-HPLC).
AdipoGen Oregon Green 488 DA
Chemical. CAS 1027558-93-5. Formula C24H14F2O7. MW 452.4. 2,7-Difluorofluorescein, also called Oregon Green 488 OG488 dye is a bright, green-fluorescent dye with excitation ideally suited to the 488 nm laser line and useful for fluorescent labeling. It has a high extinction coefficient and fluorescence quantum yield and while it is pH insensitive in the physiological range, with a pKa of 4.6 it can be used to as a fluorescent indicator for intracellular pH and monitor pH changes in acidic organelles or pathways. OG488 is a fluorinated analog of fluoresceins. The absorption and emission spectra of OG488 perfectly match those of fluorescein. Because of the near match of the absorption maxima on proteins ~498 nm and ~512 nm to the strong 488 nm and 514 nm spectral lines of the argon-ion laser, the Oregon Green 488 fluorphore is an important dye for both confocal laser-scanning microscopy and flow cytometry applications.
Medchemexpress LLC 1-aminohydantoin hydrochloride | 2827-56-7 | MFCD02181047 | 98.0% | 151.55 | C3H6ClN3O2 | 250mg
1-Aminohydantoin hydrochloride (Standard) is the analytical standard of 1-Aminohydantoin hydrochloride (HY-Y0469) This product is intended for research and analytical applications 1-Aminohydantoin hydrochloride is a major metabolite of Nitrofurantoin (HY-A0090) in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat milk et al 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of 1-Aminohydantoin hydrochloride before detection[1][2]
Medchemexpress LLC Nitrofurantoin (Standard) | 67-20-9 | 99.7% | C8H6N4O5 | 250 MG
Nitrofurantoin (Standard) is the analytical standard of Nitrofurantoin, intended for research and analytical applications. It is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. It acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections.
- Analytical standard grade, supplied as an assay reference
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS
Medchemexpress LLC 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1h-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine | 873551-53-2 | 99.3% | 358.41 g·mol⁻¹ | C18H23FN6O | 5 MG
FTIDC is an orally active, noncompetitive, selective allosteric antagonist of the metabotropic glutamate receptor 1 (mGluR1). It shows potent antagonistic activity and similar pharmacology across human, mouse, and rat recombinant receptors. Supplied for research use only, it is intended for in vitro and in vivo pharmacology and signaling studies.
- Selective allosteric mGluR1 antagonist
- Potent activity (IC50 5.8 nM for human mGluR1a)
- Cross-species activity (human, mouse, and rat)
- High purity (99.3%)
- Supplied as small solid quantities or 10 mM solution in DMSO
- Suitable for in vitro and in vivo pharmacology studies
Medchemexpress LLC JNJ-1661010 (Takeda-25) | 681136-29-8 | 5 MG
JNJ-1661010, also known as Takeda-25, is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH). It exhibits IC50 values of 34 nM for rat FAAH and 33 nM for human FAAH. This compound is capable of crossing the blood-brain barrier and is utilized as a broad-spectrum analgesic.
- Potent and selective FAAH inhibitor
- Crosses the blood-brain barrier
- Acts as a broad-spectrum analgesic
- Shows apparent inhibition of human FAAH in CHO-K1 cells with an IC50 of 11 nM
- Diminishes thermal hyperalgesia in inflammatory rat models
Medchemexpress LLC Graveobioside A | 506410-53-3 | 5 MG
Graveobioside A is an anthoxanthin glycoside.
- For research use only
- Solid appearance
- Off-white to light yellow color
- Classified as flavonoids, flavones, phenols, and polyphenols
- Derived from plants (Compositae, Baccharis sarothroides A.Gray; Umbelliferae)
Medchemexpress LLC Paederosidic acid | 18842-98-3 | MFCD28124366 | 10 MG
Paederosidic acid, isolated from P. scandens, is a chemical compound exhibiting anticancer and anti-inflammation activities. It primarily acts by inducing mitochondria-mediated apoptosis in lung cancer cells.
- Inhibits lung cancer cells by inducing mitochondria-mediated apoptosis.
- Shows effects on NCI-H1650, HCC827, and A549 cells.
- Up-regulates caspase-3, caspase-8, caspase-9, Bid, Bax.
- Down-regulates Bcl-2.
- Stimulates Cyto-C release from mitochondria.
Medchemexpress LLC Complement C5-IN-1 | 2365402-67-9 | 99.14% | 50 MG
Complement C5-IN-1 is a selective allosteric inhibitor of complement component protein C5. It inhibits the cleavage of C5 into C5a and C5b, blocking the formation of the membrane attack complex (MAC). This compound demonstrates an IC50 of 0.77 μM in 50% human whole blood and 5 nM in 2% human serum for blocking MAC deposition induced by zymosan. It is valuable for studying diseases associated with complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). This product is for research use only.
- Selective allosteric inhibitor of complement component protein C5
- Prevents C5 from being cleaved by C5 convertase
- Inhibits cleavage of C5 into C5a and C5b
- Blocks the formation of the membrane attack complex (MAC)
- Supports research into complement overactivation diseases
- Appears as a solid, white to off-white material