Lactams
Medchemexpress LLC 2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione | 2222115-19-5 | >98.0% | 294.21 g/mol | C13H8F2N2O4 | 1 G
Thalidomide-4,5-F is a fluorinated analogue of thalidomide used as a cereblon (CRBN) E3 ligase ligand in research. It promotes ubiquitinylation of target proteins and can be derivatized via substitution at the fluorine positions. Supplied as a powder with high reported purity for use in chemical biology and medicinal chemistry studies.
- Fluorinated thalidomide analogue enabling derivatization via fluorine substitution
- Acts as a cereblon (CRBN) E3 ligase ligand for targeted protein ubiquitination
- Promotes ubiquitinylation of proteins in biochemical assays
- High reported purity (≥98.0%) suitable for research use
- Powder form compatible with synthetic and analytical workflows
- Molecular formula C13H8F2N2O4 and molecular weight 294.21 g/mol
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 50 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand.
- Features a 2-unit PEG linker.
- Utilized in PROTAC technology.
- Exploits intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Targets Cereblon.
- For research use only.
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 g/mol | C15H14ClN3O4 | 25 MG
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand (compound 18) used as a cereblon (CRBN) ligand in the synthesis of PROTAC degraders and other bifunctional molecules. It is supplied as an off-white to gray solid with high purity for research use.
- High purity: 98.0%.
- Molecular weight: 335.74 g/mol.
- Molecular formula: C15H14ClN3O4.
- CAS number: 2616553-35-4.
- Physical form: off-white to gray solid.
- Storage: store dry and keep cool; in solution store at -80°C (2 years) or -20°C (1 year).
- Applications: used as an E3 ligase ligand for PROTAC synthesis.
Chemscene ChemScene | 3-Amino-2,6-piperidinedione | 1G | CS-0020118 | 0.98 | 2353-44-8| MFCD11506223 | 128.13
ChemScene | 3-Amino-2,6-piperidinedione | 1G | CS-0020118 | 0.98 | 2353-44-8| MFCD11506223 | 128.13
Medchemexpress LLC (S)-thalidomide-4-oh | 2357105-36-1 | 98.0% | 274.23 g/mol | C13H10N2O5 | 50 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-derived cereblon ligand used in chemical biology and medicinal chemistry. Supplied as a solid research reagent, it is commonly used to recruit CRBN in PROTAC design and as a building block for medicinal chemistry.
- S-enantiomer of thalidomide-4-OH for stereospecific studies.
- Cereblon (CRBN) ligand for E3 ligase recruitment.
- Suitable building block for PROTAC synthesis and linker chemistry.
- Off-white to light yellow solid; typical pack size 50 mg.
- Reported purity 98.0% and molecular weight 274.23 g/mol.
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.9% | 394.85 | 100 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide-based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | 2245697-84-9 | MFCD31656717 | 98.3% | 542.97 | C23H31ClN4O9 | 50 MG
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) E3 ligase ligand provided as a hydrochloride salt for research use in PROTAC design and chemical biology. Supplied as a solid with defined molecular properties and high reported purity, it serves as a linker/ligand building block for medicinal chemistry and degradation probe synthesis.
- High purity (>98%).
- Solid, off-white to yellow appearance.
- Molecular formula C23H31ClN4O9; molecular weight 542.97.
- Suitable as a CRBN E3 ligase ligand in PROTAC and protein degradation studies.
- Available in milligram-scale quantities for laboratory research.
Medchemexpress LLC CD3 epsilon Rhesus 50ug | 50ug
CD3 epsilon Protein a vital component of the TCR-CD3 complex on T-lymphocytes is pivotal for adaptive immune responses CD3E is crucial for proper T-cell development and contributes to TCR-CD3 complex internalization and down-regulation[1] CD3 epsilon Protein Rhesus Macaque (HEK293 His) is the recombinant Rhesus Macaque-derived CD3 epsilon protein expressed by HEK293 with C-His labeled tag
eMolecules 17557-84-5 | 3-Azetidinone hydrochloride | Advanced ChemBlocks | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 5g | 135761745
3-Azetidinone hydrochloride | Advanced ChemBlocks | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 5g | 135761745
eMolecules 28562-53-0 | 4-Acetoxy-2-azetidinone | Ambeed | MFCD00010593 | 129.115 | C5H7NO3 | 97.000 | CC(=O)OC1CC(=O)N1 | 100g | 600833386
4-Acetoxy-2-azetidinone | Ambeed | 28562-53-0 | MFCD00010593 | 129.115 | C5H7NO3 | 97.000 | CC(=O)OC1CC(=O)N1 | 100g | 600833386
eMolecules 28562-53-0 | 4-Acetoxy-2-azetidinone | Synthonix | MFCD00010593 | 129.115 | C5H7NO3 | 95.000 | CC(=O)OC1CC(=O)N1 | 10g | 266700827
4-Acetoxy-2-azetidinone | Synthonix | 28562-53-0 | MFCD00010593 | 129.115 | C5H7NO3 | 95.000 | CC(=O)OC1CC(=O)N1 | 10g | 266700827