Lactams
Medchemexpress LLC Thalidomide-O-C8-COOH | 2225148-51-4 | 97.4% | C22H26N2O7 | 10MG
Thalidomide-O-C8-COOH is a thalidomide-derived cereblon (CRBN) ligand supplied as a solid research reagent for use in PROTAC design and chemical biology studies. It has molecular formula C22H26N2O7, molecular weight 430.45 g/mol, and a reported purity of 97.44%.
- Used as a cereblon E3 ligase recruiting moiety in PROTAC synthesis.
- White to off-white solid suitable for laboratory handling.
- Reported purity of 97.4% for research applications.
- Storage guidance provided for long-term and in-solvent conditions.
- Available in small research quantities for assay development.
- For research use only; not for human or clinical use.
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 25 MG
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins and is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Related to cancer, cancer targeted therapy, cancer metabolism and metastasis
- Related to autophagy and apoptosis
Medchemexpress LLC Thalidomide-O-amido-C4-NH2 (TFA) | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g/mol | C21H23F3N4O8 | 1 G
Thalidomide-O-amido-C4-NH2 (TFA) is a thalidomide-derived cereblon ligand supplied as the trifluoroacetate salt and intended as a building block for E3 ligase ligand-linker conjugates and PROTAC research. The compound is provided as a solid research reagent with characterized purity, formula, and solubility data for in vitro and in vivo formulation.
- Intended for research use only.
- High purity 99.92%.
- Molecular weight 516.42 g/mol.
- Molecular formula C21H23F3N4O8.
- Soluble in DMSO (~42.86 mg/mL); multiple in vivo formulation protocols reported.
- Store dry at 4°C; in solvent store at -80°C for up to 6 months.
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | 485.92 g/mol | C21H28ClN3O8 | 5 MG
Thalidomide-5-PEG4-NH2 hydrochloride is a thalidomide-derived E3 ligase ligand-linker conjugate that combines a cereblon-binding thalidomide moiety with a four-unit PEG linker. It is intended as a research reagent for PROTAC design and targeted protein degradation studies and is supplied as a light yellow to yellow oil with reported high purity.
- Designed as an E3 ligase ligand-linker conjugate for PROTAC synthesis.
- Contains a cereblon-binding thalidomide moiety with a PEG4 linker for linker flexibility.
- High reported purity suitable for research applications (95.2%).
- Soluble in DMSO at 100 mg/mL; ultrasonic agitation recommended.
- Light yellow to yellow oil; easy to handle in synthetic workflows.
- Store sealed away from moisture; recommended storage at -20°C (in solvent: -80°C for long term).
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | C19H24ClN3O5 | 10MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in PROTAC research, notably as a component of the degrader dTAG-13 that directs FKBP12F36V and BET proteins for degradation. It is intended for laboratory research into E3 ligase recruitment, targeted protein degradation, apoptosis, and autophagy.
- High purity suitable for research (98.5%).
- Soluble in DMSO at 83.33 mg/mL (203.31 mM); ultrasonic assistance may be needed.
- Engages cereblon for E3 ligase-mediated protein degradation.
- Useful for PROTAC assembly and linker conjugation workflows.
- Available in small research quantities to support assay development.
- Recommended storage: 4°C sealed, away from moisture and light; in solvent, store at -80°C for long term.
Medchemexpress LLC Thalidomide-O-PEG4-amine hydrochloride | 2820929-03-9 | C23H32ClN3O9 | 250MG
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Designed for selective degradation of target proteins
Medchemexpress LLC Thalidomide-5-O-C2-NH2 hydrochloride | 2694727-89-2 | 99.6% | 353.76 | 5MG
Thalidomide-5-O-C2-NH2 hydrochloride is a cereblon ligand based on Thalidomide, designed for the recruitment of CRBN protein. This compound can be linked to a protein ligand via a linker to form PROTACs, which are relevant in cancer targeted therapy and metabolism research.
- Used for the recruitment of CRBN protein
- Can be connected to a protein ligand by a linker to form PROTACs
- Target is Cereblon
- Involved in E3 ligase ligand-linker conjugates, apoptosis, and autophagy research
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 10 MG
Thalidomide-O-COOH is a carboxylic acid-functionalized thalidomide derivative that serves as a cereblon (CRBN) ligand for targeted protein recruitment. It is used as an E3 ligase recruiter in PROTAC design and related chemical biology research.
- Carboxylic acid-functionalized thalidomide cereblon ligand.
- Used as an E3 ligase recruiter in PROTAC design and degrader development.
- Molecular formula C15H12N2O7, molecular weight 332.27 g·mol⁻¹.
- CAS number 1061605-21-7.
- For research use only; not for human or diagnostic applications.
Medchemexpress LLC Thalidomide-5-O-C8-NH2 hydrochloride | ≥98% | 437.92 | 5 MG
Thalidomide-5-O-C8-NH2 hydrochloride is a cereblon ligand derived from Thalidomide. It is utilized to recruit CRBN protein and can be linked to a target protein ligand via a linker to form PROTACs.
- It is a cereblon ligand.
- It is used in the recruitment of CRBN protein.
- It can be connected to a ligand for protein by a linker to form PROTACs.
- It is intended for research purposes only and not for sale to patients.
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | C30H42N4O11 | 50 MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide based cereblon ligand and a linker. This product can be used for the synthesis of PROTAC BET degrader.
- E3 ligase ligand-linker conjugate
- Thalidomide based cereblon ligand
- PROTAC BET degrader synthesis
- Inhibitor
Medchemexpress LLC Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | 2412056-27-8 | 95.0% | C15H13N3O6 | 25 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk) and functions as a ligand of E3 ligase. This PROTAC leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins, holding potential for researching various diseases, as extracted from patent WO2021170109A1. This product is for research use only.
- Potent and selective inhibitor of tropomyosin receptor kinase (trk)
- Functions as a ligand for E3 ligase
- PROTAC (proteolysis-targeting chimera) technology
- Utilizes the ubiquitin-proteasome system to degrade target proteins
- Potential for researching various diseases
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 276.22 g/mol | C13H9FN2O4 | 5 G
Thalidomide 5-fluoride is a 5-fluoro derivative of thalidomide that functions as a cereblon (CRBN) ligand for use in the design and synthesis of PROTACs and other E3 ligase-recruiting molecules.
- Used as a cereblon ligand in PROTAC and degrader synthesis.
- CAS number 835616-61-0.
- Molecular formula C13H9FN2O4.
- Molecular weight 276.22 g/mol.
- Packaged as a 5 g quantity.
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | C21H28ClN3O8 | 10MG
Thalidomide-5-PEG4-NH2 hydrochloride is a thalidomide-derived cereblon ligand conjugated to a PEG4 linker and supplied as the hydrochloride salt. It serves as an E3 ligase ligand-linker building block for PROTAC design and related chemical biology research.
- Incorporates thalidomide-based cereblon ligand for E3 ligase recruitment.
- PEG4 linker provides a flexible spacer for bifunctional molecule design.
- Hydrochloride salt form improves handling and solubility properties.
- Intended for use in proteolysis-targeting chimera (PROTAC) synthesis.
- Molecular weight 485.92 g/mol; chemical formula C21H28ClN3O8.
- Manufacturer-reported purity 95.2% suitable for research applications.
Medchemexpress LLC 5-((14-Aminotetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | 97.7% | 522.08 | 5 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a Thalidomide (HY-10984)-based cereblon ligand. It is utilized in the recruitment of CRBN protein and can be connected to a ligand for protein by a linker to form PROTACs. This compound is for research use only.
- Utilized in the recruitment of CRBN protein
- Can be connected to a ligand for protein by a linker
- Forms PROTACs