Carboxylic acids and derivatives
![Medchemexpress LLC N-(2-(1H-indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine | 2247950-73-6 | 98.0% | 386.42 g/mol | C22H19FN6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC N-(2-(1H-indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine | 2247950-73-6 | 98.0% | 386.42 g/mol | C22H19FN6 | 5 MG
KYN-101 is a potent, selective, orally active aryl hydrocarbon receptor (AHR) inhibitor used in research. It reduces CYP1A1 mRNA expression and has demonstrated anti-cancer activity in preclinical studies. Supplied as a small-quantity research compound with accompanying quality documentation.
- Potent, selective aryl hydrocarbon receptor (AHR) inhibitor.
- Orally active in preclinical models.
- Decreases CYP1A1 mRNA expression in cellular assays.
- Demonstrates anti-cancer activity in preclinical studies.
- Supplied as a small research quantity (e.g., 5 mg) with COA and datasheet.
- High purity (approximately 98.0%).
- For research use only; not for human or clinical use.
Apexbio Technology LLC LOXO-101 1223405-08-0 5mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Medchemexpress LLC Pigment Yellow 101 | 2387-03-3 | 98.06% | 50 MG
Pigment Yellow 101 is a yellow bis-azomethine pigment that exhibits solid-state fluorescence with excitation/emission at 411 nm/512 nm. This product is available as a commercial colorant.
- Yellow bis-azomethine pigment
- Excitation/emission: 411 nm/512 nm
- Exhibits solid-state fluorescence
- Available as a commercial colorant
Medchemexpress LLC Rhodamine 101 hydrochloride | 64339-18-0 | MFCD00210089 | >=95% | 563.51 | 5 MG
Rhodamine 101 chloride (Rhodamine 640 chloride) hydrochloride is a bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively.
- For research use only.
- We do not sell to patients.
Apexbio Technology LLC Sulforhodamine 101 60311-02-6 25mg
Sulforhodamine 101 (60311-02-6) is a red-emitting fluorescent dye primarily utilized as a selective marker for astrocytes Sulforhodamine 101 selectively accumulates in astrocytes enabling differentiation from surrounding neuronal populations In neurobiological studies using live tissue imaging including acute brain slice preparations the dye facilitates visualization of astroglial cell morphology and cellular dynamics Based on these properties Sulforhodamine 101 holds research potential in the study of astrocyte-specific responses morphological characteristics and cell cell interactions within neuronal tissues
Medchemexpress LLC PKUMDL-LC-101-D04 500mg | 2143896-83-5 | 378.93 g·mol⁻¹ | C14H23ClN4O2S2 | 500 MG
PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used in research on ferroptosis, lipid peroxidation, and inflammation. It increases GPX4 enzymatic activity in cell-free and cellular assays (reported pEC50 = 4.7) and protects cells from cholesterol peroxide-induced toxicity.
- Allosteric activator of GPX4, reported pEC50 = 4.7.
- Increases GPX4 activity to ~150% in cell-free and cellular extracts at reported concentrations.
- Demonstrated inhibition of ferroptosis and protection against lipid peroxide-induced cell death.
- Molecular weight ~378.93 g·mol⁻¹ and chemical formula C14H23ClN4O2S2.
- Supplied as a high-purity research chemical suitable for biochemical and cellular assays.
Medchemexpress LLC VH 101, acid | 2408341-97-7 | 98.8% | C28H35FN4O6S | 25 MG
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. It contains an E3 ligase ligand plus an alkyl linker with a terminal amine, making it ready for conjugation to a target protein ligand.
- Functionalized von-Hippel-Lindau (VHL) protein ligand
- For PROTAC research and development
- Contains an E3 ligase ligand
- Alkyl linker with terminal amine for conjugation
- VHL protein is a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes
- Used by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 1mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
Selleck Chemical LLC MZ-101-E1913-25MG
MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0 041 M By depleting muscle glycogen MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 50 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It demonstrates cellular effects on HEK293 cells by inhibiting human EAAT1. This product is for research use only.
- Acts as an EAAT1 inhibitor
- Demonstrates cellular effects on HEK293 cells
- Inhibits human EAAT1 anion currents
Apexbio Technology LLC LOXO-101 1223405-08-0 100mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 25 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It is for research use only.
- Inhibits EAAT1 anion currents in a concentration-dependent manner
- Suitable for research applications
Medchemexpress LLC PKUMDL-LC-101-D04 1g | 2143896-83-5 | 378.94 | C14H23ClN4O2S2 | 1 G
PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) supplied as a hydrochloride research chemical. It increases GPX4 enzymatic activity (reported pEC50 = 4.7) and has been used in cell and animal studies to inhibit ferroptosis and reduce inflammation. Molecular formula C14H23ClN4O2S2; molecular weight 378.94 Da.
- Allosteric activator of glutathione peroxidase 4 (GPX4).
- Reported activity pEC50 = 4.7 in biochemical assays.
- Hydrochloride salt form for improved stability and handling.
- Molecular formula C14H23ClN4O2S2, molecular weight 378.94 Da.
- Provided as a research reagent; not for human use.
- Typical pack size: 1 g.
Apexbio Technology LLC AT-101 90141-22-3 50mg
AT-101 (CAS 90141-22-3) is a natural BH3-mimetic isolated from cottonseed identified as a pan-inhibitor of the anti-apoptotic proteins Bcl-2 Bcl-xL and Mcl-1 Mechanistically AT-101 binds to the hydrophobic BH3-binding grooves of these Bcl-2 family proteins impeding their heterodimerization with pro-apoptotic members (e g Bad Bid and Bim) thereby restoring apoptotic signaling pathways It has been shown to promote apoptosis in cell-based assays via caspase-9 activation and modulation of Puma Noxa Bax and XIAP protein expression Preclinical studies demonstrate anti-tumor activity in prostate cancer xenografts AT-101 is currently evaluated in clinical trials against castration-resistant prostate cancer and other cancers
Medchemexpress LLC RG-101 sodium | 00-00-0 | 95.4% | 8537.6 (free acid) | C295H410N78Na19O146P19S17 | 5 MG
RG-101 sodium is a hepatocyte-targeted N-acetylgalactosamine (GalNAc)-conjugated antisense oligonucleotide that antagonizes microRNA-122 (miR-122), a host factor important for hepatitis C virus replication. Supplied as a sodium salt, it is used in research to study miR-122 biology and antiviral mechanisms.
- Hepatocyte-targeted GalNAc conjugate for liver delivery.
- Antagonizes miR-122 to modulate hepatitis C virus-related pathways.
- High molecular weight oligonucleotide for sequence-specific activity.
- High purity (95.4%) suitable for research applications.
- Soluble in water; sonication may be required for dissolution.
- Recommended storage at -20°C; in solution store at -80°C for long-term.