Tetrahydroisoquinolines
Medchemexpress LLC Nampt-IN-3 | 2121591-52-2 | 99.0% | 503.55 | 100 MG
Nampt-IN-3 (Compound 35) simultaneously inhibits nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. It effectively induces cell apoptosis and autophagy, leading to cell death.
- Inhibits nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM.
- Effectively induces cell apoptosis and autophagy.
- Leads to cell death.
- Demonstrates cytotoxicity in human HCT116 cells with an IC50 of 2.4 μM.
- Demonstrates cytotoxicity in human HepG2 cells with an IC50 of 4.5 μM.
- Demonstrates cytotoxicity in human MDA-MB-231 cells with an IC50 of 10 μM.
Medchemexpress LLC Nampt-IN-3 | 2121591-52-2 | 99.0% | 503.55 | 1 ML
Nampt-IN-3 (Compound 35) is a small molecule inhibitor that simultaneously targets nicotinamide phosphoribosyltransferase (NAMPT) and HDAC, with IC50 values of 31 nM and 55 nM, respectively. It is effective in inducing cell apoptosis and autophagy, ultimately leading to cell death.
- Simultaneously inhibits NAMPT and HDAC.
- Induces cell apoptosis.
- Induces autophagy.
- Leads to cell death.
- Demonstrates cytotoxicity in HCT-116, HepG2, and MDA-MB-231 cell lines.
- Available in various quantities for research use.
Medchemexpress LLC Nampt-IN-3 | 2121591-52-2 | 99.0% | 503.55 | 10 MG
Nampt-IN-3 (Compound 35) is an agent that simultaneously inhibits nicotinamide phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) with IC50 values of 31 nM and 55 nM, respectively. It effectively induces cell apoptosis and autophagy, ultimately leading to cell death. This product is intended for research use only and is not sold to patients. It appears as a white to off-white solid.
- Simultaneously inhibits NAMPT and HDAC.
- Induces cell apoptosis and autophagy.
- Leads to cell death.
- High purity of 98.97%.
- Available in both solid and pre-dissolved solution forms for convenience.
- Used in research for cytotoxicity studies in various cell lines such as HCT-116, HepG2, and MDA-MB-231.
Medchemexpress LLC Nampt-IN-5 | 2380013-17-0 | 98.0% | 100 MG
Nampt-IN-5 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) and also inhibits CYP3A4 activity. It demonstrates significant antiproliferative activity, with cellular IC50s of 0.7 nM against A2780 cells and 3.9 nM against COR-L23 cells.
- Potent NAMPT inhibitor
- Inhibits CYP3A4 activity
- Exhibits cellular IC50 of 0.7 nM against A2780 cells
- Exhibits cellular IC50 of 3.9 nM against COR-L23 cells
- Soluble in DMSO at 50 mg/mL
- Stable as powder for 3 years at -20°C
- Stable in solvent for 6 months at -80°C or 1 month at -20°C
Medchemexpress LLC Ecteinascidin 770 | 114899-80-8 | 99.8% | 770.85 g/mol | C40H42N4O10S | 10 MG
Ecteinascidin 770 is a 1,2,3,4-tetrahydroisoquinoline alkaloid natural product used in preclinical cancer research for its potent cytotoxic and apoptosis-inducing activities. It is typically handled as a solid and prepared in solvent for in vitro assays, showing low-nanomolar inhibitory potency across several human tumor cell lines.
- Induces apoptosis in tumor cell lines.
- Exhibits low-nanomolar potency (reported IC50 values in multiple lines).
- Molecular formula C40H42N4O10S and molecular weight ~770.85 g/mol.
- Soluble in DMSO for biological testing.
- Supplied as a small solid vial suitable for research use.
Medchemexpress LLC Nampt-IN-5 | 2380013-17-0 | >98.0% | 50 MG
Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor that also inhibits CYP3A4 activity. It exhibits cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23 cell lines, respectively, demonstrating antiproliferative effects. In vivo, it causes significant body weight loss in nude mice and shows favorable ADME data.
- Potent NAMPT inhibitor
- Inhibits CYP3A4 activity
- Exhibits antiproliferative activity against A2780 and COR-L23 cell lines
- Shows good ADME data in vitro
- Induces significant body weight loss in nude mice in vivo
Medchemexpress LLC Ecteinascidin 770 | 114899-80-8 | 99.8% | 770.85 | C40H42N4O10S | 50 MG
Ecteinascidin 770 is a tetrahydroisoquinoline alkaloid with potent cytotoxic and anticancer activity. It shows low-nanomolar IC50 values across multiple human cancer cell lines and is intended for preclinical in vitro research. The compound is provided as a high-purity solid or as a DMSO solution and is documented with CAS 114899-80-8, formula C40H42N4O10S, and molecular weight 770.85.
- High purity (≈99.8%).
- Potent cytotoxic activity with low-nanomolar IC50 in multiple human cancer cell lines.
- Suitable for in vitro and preclinical research applications.
- Available in mg-scale quantities and as DMSO solutions.
- Characterized by CAS 114899-80-8, formula C40H42N4O10S, molecular weight 770.85.
Medchemexpress LLC 1(2H)-isoquinolinone, 5-hydroxy | 5154-02-9 | MFCD00006900 | 99.1% | 161.16 g/mol | C9H7NO2 | 10 MG
1,5-Isoquinolinediol is a small-molecule PARP inhibitor used in research to modulate DNA repair and oxidative-stress pathways. It exhibits potent PARP inhibition and has been reported to reduce diabetes-induced NADPH oxidase-derived oxidative stress in retinal models. The compound is provided as a solid with high purity and is typically prepared in DMSO for in vitro and in vivo studies.
- Potent PARP inhibition (IC50 0.18-0.37 μM).
- Attenuates NADPH oxidase-derived oxidative stress in retinal models.
- High purity suitable for biochemical and cell-based assays.
- Soluble in DMSO (≈37 mg/mL) for convenient stock preparation.
- Stable as a powder when stored cold for extended periods.
- Applicable for studies of DNA repair, oxidative stress, and cell death pathways.
Selleck Chemical LLC YS-49-E0785-5MG
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1 also is an isoquinoline compound alkaloid has a strong positive inotropic action through activation of cardiac -adrenoceptors
Medchemexpress LLC HY-19344 10mg Medchemexpress, Lifitegrast CAS:1025967-78-5 Purity:>98%
Medchemexpress, HY-19344 10mg Lifitegrast CAS:1025967-78-5 Lifitegrast (SAR 1118) is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Narciclasine | 29477-83-6 | 307.26 | 1 MG
Narciclasine is a plant growth modulator that modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway. It greatly increases GTPase RhoA activity and induces actin stress fiber formation in a RhoA-dependent manner.
- Plant growth modulator
- Modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway
- Increases GTPase RhoA activity
- Induces actin stress fiber formation
- Activates Rho and stress fibers in glioblastoma multiforme cells
- Significantly increases survival in glioblastoma multiforme-bearing mice
- Effective at lower doses compared to temozolomide
Medchemexpress LLC HY-15477A 10mg Medchemexpress, YS-49 (monohydrate) CAS: Purity:>98%
Medchemexpress, HY-15477A 10mg YS-49 (monohydrate) CAS: YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II) -stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors [1] [2] [3] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Ecteinascidin 770 | 114899-80-8 | 99.8% | 770.85 g/mol | C40H42N4O10S | 5 MG
Ecteinascidin 770 (ET-770) is a tetrahydroisoquinoline alkaloid research compound with potent anticancer activity. It is supplied as a solid (white to yellow) and as a DMSO solution for laboratory use; intended for in vitro research and should be handled according to supplier documentation and SDS guidance.
- Potent anticancer activity; IC50 4.83 nM against U373MG cells.
- High purity typically around 99.8%.
- Molecular formula C40H42N4O10S and molecular weight 770.85 g/mol.
- Available in small-scale solid pack sizes and as a 10 mM solution in DMSO.
- Solid appearance: white to yellow powder; soluble in DMSO for assays.
Medchemexpress LLC Nampt-IN-3 | 2121591-52-2 | MFCD28053555 | 99.0% | 503.55 g/mol | C29H25N7O2 | 5 MG
Nampt-IN-3 is a high-purity, research-grade small molecule inhibitor that targets nicotinamide phosphoribosyltransferase (NAMPT) and histone deacetylases (HDAC). Supplied as a white to off-white solid, it exhibits low-nanomolar biochemical potency and documented cellular activity suitable for preclinical studies.
- High purity (98.97%) solid suitable for research use.
- Dual inhibitory activity against NAMPT and HDAC (IC50s ~31 nM and 55 nM).
- Documented cytotoxicity in multiple cell lines (example IC50s in μM range).
- Soluble in DMSO at high concentration; ultrasonic assistance recommended.
- Stable as powder and in solution when stored per recommendations.
- Available in small research pack sizes for early-stage studies.
Medchemexpress LLC SR10067 | 1380548-02-6 | 99.2% | 465.58 g·mol⁻1 | C31H31NO3 | 25 MG
SR10067 is a potent, selective, brain-penetrant REV-ERB agonist used as a research tool to study circadian biology, metabolic regulation, and neuropsychiatric disorders. It has reported IC50 values of approximately 160-170 nM and a molecular weight of 465.58 g·mol⁻1.
- Potent, selective REV-ERB agonist with low-nanomolar activity.
- Brain-penetrant small molecule suitable for in vivo studies.
- High chemical purity (≈99.2% by supplier analysis).
- Molecular formula C31H31NO3 and molecular weight 465.58 g·mol⁻1.
- Stable as powder at -20°C for long-term storage.
- Suitable for receptor assays, cell-based studies, and in vivo pharmacology.
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