Phenols
Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.2% | 10 MM * 1 ML
PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It recruits the E3 ligase Von Hippel-Lindau, leading to the ubiquitination and subsequent degradation of BCR-ABL1.
- Exhibits cell proliferation with specific IC50 values for BCR-ABL1 WT, T315I, and G250E cells.
- Induces the degradation of BCR-ABL1 and c-ABL1.
- Inhibits downstream signaling via the STAT5 pathway.
- Demonstrates dose- and time-dependent action in K562 and Ba/F3 cells.
Medchemexpress LLC Polyethylene glycol 4000 | 25322-68-3 | MFCD00081839 | 4000.00 | H(OCH2CH2)nOH | 100g
PEG4000 can be used as an excipient such as Ointment base lubricant etc Pharmaceutical excipients or pharmaceutical auxiliaries refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations which can improve the stability solubility and processability of pharmaceutical preparations Pharmaceutical excipients also affect the absorption distribution metabolism and elimination (ADME) processes of co-administered drugs[1]
Medchemexpress LLC Perospirone hydrochloride | 129273-38-7 | 99.9% | 10 MM * 1 ML
Perospirone hydrochloride (SM-9018) is an orally active antagonist of the 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). It also acts as a partial agonist of the 5-HT1A receptor (Ki of 2.9 nM). This compound is classified as an atypical antipsychotic agent and has potential for research related to schizophrenic disease. It is for research use only and not sold to patients.
- Orally active antagonist of the 5-HT2A receptor (Ki of 0.6 nM)
- Antagonist of the dopamine D2 receptor (Ki of 1.4 nM)
- Partial agonist of the 5-HT1A receptor (Ki of 2.9 nM)
- Classified as an atypical antipsychotic agent
- Potential for research into schizophrenic disease
eMolecules (S)-1-(2,6-dimethylphenyl)ethan-1-amine | 1213479-78-7 | MFCD08057435 | 100mg
Ambeed | (S)-1-(2,6-dimethylphenyl)ethan-1-amine | 100mg | 601096254 | A835812 | | 1213479-78-7 | MFCD08057435 | 149.237 | C10H15N
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Medchemexpress LLC (R)-BPO-27 | 1415390-47-4 | 99.9% | 548.34 | 1 MG
(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC50 of 4 nM. It inhibits the CFTR current by 50% at 0.53 nM in HEK-293T cells and prevents fluid accumulation in closed midjejunal loops in mice.
- Potent CFTR inhibitor with an IC50 of 4 nM.
- Orally active and ATP-competitive.
- The R enantiomer, (S)-BPO-27 does not affect channel parameters.
- Exhibits slow metabolism and sustained serum levels for at least 4 hours.
- Oral bioavailability of ~94% in mice.
- Solid, white to off-white appearance.
Medchemexpress LLC BDNF Human CHO 10ug
Recombinant human brain-derived neurotrophic factor (BDNF), expressed in CHO cells and supplied lyophilized for research use. The material corresponds to residues H129-R247, is >95% pure by reducing SDS-PAGE, and is formulated from 0.22 μm filtered PBS. It is intended for in vitro studies of neuronal survival, differentiation, and receptor signaling; store lyophilized at -20°C and aliquot for long-term storage at -80°C.
- Expressed in CHO cells for mammalian post-translational modifications.
- Covers residues H129-R247 relevant to receptor binding.
- Purity greater than 95% by reducing SDS-PAGE.
- Lyophilized from a 0.22 μm filtered PBS solution for stability.
- Suitable for in vitro studies of neuronal survival, differentiation, and signaling.
- Stable when frozen; aliquot and store at -20°C or -80°C for extended storage.
Medchemexpress LLC Potassium hexacyanoferrate(III) | 13746-66-2 | MFCD00011392 | 99.5% | 329.24 g/mol | K3Fe(CN)6 | 100g
Potassium hexacyanoferrate(III) 99 5% an iron-based cyanide complex is an oxidizing agent that can be used in the biocatalytic oxidation Potassium hexacyanoferrate(III) 99 5% can be used to prepare Glucose conductometric biosensor[1][2]
eMolecules Ambeed / 2-Bromo-110-phenanthroline / 250mg / 525105643 / A188184 / / 22426-14-8 / MFCD13152102 / 259.106 / C12H7BrN2
Ambeed / 2-Bromo-110-phenanthroline / 250mg / 525105643 / A188184 / / 22426-14-8 / MFCD13152102 / 259.106 / C12H7BrN2
Medchemexpress LLC 4-hydroxybenzoic acid-13C | 146672-02-8 | 99.2% | 139.11 | C6(13C)H6O3 | 50mg
4-Hydroxybenzoic acid-13C is the 13C labeled 4-Hydroxybenzoic acid[1] 4-Hydroxybenzoic acid a phenolic derivative of benzoic acid could inhibit most gram-positive and some gram-negative bacteria with an IC50 of 160 g/mL[2]