Lactams
Medchemexpress LLC Thalidomide-5-O-C3-NH2 hydrochloride | 2694727-94-9 | MFCD34475114 | 99.1% | 367.78 g/mol | C16H18ClN3O5 | 10 MG
Thalidomide-5-O-C3-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for use as a building block in targeted protein degradation research and PROTAC design. It is provided as a solid with supporting analytical data for research use.
- Acts as a cereblon-binding ligand for CRBN recruitment.
- Enables linker conjugation for PROTAC assembly.
- Supplied with high purity (99.08%).
- Provided as a solid suitable for long-term storage under recommended conditions.
- Analytical data and COA available to support research use.
Medchemexpress LLC Thalidomide-5-O-C7-NH2 hydrochloride | 98.1% | 423.89 g/mol | C20H26ClN3O5 | 10 MG
Thalidomide-5-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon ligand supplied as the hydrochloride salt for use in chemical biology and targeted protein degradation research. It is designed to be connected to target ligands via a linker to build PROTACs and other CRBN-recruiting constructs, and includes storage recommendations to preserve compound integrity.
- Facilitates cereblon (CRBN) recruitment for targeted degradation studies.
- Hydrochloride salt form for improved handling and stability.
- Compatible with linker conjugation to form PROTAC molecules.
- Provided with documented molecular and storage data to support experimental planning.
- Suitable for research applications requiring characterized E3 ligase ligands.
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | >95.0% | 676.67 g/mol | C30H44Cl2FN5O5S | 5 MG
VH 101 phenol-alkylC4-amine dihydrochloride is a functionalized von Hippel-Lindau (VHL) E3 ligase ligand supplied as the dihydrochloride salt. It is designed as a building block for PROTAC (proteolysis-targeting chimera) synthesis and degrader design, offering a linker-equipped ligand with a terminal amine for conjugation and medicinal chemistry applications.
- Functionalized VHL ligand for PROTAC synthesis.
- Dihydrochloride salt for improved stability and handling.
- Terminal amine compatible with common coupling chemistries.
- Alkyl C4 linker suitable for assembling bifunctional degraders.
- Available in small milligram quantities for medicinal chemistry research.
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | C30H42N4O11 | 10MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate supplied as a solid for research use. The compound features a PEG3 linker and a Boc-protected terminal amine, offered with high reported purity and characterized molecular data, suitable as a synthetic intermediate in chemical biology and PROTAC development.
- High reported purity suitable for synthesis and analysis.
- Characterized molecular formula and molecular weight for experimental planning.
- Boc-protected terminal amine enables selective deprotection and conjugation.
- PEG3 linker provides flexibility and improved solubility in conjugates.
- Available in small milligram quantities for research workflows.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 25 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used in targeted protein degradation research and PROTAC synthesis. It is supplied as a high-purity solid and as a DMSO solution, with analytical data and safety documentation available.
- Thalidomide-based cereblon ligand for PROTAC development and E3 ligase recruitment studies.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- High purity (99.96%).
- Available as solid in 1 g, 5 g, 10 g, 25 g quantities.
- Solution option available as 10 mM in DMSO.
- Supplied with supporting documentation including COA, SDS, HNMR, RP-HPLC, and MS.
Medchemexpress LLC Thalidomide-o-amido-c4-n3 | 2098488-36-7 | MFCD31560486 | ≥98.0% | 428.40 g·mol⁻¹ | C19H20N6O6 | 5 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate that contains an azide functional group. It is supplied as a research-grade building block for the design and synthesis of proteolysis-targeting chimeras (PROTACs) and for click-chemistry bioconjugation, compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted azide-alkyne cycloaddition.
- Contains an azide functional group for copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- Suitable for PROTAC synthesis and E3 ligase recruitment studies.
- Research-grade building block with defined molecular formula and molecular weight.
- Forms a clear solution when dissolved in common organic solvents.
- Recommended storage: store solid at 4°C under inert atmosphere; in solution -80°C for up to 6 months or -20°C for up to 1 month.
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 440.88 g·mol⁻1 | C19H25ClN4O6 | 5 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the hydrochloride salt for research use. It combines a thalidomide cereblon-binding moiety with a two-unit polyethylene glycol spacer and a C2 amino termination, designed for incorporation into PROTAC constructs and linker chemistry in targeted protein degradation studies.
- Provides a thalidomide-derived cereblon binding motif suitable for E3 ligase recruitment.
- Contains a PEG2 spacer to improve solubility and linker flexibility.
- Terminates in a C2 amino handle for straightforward conjugation chemistry.
- Supplied as the hydrochloride salt for enhanced stability and handling.
- Characterized with reported molecular weight and purity for research applications.
Medchemexpress LLC Thalidomide-nh-c4-nh-boc | 2093388-52-2 | 99.6% | 444.48 g/mol | C22H28N4O6 | 5 MG
Thalidomide-NH-C4-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate developed for PROTAC research. It combines a cereblon-binding thalidomide moiety with a Boc-protected four-carbon linker to facilitate targeted protein degradation studies. For research use only.
- High purity: 99.64% by analytical HPLC.
- Appropriate for PROTAC development as a cereblon ligand-linker conjugate.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Storage: store at 4°C and protect from light; in solvent, -80°C (6 months) or -20°C (1 month).
- Available in small mg quantities suitable for medicinal chemistry applications.
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | C26H34N2O7 | 10MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand intended for use as the E3 ligase-recruiting moiety in PROTAC design. It features an O-linked eight-carbon spacer with a Boc-protected terminus to enable linker attachment. Manufacturer data report molecular formula C26H34N2O7, molecular weight 486.56, and typical purity ~95%.
- Provides an O-linked C8 spacer with a Boc-protected terminus for linker attachment.
- Suitable for recruiting Cereblon (CRBN) as the E3 ligase in degrader strategies.
- Reported purity approximately 95.1%.
- High solubility in DMSO (100 mg/mL); manufacturer lists example in vivo formulations.
- Recommended storage: solid at -20°C under nitrogen; in solution -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-4-O-C11-NH2 hydrochloride | 99.9% | 480.00 g·mol⁻¹ | C24H34ClN3O5 | 10 MG
Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation and PROTAC development. It is intended as an E3 ligase ligand-linker conjugate for synthesis and biochemical studies involving CRBN recruitment.
- High purity (99.94%) suitable for synthetic applications.
- Hydrochloride salt form for improved handling and solubility.
- Molecular formula C24H34ClN3O5; molecular weight 480.00 g·mol⁻¹.
- Available in small mg-scale pack sizes for research workflows.
- Designed for use as a cereblon ligand in PROTAC design and E3 ligase recruitment studies.
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | 99.0% | C20H23N3O8 | 10MG
Thalidomide-NH-PEG2-COOH is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate designed as a building block for PROTAC and targeted protein degradation research. It couples a CRBN-recruiting thalidomide moiety to a short PEG2 spacer terminated with a carboxylic acid, facilitating conjugation to warheads or scaffolds for degrader design.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- PEG2 linker terminated with carboxylic acid for conjugation.
- Suitable as a building block for PROTAC synthesis and linker optimization.
- High purity (99.0%) supporting reproducible conjugation chemistry.
- Molecular formula C20H23N3O8; molecular weight 433.41 g/mol.
- Supplied in small milligram pack sizes for research use.
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | C21H28ClN3O8 | 10MG
Thalidomide-5-PEG4-NH2 hydrochloride is a thalidomide-derived cereblon ligand conjugated to a PEG4 linker and supplied as the hydrochloride salt. It serves as an E3 ligase ligand-linker building block for PROTAC design and related chemical biology research.
- Incorporates thalidomide-based cereblon ligand for E3 ligase recruitment.
- PEG4 linker provides a flexible spacer for bifunctional molecule design.
- Hydrochloride salt form improves handling and solubility properties.
- Intended for use in proteolysis-targeting chimera (PROTAC) synthesis.
- Molecular weight 485.92 g/mol; chemical formula C21H28ClN3O8.
- Manufacturer-reported purity 95.2% suitable for research applications.
![Chemscene ChemScene | tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate | 250MG | CS-0088547 | 0.98 | 208837-83-6| MFCD09040607 | 198.26](https://assets.fishersci.com/TFS-Assets/CCG/product-images/CS-0088547.JPG-250.jpg)
Chemscene ChemScene | tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate | 250MG | CS-0088547 | 0.98 | 208837-83-6| MFCD09040607 | 198.26
ChemScene | tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate | 250MG | CS-0088547 | 0.98 | 208837-83-6| MFCD09040607 | 198.26
Medchemexpress LLC Thalidomide-5-NH-C-alkyne | 2357110-24-6 | MFCD34563706 | 98.0% | 311.29 g/mol | C16H13N3O4 | 25 MG
Thalidomide-5-NH-C-alkyne is a thalidomide-derived E3 ligase ligand-linker conjugate bearing a terminal alkyne for click chemistry. It is supplied as a high-purity synthetic building block intended for conjugation in PROTAC synthesis and targeted protein degradation research.
- Contains an E3 ligase ligand with a terminal alkyne for click chemistry.
- Ready for conjugation to target molecules in PROTAC synthesis.
- High purity: 98.0%.
- Provided as 25 MG powder for small-scale research use.
- Molecular weight 311.29 g/mol; formula C16H13N3O4.
- Suitable for medicinal chemistry and chemical biology applications.
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | C22H27N3O9 | 5 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker terminating in a carboxylic acid. It is intended as a modular building block for PROTAC development to recruit CRBN and enable linker attachment to target-binding ligands.
- Designed for PROTAC assembly and CRBN recruitment.
- Contains a PEG3 linker terminating in a carboxylic acid for facile conjugation.
- Incorporates a thalidomide-based cereblon ligand.
- High chemical purity (≈98.9%).
- Suitable for medicinal chemistry and chemical biology applications.