Flavonoids
Medchemexpress LLC Catechin 7-O-β-D-glucopyranoside | 65597-47-9 | 452.41 | 1 MG
Catechin 7-O-β-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. It demonstrates antioxidant and anti-inflammatory activities, and mitigates mitochondrial dysfunction. This product can be utilized in research pertaining to intestinal inflammatory diseases.
- Exhibits antioxidant and anti-inflammatory activities
- Attenuates mitochondrial dysfunction
- Protective effect against Streptozotocin-induced cell damage
- Mild protective effect against LPS/D-GalN induced lethality in mice
- Prevents intestinal inflammatory damages in rat colitis models
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | MFCD00006835 | 50 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis* that exhibits anti-inflammatory activity. It protects renal cells from nicotine-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. This orally active compound also inhibits PKM2, COX-2, and 5-LOX, and has demonstrated antioxidant activity and efficacy in various animal models.
- Isolated from *Clerodendrum phlomidis*
- Exhibits anti-inflammatory activity
- Protects renal cells from nicotine-associated cytotoxicity
- Inhibits PKM2, COX-2, and 5-LOX
- Orally active
- Reduces malondialdehyde (MDA) and reactive oxygen species (ROS) levels
- Increases superoxide dismutase (SOD) and glutathione (GSH) levels
- Ameliorates ischemia/reperfusion injury
- Improves high-fat diet-induced non-alcoholic fatty liver disease and obesity
- Purity of 99.89%
- Appearance is a white to off-white solid
Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | 50 MG
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. It is a synthetic analogue of flavanone, with potential for hepatic steatosis and dyslipidemia research.
- Inhibitor of SREBP maturation
- Inhibitor of lipid synthesis
- Synthetic analogue of flavanone
- Potential for hepatic steatosis research
- Potential for dyslipidemia research
Medchemexpress LLC Luteolin-4'-O-glucoside | 6920-38-3 | 5 MG
Luteolin-4'-O-glucoside is identified as an IL-5 inhibitor with an IC50 of 3.7 μM. It exhibits resistance to hyperuricemia and acute gouty arthritis activity, and also demonstrates anticancer activity.
- It is an interleukin-5 (IL-5) inhibitor.
- It has an IC50 of 3.7 μM against IL-5.
- It resists hyperuricemia.
- It resists acute gouty arthritis activity.
- It shows anticancer activity.
- It exhibits cytotoxic activity against NCI-H929, U266, and OPM2 cell lines.
Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | MFCD00006734 | 5 MG
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. It is a synthetic analogue of flavanone and has potential for hepatic steatosis and dyslipidemia research.
- Inhibitor of SREBP maturation
- Inhibitor of lipid synthesis
- Synthetic analogue of flavanone
- Potential for hepatic steatosis research
- Potential for dyslipidemia research
Medchemexpress LLC Nicotiflorin | 17650-84-9 | MFCD03427292 | 99.9% | 594.52 | C27H30O15 | 10 MG
Nicotiflorin is a kaempferol-derived flavonoid glycoside extracted from Carthamus tinctorius. It exhibits antiglycation activity and has reported neuroprotective effects in preclinical studies. Supplied as a research-grade solid, it is intended for biochemical and neuropharmacology investigations.
- High purity: 99.85% (analytical)
- Molecular formula: C27H30O15; molecular weight: 594.52
- Physical form: light yellow solid
- Storage: solid at 4°C, protect from light; solutions stored at -20°C to -80°C
- Available in small solid packs suitable for research use
Medchemexpress LLC Myricetin | 529-44-2 | MFCD00006827 | 98.5% | 318.24 g/mol | C15H10O8 | 10 MG
Myricetin is an analytical reference standard of myricetin (CAS 529-44-2), a plant-derived flavonoid used as a reference material in analytical and research applications. Supplied as a high-purity solid suitable for HPLC, method validation, and quantitative analysis.
- Analytical reference standard for HPLC and method validation.
- High purity: 98.5% assay.
- Provided in small, controlled pack sizes for accurate weighing.
- Known molecular weight and formula for identification and calibration.
- Intended for research and analytical applications.
Medchemexpress LLC Methyl-hesperidin | 11013-97-1 | 98.4% | 624.59 g/mol | C29H36O15 | 10 MG
Methyl-hesperidin is a flavonoid derivative used as an analytical standard and research reagent; it exhibits vasodilating activity and is provided for laboratory use.
- Purity: 98.39%.
- Cas number: 11013-97-1.
- Molecular weight: 624.59 g/mol.
- Molecular formula: C29H36O15.
- Supplied as a dry powder for analytical and in vitro applications.
- Available in small pack sizes including 10 mg.
Medchemexpress LLC Apigenin-7-glucuronide | 29741-09-1 | 446.36 | 1 MG
Apigenin-7-glucuronide is a compound that inhibits Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, and 0.27 μM for MMP-3, MMP-8, MMP-9, and MMP-13, respectively. This product is for research use only.
- Inhibits matrix metalloproteinases (MMPs)
- Effective against MMP-3, MMP-8, MMP-9, and MMP-13
- Soluble in DMSO up to 250 mg/mL
Medchemexpress LLC 4'-Methoxyflavone | 4143-74-2 | 99.63% | 252.26 | 25 MG
4'-Methoxyflavone is a flavonoid with antioxidant properties and anti-proliferative activity against cancer cells. It can inhibit cycle-dependent kinases, leading to cell cycle arrest, and regulate cell signaling pathways to influence cell proliferation and apoptosis. This compound can be used in cancer chemoprevention research.
- Flavonoid with antioxidant properties
- Anti-proliferative activity against cancer cells
- Inhibits cycle-dependent kinases
- Leads to cell cycle arrest
- Regulates cell signaling pathways to influence cell proliferation and apoptosis
- Used in cancer chemoprevention research
Medchemexpress LLC Apigenin | 520-36-5 | 270.24 | 1 G
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor that inhibits cytochrome P450 2C9 in a purified enzyme system. It demonstrates dose- and time-dependent inhibition of cell proliferation in SGC-7901 cells.
- Competitive CYP2C9 inhibitor with a Ki of 2 μM.
- Inhibits cytochrome P450 2C9 in a purified, reconstituted enzyme system.
- Demonstrates inhibition of cell proliferation in SGC-7901 cells in a dose- and time-dependent manner.
- Achieves growth inhibition rates of 38%, 71%, and 99% at 20, 40, and 80 μM, respectively, on the 7th day.
- Cloning efficiency in SGC-7901 cells treated with 80 μM for 24 and 48 hours was 9.8% and 5%, respectively.
Apexbio Technology LLC (-)-epicatechin gallate 1257-08-5 20mg
(-)-Epicatechin gallate (ECG) is a catechin compound abundant in green tea displaying bioactivity to modulate cell proliferation apoptosis and gene expression pathways In colon HCT-116 cells ECG induces apoptosis through activating transcription factor 3 (ATF3) regulated via activation of early growth response protein 1 (EGR-1) In these cancer cells ECG upregulates apoptotic factor NAG-1 and increases caspase-3 activity at concentrations around 150 M ECG s cytotoxic potency differs among cell types with an NR50 (midpoint cytotoxic concentration) of approximately 67 M in HSC-2 oral cancer cells while normal human fibroblast HGF-2 cells show greater resistance with an NR50 near 100 M ECG metabolites identified in rat urine include various O-methylated derivatives useful as biomarkers for metabolism studies ECG serves as a research tool for oncology mechanisms and apoptosis signaling pathways
Apexbio Technology LLC (-)-epicatechin 490-46-0 10mM (in 1mL DMSO)
(-)-Epicatechin (CAS 490-46-0) is a flavonoid compound known for inducing pancreatic -cell regeneration and modulating nitric oxide (NO) metabolism It inhibits nitric oxide-related nitrite formation induced by interferon- and lipopolysaccharide in mouse macrophages and reduces peroxynitrite-mediated tyrosine nitration in HL-60 human leukemia cells Additionally in human endothelial cells (HUVECs) it enhances NO production displaying vasodilatory properties In diabetic rat models (alloxan-induced) (-)-epicatechin administration promotes -cell recovery reduces hyperglycemia and prevents -cell necrosis This profile underscores its research relevance for diabetes and vascular biology investigations
TARGETMOL CHEMICALS INC TANGERETIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tangeretin (NSC-618905) a flavonoid from citrus fruit peels has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models and was also selected as a Notch-1 inhibitor. purity: 99%
Apexbio Technology LLC Luteolin 491-70-3 10mM (in 1mL DMSO)
Luteolin (CAS 491-70-3) is a naturally occurring flavonoid characterized by anti-inflammatory antioxidant and chemopreventive properties Mechanistically it suppresses lipopolysaccharide (LPS)-mediated inflammation by inhibiting production of pro-inflammatory cytokines such as TNF- and IL-6 reducing inducible nitric oxide synthesis and blocking NF- B and AP-1 signaling pathways Additionally luteolin impedes TNF- -induced cyclooxygenase-2 (COX-2) expression In preclinical in vivo studies it exhibits antiproliferative activity against tumor cell proliferation exemplified by growth inhibition in Lewis lung carcinoma models Consequently luteolin is widely investigated in biomedical research targeting inflammation oxidative stress and cancer biology