Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist. It exhibits high affinity for the DP1, EP2, and IP receptors, with lower affinity for EP1, EP4, EP3, FP, and TP receptors. Activation of IP, DP1, and EP2 receptors can lead to vasodilation of human pulmonary arteries.
- Potent DP1 and EP2 agonist.
- High affinity for DP1, EP2, and IP receptors.
- Can lead to vasodilation of human pulmonary arteries.
- Inhibits the viability of cultured endothelial colony-forming cells.