Pyrrolidines

Organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that form a cyclic secondary amine.

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4,051 – 4,065 of 6,182 results

4,051

eMolecules 2097971-11-2 | Medchem Express | (SRS)-AHPC-PEG3-NH2 (hydrochloride) | 10mg | 475641365 | HY-103602 | 656.24 | C30H46ClN5O7S

Ambeed | Methyl 4-cyano-2-methoxybenzoate | 1g | 552720753 | A380369 | 406719-76-4 | MFCD18399095 | 191.186 | C10H9NO3

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4,052

eMolecules 1001600-54-9 | Medchem Express | MV1 | 5mg | 459606864 | HY-113534 | 576.738 | C33H44N4O5

Medchem Express | c-Kit-IN-5-1 | 5mg | 722714436 | HY-18302 | 1003311-62-3 | MFCD22989318 | 395.422 | C23H17N5O2

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eMolecules Building Block Tool

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4,053

Innovative Research Inc Hmn PAI1 Rcmb WT Act 500ug

Human PAI-1 Recombinant Wild Type Active 500 ug - Human PAI-1 Recombinant Wild Type Active from Innovative Research has been recombinantly produced in E. coli and purified by affinity chromatography. This is a Frozen liquid buffered in 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 and a purity of >95% as determined by SDS-PAGE. More Details Species Human Target PAI-1 Purification Method Affinity purified Purity >95% as determined by SDS-PAGE Analysis Source E. coli Storage Conditions -70C Additional Information Gentle purification conditions create an active fraction that is greater than 99% pure and 98% active. This product can be used as a control in applications like ELISA and Western Blot. It can be used in a wide range of in vitro applications, including blocking/inhibition, fibrinolysis, plasminogen activation, receptor binding, in hypertension studies, for protein-protein interactions, and more.

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4,054

Medchemexpress LLC 1,2,4-trideoxy-4-(methylamino)-1-(4-pentylphenyl)-D-erythro-pent-1-enitol hydrochloride | 1072443-89-0 | >=98.0% | 313.86 g/mol | C17H27NO2.HCl | 10 MG

SK1-I is a sphingosine analog and a selective, competitive inhibitor of sphingosine kinase 1 (SPHK1) with a reported Ki of approximately 10 μM. It is supplied for research use and is used in biochemical and cell-based studies to modulate sphingolipid signaling, enhance autophagy, and evaluate antitumor activity.

Selective SPHK1 inhibitor (Ki ≈ 10 μM).
Sphingosine analog used in biochemical and cellular assays.
Reported to enhance autophagy and show antitumor effects in preclinical studies.
Supplied in small milligram quantities for research use only.
Common applications include pathway modulation, proliferation, and apoptosis studies.

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4,055

Medchemexpress LLC FABPs ligand 6 (MF6) | 2988135-14-2 | 99.9% | C28H27FN2O3 | 50 MG

FABPs ligand 6 (MF6) is an inhibitor of FABP5 and FABP7, with KD values of 874 nM and 20 nM, respectively. It is utilized in multiple sclerosis research, where it can restore mitochondrial function by inhibiting voltage-dependent anion channel (VDAC)-1-dependent mitochondrial macropore formation. In vivo studies have shown that MF6 can improve the severity of experimental autoimmune encephalomyelitis (EAE) and reduce oxidative levels and inflammatory responses.

Inhibits FABP5 and FABP7
Rescues mitochondrial function
Reduces oxidative levels
Attenuates inflammatory response
Used in multiple sclerosis research

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4,056

Medchemexpress LLC (S,R,S)-AHPC-PEG2-N3 | 2010159-45-0 | 99.9% | 601.72 g/mol | C28H39N7O6S | 50 MG

(S,R,S)-AHPC-PEG2-N3 is an E3 ligase ligand-linker conjugate containing an (S,R,S)-AHPC VHL ligand connected to a two-unit PEG linker and terminating in an azide. It is provided as a click-chemistry reagent for PROTAC assembly and linker installation.

Contains a terminal azide compatible with CuAAC and SPAAC reactions.
Designed for conjugation to alkyne-bearing molecules and strain-promoted partners.
PEG2 linker provides flexibility and solubility for linker installation.
Supplied as a research-grade reagent with characterized molecular weight and formula.

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4,057

Medchemexpress LLC HY-107456 10mg Medchemexpress, E6130 CAS:1427058-33-0 Purity:>98%

Medchemexpress, HY-107456 10mg E6130 CAS:1427058-33-0 E6130 is an orally available and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,058

Medchemexpress LLC Terlipressin diacetate | 1884420-36-3 | 99.8% | 1347.48 | C56H82N16O19S2 | 25MG

Terlipressin diacetate is a synthetic vasopressin V1 receptor agonist provided as a high-purity solid peptide for laboratory research. It is typically used to investigate vasoconstriction, portal pressure modulation, and related pharmacological effects. The product includes storage and stability guidance for both powder and solution forms.

High purity (99.76%) suitable for research use.
Molecular weight 1347.48 and defined molecular formula.
Available in multiple pack sizes from 5 mg to 500 mg.
Storage conditions and stability provided for powder and in-solution forms.
Supplied as a solid peptide salt appropriate for pharmacology studies.

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4,059

Medchemexpress LLC (S,R,S)-AHPC-propargyl | 2098799-78-9 | 99.5% | 526.65 | 50 MG

(S,R,S)-AHPC-propargyl is a VHL ligand used in "click reactions" for PROTACs. It functions as a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. VHL protein, a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes, is frequently recruited by PROTACs to induce ubiquitination and subsequent proteasomal degradation of target proteins.

VHL ligand for PROTACs.
Click chemistry reagent with an alkyne group.
Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc).
Recruits VHL protein for ubiquitination and degradation of target proteins.
Used in PROTAC synthesis.
Applicable in cancer targeted therapy.

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4,060

Medchemexpress LLC SK1-I (BML-258) | 1072443-89-0 | 98.8% | 277.40 | C17H27NO2 | 5 MG

SK1-I (BML-258) is a sphingosine analog and an isozyme-specific competitive inhibitor of sphingosine kinase 1 (SPHK1) with a reported Ki of about 10 μM. It enhances autophagy and has demonstrated antitumor activity. Intended for research use only.

Isozyme-specific SPHK1 inhibition (Ki ≈ 10 μM).
Sphingosine analog scaffold.
High purity: 98.83%.
Molecular weight 277.40 g/mol; formula C17H27NO2.
Available as small solid quantities and as a 10 mM solution in DMSO.
For research use only; not for human or veterinary use.

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4,061

Medchemexpress LLC (2S)-N-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide | 1361321-96-1 | MFCD28502270 | 99.5% | 388.48 g/mol | C20H24N2O4S | 1 ML

A potent, orally active dual orexin receptor antagonist for preclinical research. Reported to be brain-penetrant, it is used in studies of sleep, stress/anxiety, and addiction, and is supplied as a concentrated DMSO stock suitable for in vitro and in vivo dosing.

Dual orexin 1/orexin 2 receptor antagonist with nanomolar potency.
Brain-penetrant profile suitable for CNS studies.
Applicable to insomnia, anxiety, and addiction research.
Available as a 10 mM stock solution in DMSO for convenient use.
High purity (~99.5%) for reproducible experimental results.

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4,062

Medchemexpress LLC MEDCHEMEXPRESS LLC

5000297725 TALTIRELIN ACETATE 10MG

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4,063

Medchemexpress LLC Mal-C6-α-amanitin | 1578249-76-9 | 98.5% | 1211.34 | C55H78N12O17S | 2 MG

Mal-C6-α-amanitin is an antibody-drug conjugate (ADC) payload consisting of α-amanitin covalently linked via a maleimide C6 (Mal-C6) linker. It is supplied as a solid for research use and acts as an RNA polymerase II inhibitor to provide targeted cytotoxicity.

Drug-linker conjugate for ADC research and payload development.
High purity: 98.5%.
Molecular weight 1211.34 Da.
Molecular formula C55H78N12O17S.
White to light yellow solid appearance.
Store at -20°C; in solvent, store at -80°C up to 6 months (protect from light).

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4,064

Medchemexpress LLC (S,R,S)-ahpc-c5-cooh (vh032-c5-cooh) | 2267282-19-7 | >98.0% | C29H42N4O5S | 10MG

(S,R,S)-AHPC-C5-COOH is a von Hippel-Lindau (VHL) E3 ligase ligand-linker conjugate used as a synthetic building block in PROTAC and degrader synthesis. It contains an AHPC recognition motif with a five-carbon linker terminating in a carboxylic acid, enabling facile amide or ester coupling to target ligands. Supplied as a high-purity solid for medicinal chemistry research.

High purity (>98%) suitable for synthesis and analytical work.
Five-carbon linker terminating in a carboxylic acid for coupling chemistry.
Designed for use as a VHL E3 ligase ligand in PROTAC assembly.
Provided in small research quantities for medicinal chemistry workflows.
Stable solid, typically white to off-white, for convenient handling.

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4,065

Medchemexpress LLC MZP-54 | 2010159-47-2 | 98.0% | 1036.67 | 10 MG

MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, exhibiting a Kd of 4 nM for Brd4BD2. This selective degrader is based on PROTAC technology, binding to VHL-EloC-EloB protein (VCB) with a Kd of 105 ± 24 nM. It shows inhibitory activity against MV4;11 and HL60 cells, and exhibits high depletion of cMyc levels.

Selective degrader of BRD3/4
Based on PROTAC technology
Binds to VHL-EloC-EloB protein (VCB)
Shows inhibitory activity against MV4;11 and HL60 cells
Exhibits high depletion of cMyc levels

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Pyrrolidines

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Medchemexpress LLC 1,2,4-trideoxy-4-(methylamino)-1-(4-pentylphenyl)-D-erythro-pent-1-enitol hydrochloride | 1072443-89-0 | >=98.0% | 313.86 g/mol | C17H27NO2.HCl | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC FABPs ligand 6 (MF6) | 2988135-14-2 | 99.9% | C28H27FN2O3 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,R,S)-AHPC-PEG2-N3 | 2010159-45-0 | 99.9% | 601.72 g/mol | C28H39N7O6S | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-107456 10mg Medchemexpress, E6130 CAS:1427058-33-0 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Terlipressin diacetate | 1884420-36-3 | 99.8% | 1347.48 | C56H82N16O19S2 | 25MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,R,S)-AHPC-propargyl | 2098799-78-9 | 99.5% | 526.65 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SK1-I (BML-258) | 1072443-89-0 | 98.8% | 277.40 | C17H27NO2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (2S)-N-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide | 1361321-96-1 | MFCD28502270 | 99.5% | 388.48 g/mol | C20H24N2O4S | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MEDCHEMEXPRESS LLC Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mal-C6-α-amanitin | 1578249-76-9 | 98.5% | 1211.34 | C55H78N12O17S | 2 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,R,S)-ahpc-c5-cooh (vh032-c5-cooh) | 2267282-19-7 | >98.0% | C29H42N4O5S | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MZP-54 | 2010159-47-2 | 98.0% | 1036.67 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More