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Filtered Search Results
Medchemexpress LLC Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-(methyl-d3)- | 1443331-82-5 | >99.8% | C21H13D3F4N4O2S | 5 MG
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Deutenzalutamide-d3 (Enzalutamide-d3) is a deuterium-labeled variant of Enzalutamide. Enzalutamide is recognized as an androgen receptor (AR) antagonist, demonstrating an IC50 of 36 nM in LNCaP prostate cells. This compound is primarily used for research purposes.
- Deuterium-labeled compound for research applications
- Potent androgen receptor antagonist
- IC50 of 36 nM in LNCaP prostate cells
- High purity with >99.8% by LCMS
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Medchemexpress LLC Nelociguat (BAY60-4552) | 625115-52-8 | 99.7% | C19H17FN8O2 | 50 MG
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Nelociguat (BAY60-4552) is a light yellow to yellow solid compound with a molecular weight of 408.39. Intended for research use only, it acts as a stimulator of nitric oxide sensitive soluble guanylate cyclase.
- Metabolite of riociguat, formed via cytochrome P450 isoenzymes.
- Decreases urine output and improves survival in spontaneously hypertensive stroke-prone rats.
- Reduces microalbuminuria and attenuates the rise in mean arterial pressure at higher doses.
- Dose-dependently decreased urine output during a 7-week treatment.
- Combination therapy with vardenafil showed synergistic beneficial effects.
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Medchemexpress LLC (R)-N-(1-(3-methoxyphenyl)ethyl)-4-(pyridin-4-yl)benzamide | 1127308-52-4 | 99.9% | 50 MG
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ROCK inhibitor-2 is a selective dual inhibitor of Rho-associated kinases ROCK1 and ROCK2 used for laboratory research. It inhibits ROCK-mediated phosphorylation such as pMYPT1 and has reported antitumor activity in preclinical studies. The compound is supplied as a solid or as a DMSO solution and is intended for research use only.
- Selective dual inhibitor of ROCK1 and ROCK2.
- Inhibits phosphorylation of pMYPT1.
- High purity (99.9%).
- Molecular weight 332.40 g·mol⁻¹, formula C21H20N2O2.
- Available as solid or 10 mM solution in DMSO.
- Intended for laboratory research use only.
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Medchemexpress LLC hSMG-1 inhibitor 11e | 1402452-10-1 | 99.9% | 517.60 g/mol | C26H27N7O3S | 10MG
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hSMG-1 inhibitor 11e is a potent, selective small-molecule inhibitor of human SMG-1 kinase with sub-nanomolar activity. It demonstrates strong selectivity versus related PI3K-like kinases and CDKs and is supplied as a high-purity research-grade compound with supporting analytical documentation for biochemical and cellular studies.
- Sub-nanomolar potency against hSMG-1 (IC50 <0.05 nM).
- Selective versus mTOR and PI3K isoforms with reported >900-fold selectivity.
- High reported purity suitable for research applications.
- Provided with supporting analytical files, including COA, LCMS, and HNMR.
- Intended for research use only; not for human or clinical use.
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Medchemexpress LLC Frakefamide TFA | 00-00-0 | 99.2% | 677.64 g·mol⁻¹ | C32H35F4N5O7 | 5 MG
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Frakefamide TFA is a peptide analgesic supplied as the trifluoroacetate salt that acts as a peripherally selective μ-opioid receptor agonist. It has limited ability to cross the blood-brain barrier, making it useful for research into peripheral analgesia and opioid receptor pharmacology. The product is provided in small solid quantities and as prepared DMSO solutions, with manufacturer-specified purity and molecular data.
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Medchemexpress LLC CCR2 antagonist 4 hydrochloride | 1313730-14-1 | MFCD16618399 | 99.9% | 476.32 g/mol | C21H22Cl2F3N3O2 | 10 MG
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CCR2 antagonist 4 hydrochloride is a research-grade small-molecule antagonist of the CC chemokine receptor 2 (CCR2), supplied as the hydrochloride salt for laboratory research use. It is used as a tool compound in studies of inflammation and chemotaxis. CAS 1313730-14-1; molecular formula C21H22Cl2F3N3O2; molecular weight 476.32 g/mol.
- High purity suitable for research applications.
- Provided as the hydrochloride salt for improved handling and stability.
- Intended for in vitro research and chemotaxis studies.
- Supplied in a 10 mg package.
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Medchemexpress LLC Brivanib | 649735-46-6 | MFCD13194684 | 99.5% | 370.38 g/mol | C19H19FN4O3 | 50 MG
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Brivanib is an ATP-competitive inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) supplied for research and analytical applications. It inhibits VEGFR2 with an IC50 of approximately 25 nM and shows activity against related kinases.
- ATP-competitive VEGFR2 inhibitor (IC50 ≈ 25 nM).
- Moderate activity against VEGFR-1 and FGFR-1; markedly less active versus PDGFR.
- Supplied as a solid powder with high purity (~99.5%).
- Suitable for biochemical and cellular research applications.
- Stable when stored under recommended conditions for powder and solutions.
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Medchemexpress LLC N'-(benzenesulfonyl)-2-fluoro-5-pyridazin-4-ylbenzohydrazide | 2055397-88-9 | MFCD31617713 | 99.6% | 372.37 g/mol | C17H13FN4O3S | 10 MG
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MOZ-IN-2 is a small-molecule inhibitor of MOZ (KAT6A) histone acetyltransferase with a reported IC50 of 125 μM. It is supplied as a solid powder and as a 10 mM DMSO solution for research use and is characterized by high purity and defined molecular properties.
- Inhibits MOZ (KAT6A) with IC50 = 125 μM.
- Available as solid (5 mg, 10 mg, 25 mg) and 10 mM solution in DMSO.
- Purity approximately 99.6%.
- Molecular weight 372.37 g/mol; formula C17H13FN4O3S.
- Suitable for biochemical and cell-based assays.
- Provided with Safety Data Sheet and characterization data.
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Medchemexpress LLC Tmp780 | 1422053-03-9 | 99.5% | 494.58 g/mol | C31H30N2O4 | 10 MG
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TMP780 is a small-molecule inverse agonist of the retinoic acid receptor-related orphan receptor γt (RORγt), reported with an in vitro IC50 of 13 nM and used as a research tool to modulate RORγt-dependent Th17 pathways and inflammatory responses.
- Potent RORγt inverse agonist with reported IC50 = 13 nM.
- Useful for cellular and preclinical studies of Th17/immunoregulatory pathways.
- Solid research compound, typically dissolved in DMSO for assays.
- Provided in small pack sizes suitable for screening and mechanistic work.
- CAS 1422053-03-9 enables database cross-referencing for structure and identifiers.
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Medchemexpress LLC MALAT1-IN-1 50mg | 827327-28-6 | 50 MG
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MALAT1-IN-1 is a small-molecule inhibitor of the MALAT1 long non-coding RNA supplied as a solid research reagent for in vitro studies of MALAT1-mediated pathways and cancer biology. The compound is provided at 50 mg and is characterized by high purity, defined storage conditions, and DMSO solubility suitable for laboratory assays.
- High purity (99.8%).
- Molecular formula C19H21N3O2, molecular weight 323.39 g/mol.
- Appearance: white to light yellow solid.
- Soluble in DMSO (100 mg/mL); ultrasonic agitation may be needed.
- Recommended storage: powder -20 °C (long term) or 4 °C; in solvent -80 °C or -20 °C.
- Supplied as a 50 mg solid and as a 10 mM solution in DMSO.
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Medchemexpress LLC BCATc Inhibitor 2 25mg | 406191-34-2 | 25 MG
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BCATc Inhibitor 2 is a selective small-molecule inhibitor of cytosolic branched-chain aminotransferase (BCATc) used in biochemical and neurodegeneration research. It is supplied as a solid and shows greater potency for cytosolic BCAT isoforms than for mitochondrial isoforms.
- Selective BCAT inhibitor with greater potency for BCATc than BCATm
- Reported IC50: 0.2 μM (rat BCATc), 0.8 μM (human BCATc), 3.0 μM (rat BCATm)
- Chemical formula C16H10ClF3N2O4S; molecular weight ~418.8 g/mol
- White to off-white solid suitable for in vitro research
- Certificate of analysis indicates typical purity around 98%
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Medchemexpress LLC Pamapimod | 449811-01-2 | >98.0% | 406.38 | C19H20F2N4O4 | 50 MG
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Pamapimod is a selective p38 mitogen-activated protein kinase (MAPK) inhibitor used as a research compound to study MAPK signaling and inflammatory pathways. It is supplied for in vitro and in vivo experimental applications and is characterized in manufacturer and distributor datasheets for research use.
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Medchemexpress LLC Dilmapimod 50mg | 444606-18-2 | 50MG
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Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease
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Medchemexpress LLC Nav1.7-IN-3 (N-linked arylsulfonamide) | 1788872-06-9 | 98.2% | 430.95 g/mol | C17H20ClFN4O2S2 | 5 MG
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Nav1.7-IN-3 is a selective, orally bioavailable inhibitor of the voltage-gated sodium channel Nav1.7 (IC50 = 8 nM). It exhibits limited central nervous system penetration and has demonstrated pain-relief activity in preclinical studies. Supplied as a research chemical with reported analytical data for use in pharmacology and mechanistic studies.
- Selective Nav1.7 inhibition (IC50 = 8 nM).
- Orally bioavailable in preclinical models.
- Limited CNS penetration, suitable for peripheral pain research.
- High reported purity (≈98.2%).
- Molecular weight 430.95 g/mol; formula C17H20ClFN4O2S2.
- Available in small research quantities for laboratory use.
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Medchemexpress LLC 2-((4,4-dimethyl-2-methylenecyclopent-1-en-1-yl)amino)-4-phenyl-1,3-naphthyridine | 511514-03-7 | ≥98.0% | 343.42 g/mol | C21H21N5 | 5 MG
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A small-molecule inhibitor that selectively binds the heterotrimeric Gαi subunit and blocks α2-adrenergic receptor-mediated regulation of intracellular cAMP. Intended for laboratory research use only.
- Selective inhibition of the Gαi subunit, blocking α2AR-mediated cAMP regulation.
- Small molecule with molecular formula C21H21N5 and molecular weight 343.42 g/mol.
- High purity (≥98%) and light yellow to yellow solid appearance.
- Soluble in DMSO (250 mg/mL); example in vivo formulations documented.
- Stable as powder at -20°C for long-term storage; defined solvent stability at lower temperatures.
- Supplied in a 5 mg quantity for laboratory testing.
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