Lactams
Medchemexpress LLC Thalidomide-O-amido-C8-NH2 (TFA) | 1950635-16-1 | MFCD31560485 | >=95.0% | 572.53 g/mol | C25H31F3N4O8 | 25 MG
Thalidomide-O-amido-C8-NH2 (TFA) is a thalidomide-derived cereblon ligand-linker conjugate supplied as the trifluoroacetic acid salt. It is intended for use as a building block in PROTAC synthesis and other E3 ligase ligand-linker research in chemical biology.
- Chemical form: TFA salt.
- Chemical formula: C25H31F3N4O8.
- CAS number: 1950635-16-1.
- Molecular weight: 572.53 g/mol.
- Appearance: solid.
- Typical use: building block for PROTAC and E3 ligase ligand-linker conjugate synthesis.
- Purity: high (≥95%).
Medchemexpress LLC Thalidomide-piperazine-PEG2-COOH | 2797430-20-5 | 99.8% | 502.52 | 25 MG
Thalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used as a linker in PROTAC technology
- Related to PROTACs, an emerging therapeutic modality in precision medicine
- Related to cereblon-based small-molecule compounds for controlling neural stem cell proliferation in regenerative medicine
eMolecules 2797619-65-7 | Medchem Express | Thalidomide-Propargyne-PEG2-COOH | 50mg | 626717252 | HY-138777 | 428.397 | C21H20N2O8
Ambeed | N2-Isobutyryl-5-O-(44-dimethoxytrityl)-2-deoxyguanosine | 1g | 490507231 | A135681 | 68892-41-1 | MFCD00010059 | 639.709 | C35H37N5O7
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Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 1 G
Thalidomide-O-COOH is a thalidomide-derived small-molecule ligand that recruits the CRBN E3 ubiquitin ligase and is commonly used as the E3 ligase component in PROTAC design and other chemical biology applications.
- Used as a cereblon (CRBN) E3 ligase ligand for PROTAC construction.
- CAS number 1061605-21-7; molecular formula C15H12N2O7; molecular weight 332.27 g·mol⁻¹.
- Reported high purity suitable for research and synthesis workflows.
- Functional handle (carboxylic acid) enables conjugation to linkers and building blocks.
- Supplied as a solid for storage and handling in synthetic and analytical protocols.
Medchemexpress LLC Thalidomide-CH2NH2 (hydrochloride) | 444287-40-5 | 98.1% | 323.73 | 25 MG
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions.
- Features a primary amine, which is a versatile group that may participate in many reactions.
Medchemexpress LLC 3-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethoxy)propanoic acid | 2731007-11-5 | 99.2% | C22H26N4O7 | 10MG
Thalidomide-Piperazine-PEG1-COOH is an E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a short PEG1-piperazine linker terminated by a carboxylic acid. It is provided as a solid research reagent intended for use as a CRBN-binding module in PROTAC design and conjugation studies.
- Enables CRBN engagement via a thalidomide-derived ligand.
- Features a PEG1-piperazine linker with a terminal carboxylic acid for conjugation.
- High reported purity enables reliable analytical and synthetic work.
- Solid, white-to-yellow appearance for easy handling and storage.
- Recommended storage at -20°C under inert gas to preserve integrity.
- Available in small milligram quantities suitable for early-stage research.
Medchemexpress LLC (S)-thalidomide | 841-67-8 | MFCD00210219 | 99.5% | C13H10N2O4 | 10MG
(S)-Thalidomide is the S-enantiomer of thalidomide, a small-molecule ligand of the E3 ubiquitin ligase substrate receptor cereblon (CRBN). It exhibits immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic activities and is used as a research reagent to study CRBN-mediated degradation pathways and molecular glue mechanisms. For research use only.
- High chemical purity suitable for analytical and biological studies.
- Known to bind cereblon and induce substrate recruitment for degradation.
- Useful in studies of immunomodulation, angiogenesis, and apoptosis.
- Available in small milligram pack sizes for screening and synthesis.
- Provided with manufacturer documentation including SDS and COA.
Medchemexpress LLC Thalidomide-PEG3-COOH | 2682112-08-7 | 96.95% | 434.40 | 25 MG
Thalidomide-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology, which exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Targets E3 ligase ligand-linker conjugates, apoptosis, and autophagy
- Targets Cereblon
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 2 MG
Thalidomide-propargyl is a Cereblon ligand derived from Thalidomide that facilitates the recruitment of the CRBN protein. It can be linked to other ligands to form IMiD-containing PROTACs. This compound is a click chemistry reagent, featuring an Alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups.
- Thalidomide-based cereblon ligand.
- Used in the recruitment of CRBN protein.
- Can be connected to ligands for protein to form IMiD containing PROTACs.
- Click chemistry reagent.
- Contains an alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 hydrochloride | 2376990-31-5 | 99.3% | 466.92 | 100 MG
Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, and can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand and a linker
- Used in the synthesis of PROTACs
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | 486.56 g·mol⁻¹ | C26H34N2O7 | 5 MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand for targeted protein degradation research. It is designed to be connected to a protein-targeting ligand via a linker to form PROTAC molecules and is provided as a research-grade chemical with manufacturer-reported purity (~95.1%).
- Acts as a cereblon ligand to recruit CRBN.
- Designed for conjugation via a linker to form PROTACs.
- Supplied at research-grade purity (~95.1%).
- Molecular formula C26H34N2O7; molecular weight 486.56 g·mol⁻¹.
- Available in milligram-scale quantities suitable for synthesis and screening.
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 500 MG
Thalidomide-O-C8-Boc is a Cereblon ligand that recruits the CRBN protein. It can be linked to target protein ligands via a linker to form PROTACs. This product is intended for research use only.
- Cereblon ligand
- Recruits CRBN protein
- Can form PROTACs when linked to a target protein ligand
- For research use only
- Purity: 95.12%
- Molecular weight: 486.56
- Formula: C26H34N2O7
- Appearance: solid, white to off-white
- Storage: -20°C, under nitrogen; in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 95% | 704.72 | 25 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Target: E3 Ligase Ligand-Linker Conjugates
- Pathway: PROTAC
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 50 MG
Thalidomide-NH-C4-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide based cereblon ligand and a linker, used in PROTAC technology. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Targets cereblon
- Solid appearance
- Color: yellow to green
- For research use only