Lactams
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | C30H42N4O11 | 10MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate supplied as a solid for research use. The compound features a PEG3 linker and a Boc-protected terminal amine, offered with high reported purity and characterized molecular data, suitable as a synthetic intermediate in chemical biology and PROTAC development.
- High reported purity suitable for synthesis and analysis.
- Characterized molecular formula and molecular weight for experimental planning.
- Boc-protected terminal amine enables selective deprotection and conjugation.
- PEG3 linker provides flexibility and improved solubility in conjugates.
- Available in small milligram quantities for research workflows.
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g/mol | C19H21BN2O6 | 250 MG
Thalidomide-pinacolborane is a thalidomide analogue that incorporates a boronic pinacol ester (Bpin). It is used as a synthetic intermediate for cross-coupling chemistry and as an E3 ligase (cereblon) ligand in chemical biology and targeted protein degradation research.
- Contains a boronic pinacol ester suitable for Suzuki-Miyaura cross-coupling.
- Functions as an E3 ligase (cereblon) ligand for PROTAC and degradation studies.
- High purity appropriate for research applications.
- Available in research-scale quantities for assay development.
- Molecular formula C19H21BN2O6; molecular weight 384.19 g/mol.
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 50 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand.
- Features a 2-unit PEG linker.
- Utilized in PROTAC technology.
- Exploits intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Targets Cereblon.
- For research use only.
Medchemexpress LLC Thalidomide-5-CH2-NH2 hydrochloride | 1010100-22-7 | MFCD32666042 | 98.6% | 323.73 | C14H14ClN3O4 | 50 MG
Thalidomide-5-CH2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiting moiety in PROTAC design and targeted protein degradation research. Supplied as a solid with high purity, it serves as a linker-compatible building block for medicinal chemistry and chemical biology applications.
- High purity suitable for research.
- Solid form, easy to handle and store.
- Compatible with linker conjugation for PROTAC synthesis.
- Facilitates CRBN-mediated target recruitment.
- Available in multiple small pack sizes for synthesis workflows.
Medchemexpress LLC Thalidomide-5-NH-C-alkyne | 2357110-24-6 | MFCD34563706 | >98.0% | 311.29 g/mol | C16H13N3O4 | 100 MG
Thalidomide-5-NH-C-alkyne is an E3 ligase ligand-linker conjugate bearing a terminal alkyne for click-style conjugation, supplied for research use in small packs for assembling PROTACs and other bioconjugates.
- Contains a terminal alkyne for click conjugation.
- Functions as an E3 ligase ligand suitable for PROTAC assembly.
- Purity >98.0%.
- Molecular formula C16H13N3O4; molecular weight 311.29 g/mol.
- CAS number 2357110-24-6 for substance identification.
- Supplied as a 100 mg research pack.
- For research use only; not for human or animal therapeutic use.
Medchemexpress LLC Thalidomide-4-F,5-Br | 2740657-28-5 | MFCD34180776 | 99.4% | 355.12 g·mol⁻1 | C13H8BrFN2O4 | 25 MG
Thalidomide-4-F,5-Br is a halogenated thalidomide analogue that functions as an E3 ligase recruiting ligand for targeted protein degradation research. Supplied as a powder in small pre-weighed quantities, it is intended for research use in PROTAC development and studies of ubiquitin-mediated proteolysis.
- Halogenated thalidomide derivative (fluoro and bromo substitutions).
- Acts as a cereblon (CRBN) E3 ligase recruiting ligand for PROTAC applications.
- High purity suitable for research (approximately 99.4%).
- Provided as a powder for easy handling and formulation.
- Available in small pre-weighed quantities for screening and synthesis workflows.
Medchemexpress LLC Thalidomide-5-NH2-CH2-COOH | 2412056-27-8 | 95.0% | C15H13N3O6 | 500 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (Trk) and a ligand of E3 ligase. It has potential for researching various diseases, as extracted from patent WO2021170109A1.
- Potent and selective Trk inhibitor
- Ligand of E3 ligase
- Researches various diseases including cancer, inflammation, and neurodegenerative conditions
- Solid appearance
- Color can range from light yellow to green yellow
![Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)amino]-, 1,1-dimethylethyl ester | 2204246-03-5 | 97.2% | 548.59 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000403850-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)amino]-, 1,1-dimethylethyl ester | 2204246-03-5 | 97.2% | 548.59 | 5 MG
Thalidomide-NH-PEG3-NH-Boc is a chemical compound that appears as a light yellow to yellow oil. This product has been thoroughly tested and complies with the given specifications, ensuring its quality and suitability for research purposes.
- Molecular formula: C26H36N4O9
- Molecular weight: 548.59
- Purity (LCMS): 97.20%
- Storage for pure form: -20°C for 3 years; 4°C for 2 years
- Storage in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Thalidomide-o-amido-c4-n3 | 2098488-36-7 | MFCD31560486 | ≥98.0% | 428.40 g·mol⁻¹ | C19H20N6O6 | 5 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate that contains an azide functional group. It is supplied as a research-grade building block for the design and synthesis of proteolysis-targeting chimeras (PROTACs) and for click-chemistry bioconjugation, compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted azide-alkyne cycloaddition.
- Contains an azide functional group for copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- Suitable for PROTAC synthesis and E3 ligase recruitment studies.
- Research-grade building block with defined molecular formula and molecular weight.
- Forms a clear solution when dissolved in common organic solvents.
- Recommended storage: store solid at 4°C under inert atmosphere; in solution -80°C for up to 6 months or -20°C for up to 1 month.
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 440.88 g·mol⁻1 | C19H25ClN4O6 | 5 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the hydrochloride salt for research use. It combines a thalidomide cereblon-binding moiety with a two-unit polyethylene glycol spacer and a C2 amino termination, designed for incorporation into PROTAC constructs and linker chemistry in targeted protein degradation studies.
- Provides a thalidomide-derived cereblon binding motif suitable for E3 ligase recruitment.
- Contains a PEG2 spacer to improve solubility and linker flexibility.
- Terminates in a C2 amino handle for straightforward conjugation chemistry.
- Supplied as the hydrochloride salt for enhanced stability and handling.
- Characterized with reported molecular weight and purity for research applications.
Medchemexpress LLC Thalidomide-nh-c4-nh-boc | 2093388-52-2 | 99.6% | 444.48 g/mol | C22H28N4O6 | 5 MG
Thalidomide-NH-C4-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate developed for PROTAC research. It combines a cereblon-binding thalidomide moiety with a Boc-protected four-carbon linker to facilitate targeted protein degradation studies. For research use only.
- High purity: 99.64% by analytical HPLC.
- Appropriate for PROTAC development as a cereblon ligand-linker conjugate.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Storage: store at 4°C and protect from light; in solvent, -80°C (6 months) or -20°C (1 month).
- Available in small mg quantities suitable for medicinal chemistry applications.
Medchemexpress LLC Thalidomide-Propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | 428.39 | 25 MG
Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide based cereblon ligand and a linker used in PROTAC technology. It is a click chemistry reagent, containing an alkyne group, and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates thalidomide based cereblon ligand.
- Uses a linker in PROTAC technology.
- Click chemistry reagent.
- Contains an alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc).
Medchemexpress LLC Thalidomide-4-o-c10-nh2 hydrochloride | 2460022-53-9 | 50 MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It is intended for use as a laboratory chemical and for the manufacture of substances, strictly for research purposes. This product has not been fully validated for medical applications.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- For research use only
- Intended for use as laboratory chemicals
- Intended for the manufacture of substances
- Recommended storage temperature: -20°C (solid)
- For solutions, store at -80°C for 6 months or -20°C for 1 month
- Shipped at room temperature if transit is less than 2 weeks
- Store away from moisture and light
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 g·mol⁻¹ | C19H21N5O5 | 10 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a six-carbon azide-containing linker. It is intended as a building block for PROTAC design and related targeted protein degradation research, providing a clickable azide handle for conjugation or labeling in chemical biology applications.
- High purity suitable for research applications (≈99.1%).
- Azide functional group enables copper-free and copper-catalyzed click chemistry.
- Six-carbon linker provides flexible spacing for bifunctional molecule design.
- Storage-stable when sealed at low temperature, with extended stability in solvent at -80°C.
- Available in multiple small-scale quantities for synthesis and assay development.
Medchemexpress LLC Thalidomide-4-O-C11-NH2 hydrochloride | 99.9% | 480.00 g·mol⁻¹ | C24H34ClN3O5 | 10 MG
Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation and PROTAC development. It is intended as an E3 ligase ligand-linker conjugate for synthesis and biochemical studies involving CRBN recruitment.
- High purity (99.94%) suitable for synthetic applications.
- Hydrochloride salt form for improved handling and solubility.
- Molecular formula C24H34ClN3O5; molecular weight 480.00 g·mol⁻¹.
- Available in small mg-scale pack sizes for research workflows.
- Designed for use as a cereblon ligand in PROTAC design and E3 ligase recruitment studies.