Lactams
Medchemexpress LLC Tetrazine-tagged thalidomide | 2087490-42-2 | MFCD34706062 | 98.6% | 571.58 g/mol | C29H29N7O6 | 5 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide developed as an E3 ligase ligand and click-chemistry reagent. It is designed to undergo inverse electron-demand Diels-Alder (iEDDA) reactions with strained alkenes and has demonstrated binding activity to BRD4 in biochemical assays.
- Tetrazine functional group for rapid iEDDA click reactions with TCO-modified partners.
- Reported BRD4 binding (IC50: 46.25 μM for BRD4-1; 62.55 μM for BRD4-2).
- High purity suitable for research applications (98.6%).
- Solid, pink to red appearance for easy handling.
- Soluble in DMSO (~50 mg/mL), facilitating stock solution preparation.
- Storage conditions provided to support stability in powder and solution.
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | MFCD32643096 | 99.3% | 388.37 | C19H20N2O7 | 10 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a tert-butyl protected thalidomide derivative used as a cereblon (CRBN) binding ligand and as a synthetic intermediate in the preparation of PROTAC molecules. It is supplied for research use only and is not intended for human use.
- Tert-butyl protected thalidomide derivative suitable for deprotection under acidic conditions.
- Functions as a cereblon (CRBN) binding ligand for use in PROTAC design.
- High reported purity (~99.3%) for reliable research applications.
- Available in small research pack sizes (mg scale) for synthetic workflows.
- Stable at room temperature for extended storage; follow solvent storage recommendations for longer-term stability.
Medchemexpress LLC CD3 epsilon Human 100ug
Recombinant human CD3 epsilon protein supplied as a lyophilized powder, expressed in HEK293 cells and carrying a C-terminal 6xHis tag. The protein is intended for T-cell signaling research, assay development, and biochemical characterization; it offers high purity and low endotoxin to support sensitive in vitro and cell-based assays.
- Lyophilized powder for convenient storage and transport.
- Expressed in HEK293 cells for human-like post-translational modifications.
- C-terminal 6xHis tag facilitates purification and detection.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Endotoxin level below 1 EU/μg, suitable for sensitive assays.
- Available in 10 μg, 50 μg, 100 μg, and 500 μg sizes.
- Recommended reconstitution at ≥100 μg/mL; refer to lot-specific COA for buffer details.
Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 26166-92-7 | MFCD30188073 | 98.4% | 337.13 | C13H9BrN2O4 | 100 MG
Thalidomide-5-Br is a brominated thalidomide derivative supplied for research use in studies of inflammation, tumor biology, and neurology. It is provided as a solid research reagent; consult lot-specific documentation for analytical details.
- Contains a bromodomain; used as a tool compound in biochemical and pharmacological research.
- Reported purity approximately 98% (see product documentation for lot-specific certificate of analysis).
- Solid, off-white to gray appearance suitable for analytical and synthetic applications.
- Storage recommendations: room temperature for shipping; in solution store at -80°C (2 years) or -20°C (1 year).
- Available in multiple pack sizes including 100 mg.
Medchemexpress LLC Thalidomide-5-Br | 26166-92-7 | 98.4% | 337.13 g/mol | C13H9BrN2O4 | 50 MG
Thalidomide-5-Br is a brominated thalidomide analogue supplied for biochemical research. It has a reported molecular weight of 337.13 g/mol and is supplied as an off-white to gray solid with reported purity around 98%.
- Used in research of inflammation, tumor biology, and neurology.
- Supplied as a solid suitable for formulation or dissolution in solvent for experimental use.
- Reported high purity for analytical and preclinical studies.
- Stable at room temperature for extended storage; in-solution storage requires low temperatures.
Medchemexpress LLC Thalidomide-NH-C9-NH2 hydrochloride | 2305936-77-8 | 99.9% | 450.96 g/mol | C22H31ClN4O4 | 10 MG
Thalidomide-NH-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt for use in proteolysis-targeting chimera (PROTAC) construction and related chemical biology research. Provided as a light yellow solid with high purity and defined storage stability, it is intended for laboratory research use only.
- High purity (99.85%) suitable for research applications.
- Hydrochloride salt form to aid handling and solubility considerations.
- Available in small research pack sizes, including 10 mg, for synthesis workflows.
- Designed to act as a CRBN-binding E3 ligase ligand in PROTAC constructs.
- Recommended storage: -20°C sealed; in solvent: -80°C up to 6 months or -20°C up to 1 month.