Alcohols and polyols
- (1)
- (55)
- (343)
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- (4)
- (8)
- (7)
- (55)
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- (1)
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- (156)
- (1)
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- (1)
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- (30)
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- (20)
- (10)
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- (395)
- (6)
- (102)
- (21)
- (50)
- (31)
- (62)
- (13)
- (14)
- (1)
- (2)
- (1)
- (25)
- (6)
- (4)
- (1)
- (6)
- (1)
- (464)
- (9)
- (46)
- (11)
- (46)
- (6)
- (1)
- (7)
- (12)
- (145)
- (116)
- (7)
- (5)
- (1)
- (1)
- (1)
- (1)
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- (1)
- (1)
- (4)
- (7)
- (14)
- (2)
- (1)
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- (1)
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- (21)
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- (2)
- (2)
- (2)
- (16)
- (2)
- (30)
- (1)
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- (1)
- (2)
- (1)
- (20)
- (10)
- (4)
- (15)
- (1)
- (4)
- (6)
- (2)
- (1)
- (2)
- (2)
- (2)
- (4)
- (3)
- (1)
- (28)
- (29)
- (7)
- (3)
- (5)
- (1)
- (36)
- (5)
- (4)
- (2)
- (5)
- (4)
- (17)
- (15)
- (4)
- (5)
- (1)
- (2)
- (5)
- (1)
- (4)
- (37)
- (4)
- (2)
- (6)
- (8)
- (2)
- (2)
- (8)
- (7)
- (7)
- (2)
- (1)
- (1)
- (26)
- (1)
- (1)
- (1)
- (2)
- (1)
- (3)
- (4)
- (2)
- (1)
- (15)
- (12)
- (1)
- (2)
- (2)
- (7)
- (12)
- (1)
- (14)
- (24)
- (1)
- (8)
- (4)
- (1)
- (2)
- (1)
- (22)
- (2)
- (6)
- (5)
- (2)
- (1)
- (5)
- (3)
- (4)
- (24)
- (5)
- (3)
- (5)
- (14)
- (1)
- (1)
- (1)
- (11)
- (3)
- (2)
- (4)
- (11)
- (2)
- (7)
- (4)
- (1)
- (1)
- (3)
- (6)
- (11)
- (5)
- (3)
- (1)
- (2)
- (11)
- (14)
- (7)
- (2)
- (2)
- (1)
- (3)
- (1)
- (2)
- (1)
- (10)
- (1)
- (2)
- (4)
- (4)
- (1)
- (3)
- (1)
- (3)
- (5)
- (1)
- (1)
- (2)
- (10)
- (2)
- (2)
- (3)
- (7)
- (1)
- (5)
- (4)
- (1)
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- (9)
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- (2)
- (12)
- (4)
- (1)
- (1)
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- (4)
- (10)
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- (1)
- (1)
- (1)
- (10)
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- (1)
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- (14)
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- (1)
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- (1)
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- (1)
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- (30)
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Filtered Search Results
Medchemexpress LLC Vatinoxan (hydrochloride) | 130466-38-5 | 99.8% | 454.97 | 50 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Vatinoxan hydrochloride is a peripheral α2 adrenergic receptor antagonist. It is for research use only and may be useful in attenuating reductions in heart rate.
- Increases cardiac index and tissue oxygen delivery without adverse effects.
- Attenuates or prevents dexmedetomidine's systemic hemodynamic effects in a dose-dependent manner.
- Induces the least alterations in cardiovascular function at a 50:1 dose ratio (Vatinoxan:dexmedetomidine).
- Attenuates bradycardia associated with dexmedetomidine.
- Shortens sedative effect without altering its quality.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Sevelamer hydrochloride | 152751-57-0 | 98.0% | 186.08 (monomer) | 500 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Sevelamer hydrochloride is an orally active phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. It consists of polyallylamine crosslinked with epichlorohydrin.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Trazodone (hydrochloride) | 25332-39-2 | 99.6% | 50 MG
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This product is a triazolopyridine derivative, classified as a serotonin receptor antagonist and reuptake inhibitor (SARI). It demonstrates antidepressant and anti-insomnia activities by antagonizing α1- and α2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects. It is intended for research use only.
- Classified as a serotonin receptor antagonist and reuptake inhibitor (SARI)
- Exhibits antidepressant and anti-insomnia activity
- Antagonizes α1- and α2-adrenergic receptors
- Antagonizes histamine H1 receptors
- Minimal anticholinergic effects
- Purity of 99.60%
- Molecular formula: C19H23Cl2N5O
- Appears as a white to off-white solid
- Soluble in DMSO and water
- Binds to 5-HT1A receptor with high affinity
- Inhibits key signaling pathways for neuroinflammatory markers
- Increases BDNF and CREB expression
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Aprindine hydrochloride | 33237-74-0 | 99.0% | C22H31ClN2 | 5 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Aprindine hydrochloride | 33237-74-0 | 99.0% | C22H31ClN2 | 5 MG
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Medchemexpress LLC Nebivolol hydrochloride | 152520-56-4 | 99.9% | 1 ML
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Nebivolol hydrochloride (R 065824) is an orally active beta receptor blocker with high beta(1)-receptor affinity. It possesses direct vasodilator properties and adrenergic blocking characteristics.
- Used for research into various diseases
- High beta(1)-receptor affinity
- Direct vasodilator properties
- Adrenergic blocking characteristics
- Orally active beta receptor blocker
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Medchemexpress LLC N,N-Dimethyl-3-(5-(2-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-indol-1-yl)propan-1-amine hydrochloride | 97.0% | C20H24ClN5O2S | 50 MG
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DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. It demonstrates remarkable inhibition against leukemia cell proliferation and is suitable for laboratory research. The compound shows minimal effects on normal cells.
- Inhibits BPTF with an IC50 value of 698 nM
- Shows remarkable inhibition against leukemia cell proliferation
- Inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM
- Significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM)
- Decreases downstream oncogene expression at concentrations between 2.5-20 μM
- Dose-dependently decreases c-Myc protein level
- Shows minimal effects on normal cells, indicating its safety
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Medchemexpress LLC Tiaramide hydrochloride | 35941-71-0 | MFCD01702832 | 98.7% | 392.30 | C15H19Cl2N3O3S | 5 MG
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Tiaramide hydrochloride is the hydrochloride salt of tiaramide, an analgesic research compound provided in milligram quantities for laboratory use. It is a light yellow solid with molecular formula C15H19Cl2N3O3S and molecular weight 392.30 g·mol-1. Typical purity is 98.7%, and the compound is commonly handled in DMSO for in vitro and pharmacological studies.
- Hydrochloride salt form for improved stability
- High purity (approximately 98.7%)
- Available in milligram-scale sizes for research use
- Light yellow solid suitable for analytical testing
- Soluble in DMSO for biological assays
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Medchemexpress LLC SRI-011381 hydrochloride | 2070014-88-7 | 99.6% | 365.94 | C20H32ClN3O | 200 MG
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SRI-011381 hydrochloride is an orally active TGF-β signaling agonist reported to exhibit neuroprotective effects in vitro and in vivo. It is supplied as a solid or as a DMSO solution for research use and is provided at high chemical purity.
- Orally active TGF-β signaling agonist.
- Promotes proliferation of mouse lung fibroblasts in vitro.
- Increases TGF-β1, NALP3, collagen-1, and α-SMA expression.
- Demonstrates neuroprotective effects in animal models, reducing inflammation and neuron loss.
- Available as a solid and as 10 mM solution in DMSO in multiple package sizes.
- High purity suitable for research applications.
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Medchemexpress LLC Alpelisib (hydrochloride) | 1584128-91-5 | C19H23ClF3N5O2S | 200 MG
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Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor. It demonstrates antineoplastic activity and effectively inhibits common PIK3CA somatic mutations.
- Potent, orally active, and selective PI3Kα inhibitor
- Effectively inhibits common PIK3CA somatic mutations
- Potently inhibits Akt phosphorylation in PI3Kα-transformed cells
- Induces G0/G1 phase cell cycle arrest in osteosarcoma cells
- Significantly reduces tumor volumes in osteosarcoma animal models
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Medchemexpress LLC SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) | 125941-87-9 | 99.8% | 324.24 | 1 MG
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SCH-23390 hydrochloride is a potent and selective dopamine D1-like receptor antagonist, also acting as a potent human 5-HT2C receptor agonist. It binds with high affinity to various serotonin receptors and inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels. This compound can reverse inhibitory effects on NLRP3 expression and inflammasome pathways in BV-2 cells, and has been used in studies of neurological disorders like psychosis and Parkinson's disease.
- Potent and selective dopamine D1-like receptor antagonist
- Potent and high efficacy human 5-HT2C receptor agonist
- Binds with high affinity to 5-HT2 and 5-HT1C receptors
- Inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels
- Used in studies of neurological disorders like psychosis and Parkinson's disease
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Medchemexpress LLC Azasetron hydrochloride | 123040-16-4 | 99.8% | C17H21Cl2N3O3 | 100 MG
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Azasetron hydrochloride is a benzamide derivative that functions as a potent and selective antagonist of the 5-HT3 receptor, demonstrating an IC50 of 0.33 nM against this target. It has been investigated for its potential in studies related to chemotherapy-induced nausea and vomiting (CINV) and has shown the ability to penetrate the skin and enter systemic circulation in in vivo models.
- Mechanism of action: Potent and selective 5-HT3 receptor antagonist.
- Target affinity: IC50 of 0.33 nM for 5-HT3 receptor.
- Chemical classification: Benzamide derivative.
- Molecular formula: C17H21Cl2N3O3.
- Molecular weight: 386.27.
- Purity: 99.76%.
- Physical characteristics: White to off-white solid.
- Solubility: Soluble in water (20 mg/mL) and DMSO (2.22 mg/mL).
- Research application: Used in CINV studies.
- Pharmacokinetic property: Penetrates skin and enters systemic circulation in animal models.
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Medchemexpress LLC PRT062607 hydrochloride (P505-15 hydrochloride) | 1370261-97-4 | C19H24ClN9O | 1 ML
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PRT062607 Hydrochloride (P505-15 Hydrochloride) is an orally available Syk inhibitor with an IC50 of 1 nM. It inhibits inflammation and induces apoptosis, demonstrating potent antitumor activity in tumor xenograft mouse models. In vitro, it also exhibits significant activity against a variety of kinases, including Fgr, MLK1, Yes, Flt3, PAK5, Lyn, cSRC, Lck, Pyk, and FAK.
- Inhibits phosphorylation of ERK(Y204), AKT(S473), and SYK(Y352) in Ramos cells
- Inhibits BLNK Tyr84 phosphorylation
- Induces apoptosis in human whole blood
- Shows dose-dependent anti-inflammatory activity in rodent models of rheumatoid arthritis
- Inhibits B-cell activation
- Prevents tumor formation in mouse xenograft models
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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG
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EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.
- Effective and selective DOT1L inhibitor
- Reduces H3K79me2 and H3K79me1 levels
- Down-regulates HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cell proliferation
- Promotes differentiation and apoptosis of leukemia cells
- Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
- Demonstrates selectivity over other histone methyltransferases (HMTs)
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eMolecules 29671-92-9 | Chloroformamidine hydrochloride | Oakwood Chemicals | MFCD00035527 | 114.960 | CH4Cl2N2 | 97.000 | Cl.NC(Cl)=N | 1g | 480138803
Chloroformamidine hydrochloride | Oakwood Chemicals | 29671-92-9 | MFCD00035527 | 114.960 | CH4Cl2N2 | 97.000 | Cl.NC(Cl)=N | 1g | 480138803
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Medchemexpress LLC Amelparib hydrochloride | 98.4% | 379.88 | 10 MG
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Amelparib hydrochloride is a potent, orally active, and water-soluble inhibitor of PARP-1. It inhibits PARP-1 activity and cellular PAR formation, acting as a potential neuroprotective agent.
- Potent, orally active, and water-soluble inhibitor of PARP-1
- Inhibits PARP-1 activity (IC50 = 18.5 nM)
- Inhibits cellular PAR formation (IC50 = 10.7 nM)
- Potential neuroprotective agent
- Potential for the research of acute ischaemic stroke
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