Lactams
Medchemexpress LLC Thalidomide-5-O-C10-NH2 hydrochloride | 99.4% | 465.97 g/mol | C23H32ClN3O5 | 10 MG
Thalidomide-5-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for chemical biology research. It is used to recruit the CRBN E3 ubiquitin ligase in PROTAC and conjugate applications to enable targeted protein ubiquitination and degradation. Molecular formula C23H32ClN3O5; molecular weight 465.97 g/mol.
- Used as a cereblon-binding ligand for PROTAC and conjugate design.
- Supplied as the hydrochloride salt for improved handling and stability.
- High purity suitable for research applications.
- Available in small research pack sizes for synthesis and screening.
- Provides a chemical handle designed for linker attachment to target ligands.
Medchemexpress LLC N-me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 | C14H11FN2O4 | 250 MG
N-Me-Thalidomide 4-fluoride is a thalidomide-based cereblon (E3 ligase) ligand used in PROTAC design and in the synthesis of related research compounds. Supplied as a characterized solid for research use, the compound is accompanied by analytical data and safety documentation to support laboratory workflows.
- High purity (99.4%) suitable for research applications.
- Molecular formula C14H11FN2O4 and molecular weight 290.25 Da.
- Available in multiple pack sizes from 250 mg to 10 g.
- Analytical documentation: COA, HNMR, and RP-HPLC provided.
- Safety documentation: SDS and handling instructions available.
- Designed for use as a cereblon ligand in PROTAC conjugation chemistry.
Medchemexpress LLC Thalidomide-4-o-c5-nh2 | 2307477-23-0 | 359.38 | 100 MG
Thalidomide-4-O-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not for sale to patients.
- Target: Cereblon
- Formula: C18H21N3O5
- For research use only
- Not for sale to patients
Apexbio Technology LLC THALIDOMIDE-4-OH-500MG
Thalidomide-4-OH (CAS No 5054-59-1) is a hydroxylated derivative of thalidomide studied primarily in the fields of pharmacology and oncology Originating from modifications of thalidomide this compound is designed to explore immunomodulatory and anti-inflammatory effects through various mechanisms such as inhibiting angiogenesis and modulating cytokine production It targets key pathways involving TNF-alpha and exhibits significant activity in the nanomolar to low micromolar range Thalidomide-4-OH is used in cell-based assays and animal studies to investigate therapeutic potentials and side effects often as part of drug screening programs Its application includes studying its efficacy in cancer cell models and exploring its potential benefits in autoimmune and chronic inflammatory diseases Experimental concentrations typically depend on the specific research design