Aminobenzoic acids and derivatives
AdipoGen Globosuxanthone A
Chemical. CAS 917091-74-8. Formula C15H12O7. MW 304.3. Isolated from fungus species unknown. Potent anticancer agent. Inhibits cell growth, proliferation and survival of human tumor cells lines in vivo and in vitro. Exhibits strong cytotoxicity against a panel of human solid tumor cell lines, disrupting the cell cycle leading to the accumulation of cells in either G2/M or S phase and inducing classic signs of apoptosis. Antifungal agent against Candida albicans.
AdipoGen Globosuxanthone A
Chemical. CAS 917091-74-8. Formula C15H12O7. MW 304.3. Isolated from fungus species unknown. Potent anticancer agent. Inhibits cell growth, proliferation and survival of human tumor cells lines in vivo and in vitro. Exhibits strong cytotoxicity against a panel of human solid tumor cell lines, disrupting the cell cycle leading to the accumulation of cells in either G2/M or S phase and inducing classic signs of apoptosis. Antifungal agent against Candida albicans.
TARGETMOL CHEMICALS INC MIVEBRESIB 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Mivebresib (ABBV-075) also known as ABBV-075 is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein(s) thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling prevents the expression of certain growth-promoting genes and leads to an inhibition of cell growth in susceptible tumors. Also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins. purity: 98%
AdipoGen Cyclosporin A
Chemical. CAS 59865-13-3. Formula C62H111N11O12. MW 1202.6. Isolated from Tolypocladium inflatum. Potent immunosuppressant same as FK-506 Prod. No. AG-CN2-0047 and rapamycin Prod. No. AG-CN2-0025. Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B PP2B calcineurin. Prevents the dephosphorylation of nuclear factor of activated T cells NFAT transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 IL-2. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases e.g. atopic dermatitis and with potential anti-rheumatic activity rheumatoid arthritis. Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor.