Lactams
Medchemexpress LLC 1H-isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 | C13H9IN2O4 | 500 MG
Thalidomide-iodo is an iodinated derivative of thalidomide used as an E3 ligase (cereblon) activator for research applications. It is intended as a building block and synthetic intermediate for further derivatization by substitution of the iodine atom.
- E3 ligase activator (cereblon ligand) for targeted protein degradation research.
- Suitable as a synthetic intermediate for iodide substitution and further derivatization.
- High purity: 98.0% (NMR).
- Molecular formula C13H9IN2O4; molecular weight 384.13.
- CAS number 2509137-01-1.
- Appearance: gray to dark gray solid.
- Storage: 4°C, protect from light; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 1 G
Thalidomide-O-COOH is a thalidomide-derived small-molecule ligand that recruits the CRBN E3 ubiquitin ligase and is commonly used as the E3 ligase component in PROTAC design and other chemical biology applications.
- Used as a cereblon (CRBN) E3 ligase ligand for PROTAC construction.
- CAS number 1061605-21-7; molecular formula C15H12N2O7; molecular weight 332.27 g·mol⁻¹.
- Reported high purity suitable for research and synthesis workflows.
- Functional handle (carboxylic acid) enables conjugation to linkers and building blocks.
- Supplied as a solid for storage and handling in synthetic and analytical protocols.
Medchemexpress LLC Thalidomide-o-amido-peg3-c2-nh2 (TFA) | 1957236-21-3 | MFCD31656717 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 50 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a Thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetate salt. It contains a three-unit polyethylene glycol (PEG3) linker and a terminal C2 primary amine for conjugation, and is intended as a building block for PROTAC synthesis and cereblon recruitment studies.
- Cereblon-binding thalidomide ligand with a three-unit PEG linker.
- Terminal primary amine (C2) for facile conjugation to targeting ligands.
- Provided as a trifluoroacetate (TFA) salt for handling stability.
- High purity confirmed by LCMS (~99.6%).
- Molecular weight 620.53 g/mol and CAS 1957236-21-3 for unambiguous identification.
![Medchemexpress LLC 11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanoic acid | 2379870-45-6 | MFCD03424822 | 99.1% | C24H30N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259722.png-250.jpg)
Medchemexpress LLC 11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanoic acid | 2379870-45-6 | MFCD03424822 | 99.1% | C24H30N2O7 | 10MG
Thalidomide-4-O-C10-COOH is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate provided for research use as a synthetic intermediate in the preparation of proteolysis-targeting chimeras (PROTACs). The molecule features a ten-carbon linker terminating in a carboxylic acid, and is supplied as a solid with formula C24H30N2O7 and molecular weight 458.50 g·mol⁻¹.
- Thalidomide-based cereblon (CRBN) ligand-linker conjugate.
- Suitable for PROTAC synthesis and E3 ligase recruitment studies.
- Contains a C10 linker with a terminal carboxylic acid for conjugation.
- High reported purity (99.1%).
- Supplied as a solid; molecular formula C24H30N2O7, molecular weight 458.50 g·mol⁻¹.
- For research use only; not for human therapeutic use.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 290.25 | C14H11FN2O4 | 250 MG
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative used as an E3 ubiquitin ligase activator in research. Supplied as a solid for laboratory use, it functions as a synthetic building block for further derivatization and for studies that probe E3 ligase-mediated pathways. Consult the product datasheet for lot-specific purity and analytical data.
- Fluorinated E3 ligase activator suitable for biochemical assays
- Reactive position enables SNAr derivatization for synthesis
- Supplied as a solid in multiple laboratory scales
- Molecular formula C14H11FN2O4; molecular weight 290.25
- Powder storage: -20°C (long term) or 4°C (short term)
- Data sheet and certificate of analysis available for purity and handling
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 250 MG
Thalidomide-4,5-F is a fluorinated thalidomide analogue used as a cereblon (CRBN) ligand and E3 ligase recruiter for chemical biology and PROTAC research. It promotes ubiquitinylation of target proteins and can be derivatized at fluorine positions. Supplied as a solid powder with high purity and recommended cold storage conditions.
- Fluorinated analogue designed for cereblon engagement.
- High purity suitable for research applications.
- Available in multiple milligram-scale pack sizes.
- Stable solid form with defined cold storage conditions.
- Modifiable at fluorine positions for derivatization.
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | C30H42N4O11 | 10MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate supplied as a solid for research use. The compound features a PEG3 linker and a Boc-protected terminal amine, offered with high reported purity and characterized molecular data, suitable as a synthetic intermediate in chemical biology and PROTAC development.
- High reported purity suitable for synthesis and analysis.
- Characterized molecular formula and molecular weight for experimental planning.
- Boc-protected terminal amine enables selective deprotection and conjugation.
- PEG3 linker provides flexibility and improved solubility in conjugates.
- Available in small milligram quantities for research workflows.
Medchemexpress LLC Thalidomide-5-NH-C-alkyne | 2357110-24-6 | MFCD34563706 | >98.0% | 311.29 g/mol | C16H13N3O4 | 100 MG
Thalidomide-5-NH-C-alkyne is an E3 ligase ligand-linker conjugate bearing a terminal alkyne for click-style conjugation, supplied for research use in small packs for assembling PROTACs and other bioconjugates.
- Contains a terminal alkyne for click conjugation.
- Functions as an E3 ligase ligand suitable for PROTAC assembly.
- Purity >98.0%.
- Molecular formula C16H13N3O4; molecular weight 311.29 g/mol.
- CAS number 2357110-24-6 for substance identification.
- Supplied as a 100 mg research pack.
- For research use only; not for human or animal therapeutic use.
Medchemexpress LLC Thalidomide-O-amido-PEG-C2-NH2 hydrochloride | 2204226-02-6 | 98.1% | 5MG
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride | 2204226-02-6 | 98.1% | 5MG
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.45% | 50 MG
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker. It can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709).
- Incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker.
- Used to design PROTAC CDK2/9 degrader-1.
- For research use only.
Medchemexpress LLC Thalidomide-O-amido-PEG4-azide | 2411681-89-3 | 99.2% | C25H32N6O10 | 50 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Functions as a PEG-based PROTAC linker
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Used in the synthesis of PROTACs
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | 2245697-84-9 | MFCD31656717 | 98.3% | 542.97 | C23H31ClN4O9 | 250 MG
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate used as an intermediate in the design and synthesis of PROTACs and targeted protein degraders. Supplied as the hydrochloride salt, it is provided as an off-white to yellow solid with high reported purity for research applications.
- High purity suitable for research and synthetic use.
- Hydrochloride salt form for improved handling and stability.
- Good solubility in DMSO and water; may require ultrasonic aid.
- Available in multiple package sizes, including 250 mg.
- Recommended storage at -20°C sealed, away from moisture.
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 5-[2-(2-chloroethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- | 2230956-57-5 | 96.6% | 380.78 | 25 MG
Thalidomide-5-PEG2-Cl is a thalidomide-based cereblon ligand that facilitates the recruitment of CRBN protein. It can be linked to a target protein ligand to create PROTACs, which are designed to harness the intracellular ubiquitin-proteasome system for selective protein degradation.
- Functions as a thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a protein ligand via a linker to form PROTACs
- PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-piperazine-PEG2-COOH | 2797430-20-5 | 99.8% | 502.52 | 25 MG
Thalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used as a linker in PROTAC technology
- Related to PROTACs, an emerging therapeutic modality in precision medicine
- Related to cereblon-based small-molecule compounds for controlling neural stem cell proliferation in regenerative medicine
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | 99.0% | 433.41 | 100 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate designed for PROTAC technology. It incorporates a Thalidomide-based cereblon ligand and is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilized in PROTAC technology
- High purity: 99.0%
- Molecular weight: 433.41
- Molecular formula: C20H23N3O8
- Appearance: Light green to green solid
- Recommended storage: -20°C, sealed, away from moisture and light
- For research use only