Lactams
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | 99.0% | 433.41 | 100 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate designed for PROTAC technology. It incorporates a Thalidomide-based cereblon ligand and is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilized in PROTAC technology
- High purity: 99.0%
- Molecular weight: 433.41
- Molecular formula: C20H23N3O8
- Appearance: Light green to green solid
- Recommended storage: -20°C, sealed, away from moisture and light
- For research use only
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.3% | 388.37 | 25 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified thalidomide that functions as a Cereblon ligand, recruiting CRBN proteins. This compound serves as a final intermediate in the synthesis of Thalidomide-4-OH. Its t-Bu protecting group can be removed under acidic conditions, making it suitable for participation in PROTAC molecule synthesis and a key intermediate for CRBN-based designed PROTAC molecules.
- t-Bu modified thalidomide
- Intermediate in Thalidomide-4-OH synthesis
- Functions as a Cereblon ligand
- Recruits CRBN proteins
- t-Bu protecting group is removable under acidic conditions
- Key intermediate for CRBN-based PROTAC molecule synthesis
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | 99.0% | 433.41 | 50 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate designed for PROTAC technology. This compound incorporates a thalidomide-based cereblon ligand and is intended for research use only, not for patient application.
- Incorporates thalidomide-based cereblon ligand
- Utilizes a linker used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system
- Target: Cereblon
![eMolecules 1208530-70-4 | tert-butyl N-(9-azabicyclo[3.3.1]nonan-3-yl)carbamate | Pharmablock | MFCD13196387 | 240.347 | C13H24N2O2 | 97.000 | CC(C)(C)OC(=O)NC1CC2CCCC(C1)N2 | 25mg | 721772855](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502451719.PNG-250.jpg)
eMolecules 1208530-70-4 | tert-butyl N-(9-azabicyclo[3.3.1]nonan-3-yl)carbamate | Pharmablock | MFCD13196387 | 240.347 | C13H24N2O2 | 97.000 | CC(C)(C)OC(=O)NC1CC2CCCC(C1)N2 | 25mg | 721772855
tert-butyl N-(9-azabicyclo[3.3.1]nonan-3-yl)carbamate | Pharmablock | 1208530-70-4 | MFCD13196387 | 240.347 | C13H24N2O2 | 97.000 | CC(C)(C)OC(=O)NC1CC2CCCC(C1)N2 | 25mg | 721772855
Medchemexpress LLC Thalidomide-CH2NH2 (hydrochloride) | 444287-40-5 | 98.1% | 323.73 | 25 MG
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions.
- Features a primary amine, which is a versatile group that may participate in many reactions.
Medchemexpress LLC 3-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethoxy)propanoic acid | 2731007-11-5 | 99.2% | C22H26N4O7 | 10MG
Thalidomide-Piperazine-PEG1-COOH is an E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a short PEG1-piperazine linker terminated by a carboxylic acid. It is provided as a solid research reagent intended for use as a CRBN-binding module in PROTAC design and conjugation studies.
- Enables CRBN engagement via a thalidomide-derived ligand.
- Features a PEG1-piperazine linker with a terminal carboxylic acid for conjugation.
- High reported purity enables reliable analytical and synthetic work.
- Solid, white-to-yellow appearance for easy handling and storage.
- Recommended storage at -20°C under inert gas to preserve integrity.
- Available in small milligram quantities suitable for early-stage research.
Medchemexpress LLC (S)-thalidomide | 841-67-8 | MFCD00210219 | 99.5% | C13H10N2O4 | 10MG
(S)-Thalidomide is the S-enantiomer of thalidomide, a small-molecule ligand of the E3 ubiquitin ligase substrate receptor cereblon (CRBN). It exhibits immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic activities and is used as a research reagent to study CRBN-mediated degradation pathways and molecular glue mechanisms. For research use only.
- High chemical purity suitable for analytical and biological studies.
- Known to bind cereblon and induce substrate recruitment for degradation.
- Useful in studies of immunomodulation, angiogenesis, and apoptosis.
- Available in small milligram pack sizes for screening and synthesis.
- Provided with manufacturer documentation including SDS and COA.
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 hydrochloride | 2376990-31-5 | 99.3% | 466.92 | 100 MG
Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, and can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand and a linker
- Used in the synthesis of PROTACs
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.2% | 274.23 | 1 ML
Thalidomide-5-OH is a Thalidomide-based cereblon ligand that recruits the CRBN protein. It can be linked to a ligand for protein to form PROTACs. It is intended for research use only.
- Thalidomide-based cereblon ligand.
- Recruits CRBN protein.
- Can be connected to a ligand for protein by a linker to form PROTACs.
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 25 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a 2-unit PEG linker, making it suitable for use in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Features a 2-unit PEG linker
- Utilized in PROTAC technology
- For research use only
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 10 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide based cereblon ligand and a 2-unit PEG linker, making it suitable for PROTAC technology applications. This product is for research use only.
- Used in PROTAC technology
- Suitable for autophagy research
- Applicable for apoptosis studies
- E3 ligase ligand-linker conjugate
- Targets cereblon
- Relevant for cancer targeted therapy research
- Used in cancer metabolism and metastasis studies
- Acts as an inhibitor
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00153873 | 100.0% | C13H10N2O4 | 10MG
Thalidomide (analytical standard) is a high-purity reference compound (CAS 50-35-1) intended for research and analytical applications. It serves as a cereblon inhibitor standard for assay calibration, method development, and reference testing. Consult the certificate of analysis and safety data sheet for batch-specific purity and handling instructions.
- High purity (99.96%) suitable for analytical standards.
- Provided in small, laboratory-scale quantities for method development.
- Supplied with certificate of analysis and safety data sheet.
- Intended for research and analytical use only.
- Suitable for assays targeting cereblon-related activity.
Medchemexpress LLC Thalidomide-1-me,4-oh | 2244568-06-5 | ≥98.0% | 288.26 g·mol-1 | C14H12N2O5 | 100 MG
Thalidomide-1-Me,4-OH is a thalidomide analogue bearing a 4-hydroxy substituent and an N-1 methyl group. It serves as a cereblon/E3 ligase ligand scaffold for research into ubiquitin-mediated proteolysis and is supplied as a solid research reagent.
- Small-molecule cereblon/E3 ligase ligand used in biochemical and cell-based assays
- High purity suitable for research applications
- Powder form with defined storage recommendations for long-term stability
- Includes chemical identifiers for traceability, including CAS and molecular formula
- Applicable for studies of targeted protein degradation and ligand design
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 250 MG
Thalidomide-4,5-F is a fluorinated thalidomide analogue used as a cereblon (CRBN) ligand and E3 ligase recruiter for chemical biology and PROTAC research. It promotes ubiquitinylation of target proteins and can be derivatized at fluorine positions. Supplied as a solid powder with high purity and recommended cold storage conditions.
- Fluorinated analogue designed for cereblon engagement.
- High purity suitable for research applications.
- Available in multiple milligram-scale pack sizes.
- Stable solid form with defined cold storage conditions.
- Modifiable at fluorine positions for derivatization.