Nitrogen mustard compounds
Medchemexpress LLC Senkyunolide A | 63038-10-8 | 192.26 | 5 MG
Senkyunolide A is a phthalide with anticancer activity, acting as an anti-tumor cell proliferation agent. It offers neuroprotective effects by decreasing protein phosphatase PP2A and α-synuclein phosphorylation, and inhibits osteoarthritis by modulating the NLRP3 signaling pathway. Furthermore, it suppresses the expression of CD137, a biomarker for atherosclerosis.
- Inhibits proliferation of HT-29 and CCD-18Co cells.
- Decreases high expression of CD137 in TNF-α treated MAECs cells.
- Enhances cell viability and reduces apoptosis in PC12 cells.
- Stimulates cell proliferation and curbs apoptosis in IL-1β-treated chondrocytes.
- Inhibits cell inflammation by blocking the NLRP3 signaling pathway.
- Demonstrates improvement in mouse models of osteoarthritis, alleviating articular cartilage destruction.
Medchemexpress LLC CDC25B-IN-1 | 2374831-10-2 | 98.1% | 321.37 g/mol | C20H19NO3 | 50MG
CDC25B-IN-1 is a small-molecule research inhibitor of the cell division cycle 25B (CDC25B) phosphatase. It has a reported Ki of approximately 8.5 μM, reduces cell proliferation and colony formation, and increases the proportion of cells in the G2/M phase. The compound is supplied at high reported purity and is available in multiple pack sizes, including mg quantities and as a DMSO solution suitable for biochemical and cell-based assays.
- Potent inhibitor of CDC25B phosphatase with reported Ki ≈ 8.5 μM.
- Inhibits cell proliferation and colony formation in cellular assays.
- Causes accumulation of cells in the G2/M phase.
- Supplied with high reported purity for research use.
- Available in multiple pack sizes and as a DMSO solution for convenience.
Medchemexpress LLC MS4077 | 2230077-10-6 | 99.7% | 1134.73 | 10 MG
MS4077 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 37 nM for binding affinity to ALK. It is for research use only and not sold to patients.
- Effectively inhibits cancer cell proliferation.
- Concentration-dependently inhibits proliferation of SU-DHL-1 cells with an IC50 of 46 ± 4 nM.
- Potently reduces ALK fusion protein levels and inhibits ALK auto-phosphorylation and downstream STAT3 phosphorylation in SU-DHL-1 and NCI-H2228 cells.
- Reduces NPM-ALK protein levels with a DC50 of 3 ± 1 nM in SU-DHL-1 cells after 16-hour treatment.
- Achieves over 90% inhibition of both ALK Y1507 and STAT3 Y705 phosphorylation at 100 nM concentration.
- Reduces EML4-ALK protein levels with a DC50 of 34 ± 9 nM in NCI-H2228 cells after 16-hour treatment, with over 90% reduction at 100 nM.
![Medchemexpress LLC Ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate | 2374831-10-2 | 98.1% | 321.37 | C20H19NO3 | 100MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000235955.png-250.jpg)
Medchemexpress LLC Ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate | 2374831-10-2 | 98.1% | 321.37 | C20H19NO3 | 100MG
CDC25B-IN-1 is a small-molecule inhibitor of the CDC25B phosphatase used for biochemical and cellular research. Reported as compound 4a, it inhibits CDC25B with a Ki of 8.5 μM, reduces cell proliferation and colony formation, and induces G2/M cell-cycle arrest. The material is typically supplied as a light brown oil or as a DMSO solution for assay use.
- Inhibits CDC25B with a reported Ki of 8.5 μM.
- Reduces cell proliferation and colony formation in cellular assays.
- Induces G2/M cell-cycle arrest.
- Molecular formula C20H19NO3; molecular weight 321.37.
- High purity (approximately 98.1%; may vary by batch).
- Available in multiple quantities and solution formats for assay convenience.
- Storage recommendations include refrigeration under inert atmosphere and low-temperature storage in solvent.
Medchemexpress LLC Iriflophenone | 52591-10-3 | MFCD20260852 | 98.1% | 246.22 g/mol | C13H10O5 | 10 MG
Iriflophenone is a plant-derived phenolic compound (C13H10O5, MW 246.22) isolated from Aquilaria sinensis and provided for laboratory research; it has been reported to stimulate proliferation of MCF-7 and T-47D human breast cancer cell lines.
- Plant-derived phenolic compound isolated from Aquilaria sinensis.
- Reported to stimulate proliferation of MCF-7 and T-47D human breast cancer cells.
- High purity suitable for in vitro research (reported purity ~98.1%).
- Available as solid or as ready-to-use DMSO solution for cell-based assays.
- Characterized chemical profile with CAS 52591-10-3 and formula C13H10O5.
Selleck Chemical LLC Bendamustine HCl 100mg 3543-75-7 SDX-105 (Cytostasane) HCl
Bendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 ?M in cell-free assay. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC ZL0580 | 2377151-10-3 | 99.4% | 532.53 | 10 MG
ZL0580, an analog of ZL0590, epigenetically suppresses HIV by binding to the BD1 domain of BRD4. It inhibits Tat transactivation and transcription elongation, and also induces a repressive chromatin structure at the HIV promoter.
- Induces HIV transcriptional suppression.
- Exhibits low toxicity.
- Suppresses both PMA-stimulated and basal HIV transcription.
- Does not cause significant cell death at concentrations below 40 μM.
- Suppresses HIV in primary CD4+ T cells.
Medchemexpress LLC Tas4464 | 1848959-10-3 | 99.2% | 10 MG
TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE) with an IC50 of 0.955 nM. This compound inhibits cullin neddylation, leading to the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in various human cancer cell lines.
- Highly potent and selective inhibitor of NEDD8 activating enzyme (NAE)
- Inhibits cullin neddylation
- Induces accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines
Medchemexpress LLC VIT-2763 | 2095668-10-1 | 99.9% | 408.43 | 50 MG
VIT-2763 is an oral ferroportin inhibitor designed to inhibit hepcidin binding to ferroportin and block iron efflux. It holds potential for treating β-thalassemia by addressing iron regulation. This compound has demonstrated significant biological activity both in vitro and in vivo.
- Reduces fluorescence polarization signal by displacing TMR-hepcidin from ferroportin.
- Induces BLA reporter gene activity, increasing intracellular iron concentrations by blocking iron export.
- Triggers ubiquitination and degradation of ferroportin.
- Corrects anemia and improves red blood cell parameters in relevant animal models.
- Decreases the percentage of ROS-positive red blood cells and extends their lifespan.
- Significantly decreases serum iron levels in animal studies.
- Currently undergoing Phase 2 clinical trials for Beta-Thalassemia and Sickle Cell Disease.
Medchemexpress LLC ML-184 25mg | 794572-10-4 | 470.63 g·mol⁻¹ | C25H34N4O3S | 25 MG
ML-184 is a small-molecule research compound described as a GPR55 agonist and used in cell-based and pharmacological studies. It is supplied as a high-purity solid for laboratory research and is identified by CAS 794572-10-4.
- Acts as a GPR55 agonist for pharmacology and cell studies.
- High reported purity suitable for research applications.
- Molecular formula C25H34N4O3S and molecular weight 470.63 g·mol⁻¹.
- Supplied as a solid in a 25 mg package for benchtop use.
- CAS number 794572-10-4 provides an unambiguous chemical identifier.
Medchemexpress LLC ZL0580 | 2377151-10-3 | 99.4% | 532.53 | 100 MG
ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. It induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.
- Induces epigenetic suppression of HIV
- Selectively binds to BD1 domain of BRD4
- Inhibits Tat transactivation and transcription elongation
- Induces repressive chromatin structure at the HIV promoter
- Suppresses HIV in primary CD4+ T cells
- Exhibits low toxicity in cell viability assays
Medchemexpress LLC ML-184 50mg | 794572-10-4 | 470.63 g/mol | C25H34N4O3S | 50 MG
ML-184 is a selective GPR55 agonist research compound (CAS 794572-10-4) used to probe GPR55-mediated signaling pathways in vitro and in vivo. It activates ERK1/2 phosphorylation, promotes PKCβII translocation, and has been shown to increase neural stem cell proliferation and differentiation.
- Selective GPR55 agonist with an EC50 of about 250 nM.
- Greater than 100-fold selectivity over GPR35, CB1, and CB2.
- Induces ERK1/2 phosphorylation and PKCβII membrane translocation.
- Demonstrated activity in neural stem cell proliferation and differentiation assays.
- Provided as a high-purity solid and as a DMSO solution for biological assays.
Medchemexpress LLC Toringin | 1329-10-8 | 5 MG
Toringin is a bioflavonoid isolated from the bark of Docyniopsis tschonoski. It decreases the cis-effect of expanded CTG repeats and cytotoxicity, and rescues PC12 neuronal cells when exposed to isosakuranetin. As a flavonoid, Toringin exhibits various biological activities beneficial against conditions such as cancers and coronary heart disease, and is effective in ameliorating RNA gain of function caused by expanded CTG repeats.
- Decreases cis-effect of expanded CTG repeats
- Decreases cytotoxicity
- Rescues PC12 neuronal cells
- Ameliorates RNA gain of function
- Exhibits various biological activities
- Beneficial against cancers and coronary heart disease
Medchemexpress LLC R-sulforaphane | 142825-10-3 | >98.0% | C6H11NOS2 | 10MG
(R)-Sulforaphane is the R-enantiomer of sulforaphane, an organosulfur isothiocyanate (CAS 142825-10-3) that induces phase II detoxification enzymes and activates the Nrf2 antioxidant pathway. It is used in biochemical and cell-based research to study antioxidant response, detoxification, inflammation, and cancer-related signaling. Supplied as a purified research-grade compound (purity >98%).
- Chiral R-enantiomer with defined stereochemistry.
- Activates Nrf2-mediated antioxidant response.
- Induces phase II detoxification enzymes.
- Suitable for cell-based and biochemical assays.
- High purity for reproducible results.
- Small, well-characterized organic molecule (C6H11NOS2, 177.29 g/mol).
Medchemexpress LLC Gamcemetinib (CC-99677) | 1887069-10-4 | 99.1% | 469.94 | 50 MG
Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway. It exhibits an IC50 of 156.3 nM in biochemical assays and an EC50 of 89 nM in cell-based assays.
- Potent, covalent, and irreversible MK2 inhibitor
- Exhibits IC50 of 156.3 nM in biochemical assays and EC50 of 89 nM in cell-based assays
- Extracted from patent WO2020236636, compound 1
- Available in solid and solution forms
- Appearance: Solid, light yellow to yellow color
- Useful for research purposes
- Offers high purity of 99.1%
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