Lactams
Medchemexpress LLC Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 96.9% | 395.84 | 50 MG
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Targets E3 ligase ligand-linker conjugates
- Targets apoptosis and autophagy pathways
- Targets cereblon
Medchemexpress LLC N-Me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 g/mol | C14H11FN2O4 | 1 G
N-Me-Thalidomide 4-fluoride is a research-grade small molecule ligand for E3 ligase used in chemical biology and PROTAC development. It functions as a building block in the synthesis of targeted degraders and related small-molecule tools. Supplied for laboratory research use only.
- Ligand for E3 ligase.
- Useful building block for synthesis of targeted degraders and anti-inflammatory agents.
- High reported purity (99.41%).
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol.
- Available in research pack sizes suitable for small-scale synthesis.
Medchemexpress LLC Thalidomide-4-O-C10-NH2 hydrochloride | 00-00-0 | 95.6% | C23H32ClN3O5 | 10MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand formulated as a hydrochloride salt for use in PROTAC design and related biochemical research. Supplied as a solid with reported high purity, it is intended for small-scale laboratory studies and compound linking applications.
- Hydrochloride salt form for improved stability
- High purity suitable for research applications
- Molecular formula C23H32ClN3O5 and molecular weight 465.97
- Available in small packaging sizes for synthesis and screening
- Solid form for convenient handling and storage
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 250 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g/mol | C19H21BN2O6 | 50 MG
Thalidomide-pinacolborane is a thalidomide analogue containing a pinacol boronate (Bpin) group, supplied as a research reagent for use in synthetic chemistry and chemical biology. It is suitable as a building block for cross-coupling reactions and as a probe to investigate E3 ligase-mediated ubiquitination in degradation studies.
- Contains a pinacol boronate functional group for cross-coupling chemistry.
- Useful as a synthetic intermediate in Suzuki-Miyaura reactions.
- Acts as a thalidomide analogue for studying E3 ligase activity.
- Supplied as a high-purity research chemical suitable for analytical and preparative use.
- Provided in small-quantity packaging for laboratory experiments.
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide | 19171-19-8 | MFCD12756407 | 5mg
Pomalidomide | 98% (HPLC) | 273.24 | 19171-19-8 | MFCD12756407 | 5mg
Medchemexpress LLC Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 96.9% | 395.84 | 25 MG
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They are utilized to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes PROTAC technology for selective degradation of target proteins
- Exploits the intracellular ubiquitin-proteasome system
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | 485.92 | 50 MG
Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker, and is used in PROTAC technology. This product is intended for research use only and is not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilizes a linker for PROTAC technology
- For research use only
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 diTFA | 00-00-0 | 99.4% | C25H29F6N5O9 | 10MG
Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a short PEG1/piperazine linker for PROTAC design. Intended for research use only, the compound is supplied as a solid (white to yellow) with characterized solubility and storage recommendations to support experimental workflows.
- High purity for research use (99.4%).
- Thalidomide-based cereblon ligand facilitates E3 ligase recruitment.
- Short PEG1/piperazine linker suitable for PROTAC assembly.
- DMSO solubility: 100 mg/mL; sonication recommended.
- In vivo formulation options reach ~2.5 mg/mL as suspended or clear solutions.
- Storage: sealed at 4°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | C25H36ClN5O9 | 10MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a thalidomide-based cereblon (CRBN) ligand-linker conjugate intended as a building block for PROTAC synthesis. The molecule combines a thalidomide-derived CRBN recruiting moiety with an amino-terminated PEG4-C2 spacer to enable straightforward coupling to target ligands. It is supplied as the hydrochloride salt for improved handling and is for research use only.
- High HPLC purity (98.0%).
- Amino-terminated PEG4-C2 linker for facile conjugation.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- Supplied as a solid hydrochloride salt, light yellow to yellow.
- Available in small-scale quantities suitable for medicinal chemistry.
- Store sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Thalidomide-Piperazine 5-fluoride | 2222114-22-7 | >96.5% | 360.34 | 5 G
Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate. Its intended use is for research purposes, specifically in the field of PROTAC (Proteolysis Targeting Chimeras) technology. It incorporates a thalidomide-based cereblon ligand and a linker. This product is not for sale to patients.
- Appearance: Solid, light yellow to green yellow
- Solubility: Soluble in DMSO (5.83 mg/mL or 16.18 mM)
- Storage: 4°C, protect from light; in solvent: -80°C for 6 months, -20°C for 1 month (protect from light)
- Related research areas: Cancer, PROTAC, autophagy, apoptosis, E3 ligase ligand-linker conjugates
- Cereblon ligand: Incorporates a thalidomide-based cereblon ligand
- PROTAC technology: Utilizes a linker commonly used in PROTAC technology
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | >98.0% | 292.68 | C13H9ClN2O4 | 5 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as an E3 ligase (cereblon) ligand/activator for research use. It is commonly used as a synthetic building block in PROTAC design and for studies involving CRBN recruitment, where the 4-chloro group can be substituted to create derivatives.
- Functions as an E3 ligase (cereblon) ligand for biochemical studies.
- Useful for PROTAC design and cereblon recruitment assays.
- Enables further derivatization via substitution at the 4-chloro position.
- Available in laboratory pack sizes suitable for synthesis and screening.
- Analytical data and a product datasheet are available for reference.
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 100 G
Thalidomide 4-fluoride, also known as Cereblon ligand 4, is a Thalidomide-based Cereblon ligand. It is utilized in the recruitment of CRBN protein, a component of the cullin-4 E3 ubiquitin ligase complex. This compound mediates the ubiquitination and subsequent proteasomal degradation of target proteins, and can be connected to other ligands to form PROTAC degraders.
- Thalidomide-based cereblon ligand.
- Used in the recruitment of CRBN protein.
- Targets cereblon (CRBN), a part of the E3 ubiquitin ligase complex.
- Mediates ubiquitination and proteasomal degradation of target proteins.
- Can be used to form PROTAC degraders.
Medchemexpress LLC Thalidomide-4-O-C7-NH2 hydrochloride | 99.8% | 423.89 g/mol | C20H26ClN3O5 | 5 MG
Thalidomide-4-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate used as an E3 ligase ligand in PROTAC development and CRBN recruitment studies.
- High chemical purity: 99.8%.
- Hydrochloride salt form for improved stability and solubility.
- Molecular formula C20H26ClN3O5; molecular weight 423.89 g/mol.
- Optimized for use as an E3 ligase ligand in biochemical and cell-based assays.
- Supplied in small research quantities suitable for synthesis and assay development.
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl) | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 | C13H11IN2O3 | 50 MG
Deoxy-thalidomide-5-iodine is an iodinated thalidomide analog intended for chemical biology and PROTAC applications; it functions as a cereblon-binding ligand for E3 ligase recruitment and is supplied with analytical data confirming identity and high purity.
- Iodinated thalidomide analog useful for PROTAC research.
- Binds cereblon to enable E3 ligase recruitment.
- High purity: 98.0% by NMR.
- Molecular weight 370.14; formula C13H11IN2O3.
- Appearance: blue to blue-green solid.
- Store protected from light at 4°C; in solvent keep at -80°C (6 months) or -20°C (1 month).
- Supplied in small research quantities (50 mg).