Pyridines and derivatives
Medchemexpress LLC Micafungin sodium (FK 463 sodium) | 208538-73-2 | 98.9% | 1292.26 | 100 MG
Micafungin sodium (FK 463 sodium) is an antifungal agent that works by inhibiting 1,3-beta-D-glucan synthesis. It is intended for research use only.
- Inhibits 1,3-beta-D-glucan synthesis
- Has a purity of 98.91%
- CAS number is 208538-73-2
- Molecular weight is 1292.26
- Formula is C56H70N9NaO23S
- Appearance is solid
- Color is white to off-white
Medchemexpress LLC Norvancomycin monohydrochloride | 213997-73-0 | 100 MG
Norvancomycin monohydrochloride | 213997-73-0 | 100 MG
Medchemexpress LLC Chlorfenapyr | 122453-73-0 | 99.4% | 50 MG
Chlorfenapyr is a pyrrole insecticide that functions as a pro-insecticide. Its active metabolite, CL 303268, is formed when mixed function oxidase oxidizes and removes the N-ethoxymethyl group. This active form uncouples oxidative phosphorylation in mitochondria, disrupting ATP production and leading to cell dysfunction and death of the organism. Chlorfenapyr is utilized for termite control and crop protection against various insect and mite pests. It has low mammalian toxicity.
- Pyrrole insecticide.
- Mode of action involves oxidation by mixed function oxidase to form active metabolite CL 303268.
- CL 303268 uncouples oxidative phosphorylation, leading to disruption of ATP production and energy loss.
- Used for termite control and crop protection against insect and mite pests.
- Low mammalian toxicity.
Medchemexpress LLC Chlorfenapyr | 122453-73-0 | 99.4% | 1 ML
Chlorfenapyr is a pyrrole insecticide that acts as a pro-insecticide. Its active metabolite, CL 303268, uncouples oxidative phosphorylation in mitochondria, disrupting ATP production. This leads to cell dysfunction and organism death. Chlorfenapyr is utilized for termite control and crop protection against various insect and mite pests.
- Functions as a pro-insecticide
- Active metabolite uncouples oxidative phosphorylation in mitochondria
- Disrupts ATP production
- Leads to cell dysfunction and organism death
- Exhibits low mammalian toxicity
- Used for termite control
- Used for crop protection against various insect and mite pests
- For research use only
Medchemexpress LLC LY3509754 | 2452464-73-0 | 99.4% | 586.51 | 100 MG
LY3509754, also known as IL-17A inhibitor 1, is a potent IL-17A inhibitor with demonstrated IC50 values of less than 9.45 nM in alphalisa assay and 9.3 nM in HT-29 cells. It exhibits high oral bioavailability (F=107%), making it a promising candidate for research.
- Potent IL-17A inhibitor
- High oral bioavailability (F=107%)
- Effective in alphalisa assay and HT-29 cells
- Supplied as 100 MG
Medchemexpress LLC Rasarfin | 674359-73-0 | 99.6% | 425.91 | 1 ML
Rasarfin is a dual Ras and ARF6 inhibitor. It potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR, preventing cancer cell proliferation. It blocks GPCR internalization by inhibiting ARF6 and leads to a dose-dependent reduction in MDA-MB-231 cells. Rasarfin inhibits the recruitment of the clathrin adaptor AP-2 to β-arrestin2 and receptor internalization. This product is for research use only.
- Inhibits agonist-induced ERK1/2 signaling by GPCRs
- Inhibits MAPK and Akt signaling by EGFR
- Prevents cancer cell proliferation
- Blocks GPCR internalization through inhibition of ARF6
- Reduces MDA-MB-231 cells in a dose-dependent manner
- Inhibits recruitment of clathrin adaptor AP-2 to β-arrestin2 and receptor internalization
Medchemexpress LLC Chlorfenapyr | 122453-73-0 | 99.4% | 407.61 | 100 MG
Chlorfenapyr is a pyrrole insecticide that acts as a pro-insecticide. It is metabolized into an active form, CL 303268, which uncouples oxidative phosphorylation in mitochondria, leading to cell dysfunction and death in target organisms, while exhibiting low mammalian toxicity.
- Functions as a pro-insecticide
- Active metabolite uncouples oxidative phosphorylation
- Disrupts ATP production in target organisms
- Low mammalian toxicity
- Effective against mites
- Used for termite control
- Protects crops against various insect and mite pests
Medchemexpress LLC Ensitrelvir | 2647530-73-0 | >99.6% | C22H17ClF3N9O2 | 1 ML
Ensitrelvir (S-217622) is the first orally active non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor. It is intended for research use only.
- Orally active non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor.
- Inhibits intrapulmonary replication of SARS-CoV-2 in mice.
- Shows antiviral activity against SARS-CoV-2 in Vero E6 cells.
Medchemexpress LLC Norvancomycin monohydrochloride | 213997-73-0 | 95.3% | 50 MG
Norvancomycin monohydrochloride | 213997-73-0 | 95.3% | 50 MG
Medchemexpress LLC Norvancomycin monohydrochloride | 213997-73-0 | 95.3% | 25 MG
Norvancomycin hydrochloride is a cell wall synthesis inhibitor that targets peptidoglycan precursors of Gram-positive bacteria and does not cross the blood-brain barrier. It competitively binds to peptidoglycan precursors, irreversibly inhibiting bacterial cell wall synthesis and exhibiting antibacterial activity. It is primarily used in the study of Gram-positive bacterial infections, particularly those caused by methicillin-resistant *Staphylococcus aureus* (MRSA) and methicillin-resistant *Staphylococcus epidermidis* (MRSE).
- Inhibits cell wall synthesis
- Targets peptidoglycan precursors of gram-positive bacteria
- Does not cross the blood-brain barrier
- Used in the study of gram-positive bacterial infections
- Can be integrated into bionic calcium phosphate coatings on titanium implants
Medchemexpress LLC Rasarfin | 674359-73-0 | 99.6% | 425.91 | 1 MG
Rasarfin is a dual Ras and ARF6 inhibitor for research use only. It potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR. This compound prevents cancer cell proliferation and blocks GPCR internalization through inhibition of ARF6. Treatment with Rasarfin results in a dose-dependent reduction in MDA-MB-231 cells.
Medchemexpress LLC Ensitrelvir | 2647530-73-0 | 99.6% | C22H17ClF3N9O2 | 25 MG
Ensitrelvir (S-217622) is the first orally active non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor (IC50=13 nM). It is for research use only.
- Orally active non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor.
- Inhibits intrapulmonary replication of SARS-CoV-2 in mice dose-dependently.
- Shows EC50 values of approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 in a cytopathic effect (cpe)-inhibition assay in VeroE6/TMPRSS2 cells.
- EC50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM, respectively.
Medchemexpress LLC Chlorfenapyr (Standard) | 122453-73-0 | 99.6% | 25 MG
Chlorfenapyr (Standard) is an analytical standard and pyrrole insecticide. It is intended for research and analytical applications, functioning by oxidation to form the active metabolite, CL 303268. This product is utilized for termite control and crop protection against various insect and mite pests. It is commonly used in qualitative, quantitative, and methodological research experiments.
- Analytical standard for research and analytical applications
- Functions as a pyrrole insecticide
- Oxidizes to form active metabolite, CL 303268
- Used for termite control and crop protection
- Utilized in HPLC, GC, and MS experiments
Apexbio Technology LLC Cordycepin 73-03-0 10mM (in 1mL DMSO)
Cordycepin (73-03-0) is a small-molecule inhibitor targeting pro-inflammatory cytokines such as IL-1 IL-6 and TNF- It is designed to inhibit inflammatory signaling pathways thereby regulating immune and inflammatory responses Cordycepin exerts its biological activity primarily through interference with RNA synthesis by incorporation into RNA chains leading to premature termination and inhibition of protein translation In cell-based studies cordycepin demonstrates inhibitory activity with IC50 values in the low micromolar range (approximately 5-15 M) depending on experimental conditions and cell models Based on these pharmacological properties cordycepin holds research potential in inflammation regulation immune-response modulation tuberculosis infection modeling and RNA transcription studies
Medchemexpress LLC N1-Methylinosine | 2140-73-0 | 99.7% | 282.25 | 1 ML
1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA. It is a metabolite that can be derived from inosine, and its levels are notably higher in urine samples from breast cancer models. It is available as a solution in DMSO.
- Target: Nucleoside antimetabolite/analog; endogenous metabolite
- Pathway: Cell cycle/DNA damage; metabolic enzyme/protease
- Appearance: White to off-white solid
- Solubility in DMSO: 83.33 mg/mL (295.23 mM)
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 2 years, -20°C for 1 year