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Filtered Search Results
Apexbio Technology LLC SAR245409 (XL765) 1349796-36-6 100mg
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SAR245409 (XL765 CAS 1349796-36-6) is a selective dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with high potency against PI3K (IC50 9 nM) It suppresses the PI3K/Akt/mTOR signaling cascade by preventing formation of phosphatidylinositol-3 4 5-triphosphate (PIP3) at the cell membrane and downstream phosphorylation of AKT p70S6 kinase and S6 SAR245409 demonstrates antitumor activity in cancer models exhibiting genetic alterations in PI3K pathways enhancing growth suppression and apoptosis It is commonly employed in preclinical studies evaluating PI3K/mTOR-targeted approaches in cancer therapy
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Medchemexpress LLC Ethyl 4-(3-(4-(1H-pyrazol-1-yl)benzyl)ureido)benzoate | 1005883-72-6 | MFCD04280228 | 98.1% | 364.40 g/mol | C20H20N4O3 | 10MM 1ML
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Z433927330 is a small-molecule inhibitor selective for aquaporin-7 (AQP7), with reduced activity against AQP3 and AQP9. It is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) for in vitro research. Key chemical attributes include molecular formula C20H20N4O3, molecular weight 364.40 g/mol, and reported purity of about 98.1%. Reported IC50 values show strong activity against mAQP7 and lower potency for mAQP3 and mAQP9.
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Medchemexpress LLC Gsk137647a | 349085-82-1 | 99.8% | 305.39 | 25 MG
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GSK137647A is a potent and selective free fatty acid receptor 4 (FFA4) agonist. It exhibits high selectivity for human, mouse, and rat FFA4 with pEC50 values of 6.3, 6.2, and 6.1, respectively, and significantly lower activity on FFA1, FFA2, and FFA3. This compound demonstrates anti-inflammatory activity, promotes insulin secretion, and inhibits epithelial ion transport, linking it to the regulation of glucose homeostasis and anti-inflammatory responses.
- Reduces the production of nitric oxide in macrophages without affecting cell viability.
- Alleviates the response to inflammatory stimuli in Caco-2 cells and induces the secretion of IL-6.
- Reduces ion flow and affects colonic epithelial ion transport in healthy cells.
- Increases glucose-stimulated insulin secretion.
- Alleviates colitis in treated mice.
- Restores intestinal permeability in studies.
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Medchemexpress LLC Tesirine intermediate-2 | 1430738-34-3 | 99.4% | 793.98 | 50 MG
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Tesirine intermediate-2 is an intermediate of Tesirine. Tesirine is a pyrrole benzodiazepine (PBD) dimer, which acts as a DNA small channel crosslinker with potent cytotoxicity. It is utilized in the synthesis of Antibody-Drug Conjugates (ADCs), where its warhead component is known for its strong anticancer cell activity. The product appears as a white to off-white solid. It is recommended for research use only and not intended for human use.
- Intermediate of Tesirine
- Utilized in the synthesis of antibody-drug conjugates (ADCs)
- Acts as a DNA small channel crosslinker
- Potent cytotoxicity
- Warhead component is known for strong anticancer cell activity
- Appears as a white to off-white solid
- Recommended for research use only
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Medchemexpress LLC Meptyldinocap | 131-72-6 | 99.9% | 364.39 | 1 ML
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Meptyldinocap (2,4-DNOPC) is a novel fungicide effective against powdery mildew (Erysiphe necator). It exhibits both protectant and post-infective activities and is intended for research use only.
- High purity of 99.91%.
- Effective against powdery mildew (Erysiphe necator).
- Exhibits protectant and post-infective activities.
- Soluble in DMSO (≥ 150 mg/mL) and ethanol (100 mg/mL).
- Stable for extended periods when stored properly: 3 years at -20°C in pure form.
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Medchemexpress LLC Lin28-let-7 antagonist 1 | 108825-65-6 | 99.4% | 281.32 | 10 MG
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Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of the Lin28/pre-let-7 interaction. It specifically inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. This compound has been shown to inhibit proliferation in human cancer cells. It is intended for research use only and not for sale to patients.
- Potent antagonist of Lin28/pre-let-7 interaction.
- Inhibits Lin28A binding to pre-let-7a-2 with an IC50 of 8 μM.
- Inhibits proliferation in human cancer cells.
- High purity: 99.43%.
- Available in various quantities.
- Ships at room temperature in continental US.
- Storage recommendations: powder at -20°C for 3 years or 4°C for 2 years; in solvent at -80°C for 6 months or -20°C for 1 month.
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Medchemexpress LLC (-)-talarozole | 201410-67-5 | MFCD17166995 | 98.1% | 377.51 g/mol | C21H23N5S | 10 MG
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(-)-Talarozole is a research-grade small molecule inhibitor of retinoic acid metabolism (RAMBA) used to modulate retinoic acid signaling in biochemical and cellular studies. The compound is the (-)-enantiomer with molecular formula C21H23N5S and molecular weight 377.51 g/mol, and is supplied at high purity for reproducible experimental dosing.
- Potent inhibitor of retinoic acid metabolism
- Modulates RAR/RXR signaling and autophagy-related pathways
- Suitable for in vitro biochemical and cell-based studies
- Defined molecular formula and molecular weight for accurate dosing
- High purity appropriate for analytical and assay use
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Medchemexpress LLC Tead-in-8 | 1008768-41-9 | 99.8% | 435.56 | C26H33N3O3 | 10 MG
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TEAD-IN-8 is a small-molecule TEAD inhibitor that potently inhibits TEAD-YAP transcriptional activity and shows antiproliferative effects in YAP-dependent cancer cell models.
- Novel TEAD inhibitor mechanism targeting TEAD-YAP transcriptional activity.
- Demonstrates antiproliferative effects in YAP-dependent cancer cells.
- High purity (99.8%) suitable for research applications.
- Molecular weight 435.56 g/mol; formula C26H33N3O3.
- Available in multiple pack sizes, including 10 MG.
- Storage: powder -20°C (stable for years) and 4°C (short-term); in solvent -80°C or -20°C per guidance.
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Medchemexpress LLC Philanthotoxin 74 dihydrochloride | 1227301-51-0 | 99.7% | 507.54 g·mol⁻¹ | C24H44Cl2N4O3 | 10 MG
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Philanthotoxin 74 dihydrochloride is a research-use AMPA receptor antagonist that inhibits GluR3 and GluR1 with reported IC50s of 263 nM and 296 nM. It is supplied in solid and solution formats for in vitro pharmacology and electrophysiology studies, with documented purity, solubility, and handling information.
- Research-use reagent; not for human or clinical use.
- Subtype-selective AMPAR antagonist; inhibits GluR3 (IC50 = 263 nM) and GluR1 (IC50 = 296 nM).
- Purity 99.72%.
- Molecular weight 507.54 g·mol⁻¹.
- CAS number 1227301-51-0.
- Soluble in DMSO (100 mg/mL) and water (50 mg/mL).
- Storage at 4°C, sealed, away from moisture.
- Available in solid and solution pack sizes including 1 mg, 5 mg, and 10 mg.
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Medchemexpress LLC γ-Neuropeptide (rabbit) | 114882-65-4 | 99.99% | 2320.59 | 10 MG
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γ-Neuropeptide (rabbit) is an endogenous neurokinin peptide isolated from rabbit intestine. It acts as a neurokinin 2 (NK2) receptor agonist and is involved in mediating the hypothalamic-pituitary-adrenal (HPA) axis and reproductive hormone release. This product is for research use only.
- Acts as a neurokinin 2 (NK2) receptor agonist
- Mediates the hypothalamic-pituitary-adrenal (HPA) axis
- Involved in reproductive hormone release
- Induces stimulation of LH release by hemipituitaries
- For research use only
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![Medchemexpress LLC N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide | 1005342-46-0 | MFCD23160049 | >99.0% | 500.6 g/mol | C26H33FN4O3S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000285871.png-250.jpg)
Medchemexpress LLC N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide | 1005342-46-0 | MFCD23160049 | >99.0% | 500.6 g/mol | C26H33FN4O3S | 10 MG
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LCL161 is a small-molecule SMAC mimetic that antagonizes inhibitor-of-apoptosis proteins (IAPs). It is used in preclinical research to promote apoptosis and to sensitize cancer cells to cytotoxic therapies, showing potent activity at nanomolar concentrations.
- Potent IAP antagonist with nanomolar activity
- Inhibits XIAP in HEK293 cells (IC50 35 nM)
- Inhibits cIAP1 in MDA-MB-231 cells (IC50 0.4 nM)
- Acts as a SMAC mimetic to promote caspase activation
- Used to study apoptosis, cell death pathways, and combination therapy effects
- Molecular formula C26H33FN4O3S
- Molecular weight 500.6 g/mol
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BIOHIPPO Research Grade Tarperprumig Biosimilar Antibody, 100 µg
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Tarperprumig is a research-grade biosimilar antibody. It reacts with Human. Suitable for ELISA, FACS, Functional assay, Research in vivo. This research-grade biosimilar supports comparability, functional, PK/PD and immunogenicity studies. Supplied as 100 ug.
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BIOHIPPO Research Grade Anti-Human CD200R1/OX2R Biosimilar Antibody (I-4P), 100 µg
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CD200R1/OX2R is a research-grade biosimilar antibody. It reacts with Human. Suitable for ELISA, FACS, Functional assay, Research in vivo. This research-grade biosimilar supports comparability, functional, PK/PD and immunogenicity studies. Supplied as 100 ug.
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![Medchemexpress LLC [Des-Pro2]-Bradykinin | 80943-05-1 | 99.68% | 963.09 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000399903.png-250.jpg)
Medchemexpress LLC [Des-Pro2]-Bradykinin | 80943-05-1 | 99.68% | 963.09 | 10 MG
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[Des-Pro2]-Bradykinin is a protease inhibitor that prevents the degradation of methionine enkephalin.
- Protease inhibitor
- Prevents the degradation of methionine enkephalin
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Medchemexpress LLC 2267290-96-8 | 99.9% | 626.66 | 10 MG
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QC-01-175 is a heterobifunctional molecule engineered to degrade aberrant tau. It effectively reduces the presence of A152T and P301L mutant tau protein, thereby protecting neurons from tau-mediated toxicity and enhancing cell survival. This compound is constructed from a ligand designed for aberrant tau, an NH2-PEG3 linker, and a ligand for E3 ligase Pomalidomide.
- Degrades aberrant tau protein
- Reduces A152T and P301L mutant tau protein levels
- Offers neuroprotection against tau-mediated toxicity
- Enhances cell survival
- High purity (99.94%)
- Solid, light yellow to green yellow appearance
- Demonstrated in vitro activity in reducing pTau-S396 levels
- Alleviates mitochondrial fragmentation and oxidative stress in SH-SY5Y cells
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