Phenylhydrazines
Medchemexpress LLC JH-X-119-01 hydrochloride | 2591344-30-6 | 99.1% | 488.93 | 10 MG
JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. It ameliorates LPS-induced sepsis in mice by decreasing phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro. It selectively inhibits IRAK1 phosphorylation. In vivo, it improves survival and decreases immunopathies of LPS-challenged mice, increasing survival at doses of 5 mg/kg and 10 mg/kg body weight.
- Potent and selective IRAK1 inhibitor
- Ameliorates LPS-induced sepsis in mice
- Decreases phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro
- Selectively inhibits IRAK1 phosphorylation
- Improves survival and decreases immunopathies in LPS-challenged mice
- For research use only
Medchemexpress LLC SYM 2081 | 31137-74-3 | 98.0% | 161.16 g/mol | C6H11NO4 | 5 MG
SYM 2081 is a potent, selective kainate receptor agonist used as a research reagent to study excitatory neurotransmission, neuroprotection, and pain models. It modulates glutamate transport and elicits activity in kainate receptor assays; supplied as a purified solid for laboratory research (CAS 31137-74-3, formula C6H11NO4). For research use only.
- Potent, selective agonist of kainate receptors.
- Useful for studies of excitatory neurotransmission and synaptic physiology.
- Supports research into neuroprotection and hypoxic-ischemic injury models.
- High purity suitable for biochemical and pharmacological assays.
- Supplied as a stable solid for storage and experimental use.
Medchemexpress LLC Medetomidine (hydrochloride) | 86347-15-1 | 99.8% | 236.74 | 5 MG
Medetomidine hydrochloride from MedChemExpress is provided for laboratory chemical applications and substance manufacturing. This product is a white to off-white solid.
- Suitable for laboratory chemicals and substance manufacturing
- White to off-white solid appearance
- Store at 4°C, sealed and away from moisture
- Purity of 99.8% confirmed by LCMS
- For research use only; not validated for medical applications
Medchemexpress LLC Methoxyamine hydrochloride | 593-56-6 | MFCD00012951 | 98.0% | 83.52 g/mol | CH5NO·HCl | 5g
Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor Methoxyamine hydrochloride binds to 3 hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents[1][2]
Medchemexpress LLC Sucunamostat (hydrochloride) | 00-00-0 | 98.1% | C22H23ClN4O8 | 10MG
Sucunamostat hydrochloride is an orally active, reversible enteropeptidase inhibitor used in biochemical and pharmacological research to investigate protein digestion and related metabolic pathways. It is supplied as a hydrochloride salt for consistent handling and formulation in laboratory studies.
- Orally active, reversible enteropeptidase inhibitor.
- Low-nanomolar potency against rat and human enteropeptidase (reported IC50s).
- Suitable for in vitro and in vivo studies of protein digestion and metabolic pathways.
- Provided as a stable hydrochloride salt for reproducible handling.
- High purity suitable for research applications (reported purity 98.1%).
Medchemexpress LLC Idalopirdine hydrochloride | 467458-02-2 | 99.6% | C20H20ClF5N2O | 1 ML
Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. It is for research use only and may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders.
- Potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM
- May be used in studies of Alzheimer's disease and schizophrenia
- Soluble in DMSO (≥ 25 mg/mL) and H₂O (2 mg/mL)
- Solid form storage: 4°C, sealed, away from moisture
- In solvent storage: -80°C for 6 months; -20°C for 1 month
- Molecular weight: 434.83
- Appearance: White to gray solid
Medchemexpress LLC Pioglitazone hydrochloride | 112529-15-4 | 100.0% | C19H21ClN2O3S | 1 ML
Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. It can ameliorate insulin resistance and diabetes, attenuates the loss of body weight and cardiac hypertrophy, reduces elevated serum glucose levels, and improves associated dyslipidemia. In vitro, it completely abrogates AGEs-induced beta cell necrosis and prevents AGEs-induced increment in caspase-3 activation.
- Potent and selective PPARγ agonist
- Ameliorates insulin resistance and diabetes
- Attenuates loss of body weight and cardiac hypertrophy
- Reduces elevated serum glucose levels
- Improves associated dyslipidemia
- Completely abrogates AGEs-induced beta cell necrosis
- Prevents AGEs-induced increment in caspase-3 activation
Medchemexpress LLC Cardiogenol C hydrochloride | 1049741-55-0 | 99.8% | 296.75 g/mol | C13H17ClN4O2 | 10MG
Cardiogenol C hydrochloride is a cardiomyogenic small-molecule research compound used to induce differentiation of pluripotent stem cells into cardiomyocytes and to study cardiac development and repair. Supplied as the hydrochloride salt with high reported purity, it is provided in small laboratory pack sizes for research applications.
- Induces cardiomyogenic differentiation in embryonic and pluripotent stem cells.
- High reported purity (99.8%).
- Molecular formula C13H17ClN4O2; molecular weight 296.75 g/mol.
- Soluble in DMSO (≥59 mg/mL) and moderately soluble in water (≈2 mg/mL).
- Provided as a solid hydrochloride salt in small pack sizes suitable for laboratory use.
- Store solids at 4°C; solutions stable at -80°C for up to 6 months and -20°C for 1 month.
Medchemexpress LLC 2-bromo-4-methylphenol | 6627-55-0 | MFCD00002151 | 99.3% | 187.03 g/mol | C7H7BrO | 25 G
2-Bromo-4-methylphenol is a brominated phenolic reagent used in biochemical research and organic synthesis. It is a high-purity solid (C7H7BrO, 187.03 g/mol) suitable for assay development, small-molecule synthesis, and use as a synthetic building block. The compound is soluble in DMSO and has recommended storage conditions to maintain stability and shelf life.
- High purity (~99.3%) suitable for analytical and synthetic applications.
- Soluble in DMSO at 100 mg/mL for concentrated stock solutions.
- In vivo formulation protocols available for dosing at ≥5 mg/mL.
- Stable when stored at -20°C in pure form, with extended shelf life under recommended conditions.
- Useful as a building block for phenolic derivatization and halogenated intermediate synthesis.
Chem-Impex International, Inc. 1,5-Diphenylcarbazone compound with 1,5-Diphenylcarbazide | MFCD00013218 | 25G
1,5-Diphenylcarbazone compound with 1,5-Diphenylcarbazide, MFCD00013218, 25G
Medchemexpress LLC Leriglitazone hydrochloride | 146062-46-6 | 99.6% | 408.90 | C19H21ClN2O4S | 50 MG
Leriglitazone hydrochloride is a research-grade PPARγ agonist used to investigate neuroprotective, anti-inflammatory, and antioxidant mechanisms. Supplied as a solid for laboratory use, the compound is characterized for purity and recommended storage conditions.
- High purity: 99.6%.
- PPARγ agonist with neuroprotective and anti-inflammatory activity.
- Solid, white to light yellow, suitable for handling in laboratory assays.
- Available in milligram-scale packages for research studies.
- Stable when stored sealed and protected from moisture; in solvent, -80 °C for up to six months.
- Molecular weight 408.90; formula C19H21ClN2O4S.
Medchemexpress LLC (+)-PD 128907 hydrochloride | 300576-59-4 | 99.5% | 285.77 | 25 MG
(+)-PD 128907 hydrochloride is a selective dopamine D2/D3 receptor agonist. It functions as a biochemical reagent and can be utilized as a biological material or organic compound for life science research. It exhibits high selectivity for dopamine D3 receptors over D2 receptors.
- Potent and selective dopamine D3 receptor agonist.
- Acts on D2 and D3 dopamine receptors.
- Inhibits dialysate DA levels in D3 knockout mice.
- Displaces [3H]spiperone binding from dopamine D3 receptors.
- Involved in GPCR/G protein and neuronal signaling pathways.
Medchemexpress LLC Pipendoxifene hydrochloride | 245124-69-0 | 99.8% | 493.04 | 50 MG
Pipendoxifene hydrochloride is a selective estrogen receptor modulator (SERM) that can be used for the research of breast cancer.
- Selective estrogen receptor modulator (SERM)
- Used for the research of breast cancer
Medchemexpress LLC M-PEG3-0-benzaldehyde | 153364-63-7 | >98% | C14H20O5 | 1 G
m-PEG3-0-benzaldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC (S)-Remoxipride hydrochloride | 73220-03-8 | 99.9% | 407.8 g·mol⁻¹ | C16H23BrN2O3·HCl | 50 MG
(S)-Remoxipride hydrochloride is the S-enantiomer of remoxipride, supplied as the hydrochloride salt for research use. It acts as a selective dopamine D2 receptor antagonist and is provided at high purity for in vitro and in vivo pharmacology studies.
- S-enantiomer with selective dopamine D2 receptor antagonist activity.
- Provided as the hydrochloride salt, white to off-white solid.
- High purity suitable for research applications.
- Commonly used in receptor binding and pharmacological assays.
- Available in small research quantities (e.g., 50 mg).