Lactams
Medchemexpress LLC Thalidomide-NH-PEG1-NH2 hydrochloride | 2154342-56-8 | 99.2% | C17H21ClN4O5 | 10MG
Thalidomide-NH-PEG1-NH2 hydrochloride is a thalidomide-derived cereblon E3 ligase ligand-linker conjugate supplied as the hydrochloride salt and intended as a building block for PROTAC design and small-molecule degradation strategies. It couples a cereblon-recruiting moiety with a short PEG1 diamine linker to facilitate conjugation to target-binding ligands and streamline synthesis workflows.
- Provides thalidomide-based cereblon recruiting moiety.
- Includes a short PEG1 diamine linker for flexibility in conjugation.
- Supplied as hydrochloride salt for improved stability and handling.
- High purity suitable for synthetic applications (99.2%).
- Available in small milligram quantities for early-stage research.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 276.22 g/mol | C13H9FN2O4 | 5 G
Thalidomide 5-fluoride is a 5-fluoro derivative of thalidomide that functions as a cereblon (CRBN) ligand for use in the design and synthesis of PROTACs and other E3 ligase-recruiting molecules.
- Used as a cereblon ligand in PROTAC and degrader synthesis.
- CAS number 835616-61-0.
- Molecular formula C13H9FN2O4.
- Molecular weight 276.22 g/mol.
- Packaged as a 5 g quantity.
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 TFA | 2097509-49-2 | 514.49 | 5 MG
Thalidomide-5-NH2-C8-NH2 TFA is a chemical compound primarily used for compound synthesis and various biochemical assay applications. It is characterized by its specific molecular weight and solubility properties.
- Used in compound synthesis
- Suitable for biochemical assay reagents
- Soluble in DMSO (up to 100 mg/mL with ultrasonic assistance)
- Requires sealed storage at -20°C, away from moisture and light
- When in solvent, store at -80°C for up to 6 months, or -20°C for up to 1 month, under sealed conditions away from moisture and light.
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 hydrochloride | 2376990-31-5 | 99.32% | 466.92 | 50 MG
Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker. It can be used in the synthesis of PROTACs. This product is for research use only.
- E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand and a linker
- Can be used in the synthesis of PROTACs
Medchemexpress LLC 1H-isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 | C13H9IN2O4 | 500 MG
Thalidomide-iodo is an iodinated derivative of thalidomide used as an E3 ligase (cereblon) activator for research applications. It is intended as a building block and synthetic intermediate for further derivatization by substitution of the iodine atom.
- E3 ligase activator (cereblon ligand) for targeted protein degradation research.
- Suitable as a synthetic intermediate for iodide substitution and further derivatization.
- High purity: 98.0% (NMR).
- Molecular formula C13H9IN2O4; molecular weight 384.13.
- CAS number 2509137-01-1.
- Appearance: gray to dark gray solid.
- Storage: 4°C, protect from light; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC (S)-thalidomide | 841-67-8 | MFCD00210219 | 99.5% | C13H10N2O4 | 10MG
(S)-Thalidomide is the S-enantiomer of thalidomide, a small-molecule ligand of the E3 ubiquitin ligase substrate receptor cereblon (CRBN). It exhibits immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic activities and is used as a research reagent to study CRBN-mediated degradation pathways and molecular glue mechanisms. For research use only.
- High chemical purity suitable for analytical and biological studies.
- Known to bind cereblon and induce substrate recruitment for degradation.
- Useful in studies of immunomodulation, angiogenesis, and apoptosis.
- Available in small milligram pack sizes for screening and synthesis.
- Provided with manufacturer documentation including SDS and COA.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | 2245697-84-9 | MFCD31656717 | 98.3% | 542.97 | C23H31ClN4O9 | 250 MG
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate used as an intermediate in the design and synthesis of PROTACs and targeted protein degraders. Supplied as the hydrochloride salt, it is provided as an off-white to yellow solid with high reported purity for research applications.
- High purity suitable for research and synthetic use.
- Hydrochloride salt form for improved handling and stability.
- Good solubility in DMSO and water; may require ultrasonic aid.
- Available in multiple package sizes, including 250 mg.
- Recommended storage at -20°C sealed, away from moisture.
Medchemexpress LLC Thalidomide-CH2NH2 (hydrochloride) | 444287-40-5 | 98.1% | 323.73 | 25 MG
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions.
- Features a primary amine, which is a versatile group that may participate in many reactions.
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.2% | 274.23 | 1 ML
Thalidomide-5-OH is a Thalidomide-based cereblon ligand that recruits the CRBN protein. It can be linked to a ligand for protein to form PROTACs. It is intended for research use only.
- Thalidomide-based cereblon ligand.
- Recruits CRBN protein.
- Can be connected to a ligand for protein by a linker to form PROTACs.
![eMolecules Pharmablock / benzyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate / 100mg / 551321315 / PB05931 / 0.000 / 31865-25-5 / MFCD09608058 / 219.240 / C12H13NO3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502516766.JPG-250.jpg)
eMolecules Pharmablock / benzyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate / 100mg / 551321315 / PB05931 / 0.000 / 31865-25-5 / MFCD09608058 / 219.240 / C12H13NO3
Pharmablock / benzyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate / 100mg / 551321315 / PB05931 / 0.000 / 31865-25-5 / MFCD09608058 / 219.240 / C12H13NO3
Medchemexpress LLC Thalidomide-NH-C6-NH2 hydrochloride | 2375194-37-7 | 99.6% | 50 MG
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand and a linker used in PROTAC technology
- For research use only
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 hydrochloride | 2376990-31-5 | 99.3% | 466.92 | 100 MG
Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, and can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand and a linker
- Used in the synthesis of PROTACs
- Appearance: Solid
- Color: White to off-white