Lactams
Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 100 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand that recruits the CRBN protein. It can be linked to a target protein ligand via a linker to form PROTACs. PROTACs utilize the intracellular ubiquitin-proteasome system to specifically degrade target proteins. It is for research use only.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Can be linked via a linker to form PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Specifically degrades target proteins
- For research use only
Chemscene ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
Medchemexpress LLC Thalidomide-piperazine-PEG2-NH2 diTFA | 00-00-0 | 99.7% | C27H33F6N5O10 | 10MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-derived cereblon (CRBN) ligand and a PEG2-piperazine amino linker. Supplied as the bis(trifluoroacetate) salt, it is designed as a building block for assembling heterobifunctional degraders (PROTACs) to recruit CRBN and enable targeted protein degradation.
- Incorporates thalidomide-based cereblon ligand for CRBN recruitment.
- Contains a PEG2-piperazine linker with a terminal primary amine for conjugation chemistry.
- Supplied as the bis(trifluoroacetate) salt to aid handling and solubility.
- High purity suitable for synthesis (99.7%).
- Water solubility up to 50 mg/mL with ultrasonic assistance.
- Store sealed at 4°C, away from moisture.
Medchemexpress LLC Thalidomide-O-PEG4-Boc | 2411681-87-1 | C28H38N2O11 | 25MG
Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Incorporates thalidomide-based cereblon ligand.
- Utilizes a linker in PROTAC technology.
- Contains two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase, and the other is for the target protein.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in PROTAC technology.
Medchemexpress LLC Thalidomide-4-O-C14-NH2 hydrochloride | 99.85% | 522.08 | 25 MG
Thalidomide-4-O-C14-NH2 hydrochloride is a Thalidomide (HY-10984)-based cereblon ligand that is used in the recruitment of CRBN protein. It can be linked to a protein ligand to create PROTACs. It is for research use only.
- Functions as a ligand for E3 Ligase.
- Involved in the recruitment of CRBN protein.
- Can be connected via a linker to a protein ligand to form PROTACs.
- Intended for research use only.
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | >98.0% | 384.13 g/mol | C13H9IN2O4 | 1 G
Thalidomide-iodo is an iodinated thalidomide derivative that acts as an E3 ligase activator and ligand for cereblon, used in targeted protein degradation and PROTAC research. The iodine substituent enables further derivatization through cross-coupling or substitution, supporting synthesis of linker conjugates and chemical probes. Supplied as a high-purity research chemical.
Medchemexpress LLC Thalidomide-5-O-C13-NH2 hydrochloride | 99.9% | 508.05 g/mol | C26H38ClN3O5 | 10 MG
Thalidomide-5-O-C13-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation. It is intended for conjugation to target-binding ligands via linkers for PROTAC design and other bifunctional degrader constructs.
- High purity suitable for research assays (approximately 99.9%).
- Hydrochloride salt form for improved stability and handling.
- Compatible with linker conjugation for PROTAC synthesis.
- Recommended storage at -20°C; protect from light and oxygen.
- Supplied in small milligram quantities for exploratory studies.