Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

Search Within Results

6,526 – 6,540 of 178,220 results

6,526

Medchemexpress LLC Baliforsen (sodium) | 1687746-79-7 | 5616 (free acid) | 5 MG

Baliforsen (sodium) is a 16-nucleotide antisense oligonucleotide that binds myotonic dystrophy protein kinase (DMPK) mRNA for use in laboratory research into myotonic dystrophy. Supplied as the sodium salt, the compound is intended for research use only and is not validated for medical applications.

Targets DMPK mRNA to reduce transcript levels.
16-nucleotide length with modified 2'-O-(2-methoxyethyl) and phosphorothioate linkages.
Sodium salt form for improved handling and solubility.
Molecular weight approximately 5,616 (free acid).
Store at -20°C sealed; in solvent keep at -80°C up to 6 months or -20°C up to 1 month.

Pricing & Availability

6,527

Medchemexpress LLC JX06 | 729-46-4 | 99.78% | 324.51 | 1 ML

JX06 is a potent, selective, and covalent inhibitor of Pyruvate Dehydrogenase Kinase (PDK), inhibiting PDK1, PDK2, and PDK3 with varying IC50s. It functions by irreversibly binding to a cysteine residue in PDK1 and has demonstrated significant antitumor activity in both in vitro and in vivo studies.

Potent, selective, and covalent PDK inhibitor.
Inhibits PDK1, PDK2, and PDK3.
Induces cell apoptosis in various cancer cell lines.
Suppresses cancer cell growth.
Inhibits PDHA1 phosphorylation.
Increases glucose uptake and intracellular ATP.
Reduces aerobic glycolysis.
Induces ROS generation in cancer cells.
Demonstrates in vivo tumor growth inhibition.

Pricing & Availability

6,528

Medchemexpress LLC 15(R)-HETE | 83603-31-0 | 99.0% | 320.47 | 50 UG

15(R)-HETE is an isomer of 15-HETE, a lipid mediator derived from arachidonic acid.

Used for the study of asthma.

Pricing & Availability

6,529

Medchemexpress LLC N-{[4-(5,9-diethoxy-6-oxo-6,8-dihydro-7h-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)aceta | 915191-42-3 | MFCD17166964 | 99.3% | 603.69 g/mol | C32H33N3O7S | 5 MG

MF498 is a selective, orally active E prostanoid receptor 4 (EP4) antagonist used in research on inflammation and prostaglandin-mediated signaling. It is supplied as a solid for in vitro and in vivo studies and includes solubility and storage guidance.

Selective and orally active EP4 antagonist.
High purity (99.3%).
Molecular weight 603.69 g/mol; formula C32H33N3O7S.
Soluble in DMSO at ≥ 31 mg/mL for in vitro use.
Provides example in vivo formulation protocols for dosing.
Stable as powder when stored at -20°C for long-term storage.

Pricing & Availability

6,530

Medchemexpress LLC Sobetirome (GC-1) | 211110-63-3 | 99.85% and 99.91% | 328.40 | 100 MG

Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist. It selectively binds to TRβ-1 with an EC50 of 0.16 μM and is also a liver uptake-selective agonist. This product is intended for research use only.

Thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist.
Reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid mice.
Reduces HDL cholesterol and triglyceride levels in hypercholesterolemic mice.
Increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice.
Treatment with 10x Sobetirome results in a fat mass gain of only 21% (1.7 g).
Treatment with 20x Sobetirome induces a decrease in fat mass of 20% (1.3 g).

Pricing & Availability

6,531

Apexbio Technology LLC [Pyr1]-Apelin-13 217082-60-5 1mg

[Pyr1]-Apelin-13 (CAS 217082-60-5) is a potent and selective endogenous agonist of the Apelin receptor (APJ) By binding to APJ it activates downstream signaling pathways involved in the regulation of vascular tone and myocardial contractility In vitro studies demonstrate that [Pyr1]-Apelin-13 modulates biological processes pertinent to cardiovascular function This compound is widely utilized in research exploring the molecular mechanisms underlying cardiovascular diseases and is being investigated for its potential therapeutic relevance in this context

Pricing & Availability

6,532

LifeSensors UBE2T 3nmol

UBE2T can mediate the transfer of ubiquitin from ubiquitin-activating enzyme E1 to a substrate protein or E3 ligase. This E2 enzyme has been shown to be essential for the Fanconi anemia pathway. UBE2T conjugating activity is involved with the monoubiquitylation of FANCD2, co-functioning with the E3 ligase FANCL.

Pricing & Availability

6,533

Medchemexpress LLC Levonadifloxacin | 154357-42-3 | 99.8% | 360.38 | 25 MG

Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent that demonstrates antibacterial activity against Methicillin-susceptible *Staphylococcus aureus* (MSSA) and Methicillin-resistant *S. aureus* (MRSA) strains, reducing those phagocytized in THP-1 monocytes. It also shows efficacy against *Staphylococcus aureus* in a Neutropenic Murine Lung Infection Model.

Broad-spectrum anti-staphylococcal agent
Active against MSSA and MRSA strains
Reduces phagocytized bacteria in THP-1 monocytes
Efficacious in Neutropenic Murine Lung Infection Model

Pricing & Availability

6,534

Medchemexpress LLC (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one | 2049868-46-2 | 99.1% | 230.31 g/mol | C14H18N2O | 1 ML

GSK963 is a chiral, highly potent, and selective small-molecule inhibitor of RIP1 (RIPK1) kinase with an IC50 of 29 nM; it is used to block necroptosis in murine and human cells in vitro.

Potent RIP1 kinase inhibitor (IC50 29 nM).
Chiral small molecule with high selectivity for RIP1.
Provided as a 10 mM solution in DMSO, 1 mL, for in vitro use.
High purity (~99.1% by HPLC).
Molecular weight 230.31 g/mol; chemical formula C14H18N2O.
Suitable for cellular and biochemical studies of necroptosis and RIP1 signaling.

Pricing & Availability

6,535

Medchemexpress LLC i-Inositol (Standard) | 87-89-8 | 99.9% | 25 MG

i-Inositol (Standard) is the analytical standard of i-Inositol and is intended for research and analytical applications. i-Inositol (myo-Inositol) is a compound of sugar alcohols involved in various biological processes, including insulin signal transduction and cytoskeletal transduction. It primarily exists in glial cells and plays an osmotic role.

Analytical standard for i-Inositol.
Intended for research and analytical applications.
Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.

Pricing & Availability

6,536

Medchemexpress LLC 2-Chloro-4-iodopyridine | 153034-86-7 | 100.0% | 239.44 | 25 G

2-Chloro-4-iodopyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Appearance: Solid
Color: White to off-white
Shipping: Room temperature in continental US; may vary elsewhere.
Storage: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light).

Pricing & Availability

6,537

Apexbio Technology LLC GS-7340 379270-37-8 10mM (in 1mL DMSO)

GS-7340 (379270-37-8) is a small-molecule inhibitor targeting HIV reverse transcriptase It is designed to inhibit this enzyme thereby interfering with viral genome replication by causing chain termination during DNA synthesis GS-7340 exerts its biological activity primarily as a phosphonamidate prodrug of tenofovir undergoing intracellular hydrolysis to produce active tenofovir diphosphate In in vitro studies GS-7340 demonstrates inhibitory activity against HIV replication with reported IC50 values ranging between 5 and 11 nM Based on these pharmacological properties GS-7340 holds research potential in antiretroviral studies and evaluations of drug metabolism pharmacokinetics and efficacy in lymphoid environments

Pricing & Availability

6,538

Medchemexpress LLC (3α,5β,6β,7β)-6-ethyl-cholane-3,7,24-triol | 1632118-69-4 | MFCD30738007 | 695.0% | 406.64 g·mol⁻1 | C26H46O3 | 1 ML

BAR501 is a synthetic small-molecule agonist of the G protein-coupled bile acid receptor GPBAR1 (TGR5). It selectively activates GPBAR1 with an EC50 of about 1 μM in HEK293 CRE-luciferase transactivation assays and is supplied for research applications in solution or solid form.

Provides selective GPBAR1 agonism with an EC50 ≈ 1 μM.
Transactivates GPBAR1 in HEK293 cells as measured by CRE-driven luciferase reporter assays.
Available as a 10 mM solution in DMSO (1 mL) or as solid vials for reconstitution.
Molecular formula C26H46O3 and molecular weight ~406.64 g·mol⁻1.
High purity suitable for biological assays (reported ≥95%).
Intended for research use only; not for human or veterinary applications.

Pricing & Availability

6,539

Apexbio Technology LLC UC2288 1394011-91-6 5mg

UC2288 (CAS 1394011-91-6) is a cell-permeable orally bioavailable small molecule structurally derived from sorafenib It selectively downregulates p21 expression at the mRNA level independent of p53 status resulting in reduced p21 protein levels with minimal impact on protein stability UC2288 does not inhibit VEGFR2 or kinase activity even at concentrations up to 10 M This compound is utilized in biomedical research to investigate the cellular functions of p21 and its regulatory pathways and to explore potential therapeutic strategies targeting p21-associated mechanisms

Pricing & Availability

6,540

Medchemexpress LLC Imetit dihydrobromide | 32385-58-3 | MFCD00153816 | ≥98.0% | 332.06 g/mol | C6H12Br2N4S | 5 MG

Imetit dihydrobromide is a potent, high-affinity histamine receptor agonist used in receptor pharmacology and cellular assays. It mimics histamine in functional assays and is supplied as a solid for in vitro research.

Potent H3 and H4 receptor agonist with Ki ≈ 0.3 nM (H3) and 2.7 nM (H4).
Demonstrated cellular activity (eosinophil shape change EC50 ≈ 25 nM).
High purity suitable for pharmacological studies (≥98% HPLC).
Molecular weight 332.06 g/mol and CAS 32385-58-3.
Available in small pack sizes for research use (1 mg, 5 mg, 10 mg).

Pricing & Availability

Pyridines and derivatives

Filtered Search Results

Narrow Results

Medchemexpress LLC Baliforsen (sodium) | 1687746-79-7 | 5616 (free acid) | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC JX06 | 729-46-4 | 99.78% | 324.51 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 15(R)-HETE | 83603-31-0 | 99.0% | 320.47 | 50 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sobetirome (GC-1) | 211110-63-3 | 99.85% and 99.91% | 328.40 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC [Pyr1]-Apelin-13 217082-60-5 1mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

LifeSensors UBE2T 3nmol Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Levonadifloxacin | 154357-42-3 | 99.8% | 360.38 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one | 2049868-46-2 | 99.1% | 230.31 g/mol | C14H18N2O | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC i-Inositol (Standard) | 87-89-8 | 99.9% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2-Chloro-4-iodopyridine | 153034-86-7 | 100.0% | 239.44 | 25 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC GS-7340 379270-37-8 10mM (in 1mL DMSO) Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (3α,5β,6β,7β)-6-ethyl-cholane-3,7,24-triol | 1632118-69-4 | MFCD30738007 | 695.0% | 406.64 g·mol⁻1 | C26H46O3 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC UC2288 1394011-91-6 5mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Imetit dihydrobromide | 32385-58-3 | MFCD00153816 | ≥98.0% | 332.06 g/mol | C6H12Br2N4S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More