Flavonoids
TARGETMOL CHEMICALS INC Apigenin 200MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sleep medication. Apigenin has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Purity 99.66%
Medchemexpress LLC (-)-Epigallocatechin | 970-74-1 | 99.7% | 306.27 | 25 MG
(-)-Epigallocatechin, a major flavonoid in green tea, prevents amyloid fibril formation by binding to unfolded polypeptides and stabilizing their native-like state. It also exhibits antimicrobial effects, eradicating E. faecalis biofilms and reducing virulence through hydroxyl radical induction.
- Most abundant flavonoid in green tea.
- Binds to unfolded native polypeptides.
- Prevents amyloid fibril conversion.
- Stabilizes native-like molecular states.
- Eradicates E. faecalis biofilms.
- Induces hydroxyl radicals in E. faecalis.
- Down-regulates E. faecalis virulence genes.
Medchemexpress LLC Apigenin (4',5,7-Trihydroxyflavone) | 520-36-5 | HY-N1201 | 98.9% | 270.24 | 500 MG
Apigenin (4',5,7-Trihydroxyflavone) is identified as a competitive CYP2C9 inhibitor with a Ki of 2 μM. It demonstrates the ability to inhibit cell proliferation, with growth inhibition rates of 38%, 71%, and 99% at concentrations of 20, 40, and 80 μM respectively. The compound also suppresses clone formation in SGC-7901 cells in a dose- and time-dependent manner.
- Competitive inhibitor of Cytochrome P450 2C9 (CYP2C9).
- Exhibits cell proliferation inhibitory activity.
- Suppresses clone formation in specific cell lines.
Apexbio Technology LLC AST 487 630124-46-8 10mM (in 1mL DMSO)
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Selleck Chemical LLC AMG 487
AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8 0 nM and 8 2 nM respectively
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C₃₂H₂₈F₃N₅O₄ | 50 MG
AMG 487 S-enantiomer is the S enantiomer of AMG 487 and functions as an antagonist of the chemokine receptor CXCR3. This chemical compound is provided as an off-white to light yellow solid with a purity of 99.94%.
- Functions as an antagonist of the chemokine receptor CXCR3
- High purity of 99.94%
- Supplied as a solid
- Soluble in DMSO
Cayman Chemical Luteolin Inhibitors
A common dietary phenolic flavone; inhibits soybean and reticulocyte 15-lipoxygenases (IC50 = 0.6 µM); inhibits the release of TNFα from neutrophils; inhibits matrix metalloproteinases
Medchemexpress LLC Myricetin (Standard) | 529-44-2 | MFCD00006827 | C₁₅H₁₀O₈ | 50 MG
Myricetin (Standard) is an analytical standard and a common plant-derived flavonoid, also identified as an endogenous human gut microbiota metabolite. It is extensively researched for its strong anti-oxidant, anticancer, antidiabetic, and anti-inflammatory properties, making it ideal for various research and analytical applications.
- For research and analytical applications
- Plant-derived flavonoid and gut microbiota metabolite
- Strong anti-oxidant, anticancer, antidiabetic, anti-inflammatory activities
- Analytical standard grade for reference assays
- Supports qualitative, quantitative, and methodological research
- Compatible with HPLC, GC, and MS techniques
- Solid, light yellow to yellow appearance
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 100 MG
AMG 487 S-enantiomer is the S enantiomer of AMG 487, which acts as an antagonist of the chemokine receptor CXCR3. This chemical compound is provided as an off-white to light yellow solid with high purity.
- High purity: 99.94%
- Antagonist of chemokine receptor CXCR3
- Stable as powder at -20°C for 3 years, and 4°C for 2 years
- Stable in solvent at -80°C for 2 years, and -20°C for 1 year
- Soluble in DMSO at 100 mg/mL
eMolecules 3,4'-Dihydroxyflavone | 14919-49-4 | MFCD00017690 | 1g
Combi-Blocks | 3,4'-Dihydroxyflavone | 1g | 267185521 | QC-6653 | 95.000 | 14919-49-4 | MFCD00017690 | 254.241 | C15H10O4
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Medchemexpress LLC Hesperidin (Standard) | 520-26-3 | C28H34O15 | 1 ML
Hesperidin, also known as Hesperetin 7-rutinoside, is a flavanone glycoside naturally isolated from citrus fruits. This compound is recognized for its various biological properties, including significant antioxidant effects, the ability to decrease inflammatory mediators, and demonstrated antitumor and antiallergic activities.
- Decreases inflammatory mediators
- Significant antioxidant effects
- Exhibits antitumor activity
- Exhibits antiallergic activity
- Supports research in cancer
- Targets apoptosis
- Targets autophagy
- Targets reactive oxygen species (ROS)
- Functions as an endogenous metabolite