Lactams
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00153873 | 100.0% | C13H10N2O4 | 10MG
Thalidomide (analytical standard) is a high-purity reference compound (CAS 50-35-1) intended for research and analytical applications. It serves as a cereblon inhibitor standard for assay calibration, method development, and reference testing. Consult the certificate of analysis and safety data sheet for batch-specific purity and handling instructions.
- High purity (99.96%) suitable for analytical standards.
- Provided in small, laboratory-scale quantities for method development.
- Supplied with certificate of analysis and safety data sheet.
- Intended for research and analytical use only.
- Suitable for assays targeting cereblon-related activity.
Medchemexpress LLC Thalidomide-1-me,4-oh | 2244568-06-5 | ≥98.0% | 288.26 g·mol-1 | C14H12N2O5 | 100 MG
Thalidomide-1-Me,4-OH is a thalidomide analogue bearing a 4-hydroxy substituent and an N-1 methyl group. It serves as a cereblon/E3 ligase ligand scaffold for research into ubiquitin-mediated proteolysis and is supplied as a solid research reagent.
- Small-molecule cereblon/E3 ligase ligand used in biochemical and cell-based assays
- High purity suitable for research applications
- Powder form with defined storage recommendations for long-term stability
- Includes chemical identifiers for traceability, including CAS and molecular formula
- Applicable for studies of targeted protein degradation and ligand design
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 50 MG
Thalidomide-NH-C4-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide based cereblon ligand and a linker, used in PROTAC technology. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Targets cereblon
- Solid appearance
- Color: yellow to green
- For research use only
Medchemexpress LLC Thalidomide-5-O-C3-NH2 hydrochloride | 2694727-94-9 | MFCD34475114 | 99.1% | 367.78 g/mol | C16H18ClN3O5 | 10 MG
Thalidomide-5-O-C3-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for use as a building block in targeted protein degradation research and PROTAC design. It is provided as a solid with supporting analytical data for research use.
- Acts as a cereblon-binding ligand for CRBN recruitment.
- Enables linker conjugation for PROTAC assembly.
- Supplied with high purity (99.08%).
- Provided as a solid suitable for long-term storage under recommended conditions.
- Analytical data and COA available to support research use.
Medchemexpress LLC HY-126457 5mg Medchemexpress, Thalidomide-propargyl CAS:2098487-39-7 Purity:>98%
Medchemexpress, HY-126457 5mg Thalidomide-propargyl CAS:2098487-39-7 Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Thalidomide-4-o-c10-nh2 hydrochloride | 2460022-53-9 | 50 MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It is intended for use as a laboratory chemical and for the manufacture of substances, strictly for research purposes. This product has not been fully validated for medical applications.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- For research use only
- Intended for use as laboratory chemicals
- Intended for the manufacture of substances
- Recommended storage temperature: -20°C (solid)
- For solutions, store at -80°C for 6 months or -20°C for 1 month
- Shipped at room temperature if transit is less than 2 weeks
- Store away from moisture and light
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 g·mol⁻¹ | C19H21N5O5 | 10 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a six-carbon azide-containing linker. It is intended as a building block for PROTAC design and related targeted protein degradation research, providing a clickable azide handle for conjugation or labeling in chemical biology applications.
- High purity suitable for research applications (≈99.1%).
- Azide functional group enables copper-free and copper-catalyzed click chemistry.
- Six-carbon linker provides flexible spacing for bifunctional molecule design.
- Storage-stable when sealed at low temperature, with extended stability in solvent at -80°C.
- Available in multiple small-scale quantities for synthesis and assay development.
Medchemexpress LLC Thalidomide-NH-C6-NH-Boc | 2093536-13-9 | 96.1% | 250 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker that was utilized in the synthesis of MI-389 (compound 22). MI-389 is recognized as a potent phthalimide PROTAC degrader, derived from the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A). This product is intended for research use only and is not sold to patients.
- E3 ligase ligand-linker conjugate: contains a Thalidomide-based cereblon ligand.
- PROTAC component: the linker is used in the synthesis of MI-389, a potent phthalimide PROTAC degrader.
- Research use only: exclusively for research purposes.
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.29% | 50 MG
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker, which is used in PROTAC (Proteolysis-Targeting Chimera) technology. This compound is intended for research use only.
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Composed of two different ligands connected by a linker
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 g/mol | C13H9IN2O4 | 250 MG
Thalidomide-iodo is an iodinated derivative of thalidomide that functions as an E3 ligase activator for chemical biology and medicinal chemistry research. It is supplied as a solid research reagent and can be used as a synthetic building block for further derivatization via substitution of the iodine atom.
- Iodinated thalidomide derivative suitable for E3 ligase activation studies.
- Useful as a synthetic building block for iodine substitution and derivatization.
- High purity (≥98.0%) appropriate for research applications.
- Molecular weight 384.13 g/mol; formula C13H9IN2O4.
- CAS number 2509137-01-1 for unambiguous identification.
Medchemexpress LLC Thalidomide-5-PEG3-NH2 hydrochloride | 2761385-81-1 | 97% | 441.86 | 1 MG
Thalidomide-5-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It has an IC 50 of Cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Solid form
- White to off-white color
Medchemexpress LLC Thalidomide-5 6-F 1g
Thalidomide-5 6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein Thalidomide-5 6-F can be connected to the ligand for protein by a linker to form PROTACs[1]
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | 586.03 | 100 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. For research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilizes a linker in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-5-methyl | 40313-92-6 | 99.9% | 272.26 | 50 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand, based on Thalidomide, used in the recruitment of CRBN protein. It can be utilized for the synthesis of PROTACs and is intended for research use only.
- Cereblon (CRBN) ligand
- Recruits CRBN protein
- Utilized for PROTAC synthesis
- Molecular weight: 272.26
- Solid appearance, gray to gray purple color
- Soluble in DMSO (50 mg/mL with warming)
- Recommended storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Thalidomide-4-o-c12-nh2 hydrochloride | 95.6% | 494.02 | 25 MG
Thalidomide-4-O-C12-NH2 hydrochloride is a thalidomide-based cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Utilized for recruitment of CRBN protein
- Can be linked to a protein ligand via a linker to form PROTACs
- Target: Cereblon