Lactams
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 50mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide | 1609389-52-7 | MFCD30342405 | 99.6% | 429.54 g·mol⁻¹ | C24H23N5OS | 25 MG
ACY-957 is a small-molecule, orally active inhibitor selective for histone deacetylases HDAC1 and HDAC2 used in preclinical research. It potently inhibits HDAC1 (IC50 = 7 nM) and HDAC2 (IC50 = 18 nM), with substantially weaker activity against HDAC3 (IC50 = 1,300 nM), and shows no significant inhibition of HDAC4-HDAC9. The compound is provided as a purified research reagent for biochemical and cellular studies of epigenetic regulation.
- Potent HDAC1 inhibition (IC50 = 7 nM).
- Selective for HDAC1/2 over HDAC3 (IC50 HDAC2 = 18 nM; HDAC3 = 1,300 nM).
- Orally active profile reported in preclinical studies.
- Suitable for biochemical and cellular assays investigating epigenetic regulation.
- High chemical purity for reproducible experimental results.
Medchemexpress LLC Thalidomide-o-amido-c4-n3 | 2098488-36-7 | 98.4% | 428.40 | C19H20N6O6 | 25 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate containing an azide functional group. It is used as a building block in PROTAC design and as a click-chemistry reagent to attach CRBN ligands to alkyne-bearing partners, enabling targeted protein degradation applications.
- Azide functional group compatible with CuAAC and SPAAC click chemistry.
- Designed as a cereblon (CRBN) ligand-linker conjugate for PROTAC synthesis.
- High purity as supplied (LCMS ~98.4%).
- Soluble in DMSO (≥ 41 mg/mL) for in vitro formulation.
- In vivo formulation examples achieve ≥ 2.5 mg/mL in common solvents and vehicles.
- Store under inert atmosphere at 4°C; in solution store at -80°C for long-term stability.
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 diTFA | 00-00-0 | 99.4% | C25H29F6N5O9 | 10MG
Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a short PEG1/piperazine linker for PROTAC design. Intended for research use only, the compound is supplied as a solid (white to yellow) with characterized solubility and storage recommendations to support experimental workflows.
- High purity for research use (99.4%).
- Thalidomide-based cereblon ligand facilitates E3 ligase recruitment.
- Short PEG1/piperazine linker suitable for PROTAC assembly.
- DMSO solubility: 100 mg/mL; sonication recommended.
- In vivo formulation options reach ~2.5 mg/mL as suspended or clear solutions.
- Storage: sealed at 4°C; in solvent -80°C (6 months) or -20°C (1 month).
![eMolecules Medchem Express / Thalidomide-4-O-C6-NH2 (hydrochloride) / 5mg / 599150703 / HY-135250B / / 2245697-88-3 / [null] / 409.870 / C19H24ClN3O5](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502484194.JPG-250.jpg)
eMolecules Medchem Express / Thalidomide-4-O-C6-NH2 (hydrochloride) / 5mg / 599150703 / HY-135250B / / 2245697-88-3 / [null] / 409.870 / C19H24ClN3O5
Medchem Express / Thalidomide-4-O-C6-NH2 (hydrochloride) / 5mg / 599150703 / HY-135250B / / 2245697-88-3 / [null] / 409.870 / C19H24ClN3O5
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | C25H36ClN5O9 | 10MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a thalidomide-based cereblon (CRBN) ligand-linker conjugate intended as a building block for PROTAC synthesis. The molecule combines a thalidomide-derived CRBN recruiting moiety with an amino-terminated PEG4-C2 spacer to enable straightforward coupling to target ligands. It is supplied as the hydrochloride salt for improved handling and is for research use only.
- High HPLC purity (98.0%).
- Amino-terminated PEG4-C2 linker for facile conjugation.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- Supplied as a solid hydrochloride salt, light yellow to yellow.
- Available in small-scale quantities suitable for medicinal chemistry.
- Store sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Fc epsilon RIA/FCER1 10ug
Recombinant human Fc epsilon RIA (FCER1A) is the extracellular alpha chain of the high-affinity IgE receptor supplied as a His-SUMO-tagged recombinant protein. The lyophilized protein is intended for use in binding studies, ELISA, and other immunological or biochemical assays requiring the human FCER1A ectodomain.
- His-SUMO tagged protein for affinity purification and detection.
- Expressed in E. coli and supplied lyophilized for enhanced stability.
- Purity >95% as determined by reducing SDS-PAGE.
- Formulated with trehalose and EDTA for increased storage stability.
- Suitable for ELISA and binding assays; functional activity characterized.
- Recommended reconstitution at or above 100 μg/mL for optimal performance.