Pyridines and derivatives
Medchemexpress LLC Sophoranone | 23057-55-8 | 5 MG
Sophoranone is a flavonoid compound that can be isolated from the root of *Sophora subprostrata*. It exhibits anti-inflammatory activity in mouse RAW264.7 cells by inhibiting LPS-induced NO production.
- Flavonoid compound
- Isolated from the root of Sophora subprostrata
- Exhibits anti-inflammatory activity
- Molecular weight: 460.60
- Formula: C30H36O4
- Appearance: White to off-white solid
- Purity: 99.67%
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC ZB-R-55 | 2416593-55-8 | 99.4% | 441.48 | 1 MG
ZB-R-55 is an orally active RIPK1 inhibitor that can be used for sepsis study. It demonstrates anti-necroptotic activity in human U-937 cells, inhibiting LPS/Z-VAD-fmk induced necroptosis with an IC50 of 0.34 nM.
- Orally active RIPK1 inhibitor.
- Applicable for sepsis studies.
- Exhibits anti-necroptotic activity.
Apexbio Technology LLC Quinapril HCl 82586-55-8 50mg
Quinapril hydrochloride (CAS 82586-55-8) is an esterified precursor that undergoes hepatic conversion to quinaprilat an active inhibitor of angiotensin-converting enzyme (ACE) By impeding the conversion of angiotensin I to angiotensin II quinapril modulates the renin-angiotensin-aldosterone system resulting in decreased vasoconstriction and reduced aldosterone secretion This molecule is frequently utilized in cardiovascular research to investigate mechanisms underlying hypertension heart failure and the biological effects of ACE inhibition on vascular and renal systems
Apexbio Technology LLC Levothyroxine sodium 55-03-8 100mg
Levothyroxine sodium (55-03-8) is a synthetic thyroid hormone analogue It is designed to restore or modulate thyroid hormone levels thereby regulating metabolic and developmental processes Levothyroxine sodium exerts its biological activity primarily through enzymatic conversion to the active form triiodothyronine (T3) by deiodinases after which T3 interacts with nuclear thyroid hormone receptors to modulate gene expression and cellular metabolism Based on these pharmacological properties levothyroxine sodium holds research potential in studies of thyroid dysfunction particularly hypothyroidism and in investigations of thyroid-regulated physiological responses and endocrine interactions
Medchemexpress LLC Atropine | 51-55-8 | 99.85% | 500 MG
Atropine is a competitive antagonist of muscarinic acetylcholine receptors (mAChR), demonstrating IC50 values of 0.39 and 0.71 nM for human mAChR M4 and chicken mAChR M4, respectively. It works by inhibiting acetylcholine-induced relaxations in human pulmonary veins.
- Acts as a competitive muscarinic acetylcholine receptor antagonist.
- Inhibits acetylcholine-induced relaxations in human pulmonary veins.
- Can be used for research related to anti-myopia.
- Can be used for research related to bradycardia.
Medchemexpress LLC Atropine | 51-55-8 | 99.9% | 1 ML
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist. It inhibits ACh-induced relaxations in human pulmonary veins and can be used for research on anti-myopia and bradycardia.
- Competitive muscarinic acetylcholine receptor (mAChR) antagonist.
- IC50 values of 0.39 and 0.71 nM for human mAChR M4 and chicken mAChR M4.
- Inhibits ACh-induced relaxations in human pulmonary veins.
- Used for research of anti-myopia and bradycardia.
Medchemexpress LLC Interiorin | 119139-55-8 | 482.52 | 1 MG
Interiorin is a chemical compound isolated from Kadsura heteroclita, known for its moderate anti-HIV activity. This product is intended for research use by qualified scientists in appropriately equipped and authorized facilities. The information provided is based on current knowledge, but the chemical, physical, and toxicological properties have not been completely investigated. The burden of safe use of this material rests entirely with the user.
- Isolated from Kadsura heteroclita
- Exhibits moderate anti-HIV activity with an EC50 value of 1.6 μg/mL
- Intended for research use only
- Requires handling by suitably qualified and experienced scientists
Medchemexpress LLC PCS1055 | 357173-55-8 | 98.0% | 5 MG
PCS1055 is a selective and competitive antagonist of the muscarinic M4 receptor (mAChR4) with low-nanomolar potency and additional cholinesterase inhibitory activity. It is intended for research use in receptor pharmacology and enzymology studies.
- Selective mAChR4 antagonist with IC50 18.1 nM.
- High affinity in radioligand binding (Ki 6.5 nM; Kd 5.72 nM).
- Cholinesterase inhibitor activity (electric eel AChE IC50 22 nM; human AChE IC50 120 nM).
- Molecular formula C27H32N4; molecular weight 412.57 g/mol.
- Supplied in small research quantities with recommended storage conditions for powder and solutions.
Apexbio Technology LLC Levothyroxine sodium 55-03-8 25mg
Levothyroxine sodium (55-03-8) is a synthetic thyroid hormone analogue It is designed to restore or modulate thyroid hormone levels thereby regulating metabolic and developmental processes Levothyroxine sodium exerts its biological activity primarily through enzymatic conversion to the active form triiodothyronine (T3) by deiodinases after which T3 interacts with nuclear thyroid hormone receptors to modulate gene expression and cellular metabolism Based on these pharmacological properties levothyroxine sodium holds research potential in studies of thyroid dysfunction particularly hypothyroidism and in investigations of thyroid-regulated physiological responses and endocrine interactions
Medchemexpress LLC Daunomycinone 10mg | 21794-55-8 | 10 MG
Daunomycinone is an anthracycline metabolite used as a research chemical and intermediate in anticancer studies. It is supplied as a high-purity solid and is soluble in dimethyl sulfoxide (DMSO) for in vitro applications.
- High purity: 98.9%.
- Molecular weight 398.36.
- Chemical formula C21H18O8.
- Physical state: solid, orange to red.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance may be required.
- Provided in a 10 mg package suitable for research use.
Medchemexpress LLC HPPE | 1325721-55-8 | C21H20F3N5O3S | 25 MG
HPPE (compound 236) is an orally active, potential Bach1 inhibitor. Bach1 is a transcription factor that regulates mitochondrial metabolism and reduces glucose utilization. This compound can be used for research in psoriasis, multiple sclerosis, and COPD.
- Orally active Bach1 inhibitor
- Modulates mitochondrial metabolism
- Reduces glucose utilization
- Supports research in psoriasis, multiple sclerosis, and COPD
- Induces Bach1 derepression
- Stabilizes Nrf2 activity
- Activates NRF2 driven transcription
- Ameliorates dopaminergic neurodegeneration in animal models
Medchemexpress LLC Interiorin | 119139-55-8 | 482.52 | 5 MG
Interiorin is a compound that can be isolated from Kadsura heteroclita. It demonstrates moderate anti-HIV activity.
- Isolated from Kadsura heteroclita
- Has moderate anti-HIV activity
- EC50 value of 1.6 lg/mL
Medchemexpress LLC 8-Geranyloxypsoralen | 7437-55-0 | 1 MG
8-Geranyloxypsoralen is a furanocoumarin isolated from grapefruit. It acts as a potent inhibitor of P450 3A4 (CYP3A4) with an IC50 of 3.93 μM. This product is for research use only and not intended for human use or for sale to patients.
- Solid form, off-white to light yellow
- Purity: 99.93%
- Molecular formula: C21H22O4
- Molecular weight: 338.40
- Store at 4°C, protect from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protect from light
- Classified as phenylpropanoid and coumarin
- Initially sourced from plants, Leguminosae, Psoralea corylifolia L.
Medchemexpress LLC Clz-8 (compound 8) | 678158-55-9 | 99.1% | 50 MG
CLZ-8 is an orally active Mcl-1-PUMA interface inhibitor (Compound 8) used in preclinical research to modulate apoptosis; reported Ki = 0.3 μM and shows protective and anti-radiation effects in cell and animal studies.
- Orally active Mcl-1-PUMA interface inhibitor with reported Ki = 0.3 μM.
- Reduces PUMA-dependent apoptosis and deactivates Mcl-1-mediated anti-apoptosis.
- High-purity solid suitable for biochemical and cellular assays.
- Available in small research packs for laboratory use.
- Recommended storage: powder at -20°C for long-term stability.
Medchemexpress LLC KT109 | 1402612-55-8 | 99.9% | 422.52 | 25 MG
KT109 is a potent and isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC50 of 42 nM. It demonstrates significant selectivity for DAGLβ over DAGLα and influences a lipid network crucial for macrophage inflammatory responses. This compound effectively lowers levels of 2-Arachidonoylglycerol, Arachidonic acid, and eicosanoids.
- Inhibits diacylglycerol lipase-β (DAGLβ) activity.
- Shows selectivity for DAGLβ over DAGLα.
- Reduces cellular 2-arachidonoylglycerol and arachidonic acid.
- Modulates lipid networks involved in macrophage inflammatory responses.
- Reverses allodynic responses in models of inflammatory and neuropathic pain.