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Filtered Search Results
Medchemexpress LLC PKI(5-24) | 99534-03-9 | 99.99% | 2222.38 | 10 MG
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PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. It corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor. This 20-residue peptide inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency (Ki of 42 μM) than that of the wild type (Ki of 160 μM). This product is for research use only.
- Potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase)
- Ki of 2.3 nM
- Corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor
- 20-residue peptide synthesized to correspond to the active site of the skeletal muscle inhibitor protein
- Inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency
- For research use only
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eMolecules Synthonix / 1-(2-Chloro-4-pyrimidinyl)-4-piperidinol / 500mg / 786490886 / AC80014 / / 94222-07-8 / MFCD09743694 / 213.670 / C9H12ClN3O
Synthonix / 1-(2-Chloro-4-pyrimidinyl)-4-piperidinol / 500mg / 786490886 / AC80014 / / 94222-07-8 / MFCD09743694 / 213.670 / C9H12ClN3O
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Medchemexpress LLC Derenofylline | 251945-92-3 | 99.9% | 308.38 | 50 MG
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Derenofylline (SLV 320) is a potent, selective, and orally active adenosine A1 receptor antagonist. It exhibits Ki values of 1 nM for human A1, 200 nM for A3, and 398 nM for A2A receptors. This compound suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats. It has also shown to inhibit TGF-β1-induced myofibroblast transformation in vitro and reduce myocardial fibrosis in vivo.
- Potent, selective, and orally active adenosine A1 receptor antagonist
- Suppresses cardiac fibrosis
- Attenuates albuminuria
- Inhibits TGF-β1-induced myofibroblast transformation (in vitro)
- Reduces myocardial fibrosis in 5/6 nephrectomy rats (in vivo)
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Medchemexpress LLC SSD114 hydrochloride | 2319790-02-6 | MFCD31619246 | 99.1% | 387.83 | C18H21ClF3N3O | 25 MG
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SSD114 hydrochloride is a small-molecule positive allosteric modulator of the GABAB receptor intended for in vitro and in vivo research use only.
- Acts as a GABAB receptor positive allosteric modulator for pharmacological studies.
- High purity suitable for research applications.
- Solid, white to off-white appearance for ease of handling.
- Available in multiple small-scale quantities for experimental flexibility.
- Stable under recommended storage conditions to preserve compound integrity.
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Medchemexpress LLC TBK1/IKKε-IN-5 | 1893397-65-3 | 100.0% | 50 MG
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This product is an orally active dual inhibitor for two specific kinases, with very low nanomolar inhibitory concentrations. It is designed for use in cancer research, particularly in the field of tumor immunity.
- Potent dual inhibition against targeted kinases (IC50: 1 nM, 5.6 nM).
- Enhances immune response to anti-PD-L1 treatments, inducing immune memory in animal models.
- Demonstrates antitumor activity and prolongs survival in animal models with anti-PD-L1 combination.
- Induces immunologic memory in tumor cells when combined with anti-PD-L1.
- Promotes IL-2 and IFN-γ secretion in T cells and IL-2 in Jurkat cells.
- Blocks immunosuppressive cytokine production by spheroid cell lines without cytotoxicity.
- Orally active for convenient administration.
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Medchemexpress LLC PKI-179 hydrochloride | 1463510-35-1 | 99.66% | 525.00 | 500 UG
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PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor. It shows IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ, and mTOR, respectively. It also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride has demonstrated anti-tumor activity in vivo.
- Potent and orally active dual PI3K/mTOR inhibitor.
- Exhibits activity against various PI3K isoforms (PI3K-α, PI3K-β, PI3K-γ, PI3K-δ) and mTOR.
- Active against E545K and H1047R.
- Shows anti-tumor activity in vivo.
- Inhibits cell proliferation in MDA361 and PC3 cells.
- Good oral bioavailability (98% in nude mouse, 46% in rat, 38% in monkey, and 61% in dog) and a high half-life (>60 min).
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Medchemexpress LLC B-Raf IN 1 | 950736-05-7 | MFCD25977055 | 10mg
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B-Raf IN 1 | Putity: 98.08% | MW: 515.53 | 950736-05-7 | MFCD25977055 | 10mg
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Medchemexpress LLC HY-114414 5mg Medchemexpress, HDACs/mTOR Inhibitor 1 CAS:2271413-06-8 Purity:>98%
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Medchemexpress, HY-114414 5mg HDACs/mTOR Inhibitor 1 CAS:2271413-06-8 HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC 50 s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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![Medchemexpress LLC Phenyl 6-[[3-methoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-3,4-dihydro-1H-isoquinoline | 913541-47-6 | MFCD28502203 | 99.0% | 546.54 g/mol | C31H25F3N2O4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243076.png-250.jpg)
Medchemexpress LLC Phenyl 6-[[3-methoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-3,4-dihydro-1H-isoquinoline | 913541-47-6 | MFCD28502203 | 99.0% | 546.54 g/mol | C31H25F3N2O4 | 5 MG
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SLX-4090 is a potent, orally active, enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor used in preclinical research on lipid metabolism and dyslipidemia.
- Potent MTP inhibitor (IC50 8.0 nM).
- Inhibits apolipoprotein B secretion in Caco-2 cells; does not inhibit apolipoprotein A1.
- Orally active in rodents; reduces postprandial lipids with an ED50 of ~7 mg/kg.
- Molecular weight 546.54 g/mol; chemical formula C31H25F3N2O4.
- High purity (~98.97% by HPLC).
- Intended for laboratory research use only; not for therapeutic use.
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eMolecules PI-103 | 371935-74-9 | MFCD11983145 | 0.1g
AstaTech | PI-103 | 0.1g | 282977604 | 22944 | 95.000 | 371935-74-9 | MFCD11983145 | 348.362 | C19H16N4O3
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Medchemexpress LLC Pyrimidin-4-yl-methanol | 33581-98-5 | MFCD03789625 | ≥97.0% | 110.11 g/mol | C5H6N2O | 250 MG
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Pyrimidin-4-yl-methanol (CAS 33581-98-5) is a small-molecule synthetic intermediate used in pharmaceutical and agrochemical synthesis and related chemical research. It is characterized by formula C5H6N2O and a molecular weight of 110.11 g/mol, and is supplied with quality documentation for research applications.
- Synthetic intermediate for pharmaceutical synthesis.
- High purity (≥97.0%) suitable for research and development.
- Compact molecular weight of 110.11 g/mol with formula C5H6N2O.
- Available in multiple pack sizes from 100 mg to 50 g.
- Certificate of analysis and safety data sheet provided for verification.
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![Medchemexpress LLC N-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide | 659730-32-2 | MFCD14584859 | 99.2% | 430.4 g·mol⁻¹ | C20H13F3N4O2S | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000242642.png-250.jpg)
Medchemexpress LLC N-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide | 659730-32-2 | MFCD14584859 | 99.2% | 430.4 g·mol⁻¹ | C20H13F3N4O2S | 100 MG
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AMG 517 is a small-molecule antagonist of the TRPV1 (vanilloid) ion channel used to probe TRPV1-mediated signaling and pharmacology. It exhibits sub-nanomolar inhibitory potency and is supplied as a research-grade chemical with batch-specific quality documentation.
- Potent TRPV1 antagonist with reported IC50 in the sub-nanomolar range.
- Molecular formula C20H13F3N4O2S and molecular weight 430.4 g·mol⁻¹.
- High purity (≈99.2% by HPLC) suitable for biochemical assays.
- Available in solid and solution formats for assay flexibility.
- Used for in vitro and in vivo pharmacology and target validation.
- Provided with batch-specific certificate of analysis for QC.
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eMolecules (2-Amino-3,5-dibromophenyl)methanol | 50739-76-9 | MFCD06202693 | 1g
Combi-Blocks | (2-Amino-3,5-dibromophenyl)methanol | 1g | 439374801 | QN-0025 | 95.000 | 50739-76-9 | MFCD06202693 | 280.947 | C7H7Br2NO
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![Medchemexpress LLC Methyl-4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl) | 1062169-56-5 | 98.0% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00132390-HY-12034-5MG.JPG-250.jpg)
Medchemexpress LLC Methyl-4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl) | 1062169-56-5 | 98.0% | 5 MG
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WYE-354 is an ATP-competitive mTOR inhibitor used in research to block mTORC1 and mTORC2 signaling and to study PI3K/mTOR pathway modulation in vitro. It is supplied as a high-purity small molecule in solid form or as a ready-to-use DMSO solution for laboratory assays.
- ATP-competitive mTOR inhibitor with IC50 ≈ 5 nM.
- High purity suitable for biochemical and cell-based assays.
- Available as solid and as a 10 mM solution in DMSO for convenience.
- Molecular weight 495.53 g·mol⁻¹ and formula C24H29N7O5.
- Commonly used for pathway, signaling, and autophagy research in vitro.
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![eMolecules Medchem Express / PI3K/Akt/mTOR-IN-2 / 5mg / 742367738 / HY-146751 / / 2757804-89-8 / [null] / 285.294 / C17H13F2NO](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502455183.PNG-250.jpg)
eMolecules Medchem Express / PI3K/Akt/mTOR-IN-2 / 5mg / 742367738 / HY-146751 / / 2757804-89-8 / [null] / 285.294 / C17H13F2NO
Medchem Express / PI3K/Akt/mTOR-IN-2 / 5mg / 742367738 / HY-146751 / / 2757804-89-8 / [null] / 285.294 / C17H13F2NO
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More