Lactams
Medchemexpress LLC 2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione | 2222115-19-5 | >98.0% | 294.21 g·mol⁻¹ | C13H8F2N2O4 | 50 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide that serves as a cereblon (CRBN) ligand for E3 ligase recruitment and targeted protein degradation research. It promotes ubiquitinylation of proteins and is suitable for derivatization at its fluorine positions, making it a useful building block in PROTAC and molecular glue chemistries.
- Promotes ubiquitinylation of proteins.
- Useful as a cereblon ligand for E3 ligase recruitment and PROTAC synthesis.
- Fluorine positions amenable to further derivatization.
- High purity (>98.0%).
- Chemical formula C13H8F2N2O4; molecular weight 294.21 g·mol⁻¹.
- Appearance: white to off-white solid; available in multiple sizes.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 500 MG
5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a fluorinated thalidomide analogue described as an E3 ligase activator for research use. Supplied as a powder, it can serve as a synthetic building block for further derivatization, particularly by nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue useful for E3 ligase activation studies.
- Suitable as a synthetic building block for derivatization via SNAr.
- Supplied as a powder suitable for laboratory handling and storage.
- High purity; commonly listed as >98.0%.
- Typical pack sizes: 100 mg-1 g.
Medchemexpress LLC Thalidomide-propargyne-PEG3-COOH | 2797649-54-6 | MFCD34473293 | 98.0% | 472.45 g/mol | C23H24N2O9 | 5 MG
Thalidomide-propargyne-PEG3-COOH is a thalidomide-based E3 ligase ligand-linker conjugate with a propargyl (alkynyl) handle and a PEG3 linker terminating in a carboxylic acid. Designed as a building block for PROTAC assembly and related chemical biology work, it is compatible with click chemistry and standard amide-coupling reactions. CAS 2797649-54-6; formula C23H24N2O9; MW 472.45; typical purity ~98%.
- Contains a propargyl (alkynyl) handle for CuAAC click chemistry.
- Includes a PEG3 linker terminating in a carboxylic acid for conjugation.
- Acts as a cereblon (CRBN) E3 ligase ligand for PROTAC design.
- Suitable for amide coupling and linker attachment.
- Supplied as a solid with high purity for research use.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 | C15H12N2O7 | 25 G
Thalidomide-O-COOH is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiter in PROTAC and chemical biology research. It is supplied as a solid research reagent with high purity and characterized molecular properties for use in biochemical and cellular assays.
- High purity: 99.85%.
- Molecular formula: C15H12N2O7.
- Molecular weight: 332.27 g/mol.
- Appearance: solid, white to off-white.
- Available package sizes include 25 G for bulk research use.
- Intended use: cereblon recruitment and PROTAC design in research applications.
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g·mol⁻¹ | C13H8F2N2O4 | 100 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide supplied for laboratory research. It promotes protein ubiquitinylation and serves as a cereblon-binding ligand; the fluorine substitutions allow further chemical derivatization. Intended for scientific research use only.
- Fluorinated thalidomide analogue enabling further derivatization.
- Promotes ubiquitinylation and binds cereblon for E3 ligase recruitment.
- High purity (98.0%) suitable for research applications.
- Available in multiple package sizes from 25 mg to 10 g.
- White to off-white solid, suitable for storage and handling.
- Recommended storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years).
Medchemexpress LLC Thalidomide-4-O-C14-NH2 hydrochloride | 99.9% | 522.08 | C27H40ClN3O5 | 10 MG
Thalidomide-4-O-C14-NH2 hydrochloride is a carbon-14 radiolabeled thalidomide derivative used as a cereblon (CRBN) ligand in research applications, including PROTAC assembly. The product is supplied as the hydrochloride salt with high purity and characterized molecular properties for use in biochemical and pharmacokinetic studies.
Apexbio Technology LLC Brucine 10mM (in 1mL DMSO)
N1490 is a small-molecule inhibitor designed for biomedical research It exerts its effects by selectively targeting and modulating specific intracellular signaling pathways implicated in disease progression N1490 has been explored in cellular assays for its ability to interfere with relevant molecular interactions resulting in altered downstream signaling events This compound serves as a valuable tool for investigating cellular mechanisms regulated by these pathways and may facilitate the discovery of novel therapeutic strategies in areas such as oncology immunology or metabolic research
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 25 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used in targeted protein degradation research and PROTAC synthesis. It is supplied as a high-purity solid and as a DMSO solution, with analytical data and safety documentation available.
- Thalidomide-based cereblon ligand for PROTAC development and E3 ligase recruitment studies.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- High purity (99.96%).
- Available as solid in 1 g, 5 g, 10 g, 25 g quantities.
- Solution option available as 10 mM in DMSO.
- Supplied with supporting documentation including COA, SDS, HNMR, RP-HPLC, and MS.
Medchemexpress LLC Thalidomide-5-O-C8-NH2 hydrochloride | 2636798-38-2 | >95.0% | 437.92 g/mol | C21H28ClN3O5 | 10 MG
Thalidomide-5-O-C8-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research applications. It is used as a recruiting moiety in PROTACs and other E3 ligase-targeting conjugates to facilitate targeted protein degradation and chemical biology studies. Supplied as a white to off-white solid in small laboratory pack sizes, it supports synthetic conjugation through an alkyl linker.
- Serves as a cereblon-recruiting ligand for targeted protein degradation
- Supplied as a hydrochloride salt for improved stability and handling
- Solid form suitable for storage and synthetic manipulation
- Provides an alkyl linker attachment point for PROTAC assembly
- Compatible with standard organic synthesis and conjugation workflows
- Intended for research use in chemical biology and drug discovery
