Pyridines and derivatives
Medchemexpress LLC Monocalcium glycerophosphate | 27214-00-2 | 98.0% | 1 G
Monocalcium glycerophosphate is an inhibitor of intestinal alkaline phosphatase F3 and exhibits anti-cavity properties. It serves as a source of calcium and phosphorus in total parenteral nutrition solutions. It helps prevent the mineralization and development of bones from intravenous nutrition and contributes to maintaining the integrity of the intestinal epithelium.
- Protects trans-epithelial electrical resistance (TEER) in Caco-2 cells and reduces the increase in mannitol permeability rate
- Significantly decreases the level of demineralization in an in vitro bacterial flow chamber model
- Acts as an effective source of calcium and phosphorus in piglet TPN solutions
- Increased the retention of calcium and phosphorus, and bone mineralization improved in animal models
Medchemexpress LLC Encaleret | 787583-71-5 | 99.88% | C29H33ClFNO4 | 25 MG
Encaleret (CLTX-305) is an orally active antagonist of the calcium-sensing receptor (CaSR) with an IC50 of 12 nM. It functions by inhibiting the excessive activity of functional gain-of-function CaSR variants. This action helps to restore blood calcium levels, promote the secretion of parathyroid hormone, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. Encaleret is intended for research purposes, particularly in studies related to diseases such as osteoporosis and autosomal dominant hypocalcemia type 1.
- Orally active
- Potent CaSR antagonist (IC50 of 12 nM)
- Restores blood calcium levels
- Promotes parathyroid hormone secretion
- Improves magnesium and phosphorus metabolism
- Increases urinary calcium excretion
Medchemexpress LLC Encaleret (CLTX-305) | 787583-71-5 | 99.9% | C29H33ClFNO4 | 5 MG
Encaleret (CLTX-305) is an orally active antagonist of the calcium-sensing receptor (CaSR) with an IC50 of 12 nM. It works by inhibiting the excessive activity of functional gain-of-function CaSR variants. This action helps to restore blood calcium levels, promote parathyroid hormone secretion, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. It is utilized in research for conditions such as osteoporosis and autosomal dominant hypocalcemia type 1.
- Orally active
- CaSR antagonist
- Inhibits excessive CaSR activity
- Restores blood calcium levels
- Promotes parathyroid hormone secretion
- Improves magnesium and phosphorus metabolism
- Increases urinary calcium excretion
Medchemexpress LLC Encaleret | 787583-71-5 | 99.9% | C29H33ClFNO4 | 1 ML
Encaleret is an orally active antagonist of the calcium-sensing receptor (CaSR) with an IC₅₀ of 12 nM. It functions by inhibiting the excessive activity of functional gain-of-function CaSR variants. This compound is primarily used in research for conditions such as osteoporosis and autosomal dominant hypocalcemia type 1.
- Restores blood calcium levels
- Promotes parathyroid hormone secretion
- Improves magnesium and phosphorus metabolism
- Increases urinary calcium excretion
Apexbio Technology LLC Ercalcidiol 21343-40-8 5mg
Ercalcidiol (CAS 21343-40-8) is a metabolite targeting vitamin D receptor (VDR)-like receptors It is involved in modulating mineral homeostasis by participating in the physiological regulation of calcium and phosphorus balance Ercalcidiol exerts its biological activity primarily through binding to VDR-related receptors In isolated perfused rat kidney experimental models Ercalcidiol is metabolized into several di- and tri-hydroxylated vitamin D2 derivatives supporting studies of vitamin D2 metabolism pathways Based on these pharmacological properties Ercalcidiol holds research potential for assessing vitamin D nutritional status and investigating vitamin D2 metabolism
Apexbio Technology LLC Ercalcitriol 60133-18-8 25mg
Ercalcitriol (60133-18-8) is a small-molecule agonist targeting the vitamin D receptor (VDR) It is designed to modulate VDR-mediated pathways thereby regulating calcium and phosphorus metabolism Ercalcitriol exerts its biological activity primarily through binding to VDR and initiating transcriptional regulation processes In preclinical studies Ercalcitriol demonstrates activity in the regulation of calcium homeostasis and bone mineralization Based on these pharmacological properties Ercalcitriol holds research potential in the investigation of VDR signaling calcium metabolism bone mineralization and potential therapeutic effects in models of rickets and related bone metabolism disorders
Medchemexpress LLC Colestilan (MCI-196) | 95522-45-5 | 25 MG
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research.
- Non-absorbed.
- Non-calcium-based phosphate binder.
- Non-metallic, anion exchange resin.
- Orally active.
- Can be used for hypercholesterolaemia research.
- Decreases cholesterol levels by bile acid adsorption through the gastrointestinal tract.
- Binds phosphate in vitro.
- Decreases blood phosphate and urinary phosphorus excretion in rats.
- Able to improve hyperphosphataemia in rats with renal failure.
Medchemexpress LLC 5'-Nucleotidase, Microorganism | 9027-73-0 | ≥50 U/mg protein | 200 U
5′-Nucleotidase, Microorganism (CD73) is an intrinsic membrane glycoprotein acting as an ectoenzyme. It catalyzes the hydrolysis of 5-nucleotides into their respective nucleosides. This enzyme is defined by its ability to hydrolyze 1.0 μmole of inorganic phosphorus from adenosine 5′-monophosphate per minute at pH 9.0 and 37°C. It is soluble in water at concentrations of 10 mg/mL or greater and presents as a white to off-white solid. This product is strictly for research purposes and not intended for patient use.
- Acts as an ectoenzyme
- Catalyzes hydrolysis of 5-nucleotides
- Soluble in water at ≥ 10 mg/mL
- Presented as a white to off-white solid
- EC Number: 3.1.3.5
Medchemexpress LLC 2-((R)-1-((R)-2-(3-((1,1-difluoro-2-(pyridin-2-yl)ethoxy)methyl)phenyl)-2-hydroxyethyl)-2,3-dihydro-1H-inden-2-yl)acetic acid | 870964-67-3 | 99.28% | 374.48 | 1 ML
Evocalcet (KHK7580) is an orally active agonist of the calcium sensing receptor (CaSR) that inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. It can be utilized in the research of hyperparathyroidism.
- Orally active CaSR agonist.
- Inhibits parathyroid hormone secretion.
- Potentially useful for hyperparathyroidism research.
- Dose-dependently increases intracellular calcium with an EC50 value of 92.7 nM in hCaR-HEK293 cells.
- Shows no significant inhibitory effects on specific activities of cytochrome P450 isozymes.
- Reduces serum parathyroid hormone and calcium levels in animal models.
- Increases serum inorganic phosphorus level in animal models.
Medchemexpress LLC Colestilan (MCI-196) | 95522-45-5 | 98.0% | 100 MG
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and a non-metallic, anion exchange resin. It is orally active and can be used for hypercholesterolaemia research. This compound decreases cholesterol levels by bile acid adsorption through the gastrointestinal tract.
- Non-absorbed, non-calcium-based phosphate binder
- Non-metallic, anion exchange resin
- Orally active
- Decreases cholesterol levels by bile acid adsorption
- Binds 2.52 mmol of phosphate at 2-4 mM phosphate concentration and pH = 7.2 in vitro
- Decreases blood phosphate and urinary phosphorus excretion in rats in vivo
- Improves hyperphosphataemia in rats with renal failure
Medchemexpress LLC Evocalcet | 870964-67-3 | 99.3% | 374.48 | 5 MG
Evocalcet is an orally active calcium sensing receptor (CaSR) agonist. It inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells and is suitable for research related to hyperparathyroidism.
- Orally active calcium sensing receptor (CaSR) agonist
- Inhibits parathyroid hormone (PTH) secretion from parathyroid gland cells
- Increases intracellular calcium ([Ca2+]i) in hCaR-HEK293 cells with an EC50 of 92.7 nM
- Does not significantly inhibit cytochrome P450 (CYP) isozymes
- Affects serum parathyroid hormone and calcium levels in vivo
- Reduces serum parathyroid hormone and calcium levels and increases inorganic phosphorus levels in animal models of secondary hyperparathyroidism
- Used for research of hyperparathyroidism
Medchemexpress LLC Doxercalciferol (1.alpha.-hydroxyvitamin D2) | 54573-75-0 | 99.9% | 412.65 | 100 MG
Doxercalciferol is a Vitamin D2 analog that acts as an activator of the Vitamin D receptor and helps prevent renal disease.
- Vitamin D2 analog
- Activator of vitamin D receptor
- Helps prevent renal disease
- Elevates serum phosphorus, calcium, and Ca x P in 5/6 nephrectomized rats
- Blocks PTH from rising and lowers serum PTH
- Improves proteinuria, prevents podocyte loss, and accumulation of extracellular matrix proteins in HF diet-induced mice
- Inhibits profibrotic growth factors (TGF-β, PAI-1, CTGF)
- Suppresses macrophage infiltration, decreases NF-κb activity, and prevents expression of proinflammatory cytokine and renal lipid accumulation
- Prevents albuminuria, attenuates podocyte loss and apoptosis, and reduces glomerular fibrosis in diabetic mice
Medchemexpress LLC Parathyroid Hormone (1-34), bovine | 12583-68-5 | 99.9% | 4108.77 | 5 MG
Parathyroid Hormone (1-34), bovine is a potent agonist of the parathyroid hormone (PTH) receptor. It increases calcium and inorganic phosphate levels in vivo and can be used in research related to osteoporosis. It is for research use only and not sold to patients.
- Potent parathyroid hormone (PTH) receptor agonist.
- Increases calcium and inorganic phosphate levels in vivo.
- Can be used for osteoporosis research.
- Inhibits osteoblast proliferation in a dose-dependent manner (in vitro).
- Induces diverse effects on calcium and phosphorus content of culture medium (in vitro).
- Increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in old animals (in vivo).
- Significantly higher serum 1,25-dihydroxyvitamin D concentrations in PTH-treated senile female rats than controls (in vivo).